Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTC25 Gene

Aliases for TTC25 Gene

  • Tetratricopeptide Repeat Domain 25 2 3 5
  • TPR Repeat Protein 25 4

External Ids for TTC25 Gene

Previous GeneCards Identifiers for TTC25 Gene

  • GC17P037341
  • GC17P040086
  • GC17P035848

Summaries for TTC25 Gene

GeneCards Summary for TTC25 Gene

TTC25 (Tetratricopeptide Repeat Domain 25) is a Protein Coding gene.

Gene Wiki entry for TTC25 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC25 Gene

Genomics for TTC25 Gene

Regulatory Elements for TTC25 Gene

Enhancers for TTC25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC25 on UCSC Golden Path with GeneCards custom track

Promoters for TTC25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC25 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC25 Gene

41,930,617 bp from pter
41,965,651 bp from pter
35,035 bases
Plus strand

Genomic View for TTC25 Gene

Genes around TTC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC25 Gene

Proteins for TTC25 Gene

  • Protein details for TTC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 25
    Protein Accession:
    Secondary Accessions:
    • Q6NX40
    • Q6PJ04
    • Q9H0K5

    Protein attributes for TTC25 Gene

    672 amino acids
    Molecular mass:
    76655 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH67297.1; Type=Frameshift; Positions=661; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC25 Gene


neXtProt entry for TTC25 Gene

Proteomics data for TTC25 Gene at MOPED

Post-translational modifications for TTC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC25 Gene

No data available for DME Specific Peptides for TTC25 Gene

Domains & Families for TTC25 Gene

Gene Families for TTC25 Gene

Protein Domains for TTC25 Gene

Suggested Antigen Peptide Sequences for TTC25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 TPR repeats.
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with TTC25: view

Function for TTC25 Gene

Phenotypes for TTC25 Gene

genes like me logo Genes that share phenotypes with TTC25: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC25 Gene

Localization for TTC25 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TTC25 Gene

Pathways & Interactions for TTC25 Gene

SuperPathways for TTC25 Gene

No Data Available

Interacting Proteins for TTC25 Gene

Gene Ontology (GO) - Biological Process for TTC25 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC25 Gene

Drugs & Compounds for TTC25 Gene

No Compound Related Data Available

Transcripts for TTC25 Gene

Unigene Clusters for TTC25 Gene

Tetratricopeptide repeat domain 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC25 Gene

No ASD Table

Relevant External Links for TTC25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC25 Gene

mRNA expression in normal human tissues for TTC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC25 Gene

This gene is overexpressed in Testis (x18.0).

Protein differential expression in normal tissues from HIPED for TTC25 Gene

This gene is overexpressed in Testis (32.2), Frontal cortex (18.9), and Rectum (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TTC25 Gene

SOURCE GeneReport for Unigene cluster for TTC25 Gene Hs.201134

genes like me logo Genes that share expression patterns with TTC25: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTC25 Gene

Orthologs for TTC25 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC25 35
  • 81.42 (n)
  • 79.31 (a)
(Canis familiaris)
Mammalia TTC25 35
  • 83.86 (n)
  • 80.27 (a)
(Mus musculus)
Mammalia Ttc25 35
  • 81.43 (n)
  • 81 (a)
Ttc25 16
(Pan troglodytes)
Mammalia TTC25 35
  • 97.97 (n)
  • 96.87 (a)
(Rattus norvegicus)
Mammalia Ttc25 35
  • 81.59 (n)
  • 84.18 (a)
(Gallus gallus)
Aves TTC25 35
  • 68.72 (n)
  • 63.89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc25 35
  • 66 (n)
  • 63.15 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1507 35
(Danio rerio)
Actinopterygii LOC100538088 35
  • 62.15 (n)
  • 58.05 (a)
zgc56362 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7662 35
fruit fly
(Drosophila melanogaster)
Insecta CG13502 35
  • 49.77 (n)
  • 41.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1274 35
Species with no ortholog for TTC25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC25 Gene

Gene Tree for TTC25 (if available)
Gene Tree for TTC25 (if available)

Paralogs for TTC25 Gene

No data available for Paralogs for TTC25 Gene

Variants for TTC25 Gene

Sequence variations from dbSNP and Humsavar for TTC25 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_031758 -
VAR_031759 -
rs2033675 -- 41,958,746(+) GAGGC(C/T)GGGTG intron-variant
rs3039814 -- 41,956,506(+) TTTTT(-/T/TA/TT/TTA)AAATA intron-variant
rs4260106 -- 41,955,791(+) TATTA(A/C)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC25 Gene

Variant ID Type Subtype PubMed ID
nsv833447 CNV Loss 17160897
nsv2056 CNV Insertion 18451855
nsv509658 CNV Insertion 20534489
esv994529 CNV Insertion 20482838

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for TTC25 Gene

Disorders for TTC25 Gene

Relevant External Links for TTC25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC25 Gene

Publications for TTC25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for TTC25 Gene

Sources for TTC25 Gene