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Aliases for TTC21A Gene

Aliases for TTC21A Gene

  • Tetratricopeptide Repeat Domain 21A 2 3 5
  • Stress-Inducible Protein 2 3 4
  • TPR Repeat Protein 21A 3 4
  • STI2 3 4
  • Tetratricopeptide Repeat Protein 21A 3
  • Testicular Tissue Protein Li 212 3
  • TPR Domain Containing STI2 3
  • IFT139A 3

External Ids for TTC21A Gene

Previous GeneCards Identifiers for TTC21A Gene

  • GC03P039125
  • GC03P039149

Summaries for TTC21A Gene

GeneCards Summary for TTC21A Gene

TTC21A (Tetratricopeptide Repeat Domain 21A) is a Protein Coding gene. An important paralog of this gene is TTC21B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC21A Gene

Genomics for TTC21A Gene

Regulatory Elements for TTC21A Gene

Enhancers for TTC21A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F039131 0.6 ENCODE 24.1 +25.3 25348 2.2 BCOR ZNF146 PKNOX1 ZMYM3 EBF1 ZKSCAN1 NR2F6 NR2F1 ATF2 MCM7 TTC21A GORASP1 MIR6822 CX3CR1 LOC101928263
GH03F039145 1 FANTOM5 ENCODE 23.4 +43.4 43436 10.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GORASP1 TTC21A CSRNP1 MIR6822 XIRP1 SNORA62 CX3CR1 EXOG WDR48 LOC101928263
GH03F039049 0.4 Ensembl 20.6 -57.7 -57660 0.4 IKZF1 SPI1 TTC21A RNU6-1227P MIR6822 GORASP1 WDR48 GC03P039025
GH03F039374 0.6 FANTOM5 19.9 +267.0 266986 0.1 POLR2A HLF ZNF600 TTC21A MOBP GC03P039372 LOC105377037
GH03F039106 0.2 ENCODE 18.6 -0.1 -67 2.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 SLC30A9 SP3 SP5 CX3CR1 TTC21A GORASP1 CSRNP1 SCN11A PIR55888 GC03M039097
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TTC21A on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC21A Gene

Chromosome:
3
Start:
39,107,661 bp from pter
End:
39,138,994 bp from pter
Size:
31,334 bases
Orientation:
Plus strand

Genomic View for TTC21A Gene

Genes around TTC21A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC21A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC21A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC21A Gene

Proteins for TTC21A Gene

  • Protein details for TTC21A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDW8-TT21A_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 21A
    Protein Accession:
    Q8NDW8
    Secondary Accessions:
    • A1L388
    • B4DYF6
    • B4DYJ3
    • D3YTE7
    • D4PHA5
    • Q6P5W8
    • Q8N7G5
    • Q8NA02

    Protein attributes for TTC21A Gene

    Size:
    1320 amino acids
    Molecular mass:
    150944 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04129.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC21A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC21A Gene

Post-translational modifications for TTC21A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC21A Gene

Domains & Families for TTC21A Gene

Protein Domains for TTC21A Gene

Suggested Antigen Peptide Sequences for TTC21A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDW8

UniProtKB/Swiss-Prot:

TT21A_HUMAN :
  • Belongs to the TTC21 family.
  • Contains 19 TPR repeats.
Family:
  • Belongs to the TTC21 family.
Similarity:
  • Contains 19 TPR repeats.
genes like me logo Genes that share domains with TTC21A: view

Function for TTC21A Gene

Phenotypes for TTC21A Gene

genes like me logo Genes that share phenotypes with TTC21A: view

Animal Model Products

miRNA for TTC21A Gene

miRTarBase miRNAs that target TTC21A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC21A Gene

Localization for TTC21A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC21A Gene COMPARTMENTS Subcellular localization image for TTC21A gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTC21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IBA --
GO:0030991 intraciliary transport particle A IBA --
genes like me logo Genes that share ontologies with TTC21A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC21A Gene

Pathways & Interactions for TTC21A Gene

SuperPathways for TTC21A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035721 intraciliary retrograde transport IBA --
GO:0060271 cilium assembly IBA --
GO:0061512 protein localization to cilium IBA --
genes like me logo Genes that share ontologies with TTC21A: view

No data available for Pathways by source and SIGNOR curated interactions for TTC21A Gene

Transcripts for TTC21A Gene

Unigene Clusters for TTC21A Gene

Tetratricopeptide repeat domain 21A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC21A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13: -

Relevant External Links for TTC21A Gene

GeneLoc Exon Structure for
TTC21A
ECgene alternative splicing isoforms for
TTC21A

Expression for TTC21A Gene

mRNA expression in normal human tissues for TTC21A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC21A Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for TTC21A Gene

This gene is overexpressed in Ovary (38.6), Testis (17.9), and Blymphocyte (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC21A Gene



Protein tissue co-expression partners for TTC21A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC21A Gene:

TTC21A

SOURCE GeneReport for Unigene cluster for TTC21A Gene:

Hs.443935

mRNA Expression by UniProt/SwissProt for TTC21A Gene:

Q8NDW8-TT21A_HUMAN
Tissue specificity: Strongly expressed in testis.
genes like me logo Genes that share expression patterns with TTC21A: view

Primer Products

Orthologs for TTC21A Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC21A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC21A 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia TTC21A 34 35
  • 85.29 (n)
cow
(Bos Taurus)
Mammalia TTC21A 34 35
  • 83.67 (n)
rat
(Rattus norvegicus)
Mammalia Ttc21a 34
  • 81.02 (n)
mouse
(Mus musculus)
Mammalia Ttc21a 34 16 35
  • 80.34 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC21A 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC21A 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC21A 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485767 34
  • 62.77 (n)
zebrafish
(Danio rerio)
Actinopterygii TTC21A 35
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK328.7 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for TTC21A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC21A Gene

ENSEMBL:
Gene Tree for TTC21A (if available)
TreeFam:
Gene Tree for TTC21A (if available)

Paralogs for TTC21A Gene

Paralogs for TTC21A Gene

(1) SIMAP similar genes for TTC21A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TTC21A: view

Variants for TTC21A Gene

Sequence variations from dbSNP and Humsavar for TTC21A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10433546 -- 39,126,560(+) ACACA(C/T)GCATG intron-variant
rs10433601 -- 39,126,561(+) CACAT(A/G)CATGC intron-variant
rs10709200 -- 39,115,349(+) GAACC(-/A)AAAAA intron-variant
rs111231532 -- 39,135,911(+) TTGGC(C/T)GGGCG intron-variant
rs1112438 -- 39,110,854(-) CTTCT(C/T)GGTCT nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TTC21A Gene

Variant ID Type Subtype PubMed ID
nsv590102 CNV loss 21841781

Variation tolerance for TTC21A Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.75; 98.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC21A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC21A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC21A Gene

Disorders for TTC21A Gene

Relevant External Links for TTC21A

Genetic Association Database (GAD)
TTC21A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC21A

No disorders were found for TTC21A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC21A Gene

Publications for TTC21A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. (PMID: 24564958) St Pourcain B. … Smith G.D. (Mol Autism 2014) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 46 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for TTC21A Gene

Sources for TTC21A Gene

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