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Aliases for TTC23 Gene

Aliases for TTC23 Gene

  • Tetratricopeptide Repeat Domain 23 2 3 5
  • Cervical Cancer Proto-Oncogene 8 Protein 3 4
  • TPR Repeat Protein 23 3 4
  • HCC-8 3 4
  • Tetratricopeptide Repeat Protein 23 3

External Ids for TTC23 Gene

Previous GeneCards Identifiers for TTC23 Gene

  • GC15M097496
  • GC15M099676
  • GC15M075806

Summaries for TTC23 Gene

GeneCards Summary for TTC23 Gene

TTC23 (Tetratricopeptide Repeat Domain 23) is a Protein Coding gene. An important paralog of this gene is TTC23L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC23 Gene

Genomics for TTC23 Gene

Regulatory Elements for TTC23 Gene

Enhancers for TTC23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F099248 1.1 ENCODE 24.1 +0.9 851 4.5 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TTC23 LRRC28 SYNM PIR36219 GC15M099193
GH15F099320 1.2 Ensembl ENCODE 19.8 -71.8 -71783 5.4 TBP THRB RARA CBX5 ETV6 FOS MIXL1 ZNF263 SMARCC1 HMG20B TTC23 SYNM ENSG00000281635 ENSG00000259257
GH15F099122 1.5 FANTOM5 Ensembl ENCODE 10.1 +126.7 126653 4.2 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 ZNF2 GLIS2 FOS ZNF263 REST SYNM ENSG00000261616 ENSG00000261054 TTC23 LRRC28 PIR61097 LOC105371016
GH15F099257 0.7 ENCODE 20.6 -6.4 -6367 1.1 MAFG NR2F2 YY1 ZNF316 HNF4G NFE2 ZBTB33 MAFK ZNF652 EMSY TTC23 SYNM HSP90B2P HNRNPA1P62
GH15F099167 1.1 Ensembl ENCODE 10.5 +81.8 81835 4.7 CTCF KLF1 ZNF175 EBF1 RAD21 RELA YY1 FOSL1 ZFHX2 POLR2A SYNM LRRC28 ENSG00000261616 ENSG00000261054 TTC23 ENSG00000259921 GC15M099193
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC23 on UCSC Golden Path with GeneCards custom track

Promoters for TTC23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000414342 925 4600 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TTC23 Gene

Chromosome:
15
Start:
99,136,323 bp from pter
End:
99,251,226 bp from pter
Size:
114,904 bases
Orientation:
Minus strand

Genomic View for TTC23 Gene

Genes around TTC23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC23 Gene

Proteins for TTC23 Gene

  • Protein details for TTC23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W5X9-TTC23_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 23
    Protein Accession:
    Q5W5X9
    Secondary Accessions:
    • A8K6M5
    • Q53HK0
    • Q96BC9
    • Q9H8W9
    • Q9H9S7

    Protein attributes for TTC23 Gene

    Size:
    447 amino acids
    Molecular mass:
    50009 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14144.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC23 Gene

Post-translational modifications for TTC23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC23 Gene

Domains & Families for TTC23 Gene

Gene Families for TTC23 Gene

Protein Domains for TTC23 Gene

Suggested Antigen Peptide Sequences for TTC23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W5X9

UniProtKB/Swiss-Prot:

TTC23_HUMAN :
  • Contains 4 TPR repeats.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with TTC23: view

Function for TTC23 Gene

Gene Ontology (GO) - Molecular Function for TTC23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC23: view
genes like me logo Genes that share phenotypes with TTC23: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC23 Gene

Localization for TTC23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC23 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC23 Gene

Pathways & Interactions for TTC23 Gene

SuperPathways for TTC23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC23 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC23 Gene

Transcripts for TTC23 Gene

mRNA/cDNA for TTC23 Gene

Unigene Clusters for TTC23 Gene

Tetratricopeptide repeat domain 23:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC23 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - -
SP6:
SP7: - -
SP8:
SP9: - - - - -

Relevant External Links for TTC23 Gene

GeneLoc Exon Structure for
TTC23
ECgene alternative splicing isoforms for
TTC23

Expression for TTC23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC23 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC23 Gene



NURSA nuclear receptor signaling pathways regulating expression of TTC23 Gene:

TTC23

SOURCE GeneReport for Unigene cluster for TTC23 Gene:

Hs.513195
genes like me logo Genes that share expression patterns with TTC23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TTC23 Gene

Orthologs for TTC23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC23 34 35
  • 98.73 (n)
dog
(Canis familiaris)
Mammalia TTC23 34 35
  • 86.05 (n)
cow
(Bos Taurus)
Mammalia TTC23 34 35
  • 82.96 (n)
mouse
(Mus musculus)
Mammalia Ttc23 34 16 35
  • 79.67 (n)
rat
(Rattus norvegicus)
Mammalia Ttc23 34
  • 78.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC23 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC23 35
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ttc23 34 35
  • 51.95 (n)
Species where no ortholog for TTC23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC23 Gene

ENSEMBL:
Gene Tree for TTC23 (if available)
TreeFam:
Gene Tree for TTC23 (if available)

Paralogs for TTC23 Gene

Paralogs for TTC23 Gene

genes like me logo Genes that share paralogs with TTC23: view

Variants for TTC23 Gene

Sequence variations from dbSNP and Humsavar for TTC23 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10162852 -- 99,217,276(+) cctca(A/G)cctcc intron-variant
rs1020589 -- 99,167,140(+) ATGGA(C/T)ATCCC intron-variant
rs1020590 -- 99,167,313(+) CCTAC(A/C)TTTGA intron-variant
rs10438467 -- 99,157,357(+) caggc(A/G)cccac intron-variant
rs10718333 -- 99,220,018(+) TATTA(-/G)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC23 Gene

Variant ID Type Subtype PubMed ID
nsv570716 CNV gain 21841781
nsv478852 CNV novel sequence insertion 20440878
nsv1055008 CNV gain 25217958
nsv1045124 CNV gain 25217958
esv3892741 CNV gain 25118596
esv3637425 CNV loss 21293372
esv3637424 CNV gain 21293372
esv3637423 CNV loss 21293372
esv3637422 CNV loss 21293372
esv3637421 CNV loss 21293372
esv2760374 CNV loss 21179565
esv2664025 CNV deletion 23128226
esv2661935 CNV deletion 23128226
esv2656470 CNV deletion 23128226

Variation tolerance for TTC23 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC23 Gene

Disorders for TTC23 Gene

Relevant External Links for TTC23

Genetic Association Database (GAD)
TTC23
Human Genome Epidemiology (HuGE) Navigator
TTC23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC23

No disorders were found for TTC23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC23 Gene

Publications for TTC23 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3 64

Products for TTC23 Gene

Sources for TTC23 Gene

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