TTC23 Gene
protein-coding GIFtS : 40
GCID: GC15 M099676
tetratricopeptide repeat domain 23
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Aliasesfor TTC23 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tetratricopeptide Repeat Domain 23 1 2 FLJ125721 HCC-81 2 3 Proto-Oncogene 82 Cervical Cancer Proto-Oncogene 8 Protein2 3 Tetratricopeptide Repeat Protein 232 TPR Repeat Protein 232 3
Export aliases for TTC23 gene to outside databases Previous GC identifers: GC15M097496 GC15M075806
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Summariesfor TTC23 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TTC23 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010274.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TTC23 gene promoter: ER-alpha SRF STAT1 SRF (504 AA) HSF1 (long) IRF-1 STAT1alpha E47 SRY HSF1short Other transcription factors Search SABiosciences Chromatin IP Primers for TTC23 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC23
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q26.3 Ensembl cytogenetic band: 15q26.3 HGNC cytogenetic band: 15q26.3 TTC23 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M099676: view genomic region
(about GC identifiers )
Start:
99,676,528 bp from pter
End:
99,791,428 bp from pter
Size:
114,901 bases
Orientation:
minus strand
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Proteinsfor TTC23 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TTC23_HUMAN, Q5W5X9 (See
protein sequence )Recommended Name: Tetratricopeptide repeat protein 23 Size : 447 amino acids; 50009 Da
Sequence caution : Sequence=BAB14144.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions : A8K6M5 Q53HK0 Q96BC9 Q9H8W9 Q9H9S7Alternative splicing : 3 isoforms : Q5W5X9-1 Q5W5X9-2 Q5W5X9-3 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)Explore the universe of human proteins at neXtProt for TTC23: NX_Q5W5X9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5W5X9 TTC23 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (7 alternative transcripts):
NP_001035745.1 NP_001035746.1 NP_001035747.1 NP_001035748.1 NP_001035749.1 NP_001035750.1 NP_075056.3 ENSEMBL proteins: ENSP00000433162 ENSP00000377690 ENSP00000452923 ENSP00000377692 ENSP00000436483 ENSP00000389470 ENSP00000457901 ENSP00000454175 ENSP00000454017 ENSP00000453419 ENSP00000453862 ENSP00000453673 ENSP00000452882 ENSP00000377693 ENSP00000262074 ENSP00000453054 ENSP00000377688 Human Recombinant Protein Products: TTC23 Antibody Products: Assay Products for TTC23:
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Protein
Domains / Familiesfor TTC23 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TTC23 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5W5X9 ProtoNet protein and cluster: Q5W5X9
UniProtKB/Swiss-Prot: TTC23_HUMAN, Q5W5X9 Similarity : Contains 4 TPR repeats
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Functionfor TTC23 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC23 (see all 12 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC23 (see all 8 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 7 ): TTC23 (NM_001040658 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC23 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC23
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC23
2 GenomeRNAi human phenotypes for TTC23 :
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Pathways & Interactionsfor TTC23 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC23
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Drugs & Compoundsfor TTC23 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TTC23 Search CenterWatch for drugs/clinical trials and news about TTC23
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Transcriptsfor TTC23 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TTC23 gene (7 alternative transcripts): NM_001040655.1 NM_001040656.1 NM_001040657.1 NM_001040658.1 NM_001040659.1 NM_001040660.1 NM_022905.4 Unigene Clusters for TTC23:
Tetratricopeptide repeat domain 23 Hs.513195 [show with all ESTs ] , Hs.621260 [show with all ESTs ] Unigene Representative Sequences: AF411456 , BC034816 18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22 ): ENST00000459771 ENST00000394132 (uc002buy.3 ) ENST00000494567 ENST00000558663 ENST00000394135 ENST00000480371 ENST00000490688 ENST00000434594 ENST00000558438 ENST00000394129 (uc002buz.2 ) ENST00000561365 ENST00000560279 ENST00000560860 ENST00000560772 ENST00000468436 ENST00000558078 ENST00000560235 ENST00000490671 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC23 (see all 12 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC23 (see all 8 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 7 ): TTC23 (NM_001040658 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC23 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC23
Additional cDNA sequence: BC034816.1
16 DOTS entries : DT.100813040 DT.121080337
DT.75116388 DT.97804559 DT.92057139 DT.101977751 DT.218401 DT.92414961 DT.121080359 DT.40128500 DT.121080319 DT.121080331 DT.121080347 DT.91661075 DT.91719461 DT.91742283 12 AceView cDNA sequences :
AI678986 AI597806 N39096 AV728153 AV706941 N48453 BC034816 BX502780 BG722511 BF792406 BF576166 BE146193 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TTC23 (see all 9 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e SP1 :         -                     -   -   -   -     -   -             SP2 :   -       -                     -   -   -       -   -             SP3 :   -       -                                             SP4 :                             -   -   -   -     -   -             SP5 :                             -           -   -            
ECgene alternative splicing isoforms for TTC23
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Expression for TTC23 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TTC23 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCGAGTTTTT
About this image See TTC23 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TTC23 SOURCE GeneReport for Unigene clusters: Hs.513195 Hs.621260 SABiosciences Custom PCR Arrays for TTC23 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TTC23Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TTC23 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TTC23 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TTC23 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC23
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Orthologsfor TTC23 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TTC23 gene from 1/11 species (see all 11 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
zebrafish (Danio rerio)
Actinopterygii
ttc231
tetratricopeptide repeat domain 23
50.86(n) 38.03(a)
 
558875 XM_003200452.1 XP_003200500.1
ENSEMBL Gene Tree for TTC23 (if available)TreeFam Gene Tree for TTC23 (if available)
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Paralogsfor TTC23 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TTC23 gene TTC23L 2
TTC23 for paralogs About GeneDecksing
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Genomic Variantsfor TTC23 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TTC23 (99676528 - 99791428 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TTC23: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TTC23
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Disorders
/ Diseasesfor TTC23 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TTC23 for disorders About GeneDecksing 3 diseases for TTC23 : About MalaCards cervical cancer cervicitis osteoporosis Human Genome Epidemiology (HuGE) Navigator: TTC23 (1 document)Export disorders for TTC23 gene to outside databases
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Publicationsfor TTC23 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TTC23 gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with TTC23) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518) 1 Warnatz H.J....Yaspo M.L. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Genome-wide pleiotropy of osteoporosis-related phenot ypes: The Framingham study. (PubMed id 20200953) 1 Karasik D....Demissie S. (2010) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 1 Oh J.H....Kim N.S. (2005) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 1 Suzuki Y.... Sugano S. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for TTC23 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TTC23 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TTC23 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TTC23 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TTC23 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TTC23 gene: Search GeneIP for patents involving TTC23 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TTC23 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TTC23 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TTC23 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TTC23 OriGene Protein Over-expression Lysate for TTC23 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TTC23 OriGene 3'-UTR Clone for TTC23 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC23 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC23 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TTC23 OriGene Custom Protein Services for TTC23 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC23 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TTC23 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC23 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TTC23 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TTC23 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TTC23
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TTC23 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC23
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC23
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Aliases for TTC23
Databases for TTC23
Disorders / Diseases for TTC23
Domains / Families for TTC23
Drugs / Compounds for TTC23
Expression for TTC23
Function for TTC23
Genomic Views for TTC23
Intellectual Property for TTC23
Orthologs for TTC23
Paralogs for TTC23
Pathways / Interactions for TTC23
Products for TTC23
Proteins for TTC23
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Summaries for TTC23
Transcripts for TTC23
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