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Aliases for TTC23L Gene

Aliases for TTC23L Gene

  • Tetratricopeptide Repeat Domain 23 Like 2 3 5
  • Tetratricopeptide Repeat Protein 23-Like 3
  • Tetratricopeptide Repeat Domain 23-Like 2
  • MC25-1 3

External Ids for TTC23L Gene

Previous GeneCards Identifiers for TTC23L Gene

  • GC05P034876
  • GC05P034840
  • GC05P034787

Summaries for TTC23L Gene

GeneCards Summary for TTC23L Gene

TTC23L (Tetratricopeptide Repeat Domain 23 Like) is a Protein Coding gene. An important paralog of this gene is TTC23.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC23L Gene

Genomics for TTC23L Gene

Regulatory Elements for TTC23L Gene

Enhancers for TTC23L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G034714 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -121.5 -121506 5.2 JUN TEAD4 ZNF140 SIN3A MAX FEZF1 RBBP5 CHD7 GATA2 POLR2A TTC23L RAI14 LOC105374753 GC05P034707 PIR47065
GH05G034585 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -251.8 -251779 3.9 HDGF FOXA2 PKNOX1 ARNT SIN3A ZNF766 FOS ZNF263 JUNB SMARCB1 RAI14 LOC105374753 TTC23L LOC105374721
GH05G034682 1.6 Ensembl ENCODE dbSUPER 10.3 -153.0 -152971 7.2 FOXA2 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 SP3 RAI14 LOC105374753 TTC23L GC05P034707
GH05G034596 1.5 Ensembl ENCODE dbSUPER 9.8 -240.2 -240199 3.5 PKNOX1 FEZF1 ZNF2 GATA2 KLF7 FOS ZNF263 SP3 JUNB TSHZ1 BRIX1 LOC643373 TTC23L LOC105374721 RAI14
GH05G034720 0.9 ENCODE dbSUPER 15.7 -117.4 -117387 1.3 GATAD2A MAX CEBPB CEBPG RAD21 YY1 FOXA1 JUND CEBPA HNF4A TTC23L LOC105374753 RAI14 PIR47065 GC05P034707
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC23L on UCSC Golden Path with GeneCards custom track

Promoters for TTC23L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000179384 367 1201 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for TTC23L Gene

34,838,833 bp from pter
34,899,650 bp from pter
60,818 bases
Plus strand

Genomic View for TTC23L Gene

Genes around TTC23L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC23L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC23L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC23L Gene

Proteins for TTC23L Gene

  • Protein details for TTC23L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 23-like
    Protein Accession:
    Secondary Accessions:
    • G8IJH6
    • Q6RGS4
    • Q8N7R3
    • Q96LJ2

    Protein attributes for TTC23L Gene

    361 amino acids
    Molecular mass:
    40837 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK097766; Type=Frameshift; Positions=52; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC23L Gene


neXtProt entry for TTC23L Gene

Post-translational modifications for TTC23L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC23L Gene

Domains & Families for TTC23L Gene

Protein Domains for TTC23L Gene

Suggested Antigen Peptide Sequences for TTC23L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC23L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TTC23L Gene

Function for TTC23L Gene

Gene Ontology (GO) - Molecular Function for TTC23L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
genes like me logo Genes that share ontologies with TTC23L: view
genes like me logo Genes that share phenotypes with TTC23L: view

Animal Model Products

CRISPR Products

miRNA for TTC23L Gene

miRTarBase miRNAs that target TTC23L

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC23L Gene

Localization for TTC23L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC23L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Exhibits dynamic subcellular localization during the cell cycle. In prophase cells, detected on split centrosomes. Translocates to the mitotic spindles during metaphase and early anaphase, then to the midbody and cleavage furrow in late anaphase. {ECO:0000269 PubMed:25751302}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC23L gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TTC23L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with TTC23L: view

Pathways & Interactions for TTC23L Gene

SuperPathways for TTC23L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC23L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034976 response to endoplasmic reticulum stress NAS 25751302
genes like me logo Genes that share ontologies with TTC23L: view

No data available for Pathways by source and SIGNOR curated interactions for TTC23L Gene

Drugs & Compounds for TTC23L Gene

No Compound Related Data Available

Transcripts for TTC23L Gene

Unigene Clusters for TTC23L Gene

Tetratricopeptide repeat domain 23-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC23L Gene

No ASD Table

Relevant External Links for TTC23L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC23L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC23L Gene

mRNA differential expression in normal tissues according to GTEx for TTC23L Gene

This gene is overexpressed in Testis (x18.2).

Protein differential expression in normal tissues from HIPED for TTC23L Gene

This gene is overexpressed in Fetal Brain (49.2) and Platelet (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC23L Gene

Protein tissue co-expression partners for TTC23L Gene

NURSA nuclear receptor signaling pathways regulating expression of TTC23L Gene:


SOURCE GeneReport for Unigene cluster for TTC23L Gene:

genes like me logo Genes that share expression patterns with TTC23L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC23L Gene

Orthologs for TTC23L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC23L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTC23L 34 35
  • 97.96 (n)
(Canis familiaris)
Mammalia TTC23L 34 35
  • 86.72 (n)
(Rattus norvegicus)
Mammalia Ttc23l 34
  • 80.66 (n)
(Bos Taurus)
Mammalia TTC23L 34 35
  • 79.38 (n)
(Mus musculus)
Mammalia Ttc23l 34 16 35
  • 79.25 (n)
(Monodelphis domestica)
Mammalia TTC23L 35
  • 39 (a)
(Anolis carolinensis)
Reptilia TTC23L 35
  • 28 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc23l 34
  • 56.61 (n)
Species where no ortholog for TTC23L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTC23L Gene

Gene Tree for TTC23L (if available)
Gene Tree for TTC23L (if available)

Paralogs for TTC23L Gene

Paralogs for TTC23L Gene

genes like me logo Genes that share paralogs with TTC23L: view

Variants for TTC23L Gene

Sequence variations from dbSNP and Humsavar for TTC23L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000138652 -- 34,865,420(+) TTAAG(A/T)CCACA intron-variant
rs1000142343 -- 34,846,278(+) AAAAT(A/G)GCTGG intron-variant
rs1000205618 -- 34,853,552(+) GGGAA(G/T)AGAAT intron-variant
rs1000258075 -- 34,867,327(+) ATCTC(A/T)GTTGG intron-variant, utr-variant-3-prime
rs1000277220 -- 34,845,989(+) GCCAG(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC23L Gene

Variant ID Type Subtype PubMed ID
dgv1020e199 CNV deletion 23128226
dgv5629n100 CNV gain 25217958
esv1002836 CNV deletion 20482838
esv2235962 CNV deletion 18987734
esv2664297 CNV deletion 23128226
esv2730057 CNV deletion 23290073
esv2730058 CNV deletion 23290073
esv3565797 CNV deletion 23714750
esv3604679 CNV gain 21293372
esv3604684 CNV gain 21293372
esv3604689 CNV loss 21293372
esv3604690 CNV gain 21293372
esv4902 CNV loss 18987735
nsv1112419 CNV deletion 24896259
nsv327644 CNV deletion 16902084
nsv522144 CNV loss 19592680
nsv597809 CNV gain 21841781

Variation tolerance for TTC23L Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC23L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC23L Gene

Disorders for TTC23L Gene

Relevant External Links for TTC23L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTC23L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC23L Gene

Publications for TTC23L Gene

  1. FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones. (PMID: 25751302) Pan T.L. … Ouyang P. (Cell Cycle 2015) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64

Products for TTC23L Gene

Sources for TTC23L Gene

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