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Aliases for TTC23L Gene

Aliases for TTC23L Gene

  • Tetratricopeptide Repeat Domain 23 Like 2 3
  • Tetratricopeptide Repeat Domain 23-Like 2 3 5
  • MC25-1 3

External Ids for TTC23L Gene

Previous GeneCards Identifiers for TTC23L Gene

  • GC05P034876
  • GC05P034840
  • GC05P034787

Summaries for TTC23L Gene

GeneCards Summary for TTC23L Gene

TTC23L (Tetratricopeptide Repeat Domain 23 Like) is a Protein Coding gene. An important paralog of this gene is TTC23.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC23L Gene

Genomics for TTC23L Gene

Regulatory Elements for TTC23L Gene

Enhancers for TTC23L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC23L on UCSC Golden Path with GeneCards custom track

Promoters for TTC23L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC23L on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC23L Gene

Chromosome:
5
Start:
34,838,833 bp from pter
End:
34,899,650 bp from pter
Size:
60,818 bases
Orientation:
Plus strand

Genomic View for TTC23L Gene

Genes around TTC23L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC23L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC23L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC23L Gene

Proteins for TTC23L Gene

  • Protein details for TTC23L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PF05-TT23L_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 23-like
    Protein Accession:
    Q6PF05
    Secondary Accessions:
    • G8IJH6
    • Q6RGS4
    • Q8N7R3
    • Q96LJ2

    Protein attributes for TTC23L Gene

    Size:
    361 amino acids
    Molecular mass:
    40837 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK097766; Type=Frameshift; Positions=52; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC23L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC23L Gene

Proteomics data for TTC23L Gene at MOPED

Post-translational modifications for TTC23L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC23L Gene

No data available for DME Specific Peptides for TTC23L Gene

Domains & Families for TTC23L Gene

Protein Domains for TTC23L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TTC23L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC23L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TTC23L Gene

Function for TTC23L Gene

genes like me logo Genes that share phenotypes with TTC23L: view

Animal Model Products

CRISPR Products

miRNA for TTC23L Gene

miRTarBase miRNAs that target TTC23L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC23L Gene

Localization for TTC23L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC23L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Exhibits dynamic subcellular localization during the cell cycle. In prophase cells, detected on split centrosomes. Translocates to the mitotic spindles during metaphase and early anaphase, then to the midbody and cleavage furrow in late anaphase. {ECO:0000269 PubMed:25751302}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC23L Gene COMPARTMENTS Subcellular localization image for TTC23L gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TTC23L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with TTC23L: view

Pathways & Interactions for TTC23L Gene

SuperPathways for TTC23L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC23L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC23L Gene

Drugs & Compounds for TTC23L Gene

No Compound Related Data Available

Transcripts for TTC23L Gene

Unigene Clusters for TTC23L Gene

Tetratricopeptide repeat domain 23-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC23L Gene

No ASD Table

Relevant External Links for TTC23L Gene

GeneLoc Exon Structure for
TTC23L
ECgene alternative splicing isoforms for
TTC23L

Expression for TTC23L Gene

mRNA expression in normal human tissues for TTC23L Gene

mRNA differential expression in normal tissues according to GTEx for TTC23L Gene

This gene is overexpressed in Testis (x18.2).

Protein differential expression in normal tissues from HIPED for TTC23L Gene

This gene is overexpressed in Fetal Brain (49.2) and Platelet (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC23L Gene



SOURCE GeneReport for Unigene cluster for TTC23L Gene Hs.435742

genes like me logo Genes that share expression patterns with TTC23L: view

Protein tissue co-expression partners for TTC23L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TTC23L Gene

Orthologs for TTC23L Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC23L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC23L 35
  • 79.38 (n)
  • 71.1 (a)
TTC23L 36
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC23L 35
  • 86.72 (n)
  • 83.29 (a)
TTC23L 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc23l 35
  • 79.25 (n)
  • 72.57 (a)
Ttc23l 16
Ttc23l 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC23L 35
  • 97.96 (n)
  • 96.1 (a)
TTC23L 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc23l 35
  • 80.66 (n)
  • 75.21 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC23L 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC23L 36
  • 28 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc23l 35
  • 56.61 (n)
  • 46.44 (a)
Species with no ortholog for TTC23L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTC23L Gene

ENSEMBL:
Gene Tree for TTC23L (if available)
TreeFam:
Gene Tree for TTC23L (if available)

Paralogs for TTC23L Gene

Paralogs for TTC23L Gene

genes like me logo Genes that share paralogs with TTC23L: view

Variants for TTC23L Gene

Sequence variations from dbSNP and Humsavar for TTC23L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_043539 -
rs6866035 - 34,845,617(+) ATCCC(A/G)AAGAG nc-transcript-variant, reference, missense
rs34566695 - 34,862,967(+) AAATA(C/T)GACCT nc-transcript-variant, reference, missense
rs35769440 - 34,862,975(+) CCTCA(A/G)ATAAG nc-transcript-variant, reference, missense
rs34702907 - 34,866,970(+) GCCAA(C/G)GGTGA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TTC23L Gene

Variant ID Type Subtype PubMed ID
nsv522144 CNV Loss 19592680
esv2730057 CNV Deletion 23290073
esv2235962 CNV Deletion 18987734
esv4902 CNV Deletion 18987735
nsv327644 CNV Loss 16902084
esv2664297 CNV Deletion 23128226
esv1002836 CNV Deletion 20482838
esv2730058 CNV Deletion 23290073
dgv1020e199 CNV Deletion 23128226

Variation tolerance for TTC23L Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TTC23L Gene

Disorders for TTC23L Gene

Relevant External Links for TTC23L

Genetic Association Database (GAD)
TTC23L
Human Genome Epidemiology (HuGE) Navigator
TTC23L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC23L

No disorders were found for TTC23L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC23L Gene

Publications for TTC23L Gene

  1. FLJ25439, a novel cytokinesis-associated protein, induces tetraploidization and maintains chromosomal stability via enhancing expression of endoplasmic reticulum stress chaperones. (PMID: 25751302) Pan T.L. … Ouyang P. (Cell Cycle 2015) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3

Products for TTC23L Gene

Sources for TTC23L Gene

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