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Aliases for TTC23 Gene

Aliases for TTC23 Gene

  • Tetratricopeptide Repeat Domain 23 2 3
  • Cervical Cancer Proto-Oncogene 8 Protein 3 4
  • TPR Repeat Protein 23 3 4
  • HCC-8 3 4
  • Tetratricopeptide Repeat Protein 23 3

External Ids for TTC23 Gene

Previous GeneCards Identifiers for TTC23 Gene

  • GC15M097496
  • GC15M099676
  • GC15M075806

Summaries for TTC23 Gene

GeneCards Summary for TTC23 Gene

TTC23 (Tetratricopeptide Repeat Domain 23) is a Protein Coding gene. An important paralog of this gene is TTC23L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC23 Gene

Genomics for TTC23 Gene

Regulatory Elements for TTC23 Gene

Genomic Location for TTC23 Gene

99,136,323 bp from pter
99,251,226 bp from pter
114,904 bases
Minus strand

Genomic View for TTC23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC23 Gene

Proteins for TTC23 Gene

  • Protein details for TTC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 23
    Protein Accession:
    Secondary Accessions:
    • A8K6M5
    • Q53HK0
    • Q96BC9
    • Q9H8W9
    • Q9H9S7

    Protein attributes for TTC23 Gene

    447 amino acids
    Molecular mass:
    50009 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14144.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC23 Gene


neXtProt entry for TTC23 Gene

Proteomics data for TTC23 Gene at MOPED

Post-translational modifications for TTC23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC23 Gene

Domains for TTC23 Gene

Gene Families for TTC23 Gene

  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC23 Gene


Suggested Antigen Peptide Sequences for TTC23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5W5X9
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with TTC23: view

Function for TTC23 Gene

Gene Ontology (GO) - Molecular Function for TTC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC23: view

Phenotypes for TTC23 Gene

GenomeRNAi human phenotypes for TTC23:
genes like me logo Genes that share phenotypes with TTC23: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTC23 Gene

Localization for TTC23 Gene

Subcellular locations from

Jensen Localization Image for TTC23 Gene COMPARTMENTS Subcellular localization image for TTC23 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC23 Gene

Pathways for TTC23 Gene

SuperPathways for TTC23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC23 Gene


No data available for Pathways by source for TTC23 Gene

Transcripts for TTC23 Gene

mRNA/cDNA for TTC23 Gene

Unigene Clusters for TTC23 Gene

Tetratricopeptide repeat domain 23:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC23

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC23 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - -
SP7: - -
SP9: - - - - -

Relevant External Links for TTC23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC23 Gene

mRNA expression in normal human tissues for TTC23 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TTC23 Gene

SOURCE GeneReport for Unigene cluster for TTC23 Gene Hs.513195

genes like me logo Genes that share expressions with TTC23: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC23 Gene

Orthologs for TTC23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTC23 35
  • 98.73 (n)
  • 98.43 (a)
TTC23 36
  • 98 (a)
(Bos Taurus)
Mammalia TTC23 35
  • 82.96 (n)
  • 76.92 (a)
TTC23 36
  • 77 (a)
(Canis familiaris)
Mammalia TTC23 35
  • 86.05 (n)
  • 81.45 (a)
TTC23 36
  • 74 (a)
(Mus musculus)
Mammalia Ttc23 35
  • 79.67 (n)
  • 74.6 (a)
Ttc23 16
Ttc23 36
  • 67 (a)
(Monodelphis domestica)
Mammalia TTC23 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia TTC23 36
  • 53 (a)
(Rattus norvegicus)
Mammalia Ttc23 35
  • 78.99 (n)
  • 73.02 (a)
(Danio rerio)
Actinopterygii ttc23 35
  • 51.95 (n)
  • 39.74 (a)
ttc23 36
  • 33 (a)
Species with no ortholog for TTC23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC23 Gene

Gene Tree for TTC23 (if available)
Gene Tree for TTC23 (if available)

Paralogs for TTC23 Gene

Paralogs for TTC23 Gene

genes like me logo Genes that share paralogs with TTC23: view

Variants for TTC23 Gene

Sequence variations from dbSNP and Humsavar for TTC23 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs181987 -- 99,139,450(-) TTCCT(G/T)CTCTC intron-variant, nc-transcript-variant, reference, missense
rs187755 -- 99,144,227(-) CCCAG(C/G)TTTCT intron-variant
rs260088 -- 99,137,111(-) CCCAG(G/T)GGTAG utr-variant-3-prime, nc-transcript-variant
rs260089 -- 99,137,940(-) ACCTC(C/T)GCCTA utr-variant-3-prime, nc-transcript-variant
rs260112 -- 99,146,309(-) CTTTA(A/G)GAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC23 Gene

Variant ID Type Subtype PubMed ID
nsv904543 CNV Gain 21882294
nsv904546 CNV Gain 21882294
esv2664025 CNV Deletion 23128226
esv2656470 CNV Deletion 23128226
esv2661935 CNV Deletion 23128226

Relevant External Links for TTC23 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC23 Gene

Disorders for TTC23 Gene

Relevant External Links for TTC23

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TTC23: view

No data available for UniProtKB/Swiss-Prot for TTC23 Gene

Publications for TTC23 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TTC23 Gene

Sources for TTC23 Gene

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