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Aliases for TTC22 Gene

Aliases for TTC22 Gene

  • Tetratricopeptide Repeat Domain 22 2 3 5
  • TPR Repeat Protein 22 4

External Ids for TTC22 Gene

Previous GeneCards Identifiers for TTC22 Gene

  • GC01M054963
  • GC01M055022
  • GC01M055246
  • GC01M053360

Summaries for TTC22 Gene

Entrez Gene Summary for TTC22 Gene

  • This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for TTC22 Gene

TTC22 (Tetratricopeptide Repeat Domain 22) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC22 Gene

Genomics for TTC22 Gene

Regulatory Elements for TTC22 Gene

Enhancers for TTC22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F054484 1.8 FANTOM5 Ensembl ENCODE 10.4 +313.9 313915 6.8 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF143 ZNF207 TCEANC2 SSBP3 HSPB11 ENSG00000237453 TTC22 TMEM59 MIR4781 LOC105378735 ENSG00000232245
GH01F054271 1.6 FANTOM5 Ensembl ENCODE 10 +525.2 525176 10.6 HDGF ATF1 PKNOX1 FEZF1 ZNF2 YY1 ZNF121 GLIS2 CBX5 ZNF143 SSBP3-AS1 SSBP3 TMEM59 HSPB11 MIR4781 TCEANC2 ENSG00000237453 TTC22 ENSG00000225632 GC01P054263
GH01F054296 1.6 FANTOM5 Ensembl ENCODE 9.8 +503.3 503268 4.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SSBP3 SSBP3-AS1 CDCP2 ENSG00000237453 TTC22 MROH7 ENSG00000225632 GC01M054384
GH01F054309 1.5 FANTOM5 Ensembl ENCODE 9.8 +489.4 489384 6.3 CBX3 PKNOX1 KLF17 FEZF1 RAD21 RARA ZNF121 GLIS2 ZNF143 EGR2 HSPB11 ENSG00000225632 SSBP3 SSBP3-AS1 CDCP2 MIR4781 TCEANC2 TMEM59 TTC22 ENSG00000237453
GH01F054856 1.3 Ensembl ENCODE 10.1 -58.1 -58139 7.5 MLX ZFP64 ARID4B FEZF1 DMAP1 GATA2 FOS PAF1 SP5 MXD4 ENSG00000233203 DHCR24 LEXM ENSG00000242396 TTC22 ENSG00000237453 LDLRAD1 MIR4781 TCEANC2 TMEM59
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC22 on UCSC Golden Path with GeneCards custom track

Promoters for TTC22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000165404 717 1201 HDGF CTCF CREB3L1 CEBPG RAD21 ZNF316 DIDO1 POLR2A ZNF143 NFE2

Genomic Location for TTC22 Gene

Chromosome:
1
Start:
54,779,712 bp from pter
End:
54,801,717 bp from pter
Size:
22,006 bases
Orientation:
Minus strand

Genomic View for TTC22 Gene

Genes around TTC22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC22 Gene

Proteins for TTC22 Gene

  • Protein details for TTC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TAA0-TTC22_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 22
    Protein Accession:
    Q5TAA0
    Secondary Accessions:
    • Q9NWT4

    Protein attributes for TTC22 Gene

    Size:
    569 amino acids
    Molecular mass:
    63361 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC22 Gene

Post-translational modifications for TTC22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC22 Gene

No data available for DME Specific Peptides for TTC22 Gene

Domains & Families for TTC22 Gene

Gene Families for TTC22 Gene

Protein Domains for TTC22 Gene

Suggested Antigen Peptide Sequences for TTC22 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TAA0

UniProtKB/Swiss-Prot:

TTC22_HUMAN :
  • Contains 7 TPR repeats.
Similarity:
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with TTC22: view

Function for TTC22 Gene

genes like me logo Genes that share phenotypes with TTC22: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC22 Gene

Localization for TTC22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC22 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC22 Gene

Pathways & Interactions for TTC22 Gene

SuperPathways for TTC22 Gene

No Data Available

Interacting Proteins for TTC22 Gene

Gene Ontology (GO) - Biological Process for TTC22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC22 Gene

Transcripts for TTC22 Gene

Unigene Clusters for TTC22 Gene

Tetratricopeptide repeat domain 22:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC22 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: - -
SP3:

Relevant External Links for TTC22 Gene

GeneLoc Exon Structure for
TTC22
ECgene alternative splicing isoforms for
TTC22

Expression for TTC22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC22 Gene

mRNA differential expression in normal tissues according to GTEx for TTC22 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.2) and Vagina (x6.2).

Protein differential expression in normal tissues from HIPED for TTC22 Gene

This gene is overexpressed in Cervix (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TTC22 Gene



Protein tissue co-expression partners for TTC22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC22 Gene:

TTC22

SOURCE GeneReport for Unigene cluster for TTC22 Gene:

Hs.16230
genes like me logo Genes that share expression patterns with TTC22: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TTC22 Gene

Orthologs for TTC22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC22 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia TTC22 34 35
  • 90.67 (n)
dog
(Canis familiaris)
Mammalia TTC22 34 35
  • 88.71 (n)
mouse
(Mus musculus)
Mammalia Ttc22 34 16 35
  • 84.22 (n)
rat
(Rattus norvegicus)
Mammalia Ttc22 34
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC22 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC22 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc22 34
  • 56.62 (n)
zebrafish
(Danio rerio)
Actinopterygii ttc22 34 35
  • 56.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for TTC22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC22 Gene

ENSEMBL:
Gene Tree for TTC22 (if available)
TreeFam:
Gene Tree for TTC22 (if available)

Paralogs for TTC22 Gene

Pseudogenes.org Pseudogenes for TTC22 Gene

genes like me logo Genes that share paralogs with TTC22: view

No data available for Paralogs for TTC22 Gene

Variants for TTC22 Gene

Sequence variations from dbSNP and Humsavar for TTC22 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157621 -- 54,799,976(+) GCACG(A/G)GGGAG intron-variant
rs10888880 -- 54,784,003(+) tctct(A/G)aaata intron-variant
rs111226421 -- 54,793,072(+) GCCTC(C/T)GGTCA intron-variant
rs111350490 -- 54,784,807(+) GCTCC(A/G)AGTCG intron-variant, utr-variant-3-prime
rs111387728 -- 54,803,607(+) TTTTT(-/T)AAGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TTC22 Gene

Variant ID Type Subtype PubMed ID
nsv817614 CNV gain 22305530
nsv546300 CNV loss 21841781
nsv546266 CNV gain 21841781
nsv461561 CNV gain 19166990
nsv1000673 CNV gain 25217958
dgv38e212 CNV gain 25503493
dgv166n100 CNV gain 25217958

Variation tolerance for TTC22 Gene

Gene Damage Index Score: 12.07; 93.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC22 Gene

Disorders for TTC22 Gene

Relevant External Links for TTC22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC22

No disorders were found for TTC22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC22 Gene

Publications for TTC22 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for TTC22 Gene

Sources for TTC22 Gene

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