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Aliases for TTC26 Gene

Aliases for TTC26 Gene

  • Tetratricopeptide Repeat Domain 26 2 3 5
  • Tetratricopeptide Repeat Protein 26 3 4
  • TPR Repeat Protein 26 3 4
  • IFT56 3 4
  • Intraflagellar Transport Protein 56 3
  • Dyf-13 3
  • DYF13 3

External Ids for TTC26 Gene

Previous GeneCards Identifiers for TTC26 Gene

  • GC07P138469
  • GC07P138818
  • GC07P133128

Summaries for TTC26 Gene

GeneCards Summary for TTC26 Gene

TTC26 (Tetratricopeptide Repeat Domain 26) is a Protein Coding gene. Diseases associated with TTC26 include Joubert Syndrome 1. Among its related pathways are Intraflagellar transport and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for TTC26 Gene

  • Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.

Additional gene information for TTC26 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC26 Gene

Genomics for TTC26 Gene

Regulatory Elements for TTC26 Gene

Enhancers for TTC26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H139101 2.1 FANTOM5 Ensembl ENCODE dbSUPER 32 -25.9 -25884 11 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 LUC7L2 UBN2 TTC26 ZC3HAV1 ZC3HAV1L PARP12 RPL17P28
GH07H138527 1 ENCODE 35 -605.2 -605151 0 PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ZNF143 ATF7 CEBPZ LUC7L2 TTC26 UBN2 RPS3AP28 ENSG00000252188 GC07M138626
GH07H139339 1.5 ENCODE dbSUPER 18.7 +207.9 207915 3 MLX DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 LUC7L2 UBN2 ENSG00000273391 TTC26 KLRG2 LOC100499191 C7orf55-LUC7L2
GH07H138349 1.6 FANTOM5 ENCODE dbSUPER 13 -780.9 -780929 4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 SLC30A9 ZNF766 CBX5 LUC7L2 UBN2 TRIM24 TTC26 SVOPL CREB3L2 RPS17P12 GC07M138404
GH07H139482 1.1 Ensembl ENCODE 17.2 +350.1 350132 1 RING1 CTCF MXI1 PKNOX1 KLF1 ZNF384 ZIC2 ZNF2 GLIS2 POLR2A TTC26 UBN2 KLRG2 RNU6-911P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC26 on UCSC Golden Path with GeneCards custom track

Promoters for TTC26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218918 330 1401 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for TTC26 Gene

Chromosome:
7
Start:
139,133,370 bp from pter
End:
139,191,986 bp from pter
Size:
58,617 bases
Orientation:
Plus strand

Genomic View for TTC26 Gene

Genes around TTC26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC26 Gene

Proteins for TTC26 Gene

  • Protein details for TTC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVF1-IFT56_HUMAN
    Recommended name:
    Intraflagellar transport protein 56
    Protein Accession:
    A0AVF1
    Secondary Accessions:
    • A4D1S3
    • B7Z5M0
    • C9J2N7
    • F8W724
    • Q9H9S8
    • Q9NTC0

    Protein attributes for TTC26 Gene

    Size:
    554 amino acids
    Molecular mass:
    64178 Da
    Quaternary structure:
    • Component of the IFT complex B. Interacts with IFT46; the interaction is direct.
    SequenceCaution:
    • Sequence=EAL24039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC26 Gene

Post-translational modifications for TTC26 Gene

  • Ubiquitination at Lys257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC26 Gene

Domains & Families for TTC26 Gene

Protein Domains for TTC26 Gene

Suggested Antigen Peptide Sequences for TTC26 Gene

Graphical View of Domain Structure for InterPro Entry

A0AVF1

UniProtKB/Swiss-Prot:

IFT56_HUMAN :
  • Belongs to the IFT56 family.
Family:
  • Belongs to the IFT56 family.
genes like me logo Genes that share domains with TTC26: view

Function for TTC26 Gene

Molecular function for TTC26 Gene

UniProtKB/Swiss-Prot Function:
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.

Phenotypes From GWAS Catalog for TTC26 Gene

Gene Ontology (GO) - Molecular Function for TTC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with TTC26: view
genes like me logo Genes that share phenotypes with TTC26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC26 Gene

Localization for TTC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC26 Gene

Cell projection, cilium. Note=Localizes at the base to the ciliary transition zone. {ECO:0000250 UniProtKB:Q8BS45}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC26 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TTC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IEA --
GO:0005929 cilium TAS --
GO:0030992 intraciliary transport particle B ISS --
GO:0036064 ciliary basal body IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TTC26: view

Pathways & Interactions for TTC26 Gene

genes like me logo Genes that share pathways with TTC26: view

Pathways by source for TTC26 Gene

Gene Ontology (GO) - Biological Process for TTC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007224 smoothened signaling pathway ISS --
GO:0007286 spermatid development IEA --
GO:0015031 protein transport IEA --
GO:0035735 intraciliary transport involved in cilium assembly TAS --
genes like me logo Genes that share ontologies with TTC26: view

No data available for SIGNOR curated interactions for TTC26 Gene

Drugs & Compounds for TTC26 Gene

No Compound Related Data Available

Transcripts for TTC26 Gene

Unigene Clusters for TTC26 Gene

Tetratricopeptide repeat domain 26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC26 Gene

No ASD Table

Relevant External Links for TTC26 Gene

GeneLoc Exon Structure for
TTC26
ECgene alternative splicing isoforms for
TTC26

Expression for TTC26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTC26 Gene

This gene is overexpressed in Testis (45.5) and Urine (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC26 Gene



Protein tissue co-expression partners for TTC26 Gene

NURSA nuclear receptor signaling pathways regulating expression of TTC26 Gene:

TTC26

SOURCE GeneReport for Unigene cluster for TTC26 Gene:

Hs.644553

Evidence on tissue expression from TISSUES for TTC26 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TTC26: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC26 Gene

Orthologs for TTC26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC26 33 34
  • 99.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TTC26 33 34
  • 93.62 (n)
cow
(Bos Taurus)
Mammalia TTC26 33 34
  • 93.5 (n)
rat
(Rattus norvegicus)
Mammalia Ttc26 33
  • 90.79 (n)
mouse
(Mus musculus)
Mammalia Ttc26 33 16 34
  • 90.73 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC26 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC26 33 34
  • 78.16 (n)
lizard
(Anolis carolinensis)
Reptilia TTC26 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc26 33
  • 77.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10313 33
zebrafish
(Danio rerio)
Actinopterygii ttc26 33 34
  • 72.44 (n)
Dr.14525 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2641 33
fruit fly
(Drosophila melanogaster)
Insecta CG4525 33 34
  • 58.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001809 33
  • 56.97 (n)
worm
(Caenorhabditis elegans)
Secernentea dyf-13 33 34
  • 49.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 75 (a)
OneToOne
Species where no ortholog for TTC26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC26 Gene

ENSEMBL:
Gene Tree for TTC26 (if available)
TreeFam:
Gene Tree for TTC26 (if available)

Paralogs for TTC26 Gene

No data available for Paralogs for TTC26 Gene

Variants for TTC26 Gene

Sequence variations from dbSNP and Humsavar for TTC26 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000009137 -- 139,155,415(+) TATTT(C/T)ACTGT intron-variant
rs1000029123 -- 139,175,099(+) ACTGA(C/T)CATCA intron-variant
rs1000042011 -- 139,175,331(+) CACTA(A/C)AAATA intron-variant
rs1000066498 -- 139,155,023(+) TATGG(A/G)GCAAG intron-variant
rs1000101529 -- 139,167,537(+) GGATA(A/G)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC26 Gene

Variant ID Type Subtype PubMed ID
esv2669645 CNV deletion 23128226
esv2735212 CNV deletion 23290073
esv2759567 CNV gain 17122850
esv3368950 CNV insertion 20981092
esv3615209 CNV loss 21293372
nsv831155 CNV loss 17160897

Variation tolerance for TTC26 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC26 Gene

Disorders for TTC26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TTC26 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTC26

Genetic Association Database (GAD)
TTC26
Human Genome Epidemiology (HuGE) Navigator
TTC26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC26
genes like me logo Genes that share disorders with TTC26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC26 Gene

Publications for TTC26 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60

Products for TTC26 Gene

Sources for TTC26 Gene

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