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Aliases for TTC16 Gene

Aliases for TTC16 Gene

  • Tetratricopeptide Repeat Domain 16 2 3 5
  • TPR Repeat Protein 16 4

External Ids for TTC16 Gene

Previous GeneCards Identifiers for TTC16 Gene

  • GC09P125854
  • GC09P127557
  • GC09P129518
  • GC09P130466
  • GC09P100094
  • GC09P130478

Summaries for TTC16 Gene

GeneCards Summary for TTC16 Gene

TTC16 (Tetratricopeptide Repeat Domain 16) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC16 Gene

Genomics for TTC16 Gene

Regulatory Elements for TTC16 Gene

Enhancers for TTC16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F127628 1 Ensembl ENCODE 17.8 -86.6 -86643 2.0 TBP PKNOX1 RAD21 EGR2 ZBTB11 SMARCA4 PBX2 IKZF1 HMBOX1 PRDM1 TTC16 FAM129B CFAP157 GC09M127606 MIR3911
GH09F127682 0.9 ENCODE 12.4 -31.9 -31946 2.5 ATF1 CREB3L1 ARID4B SIN3A GLI4 FEZF1 YY1 GLIS2 FOS DEK CFAP157 TTC16 FAM129B TOR2A MIR3911 GC09M127606
GH09F127654 0.8 ENCODE 12.2 -61.3 -61317 1.0 POLR2A FAM129B CFAP157 TTC16 STXBP1 PTRH1 MIR3911 GC09M127606
GH09F127660 0.4 ENCODE 12.2 -54.6 -54643 1.7 PKNOX1 SMARCA4 POLR2A CFAP157 TTC16 STXBP1 PTRH1 FAM129B MIR3911 GC09M127606
GH09F127689 0.2 ENCODE 12 -26.6 -26585 0.5 PKNOX1 ATF1 SREBF2 FEZF1 RAD21 THRB RARA ZNF335 GLIS2 ZNF366 TTC16 PTRH1 STXBP1 LOC102723566 ZNF79 FAM129B ANGPTL2 URM1 SNORA65 MIR3911
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TTC16 on UCSC Golden Path with GeneCards custom track

Promoters for TTC16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001314868 -564 1801 PKNOX1 ATF1 ARID4B SIN3A BRCA1 ETS1 YY1 GLIS2 ELK1 ZNF143

Genomic Location for TTC16 Gene

Chromosome:
9
Start:
127,716,064 bp from pter
End:
127,731,600 bp from pter
Size:
15,537 bases
Orientation:
Plus strand

Genomic View for TTC16 Gene

Genes around TTC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC16 Gene

Proteins for TTC16 Gene

  • Protein details for TTC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEE8-TTC16_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 16
    Protein Accession:
    Q8NEE8
    Secondary Accessions:
    • B4DYG4
    • B5ME24
    • Q5JU66
    • Q96M72

    Protein attributes for TTC16 Gene

    Size:
    873 amino acids
    Molecular mass:
    98309 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC16 Gene

Post-translational modifications for TTC16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC16 Gene

Domains & Families for TTC16 Gene

Gene Families for TTC16 Gene

Protein Domains for TTC16 Gene

Suggested Antigen Peptide Sequences for TTC16 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEE8

UniProtKB/Swiss-Prot:

TTC16_HUMAN :
  • Contains 8 TPR repeats.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with TTC16: view

Function for TTC16 Gene

genes like me logo Genes that share phenotypes with TTC16: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC16 Gene

Localization for TTC16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC16 Gene COMPARTMENTS Subcellular localization image for TTC16 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC16 Gene

Pathways & Interactions for TTC16 Gene

SuperPathways for TTC16 Gene

No Data Available

Interacting Proteins for TTC16 Gene

Gene Ontology (GO) - Biological Process for TTC16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC16 Gene

Transcripts for TTC16 Gene

Unigene Clusters for TTC16 Gene

Tetratricopeptide repeat domain 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC16 Gene

No ASD Table

Relevant External Links for TTC16 Gene

GeneLoc Exon Structure for
TTC16
ECgene alternative splicing isoforms for
TTC16

Expression for TTC16 Gene

mRNA expression in normal human tissues for TTC16 Gene

mRNA differential expression in normal tissues according to GTEx for TTC16 Gene

This gene is overexpressed in Testis (x31.1) and Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for TTC16 Gene

This gene is overexpressed in Adipocyte (51.2) and Synovial fluid (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC16 Gene



Protein tissue co-expression partners for TTC16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TTC16 Gene:

TTC16

SOURCE GeneReport for Unigene cluster for TTC16 Gene:

Hs.642748
genes like me logo Genes that share expression patterns with TTC16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TTC16 Gene

Orthologs for TTC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC16 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia TTC16 34 35
  • 79.12 (n)
cow
(Bos Taurus)
Mammalia TTC16 34 35
  • 76.97 (n)
mouse
(Mus musculus)
Mammalia Ttc16 34 16 35
  • 72.13 (n)
rat
(Rattus norvegicus)
Mammalia LOC100362059 34
  • 69.21 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC16 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC16 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC16 34 35
  • 55.46 (n)
lizard
(Anolis carolinensis)
Reptilia TTC16 35
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToOne
Species where no ortholog for TTC16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTC16 Gene

ENSEMBL:
Gene Tree for TTC16 (if available)
TreeFam:
Gene Tree for TTC16 (if available)

Paralogs for TTC16 Gene

No data available for Paralogs for TTC16 Gene

Variants for TTC16 Gene

Sequence variations from dbSNP and Humsavar for TTC16 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10851 -- 127,714,232(+) TGAAC(A/C/T)GCCTC intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, missense, utr-variant-3-prime
rs10987724 -- 127,726,067(+) GGCAT(A/C)GAAGT intron-variant
rs111239934 -- 127,726,175(+) CCCAG(C/T)AGCCA intron-variant
rs111292713 -- 127,722,483(+) CGTCA(-/CAGT)CAGGA intron-variant
rs111378450 -- 127,714,251(+) CCGGG(A/C/T)GCCCG intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for TTC16 Gene

Variant ID Type Subtype PubMed ID
dgv12879n54 CNV loss 21841781
nsv1137506 CNV deletion 24896259
nsv466571 CNV loss 19166990
nsv471323 CNV loss 18288195
nsv615369 CNV loss 21841781

Variation tolerance for TTC16 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.99; 84.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC16 Gene

Disorders for TTC16 Gene

Relevant External Links for TTC16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC16

No disorders were found for TTC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC16 Gene

Publications for TTC16 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for TTC16 Gene

Sources for TTC16 Gene

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