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TTC26 Gene

protein-coding   GIFtS: 50
GCID: GC07P138818

Tetratricopeptide Repeat Domain 26

  Search for TTC26
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetratricopeptide Repeat Domain 261 2
TPR Repeat Protein 262 3
DYF132
dyf-132
Tetratricopeptide Repeat Protein 262

External Ids:    HGNC: 218821   Entrez Gene: 799892   Ensembl: ENSG000001059487   UniProtKB: A0AVF13   

Export aliases for TTC26 gene to outside databases

Previous GC identifers: GC07P138469 GC07P133128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTC26 Gene:
TTC26 (tetratricopeptide repeat domain 26) is a protein-coding gene.

UniProtKB/Swiss-Prot: TTC26_HUMAN, A0AVF1
Function: May play a critical role in ciliogenesis and normal cilia function (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTC26 gene promoter:
         E2F-3a   E2F-4   E2F-5   HSF1 (long)   CUTL1   E2F-2   Evi-1   E2F-1   E2F   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTC26 promoter sequence
   Search Chromatin IP Primers for TTC26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTC26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

TTC26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC26 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P138818:  view genomic region     (about GC identifiers)

Start:
138,818,490 bp from pter      End:
138,876,732 bp from pter
Size:
58,243 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 138,163,056-138,219,118     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTC26_HUMAN, A0AVF1 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 26  
Size: 554 amino acids; 64178 Da
Sequence caution: Sequence=EAL24039.1; Type=Erroneous initiation;
Secondary accessions: A4D1S3 B7Z5M0 C9J2N7 F8W724 Q9H9S8 Q9NTC0
Alternative splicing: 3 isoforms:  A0AVF1-1   A0AVF1-2   A0AVF1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTC26: NX_A0AVF1

Explore proteomics data for TTC26 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys257
  • Modification sites at PhosphoSitePlus

  • See TTC26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001138392.1  NP_001138395.1  NP_001274441.1  NP_001274442.1  NP_079202.2  

    ENSEMBL proteins: 
     ENSP00000418788   ENSP00000443253   ENSP00000419178   ENSP00000419279   ENSP00000339135  
     ENSP00000419639   ENSP00000410655  

    TTC26 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TTC26
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    Cloud-Clone Corp. Proteins for TTC26

     
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    Search eBioscience for ELISAs for TTC26 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFT: Intraflagellar transport homologs
    TTC: Tetratricopeptide (TTC) repeat domain containing

    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry A0AVF1

    ProtoNet protein and cluster: A0AVF1

    UniProtKB/Swiss-Prot: TTC26_HUMAN, A0AVF1
    Similarity: Contains 4 TPR repeats


    Find genes that share domains with TTC26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTC26_HUMAN, A0AVF1
    Function: May play a critical role in ciliogenesis and normal cilia function (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TTC26           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TTC26:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTC26
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTC26

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    miRNA
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    miRTarBase miRNAs that target TTC26:
    hsa-let-7a-5p (MIRT052556)

    Block miRNA regulation of human, mouse, rat TTC26 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TTC26:
    hsa-miR-124 hsa-miR-137 hsa-miR-593* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTTC26 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TTC26

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC26


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTC26_HUMAN, A0AVF1: Cell projection, cilium (By similarity). Note=Localizes at the base to the ciliary
    transition zone (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005929cilium ----
    GO:0036064ciliary basal body IEA--
    GO:0072372primary cilium ISS--

    Find genes that share ontologies with TTC26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTC26
    Interactions:

        Search GeneGlobe Interaction Network for TTC26

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TTC26 (A0AVF13 ENSP000004192794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WIPI2Q9Y4P83I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042384cilium assembly ISS--

    Find genes that share ontologies with TTC26           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTC26



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTC26 gene (5 alternative transcripts): 
    NM_001144920.2  NM_001144923.2  NM_001287512.1  NM_001287513.1  NM_024926.3  

    Unigene Cluster for TTC26:

    Tetratricopeptide repeat domain 26
    Hs.644553  [show with all ESTs]
    Unigene Representative Sequence: BC034466
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495038 ENST00000479132 ENST00000474035(uc003vuq.2) ENST00000478836
    ENST00000464848(uc003vus.2 uc011kqo.1 uc011kqp.1 uc011kqq.1)
    ENST00000481482(uc003vur.4) ENST00000343187 ENST00000476296(uc003vut.2)
    ENST00000468866 ENST00000430935(uc011kqm.1 uc011kqn.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TTC26 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TTC26:
    hsa-miR-124 hsa-miR-137 hsa-miR-593* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTTC26 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TTC26
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    GenScript: all cDNA clones in your preferred vector (see all 3): TTC26 (NM_024926)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TTC26
      QuantiFast Probe-based Assays in human, mouse, rat TTC26

    Additional mRNA sequence: 

    AK022633.1 AK293444.1 AK295092.1 AK299132.1 AK300807.1 AL137393.1 BC013912.1 BC034466.1 
    BC126331.1 BC130339.1 BC144151.1 

    9 DOTS entries:

    DT.436141  DT.95269125  DT.110028  DT.100778702  DT.121036464  DT.100843449  DT.75142937  DT.95210097 
    DT.121036461 

    Selected AceView cDNA sequences (see all 59):

    BF062002 BU676182 CB145788 BX280580 BX420428 BM462302 N26633 AI652882 
    BC013912 AI375270 BP356733 AL044528 AA889084 BI822230 AL137393 AA465643 
    BX509659 BU531877 NM_024926 AI687027 BG150368 BX327891 AK022633 AA307102 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTC26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAATGGG
    TTC26 Expression
    About this image

    TTC26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTC26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644553
        Custom PCR Arrays for TTC26
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TTC26 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc261 , 5 tetratricopeptide repeat domain 261, 5 90.73(n)1
    96.39(a)1
      6 (17.76 cM)5
    2641341  NM_153600.21  NP_705828.21 
     383814695 
    chicken
    (Gallus gallus)
    Aves TTC261 tetratricopeptide repeat domain 26 78.16(n)
    86.1(a)
      417969  XM_004937683.1  XP_004937740.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTC266
    tetratricopeptide repeat domain 26
    90(a)
    1 ↔ 1
    GL343614.1(322060-351360)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.103132 Xenopus laevis transcribed sequence with moderate similarity more 78.82(n)    BU906838.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145252 Transcribed sequence with moderate similarity to protein more 75.75(n)    CK362868.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45251 CG4525 58.61(n)
    56.37(a)
      41905  NM_142229.3  NP_650486.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dyf-131 dyf-13 49.19(n)
    39.66(a)
      182970  NM_171019.1  NP_741021.1 


    ENSEMBL Gene Tree for TTC26 (if available)
    TreeFam Gene Tree for TTC26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTC26 (see all 1109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393581691,2
    C--138816514(+) ATCTGC/TAAGAG 3 -- us2k10--------
    rs1858350081,2
    --138816545(+) TGTTGC/TTTGGT 3 -- us2k10--------
    rs38136971,2
    C,F,A,H--138816558(-) catgcG/Atctgt 3 -- us2k17Minor allele frequency- A:0.33NA WA CSA EA 365
    rs38136961,2
    C,F,A,H--138816560(-) aacatC/Gcgtct 3 -- us2k18Minor allele frequency- G:0.41NA WA CSA EA 367
    rs38136951,2
    C,F,A,H--138816604(-) attgcG/Ataaac 3 -- us2k1 tfbs327Minor allele frequency- A:0.31NS EA NA WA CSA 2140
    rs745076511,2
    C,F--138816605(+) TTTACG/ACAATA 3 -- us2k12Minor allele frequency- A:0.18CSA WA 120
    rs1395829591,2
    C--138816660(+) CACTT-/AGATTC 3 -- us2k10--------
    rs96327731,2
    C,F,H--138816717(+) atgtaG/Caggcc 3 -- us2k111Minor allele frequency- C:0.42NA WA CSA EA 372
    rs1479373611,2
    --138816742(+) ACAAA-/AG    
       GCCCT
    AAATA
    3 -- us2k10--------
    rs77788251,2
    C,F,A,H--138816931(+) ttaatG/Aactga 3 -- us2k1 tfbs323Minor allele frequency- A:0.48NS EA NA WA CSA 2348

    HapMap Linkage Disequilibrium report for TTC26 (138818490 - 138876732 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TTC26:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735212CNV Deletion23290073
    esv2669645CNV Deletion23128226
    nsv831155CNV Loss17160897
    dgv2141e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTC26
    DNA2.0 Custom Variant and Variant Library Synthesis for TTC26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases from the University of Copenhagen DISEASES database for TTC26:
    Bardet-Biedl syndrome     Fundus dystrophy

    Find genes that share disorders with TTC26           About GenesLikeMe

    Genetic Association Database (GAD): TTC26
    Human Genome Epidemiology (HuGE) Navigator: TTC26 (3 documents)

    Export disorders for TTC26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTC26 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TTC26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (Science 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79989 HGNC: 21882 AceView: FLJ12571 Ensembl:ENSG00000105948 euGenes: HUgn79989
    ECgene: TTC26 H-InvDB: TTC26

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TTC26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TTC26 gene:
    Search GeneIP for patents involving TTC26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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