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Aliases for TTC17 Gene

Aliases for TTC17 Gene

  • Tetratricopeptide Repeat Domain 17 2 3
  • TPR Repeat Protein 17 4

External Ids for TTC17 Gene

Previous GeneCards Identifiers for TTC17 Gene

  • GC11P043344
  • GC11P043337
  • GC11P043090

Summaries for TTC17 Gene

GeneCards Summary for TTC17 Gene

TTC17 (Tetratricopeptide Repeat Domain 17) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TTC17 Gene

  • Plays a role in primary ciliogenesis by modulating actin polymerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC17 Gene

Genomics for TTC17 Gene

Regulatory Elements for TTC17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC17 Gene

Start:
43,358,885 bp from pter
End:
43,494,933 bp from pter
Size:
136,049 bases
Orientation:
Plus strand

Genomic View for TTC17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC17 Gene

Proteins for TTC17 Gene

  • Protein details for TTC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AE7-TTC17_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 17
    Protein Accession:
    Q96AE7
    Secondary Accessions:
    • G3XAB3
    • Q8NEC0

    Protein attributes for TTC17 Gene

    Size:
    1141 amino acids
    Molecular mass:
    129558 Da
    Quaternary structure:
    • Interacts with CATIP.

    Alternative splice isoforms for TTC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC17 Gene

Proteomics data for TTC17 Gene at MOPED

Post-translational modifications for TTC17 Gene

  • Ubiquitination at Lys261
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC17 Gene

No data available for DME Specific Peptides for TTC17 Gene

Domains for TTC17 Gene

Gene Families for TTC17 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC17 Gene

Suggested Antigen Peptide Sequences for TTC17 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AE7

UniProtKB/Swiss-Prot:

TTC17_HUMAN :
  • Q96AE7
Family:
  • Belongs to the TTC17 family.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with TTC17: view

Function for TTC17 Gene

Molecular function for TTC17 Gene

UniProtKB/Swiss-Prot Function: Plays a role in primary ciliogenesis by modulating actin polymerization.

Gene Ontology (GO) - Molecular Function for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24475127
genes like me logo Genes that share ontologies with TTC17: view

Phenotypes for TTC17 Gene

GenomeRNAi human phenotypes for TTC17:
genes like me logo Genes that share phenotypes with TTC17: view

Animal Model Products

CRISPR Products

miRNA for TTC17 Gene

miRTarBase miRNAs that target TTC17

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTC17 Gene

Localization for TTC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTC17 Gene

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized with CATIP at F-actin rich zones and at dynamic plasma membrane protrusions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC17 Gene COMPARTMENTS Subcellular localization image for TTC17 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 24475127
GO:0005886 plasma membrane IDA 24475127
GO:0015629 actin cytoskeleton IDA 24475127
genes like me logo Genes that share ontologies with TTC17: view

Pathways for TTC17 Gene

SuperPathways for TTC17 Gene

No Data Available

Interacting Proteins for TTC17 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000039989%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000039989 Q96AE7-TTC17_HUMAN for TTC17 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TTC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030041 actin filament polymerization IMP 24475127
GO:0044782 cilium organization IMP 24475127
genes like me logo Genes that share ontologies with TTC17: view

No data available for Pathways by source for TTC17 Gene

Transcripts for TTC17 Gene

Unigene Clusters for TTC17 Gene

Tetratricopeptide repeat domain 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC17

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ·
SP1: - - - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 18c ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1: - - - - - - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:

Relevant External Links for TTC17 Gene

GeneLoc Exon Structure for
TTC17
ECgene alternative splicing isoforms for
TTC17

Expression for TTC17 Gene

mRNA expression in normal human tissues for TTC17 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC17 Gene

SOURCE GeneReport for Unigene cluster for TTC17 Gene Hs.191186

mRNA Expression by UniProt/SwissProt for TTC17 Gene

Q96AE7-TTC17_HUMAN
Tissue specificity: Expressed in germ cells as well as in somatic cells of the testis (at protein level).
genes like me logo Genes that share expressions with TTC17: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TTC17 Gene

Orthologs for TTC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC17 35
  • 99.8 (n)
  • 99.65 (a)
TTC17 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC17 35
  • 92.81 (n)
  • 97.28 (a)
TTC17 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC17 35
  • 92.67 (n)
  • 97.2 (a)
TTC17 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc17 35
  • 88.96 (n)
  • 95.09 (a)
Ttc17 16
Ttc17 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC17 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC17 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc17 35
  • 88.96 (n)
  • 94.74 (a)
chicken
(Gallus gallus)
Aves TTC17 35
  • 77.23 (n)
  • 80.73 (a)
TTC17 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC17 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17174 35
ttc17 35
  • 67.46 (n)
  • 70.98 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc17 35
  • 65.16 (n)
  • 64.73 (a)
TTC17 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11436 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T19A5.1 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1286 36
  • 30 (a)
OneToOne
Species with no ortholog for TTC17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC17 Gene

ENSEMBL:
Gene Tree for TTC17 (if available)
TreeFam:
Gene Tree for TTC17 (if available)

Paralogs for TTC17 Gene

Selected SIMAP similar genes for TTC17 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TTC17: view

No data available for Paralogs for TTC17 Gene

Variants for TTC17 Gene

Sequence variations from dbSNP and Humsavar for TTC17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10740 -- 43,494,149(+) TTCAA(G/T)ATATT utr-variant-3-prime
rs719777 -- 43,457,272(+) ACTGT(A/G)TGCCC intron-variant
rs719778 -- 43,457,322(+) TACGA(A/C)CTCTT intron-variant
rs721700 -- 43,448,425(+) GGTTT(C/G)TCATG intron-variant
rs721701 -- 43,448,705(+) CAGAT(A/C)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC17 Gene

Variant ID Type Subtype PubMed ID
nsv519819 CNV Gain 19592680
nsv7753 CNV Insertion 18451855
esv2678898 CNV Deletion 23128226

Relevant External Links for TTC17 Gene

HapMap Linkage Disequilibrium report
TTC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC17 Gene

Disorders for TTC17 Gene

Relevant External Links for TTC17

Genetic Association Database (GAD)
TTC17
Human Genome Epidemiology (HuGE) Navigator
TTC17
genes like me logo Genes that share disorders with TTC17: view

No data available for UniProtKB/Swiss-Prot for TTC17 Gene

Publications for TTC17 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. C2orf62 and TTC17 Are Involved in Actin Organization and Ciliogenesis in Zebrafish and Human. (PMID: 24475127) Bontems F. … Lane L. (PLoS ONE 2014) 3 4
  5. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. (PMID: 11022011) Ober C. … Cox N.J. (Am. J. Hum. Genet. 2000) 48

Products for TTC17 Gene

Sources for TTC17 Gene

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