Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTC25 Gene

Aliases for TTC25 Gene

  • Tetratricopeptide Repeat Domain 25 2 3
  • TPR Repeat Protein 25 4

External Ids for TTC25 Gene

Summaries for TTC25 Gene

GeneCards Summary for TTC25 Gene

TTC25 (Tetratricopeptide Repeat Domain 25) is a Protein Coding gene.

Gene Wiki entry for TTC25 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC25 Gene

Genomics for TTC25 Gene

Genomic Location for TTC25 Gene

41,930,635 bp from pter
41,965,651 bp from pter
35,017 bases
Plus strand

Genomic View for TTC25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC25 Gene

Regulatory Elements for TTC25 Gene

Proteins for TTC25 Gene

  • Protein details for TTC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 25
    Protein Accession:
    Secondary Accessions:
    • Q6NX40
    • Q6PJ04
    • Q9H0K5

    Protein attributes for TTC25 Gene

    672 amino acids
    Molecular mass:
    76655 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH67297.1; Type=Frameshift; Positions=661; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC25 Gene


neXtProt entry for TTC25 Gene

Proteomics data for TTC25 Gene at MOPED

Post-translational modifications for TTC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC25 Gene

No data available for DME Specific Peptides for TTC25 Gene

Domains for TTC25 Gene

Gene Families for TTC25 Gene

  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC25 Gene

Suggested Antigen Peptide Sequences for TTC25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 TPR repeats.:
    • Q96NG3
genes like me logo Genes that share domains with TTC25: view

Function for TTC25 Gene

Gene Ontology (GO) - Molecular Function for TTC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC25: view

Phenotypes for TTC25 Gene

GenomeRNAi human phenotypes for TTC25:
genes like me logo Genes that share phenotypes with TTC25: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTC25 Gene

Localization for TTC25 Gene

Subcellular locations from

Jensen Localization Image for TTC25 Gene COMPARTMENTS Subcellular localization image for TTC25 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TTC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TTC25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC25 Gene

Pathways for TTC25 Gene

SuperPathways for TTC25 Gene

No Data Available

Interacting Proteins for TTC25 Gene

Gene Ontology (GO) - Biological Process for TTC25 Gene


No data available for Pathways by source for TTC25 Gene

Transcripts for TTC25 Gene

Unigene Clusters for TTC25 Gene

Tetratricopeptide repeat domain 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC25 Gene

No ASD Table

Relevant External Links for TTC25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC25 Gene

mRNA expression in normal human tissues for TTC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC25 Gene

This gene is overexpressed in Testis (18.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TTC25 Gene

SOURCE GeneReport for Unigene cluster for TTC25 Gene Hs.201134

genes like me logo Genes that share expressions with TTC25: view

No data available for mRNA Expression by UniProt/SwissProt for TTC25 Gene

Orthologs for TTC25 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTC25 35
  • 97.97 (n)
  • 96.87 (a)
(Bos Taurus)
Mammalia TTC25 35
  • 81.42 (n)
  • 79.31 (a)
(Canis familiaris)
Mammalia TTC25 35
  • 83.86 (n)
  • 80.27 (a)
(Mus musculus)
Mammalia Ttc25 35
  • 81.43 (n)
  • 81 (a)
Ttc25 16
(Rattus norvegicus)
Mammalia Ttc25 35
  • 81.59 (n)
  • 84.18 (a)
(Gallus gallus)
Aves TTC25 35
  • 68.72 (n)
  • 63.89 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1507 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc25 35
  • 66 (n)
  • 63.15 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7662 35
(Danio rerio)
Actinopterygii LOC100538088 35
  • 62.15 (n)
  • 58.05 (a)
zgc56362 35
fruit fly
(Drosophila melanogaster)
Insecta CG13502 35
  • 49.77 (n)
  • 41.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1274 35
Species with no ortholog for TTC25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC25 Gene

Gene Tree for TTC25 (if available)
Gene Tree for TTC25 (if available)

Paralogs for TTC25 Gene

No data available for Paralogs for TTC25 Gene

Variants for TTC25 Gene

Sequence variations from dbSNP and Humsavar for TTC25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2033675 -- 41,958,746(+) GAGGC(C/T)GGGTG intron-variant
rs2883066 -- 41,963,690(+) CTGGA(A/G)TGCAG intron-variant
rs3039814 -- 41,956,506(+) TTTTT(-/T/TT)AAATA intron-variant
rs3809878 -- 41,938,582(+) AAGGG(C/T)GGCCT reference, synonymous-codon, intron-variant
rs4260106 -- 41,955,791(+) TATTA(A/C)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC25 Gene

Variant ID Type Subtype PubMed ID
nsv833447 CNV Loss 17160897
nsv2056 CNV Insertion 18451855
nsv509658 CNV Insertion 20534489
esv994529 CNV Insertion 20482838

Relevant External Links for TTC25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC25 Gene

Disorders for TTC25 Gene

No disorders were found for TTC25 Gene.

No data available for UniProtKB/Swiss-Prot for TTC25 Gene

Publications for TTC25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3

Products for TTC25 Gene

Sources for TTC25 Gene

Back to Top