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Aliases for TTC22 Gene

Aliases for TTC22 Gene

  • Tetratricopeptide Repeat Domain 22 2 3
  • TPR Repeat Protein 22 4

External Ids for TTC22 Gene

Previous GeneCards Identifiers for TTC22 Gene

  • GC01M054963
  • GC01M055022
  • GC01M055246
  • GC01M053360

Summaries for TTC22 Gene

Entrez Gene Summary for TTC22 Gene

  • This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for TTC22 Gene

TTC22 (Tetratricopeptide Repeat Domain 22) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC22 Gene

Genomics for TTC22 Gene

Regulatory Elements for TTC22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC22 Gene

54,779,712 bp from pter
54,801,717 bp from pter
22,006 bases
Minus strand

Genomic View for TTC22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC22 Gene

Proteins for TTC22 Gene

  • Protein details for TTC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 22
    Protein Accession:
    Secondary Accessions:
    • Q9NWT4

    Protein attributes for TTC22 Gene

    569 amino acids
    Molecular mass:
    63361 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC22 Gene


neXtProt entry for TTC22 Gene

Proteomics data for TTC22 Gene at MOPED

Post-translational modifications for TTC22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC22 Gene

No data available for DME Specific Peptides for TTC22 Gene

Domains & Families for TTC22 Gene

Gene Families for TTC22 Gene

Protein Domains for TTC22 Gene

Suggested Antigen Peptide Sequences for TTC22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 TPR repeats.
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with TTC22: view

Function for TTC22 Gene

Gene Ontology (GO) - Molecular Function for TTC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC22: view
genes like me logo Genes that share phenotypes with TTC22: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC22

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC22 Gene

Localization for TTC22 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TTC22 Gene

Pathways & Interactions for TTC22 Gene

SuperPathways for TTC22 Gene

No Data Available

Interacting Proteins for TTC22 Gene

Gene Ontology (GO) - Biological Process for TTC22 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC22 Gene

Drugs & Compounds for TTC22 Gene

No Compound Related Data Available

Transcripts for TTC22 Gene

Unigene Clusters for TTC22 Gene

Tetratricopeptide repeat domain 22:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC22 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: - -

Relevant External Links for TTC22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC22 Gene

mRNA expression in normal human tissues for TTC22 Gene

mRNA differential expression in normal tissues according to GTEx for TTC22 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.2) and Vagina (x6.2).

Protein differential expression in normal tissues from HIPED for TTC22 Gene

This gene is overexpressed in Cervix (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC22 Gene

SOURCE GeneReport for Unigene cluster for TTC22 Gene Hs.16230

genes like me logo Genes that share expression patterns with TTC22: view

Protein tissue co-expression partners for TTC22 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TTC22 Gene

Orthologs for TTC22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC22 35
  • 90.67 (n)
  • 91.02 (a)
TTC22 36
  • 91 (a)
(Canis familiaris)
Mammalia TTC22 35
  • 88.71 (n)
  • 87.89 (a)
TTC22 36
  • 90 (a)
(Mus musculus)
Mammalia Ttc22 35
  • 84.22 (n)
  • 85.37 (a)
Ttc22 16
Ttc22 36
  • 84 (a)
(Pan troglodytes)
Mammalia TTC22 35
  • 99.47 (n)
  • 99.65 (a)
TTC22 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ttc22 35
  • 83.33 (n)
  • 85.04 (a)
(Monodelphis domestica)
Mammalia TTC22 36
  • 67 (a)
(Anolis carolinensis)
Reptilia TTC22 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc22 35
  • 56.62 (n)
  • 55.33 (a)
(Danio rerio)
Actinopterygii ttc22 35
  • 56.11 (n)
  • 50.93 (a)
ttc22 36
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for TTC22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC22 Gene

Gene Tree for TTC22 (if available)
Gene Tree for TTC22 (if available)

Paralogs for TTC22 Gene Pseudogenes for TTC22 Gene

genes like me logo Genes that share paralogs with TTC22: view

No data available for Paralogs for TTC22 Gene

Variants for TTC22 Gene

Sequence variations from dbSNP and Humsavar for TTC22 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1731 -- 54,779,866(+) TGGAG(C/T)GTGTG utr-variant-3-prime
rs122283 -- 54,796,778(-) GGATT(C/T)TGTCT intron-variant
rs584172 -- 54,786,543(-) TAGTG(A/G)GGGTA intron-variant
rs586462 -- 54,786,016(-) CCAGA(A/G)CTCAA synonymous-codon, reference
rs591867 -- 54,795,195(-) AGCCA(C/T)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC22 Gene

Variant ID Type Subtype PubMed ID
nsv461561 CNV Gain 19166990
nsv817614 CNV Gain 22305530
dgv229n71 CNV Gain 21882294
nsv871008 CNV Loss 21882294

Variation tolerance for TTC22 Gene

Gene Damage Index Score: 12.07; 93.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC22 Gene

Disorders for TTC22 Gene

Relevant External Links for TTC22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTC22: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC22 Gene

Publications for TTC22 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 67

Products for TTC22 Gene

Sources for TTC22 Gene

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