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Aliases for TTC22 Gene

Aliases for TTC22 Gene

  • Tetratricopeptide Repeat Domain 22 2 3
  • TPR Repeat Protein 22 4

External Ids for TTC22 Gene

Summaries for TTC22 Gene

Entrez Gene Summary for TTC22 Gene

  • This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for TTC22 Gene

TTC22 (Tetratricopeptide Repeat Domain 22) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC22 Gene

Genomics for TTC22 Gene

Genomic Location for TTC22 Gene

Start:
54,779,712 bp from pter
End:
54,801,268 bp from pter
Size:
21,557 bases
Orientation:
Minus strand

Genomic View for TTC22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC22 Gene

Regulatory Elements for TTC22 Gene

Proteins for TTC22 Gene

  • Protein details for TTC22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TAA0-TTC22_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 22
    Protein Accession:
    Q5TAA0
    Secondary Accessions:
    • Q9NWT4

    Protein attributes for TTC22 Gene

    Size:
    569 amino acids
    Molecular mass:
    63361 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC22 Gene

Proteomics data for TTC22 Gene at MOPED

Post-translational modifications for TTC22 Gene

No Post-translational modifications

Other Protein References for TTC22 Gene

No data available for DME Specific Peptides for TTC22 Gene

Domains for TTC22 Gene

Gene Families for TTC22 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC22 Gene

UniProtKB/Swiss-Prot:

TTC22_HUMAN
Similarity:
  • Contains 7 TPR repeats.:
    • Q5TAA0
genes like me logo Genes that share domains with TTC22: view

Function for TTC22 Gene

Gene Ontology (GO) - Molecular Function for TTC22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC22: view

Phenotypes for TTC22 Gene

GenomeRNAi human phenotypes for TTC22:
genes like me logo Genes that share phenotypes with TTC22: view

miRNA for TTC22 Gene

miRTarBase miRNAs that target TTC22

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTC22 Gene

Localization for TTC22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC22 Gene COMPARTMENTS Subcellular localization image for TTC22 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TTC22 Gene

Pathways for TTC22 Gene

SuperPathways for TTC22 Gene

No Data Available

Interacting Proteins for TTC22 Gene

Gene Ontology (GO) - Biological Process for TTC22 Gene

None

No data available for Pathways by source for TTC22 Gene

Transcripts for TTC22 Gene

Unigene Clusters for TTC22 Gene

Tetratricopeptide repeat domain 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC22 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - -
SP2: - -
SP3:

Relevant External Links for TTC22 Gene

GeneLoc Exon Structure for
TTC22
ECgene alternative splicing isoforms for
TTC22

Expression for TTC22 Gene

mRNA expression in normal human tissues for TTC22 Gene

mRNA differential expression in normal tissues according to GTEx for TTC22 Gene

This gene is overexpressed in Esophagus - Mucosa (16.2) and Vagina (6.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TTC22 Gene

SOURCE GeneReport for Unigene cluster for TTC22 Gene Hs.16230

genes like me logo Genes that share expressions with TTC22: view

Orthologs for TTC22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC22 36
  • 99.47 (n)
  • 99.65 (a)
TTC22 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC22 36
  • 90.67 (n)
  • 91.02 (a)
TTC22 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC22 36
  • 88.71 (n)
  • 87.89 (a)
TTC22 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc22 36
  • 84.22 (n)
  • 85.37 (a)
Ttc22 16
Ttc22 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC22 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc22 36
  • 83.33 (n)
  • 85.04 (a)
lizard
(Anolis carolinensis)
Reptilia TTC22 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc22 36
  • 56.62 (n)
  • 55.33 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc22 36
  • 56.11 (n)
  • 50.93 (a)
ttc22 37
  • 49 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToOne
Species with no ortholog for TTC22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC22 Gene

ENSEMBL:
Gene Tree for TTC22 (if available)
TreeFam:
Gene Tree for TTC22 (if available)

Paralogs for TTC22 Gene

Pseudogenes.org Pseudogenes for TTC22 Gene

genes like me logo Genes that share paralogs with TTC22: view

No data available for Paralogs for TTC22 Gene

Variants for TTC22 Gene

Sequence variations from dbSNP and Humsavar for TTC22 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs122283 -- 54,796,778(-) GGATT(C/T)TGTCT intron-variant
rs584172 -- 54,786,543(-) TAGTG(A/G)GGGTA intron-variant
rs591867 -- 54,795,195(-) AGCCA(C/T)GCCAG intron-variant
rs594487 -- 54,794,598(-) GAAAA(C/T)TAGTC intron-variant
rs602152 -- 54,792,805(-) CCCCT(A/G)GTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC22 Gene

Variant ID Type Subtype PubMed ID
nsv461561 CNV Gain 19166990
nsv817614 CNV Gain 22305530
dgv229n71 CNV Gain 21882294
nsv871008 CNV Loss 21882294

Relevant External Links for TTC22 Gene

HapMap Linkage Disequilibrium report
TTC22

Disorders for TTC22 Gene

No disorders were found for TTC22 Gene.

No data available for UniProtKB/Swiss-Prot for TTC22 Gene

Publications for TTC22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for TTC22 Gene

Sources for TTC22 Gene

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