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Aliases for TTC17 Gene

Aliases for TTC17 Gene

  • Tetratricopeptide Repeat Domain 17 2 3 5
  • TPR Repeat Protein 17 4

External Ids for TTC17 Gene

Previous GeneCards Identifiers for TTC17 Gene

  • GC11P043344
  • GC11P043337
  • GC11P043090

Summaries for TTC17 Gene

GeneCards Summary for TTC17 Gene

TTC17 (Tetratricopeptide Repeat Domain 17) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TTC17 Gene

  • Plays a role in primary ciliogenesis by modulating actin polymerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC17 Gene

Genomics for TTC17 Gene

Regulatory Elements for TTC17 Gene

Enhancers for TTC17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC17 on UCSC Golden Path with GeneCards custom track

Promoters for TTC17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC17 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC17 Gene

43,358,885 bp from pter
43,494,933 bp from pter
136,049 bases
Plus strand

Genomic View for TTC17 Gene

Genes around TTC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC17 Gene

Proteins for TTC17 Gene

  • Protein details for TTC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 17
    Protein Accession:
    Secondary Accessions:
    • G3XAB3
    • Q8NEC0

    Protein attributes for TTC17 Gene

    1141 amino acids
    Molecular mass:
    129558 Da
    Quaternary structure:
    • Interacts with CATIP.

    Alternative splice isoforms for TTC17 Gene


neXtProt entry for TTC17 Gene

Proteomics data for TTC17 Gene at MOPED

Post-translational modifications for TTC17 Gene

  • Ubiquitination at Lys 261
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC17 Gene

No data available for DME Specific Peptides for TTC17 Gene

Domains & Families for TTC17 Gene

Gene Families for TTC17 Gene

Protein Domains for TTC17 Gene

Suggested Antigen Peptide Sequences for TTC17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TTC17 family.
  • Contains 6 TPR repeats.
  • Belongs to the TTC17 family.
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with TTC17: view

Function for TTC17 Gene

Molecular function for TTC17 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in primary ciliogenesis by modulating actin polymerization.
genes like me logo Genes that share phenotypes with TTC17: view

Animal Model Products

miRNA for TTC17 Gene

miRTarBase miRNAs that target TTC17

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC17 Gene

Localization for TTC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC17 Gene

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.

Subcellular locations from

Jensen Localization Image for TTC17 Gene COMPARTMENTS Subcellular localization image for TTC17 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TTC17 Gene

Pathways & Interactions for TTC17 Gene

SuperPathways for TTC17 Gene

No Data Available

Interacting Proteins for TTC17 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000039989 Q96AE7-TTC17_HUMAN for TTC17 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044782 cilium organization IMP 24475127
genes like me logo Genes that share ontologies with TTC17: view

No data available for Pathways by source and SIGNOR curated interactions for TTC17 Gene

Drugs & Compounds for TTC17 Gene

No Compound Related Data Available

Transcripts for TTC17 Gene

Unigene Clusters for TTC17 Gene

Tetratricopeptide repeat domain 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: - - - - -
SP2: - - -
SP6: -

ExUns: 18c ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1: - - - - - - -
SP2: -
SP4: - -
SP5: - -
SP8: -

Relevant External Links for TTC17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC17 Gene

mRNA expression in normal human tissues for TTC17 Gene

Protein differential expression in normal tissues from HIPED for TTC17 Gene

This gene is overexpressed in Placenta (25.9), Testis (17.0), Peripheral blood mononuclear cells (12.9), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TTC17 Gene

SOURCE GeneReport for Unigene cluster for TTC17 Gene Hs.191186

mRNA Expression by UniProt/SwissProt for TTC17 Gene

Tissue specificity: Expressed in germ cells as well as in somatic cells of the testis (at protein level).
genes like me logo Genes that share expression patterns with TTC17: view

Protein tissue co-expression partners for TTC17 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TTC17 Gene

Orthologs for TTC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC17 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC17 35
  • 92.81 (n)
  • 97.28 (a)
TTC17 36
  • 93 (a)
(Canis familiaris)
Mammalia TTC17 35
  • 92.67 (n)
  • 97.2 (a)
TTC17 36
  • 98 (a)
(Mus musculus)
Mammalia Ttc17 35
  • 88.96 (n)
  • 95.09 (a)
Ttc17 16
Ttc17 36
  • 91 (a)
(Pan troglodytes)
Mammalia TTC17 35
  • 99.8 (n)
  • 99.65 (a)
TTC17 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ttc17 35
  • 88.96 (n)
  • 94.74 (a)
(Monodelphis domestica)
Mammalia TTC17 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia TTC17 36
  • 84 (a)
(Gallus gallus)
Aves TTC17 35
  • 77.23 (n)
  • 80.73 (a)
TTC17 36
  • 75 (a)
(Anolis carolinensis)
Reptilia TTC17 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17174 35
ttc17 35
  • 67.46 (n)
  • 70.98 (a)
(Danio rerio)
Actinopterygii ttc17 35
  • 65.16 (n)
  • 64.73 (a)
TTC17 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11436 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea T19A5.1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1286 36
  • 30 (a)
Species with no ortholog for TTC17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC17 Gene

Gene Tree for TTC17 (if available)
Gene Tree for TTC17 (if available)

Paralogs for TTC17 Gene

(1) SIMAP similar genes for TTC17 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TTC17: view

No data available for Paralogs for TTC17 Gene

Variants for TTC17 Gene

Sequence variations from dbSNP and Humsavar for TTC17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12099204 - 43,391,478(+) ATTAT(A/C)TAGAC reference, missense, utr-variant-5-prime
rs16937479 - 43,397,381(+) TGGCA(A/C)ACGTT reference, missense
rs719777 -- 43,457,272(+) ACTGT(A/G)TGCCC intron-variant
rs719778 -- 43,457,322(+) TACGA(A/C)CTCTT intron-variant
rs721700 -- 43,448,425(+) GGTTT(C/G)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC17 Gene

Variant ID Type Subtype PubMed ID
nsv519819 CNV Gain 19592680
nsv7753 CNV Insertion 18451855
esv2678898 CNV Deletion 23128226

Variation tolerance for TTC17 Gene

Residual Variation Intolerance Score: 4.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TTC17 Gene

Disorders for TTC17 Gene

Relevant External Links for TTC17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTC17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC17 Gene

Publications for TTC17 Gene

  1. C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in Zebrafish and Human. (PMID: 24475127) Bontems F. … Lane L. (PLoS ONE 2014) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk R.J. … Jaddoe V.W. (Hum. Mol. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TTC17 Gene

Sources for TTC17 Gene