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Aliases for TTC26 Gene

Aliases for TTC26 Gene

  • Tetratricopeptide Repeat Domain 26 2 3 5
  • Tetratricopeptide Repeat Protein 26 3 4
  • TPR Repeat Protein 26 3 4
  • IFT56 3 4
  • Dyf-13 3
  • DYF13 3

External Ids for TTC26 Gene

Previous GeneCards Identifiers for TTC26 Gene

  • GC07P138469
  • GC07P138818
  • GC07P133128

Summaries for TTC26 Gene

GeneCards Summary for TTC26 Gene

TTC26 (Tetratricopeptide Repeat Domain 26) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport.

UniProtKB/Swiss-Prot for TTC26 Gene

  • Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC26 Gene

Genomics for TTC26 Gene

Regulatory Elements for TTC26 Gene

Promoters for TTC26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC26 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC26 Gene

Chromosome:
7
Start:
139,133,370 bp from pter
End:
139,191,986 bp from pter
Size:
58,617 bases
Orientation:
Plus strand

Genomic View for TTC26 Gene

Genes around TTC26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC26 Gene

Proteins for TTC26 Gene

  • Protein details for TTC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AVF1-IFT56_HUMAN
    Recommended name:
    Intraflagellar transport protein 56
    Protein Accession:
    A0AVF1
    Secondary Accessions:
    • A4D1S3
    • B7Z5M0
    • C9J2N7
    • F8W724
    • Q9H9S8
    • Q9NTC0

    Protein attributes for TTC26 Gene

    Size:
    554 amino acids
    Molecular mass:
    64178 Da
    Quaternary structure:
    • Component of the IFT complex B. Interacts with IFT46; the interaction is direct.
    SequenceCaution:
    • Sequence=EAL24039.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC26 Gene

Proteomics data for TTC26 Gene at MOPED

Post-translational modifications for TTC26 Gene

  • Ubiquitination at Lys 257
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC26 Gene

Domains & Families for TTC26 Gene

Protein Domains for TTC26 Gene

Suggested Antigen Peptide Sequences for TTC26 Gene

Graphical View of Domain Structure for InterPro Entry

A0AVF1

UniProtKB/Swiss-Prot:

IFT56_HUMAN :
  • Belongs to the IFT56 family.
  • Contains 4 TPR repeats.
Family:
  • Belongs to the IFT56 family.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with TTC26: view

Function for TTC26 Gene

Molecular function for TTC26 Gene

UniProtKB/Swiss-Prot Function:
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.
genes like me logo Genes that share phenotypes with TTC26: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC26 Gene

Localization for TTC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC26 Gene

Cell projection, cilium. Note=Localizes at the base to the ciliary transition zone. {ECO:0000250 UniProtKB:Q8BS45}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC26 Gene COMPARTMENTS Subcellular localization image for TTC26 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0030992 intraciliary transport particle B ISS --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with TTC26: view

Pathways & Interactions for TTC26 Gene

genes like me logo Genes that share pathways with TTC26: view

Pathways by source for TTC26 Gene

Interacting Proteins for TTC26 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000419279%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000419279 A0AVF1-IFT56_HUMAN for TTC26 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TTC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway ISS --
GO:0015031 protein transport IEA --
GO:0042073 intraciliary transport ISS --
genes like me logo Genes that share ontologies with TTC26: view

No data available for SIGNOR curated interactions for TTC26 Gene

Drugs & Compounds for TTC26 Gene

No Compound Related Data Available

Transcripts for TTC26 Gene

Unigene Clusters for TTC26 Gene

Tetratricopeptide repeat domain 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC26 Gene

No ASD Table

Relevant External Links for TTC26 Gene

GeneLoc Exon Structure for
TTC26
ECgene alternative splicing isoforms for
TTC26

Expression for TTC26 Gene

mRNA expression in normal human tissues for TTC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTC26 Gene

This gene is overexpressed in Testis (45.5) and Urine (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TTC26 Gene



SOURCE GeneReport for Unigene cluster for TTC26 Gene Hs.644553

genes like me logo Genes that share expression patterns with TTC26: view

Protein tissue co-expression partners for TTC26 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC26 Gene

Orthologs for TTC26 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC26 36
  • 100 (a)
OneToOne
TTC26 35
  • 99.64 (n)
  • 99.82 (a)
cow
(Bos Taurus)
Mammalia TTC26 35
  • 93.5 (n)
  • 96.21 (a)
TTC26 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC26 36
  • 97 (a)
OneToOne
TTC26 35
  • 93.62 (n)
  • 97.29 (a)
mouse
(Mus musculus)
Mammalia Ttc26 36
  • 96 (a)
OneToOne
Ttc26 16
Ttc26 35
  • 90.73 (n)
  • 96.39 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC26 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ttc26 35
  • 90.79 (n)
  • 96.39 (a)
chicken
(Gallus gallus)
Aves TTC26 35
  • 78.16 (n)
  • 86.1 (a)
TTC26 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC26 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10313 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc26 35
  • 77.08 (n)
  • 86.1 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2641 35
zebrafish
(Danio rerio)
Actinopterygii ttc26 36
  • 80 (a)
OneToOne
Dr.14525 35
ttc26 35
  • 72.44 (n)
  • 79.78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001809 35
  • 56.97 (n)
  • 56.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4525 36
  • 51 (a)
OneToOne
CG4525 35
  • 58.61 (n)
  • 56.37 (a)
worm
(Caenorhabditis elegans)
Secernentea dyf-13 35
  • 49.19 (n)
  • 39.66 (a)
dyf-13 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 75 (a)
OneToOne
Species with no ortholog for TTC26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC26 Gene

ENSEMBL:
Gene Tree for TTC26 (if available)
TreeFam:
Gene Tree for TTC26 (if available)

Paralogs for TTC26 Gene

No data available for Paralogs for TTC26 Gene

Variants for TTC26 Gene

Sequence variations from dbSNP and Humsavar for TTC26 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs13225917 - 139,166,872(+) TTAAG(A/G)ATCTG reference, missense
rs2305330 -- 139,140,103(-) AATTT(C/T)TTTTT intron-variant
rs2305331 -- 139,133,765(-) CGGTA(A/T)CCCCG upstream-variant-2KB, utr-variant-5-prime
rs2249070 -- 139,187,599(+) AAATA(A/C)TTGTT intron-variant
rs2883601 -- 139,191,252(+) AGCTT(C/G/T)TGTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TTC26 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv831155 CNV Loss 17160897
dgv2141e1 CNV Complex 17122850
esv2669645 CNV Deletion 23128226

Variation tolerance for TTC26 Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC26 Gene

HapMap Linkage Disequilibrium report
TTC26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC26 Gene

Disorders for TTC26 Gene

Relevant External Links for TTC26

Genetic Association Database (GAD)
TTC26
Human Genome Epidemiology (HuGE) Navigator
TTC26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC26

No disorders were found for TTC26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC26 Gene

Publications for TTC26 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for TTC26 Gene

Sources for TTC26 Gene

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