External Ids for TTC25 Gene
Previous GeneCards Identifiers for TTC25 Gene
This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
GeneCards Summary for TTC25 Gene
TTC25 (Tetratricopeptide Repeat Domain 25) is a Protein Coding gene. Diseases associated with TTC25 include Ciliary Dyskinesia, Primary, 35 and Primary Ciliary Dyskinesia 35: Ttc25-Related Primary Ciliary Dyskinesia.
UniProtKB/Swiss-Prot for TTC25 Gene
Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility.