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Aliases for TTC17 Gene

Aliases for TTC17 Gene

  • Tetratricopeptide Repeat Domain 17 2 3 5
  • TPR Repeat Protein 17 4

External Ids for TTC17 Gene

Previous GeneCards Identifiers for TTC17 Gene

  • GC11P043344
  • GC11P043337
  • GC11P043090

Summaries for TTC17 Gene

GeneCards Summary for TTC17 Gene

TTC17 (Tetratricopeptide Repeat Domain 17) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TTC17 Gene

  • Plays a role in primary ciliogenesis by modulating actin polymerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC17 Gene

Genomics for TTC17 Gene

Regulatory Elements for TTC17 Gene

Enhancers for TTC17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F043394 0.5 ENCODE 11.6 +35.3 35291 0.1 HDAC1 ATF1 TAL1 ZNF175 PYGO2 CCNT2 GATA2 NCOR1 ADNP TRIM24 LOC105376643 TTC17 API5 ENSG00000254577 RN7SKP287
GH11F043357 0.2 ENCODE 5.8 +0.5 531 3.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF263 SEC14L1P1 ACCS EXT2 ENSG00000244953 ENSG00000255165 C11orf96 ALKBH3 API5 TTC17 LOC105376643
GH11F043268 0.7 ENCODE 5.4 -89.9 -89922 1.8 CTCF SMARCA4 POLR2A API5 TTC17 HNRNPKP3 ENSG00000254725
GH11F043130 1.1 ENCODE 5.4 -228.1 -228120 0.2 CTCF RAD21 TTC17 ENSG00000254725 HNRNPKP3
GH11F043135 0.7 ENCODE 5.3 -222.6 -222609 1.2 SP1 MTA2 IKZF1 ASH2L JUNB CREM EP300 TTC17 ENSG00000254725 HNRNPKP3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TTC17 on UCSC Golden Path with GeneCards custom track

Promoters for TTC17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108801 515 2801 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF263 SP3

Genomic Location for TTC17 Gene

Chromosome:
11
Start:
43,358,885 bp from pter
End:
43,494,933 bp from pter
Size:
136,049 bases
Orientation:
Plus strand

Genomic View for TTC17 Gene

Genes around TTC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC17 Gene

Proteins for TTC17 Gene

  • Protein details for TTC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AE7-TTC17_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 17
    Protein Accession:
    Q96AE7
    Secondary Accessions:
    • G3XAB3
    • Q8NEC0

    Protein attributes for TTC17 Gene

    Size:
    1141 amino acids
    Molecular mass:
    129558 Da
    Quaternary structure:
    • Interacts with CATIP.

    Alternative splice isoforms for TTC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC17 Gene

Post-translational modifications for TTC17 Gene

  • Ubiquitination at Lys 261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC17 Gene

Domains & Families for TTC17 Gene

Gene Families for TTC17 Gene

Protein Domains for TTC17 Gene

Suggested Antigen Peptide Sequences for TTC17 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AE7

UniProtKB/Swiss-Prot:

TTC17_HUMAN :
  • Belongs to the TTC17 family.
  • Contains 6 TPR repeats.
Family:
  • Belongs to the TTC17 family.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with TTC17: view

Function for TTC17 Gene

Molecular function for TTC17 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in primary ciliogenesis by modulating actin polymerization.

Gene Ontology (GO) - Molecular Function for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24475127
genes like me logo Genes that share ontologies with TTC17: view
genes like me logo Genes that share phenotypes with TTC17: view

Animal Model Products

miRNA for TTC17 Gene

miRTarBase miRNAs that target TTC17

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC17 Gene

Localization for TTC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC17 Gene

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC17 Gene COMPARTMENTS Subcellular localization image for TTC17 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 24475127
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA,IDA 24475127
GO:0015629 actin cytoskeleton IDA 24475127
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TTC17: view

Pathways & Interactions for TTC17 Gene

SuperPathways for TTC17 Gene

No Data Available

Interacting Proteins for TTC17 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000039989%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000039989 Q96AE7-TTC17_HUMAN for TTC17 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0030041 actin filament polymerization IMP 24475127
GO:0044782 cilium organization IMP 24475127
genes like me logo Genes that share ontologies with TTC17: view

No data available for Pathways by source and SIGNOR curated interactions for TTC17 Gene

Transcripts for TTC17 Gene

Unigene Clusters for TTC17 Gene

Tetratricopeptide repeat domain 17:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: - - - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 18c ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1: - - - - - - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:

Relevant External Links for TTC17 Gene

GeneLoc Exon Structure for
TTC17
ECgene alternative splicing isoforms for
TTC17

Expression for TTC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TTC17 Gene

Protein differential expression in normal tissues from HIPED for TTC17 Gene

This gene is overexpressed in Placenta (25.9), Testis (17.0), Peripheral blood mononuclear cells (12.9), and Retina (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTC17 Gene



Protein tissue co-expression partners for TTC17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC17 Gene:

TTC17

SOURCE GeneReport for Unigene cluster for TTC17 Gene:

Hs.191186

mRNA Expression by UniProt/SwissProt for TTC17 Gene:

Q96AE7-TTC17_HUMAN
Tissue specificity: Expressed in germ cells as well as in somatic cells of the testis (at protein level).
genes like me logo Genes that share expression patterns with TTC17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TTC17 Gene

Orthologs for TTC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC17 34 35
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia TTC17 34 35
  • 92.81 (n)
dog
(Canis familiaris)
Mammalia TTC17 34 35
  • 92.67 (n)
mouse
(Mus musculus)
Mammalia Ttc17 34 16 35
  • 88.96 (n)
rat
(Rattus norvegicus)
Mammalia Ttc17 34
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TTC17 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC17 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC17 34 35
  • 77.23 (n)
lizard
(Anolis carolinensis)
Reptilia TTC17 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc17 34
  • 67.46 (n)
Str.17174 34
zebrafish
(Danio rerio)
Actinopterygii ttc17 34
  • 65.16 (n)
TTC17 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11436 35
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T19A5.1 35
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1286 35
  • 30 (a)
OneToOne
Species where no ortholog for TTC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC17 Gene

ENSEMBL:
Gene Tree for TTC17 (if available)
TreeFam:
Gene Tree for TTC17 (if available)

Paralogs for TTC17 Gene

(1) SIMAP similar genes for TTC17 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TTC17: view

No data available for Paralogs for TTC17 Gene

Variants for TTC17 Gene

Sequence variations from dbSNP and Humsavar for TTC17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1006813 -- 43,439,199(-) AAGAT(G/T)TTGAA intron-variant
rs1006814 -- 43,438,931(-) TATCC(A/G)GGAAG intron-variant
rs10501296 -- 43,385,256(+) TAAAT(A/T)GAACG intron-variant
rs10501297 -- 43,400,172(+) CATCT(C/T)GAAAG intron-variant
rs10501298 -- 43,411,798(+) GTGAA(C/T)TACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC17 Gene

Variant ID Type Subtype PubMed ID
esv2678898 CNV deletion 23128226
esv3578660 CNV gain 25503493
esv3626145 CNV loss 21293372
esv3626146 CNV gain 21293372
nsv519819 CNV gain 19592680
nsv554119 CNV gain 21841781
nsv7753 CNV insertion 18451855
nsv975169 CNV duplication 23825009

Variation tolerance for TTC17 Gene

Residual Variation Intolerance Score: 4.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC17 Gene

Disorders for TTC17 Gene

Relevant External Links for TTC17

Genetic Association Database (GAD)
TTC17
Human Genome Epidemiology (HuGE) Navigator
TTC17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC17

No disorders were found for TTC17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC17 Gene

Publications for TTC17 Gene

  1. C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in Zebrafish and Human. (PMID: 24475127) Bontems F. … Lane L. (PLoS ONE 2014) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk R.J. … Jaddoe V.W. (Hum. Mol. Genet. 2015) 3 64

Products for TTC17 Gene

Sources for TTC17 Gene

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