Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTC21A Gene

Aliases for TTC21A Gene

  • Tetratricopeptide Repeat Domain 21A 2 3
  • Stress-Inducible Protein 2 3 4
  • TPR Repeat Protein 21A 3 4
  • STI2 3 4
  • Tetratricopeptide Repeat Protein 21A 3
  • TPR Domain Containing STI2 3

External Ids for TTC21A Gene

Previous GeneCards Identifiers for TTC21A Gene

  • GC03P039125
  • GC03P039149

Summaries for TTC21A Gene

GeneCards Summary for TTC21A Gene

TTC21A (Tetratricopeptide Repeat Domain 21A) is a Protein Coding gene. An important paralog of this gene is TTC21B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC21A Gene

Genomics for TTC21A Gene

Regulatory Elements for TTC21A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC21A Gene

39,107,661 bp from pter
39,138,903 bp from pter
31,243 bases
Plus strand

Genomic View for TTC21A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC21A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC21A Gene

Proteins for TTC21A Gene

  • Protein details for TTC21A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 21A
    Protein Accession:
    Secondary Accessions:
    • A1L388
    • B4DYF6
    • B4DYJ3
    • D3YTE7
    • D4PHA5
    • Q6P5W8
    • Q8N7G5
    • Q8NA02

    Protein attributes for TTC21A Gene

    1320 amino acids
    Molecular mass:
    150944 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04129.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC21A Gene


neXtProt entry for TTC21A Gene

Proteomics data for TTC21A Gene at MOPED

Post-translational modifications for TTC21A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC21A Gene

No data available for DME Specific Peptides for TTC21A Gene

Domains for TTC21A Gene

Protein Domains for TTC21A Gene

Suggested Antigen Peptide Sequences for TTC21A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TTC21 family.
  • Contains 19 TPR repeats.
  • Belongs to the TTC21 family.
  • Contains 19 TPR repeats.
genes like me logo Genes that share domains with TTC21A: view

Function for TTC21A Gene

Gene Ontology (GO) - Molecular Function for TTC21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC21A: view

Animal Model Products

miRNA for TTC21A Gene

miRTarBase miRNAs that target TTC21A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTC21A Gene

Localization for TTC21A Gene

Subcellular locations from

Jensen Localization Image for TTC21A Gene COMPARTMENTS Subcellular localization image for TTC21A gene
Compartment Confidence
cytosol 3
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC21A Gene

Pathways for TTC21A Gene

SuperPathways for TTC21A Gene

No Data Available

Interacting Proteins for TTC21A Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000398211 for TTC21A Gene via STRING

Gene Ontology (GO) - Biological Process for TTC21A Gene


No data available for Pathways by source for TTC21A Gene

Transcripts for TTC21A Gene

Unigene Clusters for TTC21A Gene

Tetratricopeptide repeat domain 21A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC21A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC21A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: -
SP5: -
SP6: -

ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP9: - - -
SP13: -

Relevant External Links for TTC21A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC21A Gene

mRNA expression in normal human tissues for TTC21A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC21A Gene

This gene is overexpressed in Testis (12.4).

Protein differential expression in normal tissues for TTC21A Gene

This gene is overexpressed in Ovary (38.6), Testis (17.9), and Blymphocyte (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTC21A Gene

SOURCE GeneReport for Unigene cluster for TTC21A Gene Hs.443935

mRNA Expression by UniProt/SwissProt for TTC21A Gene

Tissue specificity: Strongly expressed in testis.
genes like me logo Genes that share expressions with TTC21A: view

Expression partners for TTC21A Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for TTC21A Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC21A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC21A 35
  • 83.67 (n)
  • 80.02 (a)
TTC21A 36
  • 80 (a)
(Canis familiaris)
Mammalia TTC21A 35
  • 85.29 (n)
  • 81.08 (a)
TTC21A 36
  • 81 (a)
(Mus musculus)
Mammalia Ttc21a 35
  • 80.34 (n)
  • 77.13 (a)
Ttc21a 16
Ttc21a 36
  • 77 (a)
(Pan troglodytes)
Mammalia TTC21A 35
  • 99.55 (n)
  • 99.62 (a)
TTC21A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ttc21a 35
  • 81.02 (n)
  • 77.74 (a)
(Monodelphis domestica)
Mammalia TTC21A 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia TTC21A 36
  • 64 (a)
(Anolis carolinensis)
Reptilia TTC21A 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485767 35
  • 62.77 (n)
  • 59.48 (a)
(Danio rerio)
Actinopterygii TTC21A 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea ZK328.7 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for TTC21A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC21A Gene

Gene Tree for TTC21A (if available)
Gene Tree for TTC21A (if available)

Paralogs for TTC21A Gene

Paralogs for TTC21A Gene

(1) SIMAP similar genes for TTC21A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TTC21A: view

Variants for TTC21A Gene

Sequence variations from dbSNP and Humsavar for TTC21A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs704959 - 39,138,772(-) GGGAC(C/T)TTCGG missense, reference, nc-transcript-variant
rs784488 -- 39,131,644(-) cacca(C/G)atgtg intron-variant
rs784489 -- 39,131,935(-) cccca(A/G)atgtc intron-variant
rs784490 -- 39,132,039(-) ctata(C/T)catct intron-variant
rs784491 -- 39,132,971(-) ATTCA(A/G)AGCCA intron-variant

Relevant External Links for TTC21A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTC21A Gene

Disorders for TTC21A Gene

Relevant External Links for TTC21A

Genetic Association Database (GAD)

No disorders were found for TTC21A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TTC21A Gene

Publications for TTC21A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. (PMID: 24564958) St Pourcain B. … Smith G.D. (Mol Autism 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 48

Products for TTC21A Gene

Sources for TTC21A Gene

Back to Top