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Aliases for TTC21A Gene

Aliases for TTC21A Gene

  • Tetratricopeptide Repeat Domain 21A 2 3 5
  • Stress-Inducible Protein 2 3 4
  • TPR Repeat Protein 21A 3 4
  • STI2 3 4
  • Tetratricopeptide Repeat Protein 21A 3
  • Testicular Tissue Protein Li 212 3
  • TPR Domain Containing STI2 3
  • IFT139A 3

External Ids for TTC21A Gene

Previous GeneCards Identifiers for TTC21A Gene

  • GC03P039125
  • GC03P039149

Summaries for TTC21A Gene

GeneCards Summary for TTC21A Gene

TTC21A (Tetratricopeptide Repeat Domain 21A) is a Protein Coding gene. An important paralog of this gene is TTC21B.

Additional gene information for TTC21A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC21A Gene

Genomics for TTC21A Gene

Regulatory Elements for TTC21A Gene

Enhancers for TTC21A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H039145 2.1 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +43.4 43436 10 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF207 GORASP1 SNORA62 TTC21A CX3CR1 OXSR1 WDR48 CSRNP1 XIRP1 MOBP ACVR2B-AS1
GH03H039106 1.1 ENCODE 18.6 -0.1 -67 2 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 SP3 SP5 CX3CR1 TTC21A GORASP1 CSRNP1 MOBP SCN11A PIR55888 GC03M039097
GH03H039131 0.8 ENCODE dbSUPER 24.1 +25.3 25348 2 GATA3 PKNOX1 MNT EBF1 ZKSCAN1 FOXA1 TTC21A GORASP1 CX3CR1 MIR6822
GH03H039124 1.4 Ensembl ENCODE dbSUPER 13.2 +18.8 18804 3 HDGF ARNT ZSCAN4 RAD21 ZNF143 FOS RUNX3 ZHX1 EGR2 SMARCA5 TTC21A CSRNP1 GORASP1 OXSR1 SNORA62 XIRP1 CX3CR1 MIR6822
GH03H039175 1.6 Ensembl ENCODE dbSUPER 11.5 +72.4 72386 8 HDGF FOXA2 ARID4B SIN3A YBX1 YY1 FOS SP3 SP5 ZHX2 GORASP1 CSRNP1 CX3CR1 TTC21A RPSA PIR56273 XIRP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC21A on UCSC Golden Path with GeneCards custom track

Promoters for TTC21A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151056 -261 1601 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 YY1 ETS1 SLC30A9 GLIS2

Genomic Location for TTC21A Gene

Chromosome:
3
Start:
39,107,661 bp from pter
End:
39,138,994 bp from pter
Size:
31,334 bases
Orientation:
Plus strand

Genomic View for TTC21A Gene

Genes around TTC21A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC21A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC21A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC21A Gene

Proteins for TTC21A Gene

  • Protein details for TTC21A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDW8-TT21A_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 21A
    Protein Accession:
    Q8NDW8
    Secondary Accessions:
    • A1L388
    • B4DYF6
    • B4DYJ3
    • D3YTE7
    • D4PHA5
    • Q6P5W8
    • Q8N7G5
    • Q8NA02

    Protein attributes for TTC21A Gene

    Size:
    1320 amino acids
    Molecular mass:
    150944 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04129.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC21A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC21A Gene

Post-translational modifications for TTC21A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC21A Gene

Domains & Families for TTC21A Gene

Protein Domains for TTC21A Gene

Suggested Antigen Peptide Sequences for TTC21A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDW8

UniProtKB/Swiss-Prot:

TT21A_HUMAN :
  • Belongs to the TTC21 family.
Family:
  • Belongs to the TTC21 family.
genes like me logo Genes that share domains with TTC21A: view

Function for TTC21A Gene

Phenotypes From GWAS Catalog for TTC21A Gene

Phenotypes for TTC21A Gene

genes like me logo Genes that share phenotypes with TTC21A: view

Animal Model Products

CRISPR Products

miRNA for TTC21A Gene

miRTarBase miRNAs that target TTC21A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC21A Gene

Localization for TTC21A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC21A gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TTC21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0030991 intraciliary transport particle A IBA --
genes like me logo Genes that share ontologies with TTC21A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC21A Gene

Pathways & Interactions for TTC21A Gene

SuperPathways for TTC21A Gene

No Data Available

Interacting Proteins for TTC21A Gene

Gene Ontology (GO) - Biological Process for TTC21A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035721 intraciliary retrograde transport IBA --
GO:0061512 protein localization to cilium IBA --
genes like me logo Genes that share ontologies with TTC21A: view

No data available for Pathways by source and SIGNOR curated interactions for TTC21A Gene

Drugs & Compounds for TTC21A Gene

No Compound Related Data Available

Transcripts for TTC21A Gene

Unigene Clusters for TTC21A Gene

Tetratricopeptide repeat domain 21A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC21A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13: -

Relevant External Links for TTC21A Gene

GeneLoc Exon Structure for
TTC21A
ECgene alternative splicing isoforms for
TTC21A

Expression for TTC21A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC21A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC21A Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for TTC21A Gene

This gene is overexpressed in Ovary (38.6), Testis (17.9), and Blymphocyte (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC21A Gene



Protein tissue co-expression partners for TTC21A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC21A Gene:

TTC21A

SOURCE GeneReport for Unigene cluster for TTC21A Gene:

Hs.443935

mRNA Expression by UniProt/SwissProt for TTC21A Gene:

Q8NDW8-TT21A_HUMAN
Tissue specificity: Strongly expressed in testis.

Evidence on tissue expression from TISSUES for TTC21A Gene

  • Pancreas(4)
genes like me logo Genes that share expression patterns with TTC21A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC21A Gene

Orthologs for TTC21A Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC21A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC21A 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia TTC21A 33 34
  • 85.29 (n)
cow
(Bos Taurus)
Mammalia TTC21A 33 34
  • 83.67 (n)
rat
(Rattus norvegicus)
Mammalia Ttc21a 33
  • 81.02 (n)
mouse
(Mus musculus)
Mammalia Ttc21a 33 16 34
  • 80.34 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC21A 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC21A 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC21A 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485767 33
  • 62.77 (n)
zebrafish
(Danio rerio)
Actinopterygii TTC21A 34
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK328.7 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToMany
Species where no ortholog for TTC21A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC21A Gene

ENSEMBL:
Gene Tree for TTC21A (if available)
TreeFam:
Gene Tree for TTC21A (if available)

Paralogs for TTC21A Gene

Paralogs for TTC21A Gene

(1) SIMAP similar genes for TTC21A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TTC21A: view

Variants for TTC21A Gene

Sequence variations from dbSNP and Humsavar for TTC21A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000004192 -- 39,116,649(+) TTTTT(A/T)ATAAG intron-variant
rs1000035498 -- 39,116,430(+) TATTA(C/T)AAATT intron-variant
rs1000081207 -- 39,137,988(+) AGCTG(C/G)AGGGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000125824 -- 39,116,586(+) TCCTC(C/T)CAACT intron-variant
rs1000172032 -- 39,110,173(+) GACCC(A/G)CCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TTC21A Gene

Variant ID Type Subtype PubMed ID
nsv590102 CNV loss 21841781

Variation tolerance for TTC21A Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.75; 98.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC21A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC21A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC21A Gene

Disorders for TTC21A Gene

Relevant External Links for TTC21A

Genetic Association Database (GAD)
TTC21A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC21A

No disorders were found for TTC21A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC21A Gene

Publications for TTC21A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  3. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. (PMID: 24564958) St Pourcain B … Smith GD (Molecular autism 2014) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 45 60

Products for TTC21A Gene

Sources for TTC21A Gene

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