TTC21B Gene
protein-coding GIFtS: 50
GCID: GC02M166713
|
|
tetratricopeptide repeat domain 21B
| |
Aliases
for TTC21B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 21B1 2 | | FLJ114571 | | IFT1391 2 | | ATD42 | | JBTS111 2 | | Putative Protein Product Of Nbla106962 | | NPHP121 2 | | Tetratricopeptide Repeat Protein 21B2 | | TPR Repeat Protein 21B2 3 | | KIAA19923 | | THM12 5 | | |
Export aliases for TTC21B gene to outside databasesPrevious GC identifers: GC02M166491 GC02M165905 GC02M158612 |
Summaries
for TTC21B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TTC21B:
This gene encodes a member of TTC21 family, containing several tetratricopeptide repeat (TPR) domains. This protein islocalized to the cilium axoneme, and may play a role in retrograde intraflagellar transport in cilia. Mutations inthis gene are associated with various ciliopathies, nephronophthisis 12, and asphyxiating thoracic dystrophy 4.(provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: TT21B_HUMAN, Q7Z4L5Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negativelymodulates the SHH signal transduction (By similarity)
|
Genomic Views
for TTC21B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC21B gene promoter:
GR TBP GR-beta Nkx2-2 FOXD3 CREB Ik-2 TFIID deltaCREB GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC21B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC21B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q24.3TTC21B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M166713: view genomic region
(about GC identifiers)
Start:
|
166,713,985 bp from pter |
End:
|
166,810,353 bp from pter |
Size:
|
96,369 bases |
Orientation:
|
minus strand |
|
Proteins
for TTC21B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TT21B_HUMAN, Q7Z4L5 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 21B Size: 1316 amino acids; 150937 Da
Subunit: Component of the IFT complex A (IFT-A)
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme (By similarity)
Sequence caution: Sequence=AAY14750.1; Type=Erroneous gene model prediction; Sequence=BAB13836.1; Type=Erroneousinitiation; Note=Translation N-terminally extended;
Secondary accessions: A8MUZ3 Q3LIE4 Q53T84 Q6P4A1 Q6PIF5 Q8NCN3 Q96MA4 Q9HAK8Alternative splicing: 2 isoforms: Q7Z4L5-1 Q7Z4L5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TTC21B: NX_Q7Z4L5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z4L5
TTC21B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079029.3
ENSEMBL proteins: ENSP00000376460 ENSP00000243344 ENSP00000438692
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TTC21B for ontologies About GeneDecksing
TTC21B Antibody Products:
Assay Products for TTC21B: |
Protein
Domains /
Families
for TTC21B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC21B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z4L5ProtoNet protein and cluster: Q7Z4L5 UniProtKB/Swiss-Prot: TT21B_HUMAN, Q7Z4L5Similarity: Belongs to the TTC21 familySimilarity: Contains 19 TPR repeats |
Function
for TTC21B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TT21B_HUMAN, Q7Z4L5Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negativelymodulates the SHH signal transduction (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC21B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC21B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TTC21B (NM_024753) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC21B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC21B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC21B |
1 GenomeRNAi human phenotype for TTC21B:
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ttc21b):
TTC21B for phenotypes About GeneDecksing
|
Pathways & Interactions
for TTC21B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC21B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for TTC21B (Q7Z4L53 ENSP000002433444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007224 | smoothened signaling pathway |
IEA | -- | | GO:0042073 | intraflagellar transport |
IEA | -- | | GO:0060271 | cilium morphogenesis |
IEA | -- |
TTC21B for ontologies About GeneDecksing
|
Drugs & Compounds
for TTC21B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC21B
Search CenterWatch for drugs/clinical trials and news about TTC21B / TT21B
|
Transcripts
for TTC21B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC21B gene: NM_024753.4 Unigene Cluster for TTC21B: Tetratricopeptide repeat domain 21B Hs.310672 [show with all ESTs]Unigene Representative Sequence: NM_0247539 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000486672(uc021vrz.1) ENST00000489714 ENST00000392695 ENST00000243344(uc002udk.3)
ENST00000497425 ENST00000484129 ENST00000464374(uc002udl.3) ENST00000476227
ENST00000536175(uc002udj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC21B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC21B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTC21B (NM_024753) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC21B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC21B |
Additional cDNA sequence: AB073395.1 AK057268.1 AK096451.1 AK292942.1 BC035767.2 BC055424.1 BC063579.1 BX647903.1 8 DOTS entries: DT.101983099 DT.95259000 DT.95104689 DT.101969023 DT.100783939 DT.91998178 DT.75166790 DT.75196290 24/105 AceView cDNA sequences (see all 105): CD251890 CK905149 BX092716 AI091098 BX280579 CD251671 BP872584 CR608010 BX647903 AI248774 BM974112 BM990589 BC063579 BX504175 BU735940 AW005879 AV711245 BC035767 BQ434846 CD678627 AK057906 BG548940 AL602821 AK057268
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TTC21B (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31a | · | 31b | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TTC21B
|
Expression
for TTC21B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC21B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAGACAA
About this image
See TTC21B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC21B
SOURCE GeneReport for Unigene cluster: Hs.310672
SABiosciences Custom PCR Arrays for TTC21B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC21B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC21B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC21B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC21B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC21B |
Orthologs
for TTC21B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TTC21B gene from 5/22 species (see all 22) About this table
ENSEMBL Gene Tree for TTC21B (if available)
TreeFam Gene Tree for TTC21B (if available) |
Paralogs
for TTC21B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTC21B gene
- TTC21A2
1 SIMAP similar gene for TTC21B using alignment to 2 protein entries: TT21B_HUMAN (see all proteins):TTC21A
TTC21B for paralogs About GeneDecksing
|
Genomic Variants
for TTC21B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC21B (166713985 - 166810353 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TTC21B
1 CNV: 4317
Human Gene Mutation Database (HGMD): TTC21B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC21B |
|
Disorders
/ Diseases
for TTC21B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TTC21B for disorders About GeneDecksing
OMIM gene information: 612014
OMIM disorders: --
UniProtKB/Swiss-Prot: TT21B_HUMAN, Q7Z4L5
Note=Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Overlappingclinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of variousorgan, and a complex range of anatomical and functional defects of the central and peripheral nervous system. Theciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome,nephronophtisis, Senior-Loken syndrome, and Jeune asphyxiating thoracic dystrophy among others. TTC21B is causallyassociated with diverse ciliopathies, and also acts as a modifier gene across the ciliopathy spectrum. TTC21Bmutations interact in trans with mutations in other ciliopathy-causing genes and contribute to disease manifestationand severity Defects in TTC21B are the cause of nephronophthisis type 12 (NPHP12) [MIM:613820]. NPHP12 is an autosomalrecessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorderhistologically characterized by modifications of the tubules with thickening of the basement membrane, interstitialfibrosis and, in the advanced stages, medullary cysts. Some patients manifest extra-renal features including retinal,skeletal and central nervous system defects Defects in TTC21B are the cause of asphyxiating thoracic dystrophy type 4 (ATD4) [MIM:613819]. ATD4 is anautosomal recessive chondrodysplasia characterized by a severely constricted thoracic cage, short-limbed shortstature, and polydactyly. It often leads to death in infancy because of respiratory insufficiency. Retinaldegeneration, cystic renal disease and hepatic disease can be present in affected individuals who survive earlychildhood Defects in TTC21B may be a cause of Bardet-Biedl syndrome (BBS) [MIM:209900]. A syndrome characterized byusually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mentalretardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedlsyndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a secondlocus) may be required for clinical manifestation of some forms of the disease Defects in TTC21B may be a cause of Joubert syndrome (JBTS) [MIM:213300]. A disorder presenting withcerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay.Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superiorcerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth ontransaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease
20/23  diseases for TTC21B (see all 23): About MalaCardsasphyxiating thoracic dystrophy asphyxiating thoracic dystrophy 4 ellis-van creveld syndrome nephronophthisis
oculomotor apraxia senior-loken syndrome bardet-biedl syndrome apraxia
pigmentary retinopathy short stature sensenbrenner syndrome congenital nystagmus
joubert syndrome cerebellar ataxia retinal degeneration nystagmus
chondrodysplasia polydactyly ataxia hypotonia
6 diseases from the University of Copenhagen DISEASES database for TTC21B:Asphyxiating thoracic dystrophy Sensenbrenner syndrome Seckel syndrome Congenital nystagmus
Nephronophthisis Ellis-Van Creveld syndrome Human Genome Epidemiology (HuGE) Navigator: TTC21B (1 document)
Export disorders for TTC21B gene to outside databases
|
Publications
for TTC21B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC21B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TTC21B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. (PubMed id 21258341)1, 2, 3 Davis E.E....Katsanis N. (2011)
- Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2, 3 Ohara O.... Koseki H. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Mutations in C5ORF42 cause Joubert syndrome in the French Canadian population. (PubMed id 22425360)2 Srour M....Michaud J.L. (2012)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Mutation analysis of 18 nephronophthisis associated c iliopathy disease genes using a DNA pooling and next generation sequencing stra tegy. (PubMed id 21068128)1 Otto E.A....Hildebrandt F. (2010)
- TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. (PubMed id 20889716)2 Mukhopadhyay S....Jackson P.K. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for TTC21B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTC21B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC21B gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TTC21B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC21B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTC21B gene:
Search GeneIP for patents involving TTC21B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC21B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC21B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC21B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC21B | | | OriGene Protein Over-expression Lysate for TTC21B | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TTC21B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC21B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC21B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TTC21B | | OriGene Custom Protein Services for TTC21B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC21B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC21B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC21B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC21B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC21B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC21B |
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| | | | Search Tocris compounds for TTC21B |
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 | | | TTC21B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC21B |
|  |  |  | | | | Search ThermoFisher Antibodies for TTC21B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC21B |
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