TTC26 Gene
protein-coding GIFtS: 45
GCID: GC07P138818
|
|
tetratricopeptide repeat domain 26
| |
Aliases
for TTC26 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 261 2 | | DYF131 2 | | Dyf-131 | | TPR Repeat Protein 262 3 | | FLJ125711 | | Tetratricopeptide Repeat Protein 262 |
Export aliases for TTC26 gene to outside databasesPrevious GC identifers: GC07P138469 GC07P133128 |
Summaries
for TTC26 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TTC26_HUMAN, A0AVF1Function: May play a critical role in ciliogenesis and normal cilia function (By similarity)
|
Genomic Views
for TTC26 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC26 gene promoter:
E2F-3a E2F-4 E2F-5 HSF1 (long) CUTL1 E2F-2 Evi-1 E2F-1 E2F HSF1short
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC26
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC26 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34TTC26 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P138818: view genomic region
(about GC identifiers)
Start:
|
138,818,490 bp from pter |
End:
|
138,876,732 bp from pter |
Size:
|
58,243 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 138,163,056-138,219,118 |
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Proteins
for TTC26 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC26_HUMAN, A0AVF1 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 26 Size: 554 amino acids; 64178 Da
Subcellular location: Cell projection, cilium (By similarity). Note=Localizes at the base to the ciliary transitionzone (By similarity)
Sequence caution: Sequence=EAL24039.1; Type=Erroneous initiation;
Secondary accessions: A4D1S3 B7Z5M0 C9J2N7 F8W724 Q9H9S8 Q9NTC0Alternative splicing: 3 isoforms: A0AVF1-1 A0AVF1-2 A0AVF1-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TTC26: NX_A0AVF1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A0AVF1
TTC26 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001138392.1 NP_001138395.1 NP_079202.2
ENSEMBL proteins: ENSP00000418788 ENSP00000443253 ENSP00000419178 ENSP00000419279 ENSP00000339135 ENSP00000419639 ENSP00000410655
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0072372 | primary cilium |
ISS | -- |
TTC26 for ontologies About GeneDecksing
TTC26 Antibody Products:
Assay Products for TTC26: |
Protein
Domains /
Families
for TTC26 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC26 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A0AVF1ProtoNet protein and cluster: A0AVF1 UniProtKB/Swiss-Prot: TTC26_HUMAN, A0AVF1Similarity: Contains 4 TPR repeats |
Function
for TTC26 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TTC26_HUMAN, A0AVF1Function: May play a critical role in ciliogenesis and normal cilia function (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC26 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC26 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TTC26 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC26 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC26 |
1 GenomeRNAi human phenotype for TTC26:
|
Pathways & Interactions
for TTC26 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC26
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for TTC26 (A0AVF13 ENSP000004192794) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042384 | cilium assembly |
ISS | -- |
TTC26 for ontologies About GeneDecksing
|
Drugs & Compounds
for TTC26 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC26
Search CenterWatch for drugs/clinical trials and news about TTC26
|
Transcripts
for TTC26 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC26 gene (3 alternative transcripts): NM_001144920.1 NM_001144923.1 NM_024926.2 Unigene Cluster for TTC26: Tetratricopeptide repeat domain 26 Hs.644553 [show with all ESTs]Unigene Representative Sequence: BC03446610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495038 ENST00000479132 ENST00000474035(uc003vuq.2) ENST00000478836
ENST00000464848(uc003vus.2 uc011kqo.1 uc011kqp.1 uc011kqq.1)
ENST00000481482(uc003vur.4) ENST00000343187 ENST00000476296(uc003vut.2)
ENST00000468866 ENST00000430935(uc011kqm.1 uc011kqn.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC26 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC26 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TTC26 (NM_024926) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC26 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC26 |
Additional cDNA sequence: AK022633.1 AK293444.1 AK295092.1 AK299132.1 AK300807.1 AL137393.1 BC013912.1 BC034466.1 BC126331.1 BC130339.1 BC144151.1 9 DOTS entries: DT.436141 DT.95269125 DT.110028 DT.100778702 DT.121036464 DT.100843449 DT.75142937 DT.95210097 DT.121036461 24/59 AceView cDNA sequences (see all 59): AA889084 AL137393 AL044528 BM462302 BI822230 AI375270 BC013912 CB145788 BF062002 AI652882 BP356733 BX420428 BX280580 N26633 BU676182 AA465643 AA329417 AI687027 BP363212 BX327891 CD704513 BP368918 CB145797 AK022633
GeneLoc Exon Structure
|
Expression
for TTC26 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAAATGGG
About this image
See TTC26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC26
SOURCE GeneReport for Unigene cluster: Hs.644553
SABiosciences Custom PCR Arrays for TTC26
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC26
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC26 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC26 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC26 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC26 |
Orthologs
for TTC26 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TTC26 gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for TTC26 (if available)
TreeFam Gene Tree for TTC26 (if available) |
Paralogs
for TTC26 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TTC26 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC26 (138818490 - 138876732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TTC26
2 CNVs: 3705 4562
3 Indels: 94894 82199 82198 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC26 |
|
Disorders
/ Diseases
for TTC26 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TTC26 for disorders About GeneDecksing
3  diseases for TTC26: About MalaCardsbardet-biedl syndrome hermaphroditism neuronitis
Human Genome Epidemiology (HuGE) Navigator: TTC26 (3 documents)
Export disorders for TTC26 gene to outside databases
|
Publications
for TTC26 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC26 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TTC26) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
|
External Searches for TTC26 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTC26 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC26 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC26 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC26 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTC26 gene:
Search GeneIP for patents involving TTC26
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC26 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC26 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC26 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC26 | | | OriGene Protein Over-expression Lysate for TTC26 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC26 | | OriGene 3'-UTR Clone for TTC26 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC26 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC26 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for TTC26 |
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 | | | TTC26 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC26 |
|  |  |  | | | | ThermoFisher Antibodies for TTC26 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC26 |
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