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Aliases for TTC16 Gene

Aliases for TTC16 Gene

  • Tetratricopeptide Repeat Domain 16 2 3 5
  • TPR Repeat Protein 16 4

External Ids for TTC16 Gene

Previous GeneCards Identifiers for TTC16 Gene

  • GC09P125854
  • GC09P127557
  • GC09P129518
  • GC09P130466
  • GC09P100094
  • GC09P130478

Summaries for TTC16 Gene

GeneCards Summary for TTC16 Gene

TTC16 (Tetratricopeptide Repeat Domain 16) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC16 Gene

Genomics for TTC16 Gene

Regulatory Elements for TTC16 Gene

Enhancers for TTC16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC16 on UCSC Golden Path with GeneCards custom track

Promoters for TTC16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC16 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC16 Gene

127,716,064 bp from pter
127,731,600 bp from pter
15,537 bases
Plus strand

Genomic View for TTC16 Gene

Genes around TTC16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC16 Gene

Proteins for TTC16 Gene

  • Protein details for TTC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 16
    Protein Accession:
    Secondary Accessions:
    • B4DYG4
    • B5ME24
    • Q5JU66
    • Q96M72

    Protein attributes for TTC16 Gene

    873 amino acids
    Molecular mass:
    98309 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC16 Gene


neXtProt entry for TTC16 Gene

Proteomics data for TTC16 Gene at MOPED

Post-translational modifications for TTC16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTC16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TTC16 Gene

Domains & Families for TTC16 Gene

Gene Families for TTC16 Gene

Protein Domains for TTC16 Gene

Suggested Antigen Peptide Sequences for TTC16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 TPR repeats.
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with TTC16: view

Function for TTC16 Gene

genes like me logo Genes that share phenotypes with TTC16: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TTC16 Gene

Localization for TTC16 Gene

Subcellular locations from

Jensen Localization Image for TTC16 Gene COMPARTMENTS Subcellular localization image for TTC16 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC16 Gene

Pathways & Interactions for TTC16 Gene

SuperPathways for TTC16 Gene

No Data Available

Interacting Proteins for TTC16 Gene

Gene Ontology (GO) - Biological Process for TTC16 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC16 Gene

Drugs & Compounds for TTC16 Gene

No Compound Related Data Available

Transcripts for TTC16 Gene

Unigene Clusters for TTC16 Gene

Tetratricopeptide repeat domain 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC16 Gene

No ASD Table

Relevant External Links for TTC16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC16 Gene

mRNA expression in normal human tissues for TTC16 Gene

mRNA differential expression in normal tissues according to GTEx for TTC16 Gene

This gene is overexpressed in Testis (x31.1) and Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for TTC16 Gene

This gene is overexpressed in Adipocyte (51.2) and Synovial fluid (17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC16 Gene

SOURCE GeneReport for Unigene cluster for TTC16 Gene Hs.642748

genes like me logo Genes that share expression patterns with TTC16: view

Protein tissue co-expression partners for TTC16 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TTC16 Gene

Orthologs for TTC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TTC16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTC16 36
  • 99 (a)
TTC16 35
  • 99.12 (n)
  • 98.63 (a)
(Ornithorhynchus anatinus)
Mammalia TTC16 36
  • 46 (a)
(Mus musculus)
Mammalia Ttc16 36
  • 52 (a)
Ttc16 16
Ttc16 35
  • 72.13 (n)
  • 60.31 (a)
(Monodelphis domestica)
Mammalia TTC16 36
  • 58 (a)
(Bos Taurus)
Mammalia TTC16 36
  • 58 (a)
TTC16 35
  • 76.97 (n)
  • 67.45 (a)
(Rattus norvegicus)
Mammalia LOC100362059 35
  • 69.21 (n)
  • 57.77 (a)
(Canis familiaris)
Mammalia TTC16 35
  • 79.12 (n)
  • 70.59 (a)
TTC16 36
  • 50 (a)
(Gallus gallus)
Aves TTC16 35
  • 55.46 (n)
  • 41 (a)
TTC16 36
  • 41 (a)
(Anolis carolinensis)
Reptilia TTC16 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for TTC16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TTC16 Gene

Gene Tree for TTC16 (if available)
Gene Tree for TTC16 (if available)

Paralogs for TTC16 Gene

No data available for Paralogs for TTC16 Gene

Variants for TTC16 Gene

Sequence variations from dbSNP and Humsavar for TTC16 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs17852941 - 127,724,852(+) GCGCA(A/C/T)GGGCC intron-variant, nc-transcript-variant, reference, synonymous-codon, missense
rs13298768 - 127,727,464(+) AAAAG(A/G)GGTAA nc-transcript-variant, downstream-variant-500B, reference, missense
VAR_025544 -
VAR_052626 -
rs836333 -- 127,724,105(+) TCCCA(C/T)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC16 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
nsv893866 CNV Gain 21882294
nsv893867 CNV Loss 21882294
nsv893868 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
nsv466571 CNV Loss 19166990
nsv893870 CNV Loss 21882294
nsv471323 CNV Loss 18288195

Variation tolerance for TTC16 Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.99; 84.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC16 Gene

Disorders for TTC16 Gene

Relevant External Links for TTC16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTC16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC16 Gene

Publications for TTC16 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for TTC16 Gene

Sources for TTC16 Gene