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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TTC23 Gene

protein-coding   GIFtS: 43
GCID: GC15M099676

Tetratricopeptide Repeat Domain 23

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tetratricopeptide Repeat Domain 231 2
Cervical Cancer Proto-Oncogene 8 Protein2 3
HCC-82 3
TPR Repeat Protein 232 3
Proto-Oncogene 82
Tetratricopeptide Repeat Protein 232

External Ids:    HGNC: 257301   Entrez Gene: 649272   Ensembl: ENSG000001038527   UniProtKB: Q5W5X93   

Export aliases for TTC23 gene to outside databases

Previous GC identifers: GC15M097496 GC15M075806


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TTC23 Gene: 
TTC23 (tetratricopeptide repeat domain 23) is a protein-coding gene. Diseases associated with TTC23 include cervical cancer, and cervicitis. An important paralog of this gene is TTC23L.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TTC23 gene promoter:
         ER-alpha   SRF   STAT1   SRF (504 AA)   HSF1 (long)   IRF-1   STAT1alpha   E47   SRY   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTC23 promoter sequence
   Search SABiosciences Chromatin IP Primers for TTC23

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC23


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

TTC23 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC23 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M099676:  view genomic region     (about GC identifiers)

Start:
99,676,528 bp from pter      End:
99,791,428 bp from pter
Size:
114,901 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TTC23_HUMAN, Q5W5X9 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 23  
Size: 447 amino acids; 50009 Da
Sequence caution: Sequence=BAB14144.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K6M5 Q53HK0 Q96BC9 Q9H8W9 Q9H9S7
Alternative splicing: 3 isoforms:  Q5W5X9-1   Q5W5X9-2   Q5W5X9-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTC23: NX_Q5W5X9

Explore proteomics data for TTC23 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5W5X9

  • TTC23 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TTC23 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001035745.1  NP_001035746.1  NP_001035747.1  NP_001035748.1  NP_001035749.1  NP_001035750.1  NP_075056.3  

    ENSEMBL proteins: 
     ENSP00000433162   ENSP00000377690   ENSP00000452923   ENSP00000377692   ENSP00000436483  
     ENSP00000389470   ENSP00000457901   ENSP00000454175   ENSP00000454017   ENSP00000453419  
     ENSP00000453862   ENSP00000453673   ENSP00000452882   ENSP00000377693   ENSP00000262074  
     ENSP00000453054   ENSP00000377688  

    Human Recombinant Protein Products for TTC23: 
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    Novus Biologicals TTC23 Lysates
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for TTC23 


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    Cloud-Clone Corp. ELISAs for TTC23 
    Cloud-Clone Corp. CLIAs for TTC23


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013105 TPR_2

    Graphical View of Domain Structure for InterPro Entry Q5W5X9

    ProtoNet protein and cluster: Q5W5X9

    UniProtKB/Swiss-Prot: TTC23_HUMAN, Q5W5X9
    Similarity: Contains 4 TPR repeats


    TTC23 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TTC23 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TTC23:
     Decreased viability  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TTC23 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TTC23

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTC23 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTTC23 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC23


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC23

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TTC23

    Search CenterWatch for drugs/clinical trials and news about TTC23

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TTC23 gene (7 alternative transcripts): 
    NM_001040655.1  NM_001040656.1  NM_001040657.1  NM_001040658.1  NM_001040659.1  NM_001040660.1  NM_022905.4  

    Unigene Clusters for TTC23:

    Tetratricopeptide repeat domain 23
    Hs.513195  [show with all ESTs], Hs.621260  [show with all ESTs]
    Unigene Representative Sequences: AF411456, BC034816
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000459771 ENST00000394132(uc002buy.3) ENST00000494567 ENST00000558663
    ENST00000394135 ENST00000480371 ENST00000490688 ENST00000434594 ENST00000558438
    ENST00000394129(uc002buz.2) ENST00000561365 ENST00000560279 ENST00000560860
    ENST00000560772 ENST00000468436 ENST00000558078 ENST00000560235 ENST00000490671

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TTC23:
    hsa-miR-31 hsa-miR-204 hsa-miR-497* hsa-miR-3157-5p hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidTTC23 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TTC23
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC23
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    GenScript: all cDNA clones in your preferred vector (see all 7): TTC23 (NM_001040658)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC23
    Sirion Biotech Customized lentivirus for stable overexpression of TTC23 
                         Customized lentivirus expression plasmids for stable overexpression of TTC23 
    Primer
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    OriGene qPCR primer pairs and template standards for TTC23
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC23
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC23

    Additional mRNA sequence: BC034816.1 

    16 DOTS entries:

    DT.100813040  DT.121080337  DT.75116388  DT.97804559  DT.92057139  DT.101977751  DT.218401  DT.92414961 
    DT.121080359  DT.40128500  DT.121080319  DT.121080331  DT.121080347  DT.91661075  DT.91719461  DT.91742283 

    12 AceView cDNA sequences:

    AI678986 AV728153 AI597806 N39096 N48453 AV706941 BX502780 BC034816 
    BG722511 BF792406 BF576166 BE146193 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TTC23 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e
    SP1:                          -                                                           -     -     -     -           -     -                                 
    SP2:        -                 -                                                           -     -     -                 -     -                                 
    SP3:        -                 -                                                                                                                                 
    SP4:                                                                                      -     -     -     -           -     -                                 
    SP5:                                                                                      -                             -     -                                 


    ECgene alternative splicing isoforms for TTC23

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TTC23 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGAGTTTTT
    TTC23 Expression
    About this image


    See TTC23 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TTC23

    SOURCE GeneReport for Unigene clusters: Hs.513195 Hs.621260
        SABiosciences Custom PCR Arrays for TTC23
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC23

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TTC23 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc231 , 5 tetratricopeptide repeat domain 231, 5 79.67(n)1
    74.6(a)1
      7 (37.06 cM)5
    670091  NM_001168475.11  NP_001161947.11 
     676474105 
    zebrafish
    (Danio rerio)
    Actinopterygii ttc231 tetratricopeptide repeat domain 23 50.86(n)
    38.03(a)
      558875  XM_003200452.1  XP_003200500.1 


    ENSEMBL Gene Tree for TTC23 (if available)
    TreeFam Gene Tree for TTC23 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TTC23 gene
    TTC23L2  

    TTC23 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2185 SNPs in TTC23 are shown (see all 2185)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1159387491,2
    F--99676306(+) TACCCG/ATTTGT 7 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1128672951,2
    C--99676471(+) AAAAAC/TGTGTT 7 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1836584971,2
    --99676627(+) CAAACA/GTTTAT 7 -- ut310--------
    rs11342671,2
    C--99676745(-) tctccA/Cccatg 7 -- ut311Minor allele frequency- C:0.00NA 2
    rs1879734001,2
    --99676804(+) CATCAG/TGGCTC 7 -- ut310--------
    rs1387792551,2
    C--99676889(+) GAATTA/GGGAGC 7 -- ut310--------
    rs762637021,2
    C--99676908(+) ATTCAA/C/GCCCTT 14 -- ut311NA 2
    rs354370951,2
    C--99676961(+) AGTGA-/ACCCATCT 7 -- cds10--------
    rs572107951,2
    C--99676962(+) GTGACCAC/-ATCTT 7 -- cds11Minor allele frequency- -:0.00NA 2
    rs1997254061,2
    C--99676963(-) TAAGAG/TGTCAC 7 -- ut310--------

    HapMap Linkage Disequilibrium report for TTC23 (99676528 - 99791428 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TTC23:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2661935CNV Deletion23128226
    esv2664025CNV Deletion23128226
    esv2656470CNV Deletion23128226
    nsv904543CNV Gain21882294
    nsv904546CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for TTC23:    About MalaCards
    cervical cancer    cervicitis    gastric cancer


    TTC23 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TTC23
    Human Genome Epidemiology (HuGE) Navigator: TTC23 (1 document)

    Export disorders for TTC23 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TTC23 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with TTC23)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    4. The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Genome-wide pleiotropy of osteoporosis-related phenot ypes: The Framingham study. (PubMed id 20200953)1 Karasik D....Demissie S. (2010)
    7. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. (PubMed id 17434096)4 Matarin M....Meschia J.F. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64927 HGNC: 25730 AceView: FLJ12572.1 Ensembl:ENSG00000103852 euGenes: HUgn64927
    ECgene: TTC23 H-InvDB: TTC23

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TTC23 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TTC23 gene:
    Search GeneIP for patents involving TTC23

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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