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Aliases for TTC14 Gene

Aliases for TTC14 Gene

  • Tetratricopeptide Repeat Domain 14 2 3
  • TPR Repeat Protein 14 3 4
  • Tetratricopeptide Repeat Protein 14 3
  • DRDL5813 3
  • PRO19630 3
  • KIAA1980 4

External Ids for TTC14 Gene

Previous GeneCards Identifiers for TTC14 Gene

  • GC03P181640
  • GC03P181802
  • GC03P180319
  • GC03P177724

Summaries for TTC14 Gene

GeneCards Summary for TTC14 Gene

TTC14 (Tetratricopeptide Repeat Domain 14) is a Protein Coding gene. GO annotations related to this gene include RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC14 Gene

Genomics for TTC14 Gene

Regulatory Elements for TTC14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC14 Gene

Start:
180,602,130 bp from pter
End:
180,618,347 bp from pter
Size:
16,218 bases
Orientation:
Plus strand

Genomic View for TTC14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC14 Gene

Proteins for TTC14 Gene

  • Protein details for TTC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N46-TTC14_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 14
    Protein Accession:
    Q96N46
    Secondary Accessions:
    • G5E9X0
    • Q6UWJ7
    • Q8TF22

    Protein attributes for TTC14 Gene

    Size:
    770 amino acids
    Molecular mass:
    88319 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC14 Gene

Proteomics data for TTC14 Gene at MOPED

Post-translational modifications for TTC14 Gene

  • Ubiquitination at Lys287
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TTC14 Gene

Domains for TTC14 Gene

Gene Families for TTC14 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Suggested Antigen Peptide Sequences for TTC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96N46

UniProtKB/Swiss-Prot:

TTC14_HUMAN :
  • Q96N46
Domain:
  • Contains 1 S1 motif domain.
Family:
  • Belongs to the TTC14 family.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with TTC14: view

Function for TTC14 Gene

Gene Ontology (GO) - Molecular Function for TTC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TTC14: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC14

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTC14 Gene

Localization for TTC14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC14 Gene COMPARTMENTS Subcellular localization image for TTC14 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC14 Gene

Pathways for TTC14 Gene

SuperPathways for TTC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC14 Gene

None

No data available for Pathways by source for TTC14 Gene

Transcripts for TTC14 Gene

Unigene Clusters for TTC14 Gene

Tetratricopeptide repeat domain 14:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - -
SP6: -
SP7:

Relevant External Links for TTC14 Gene

GeneLoc Exon Structure for
TTC14
ECgene alternative splicing isoforms for
TTC14

Expression for TTC14 Gene

mRNA expression in normal human tissues for TTC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TTC14 Gene

This gene is overexpressed in Blymphocyte (34.3), Fetal gut (20.4), and Fetal heart (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC14 Gene

SOURCE GeneReport for Unigene cluster for TTC14 Gene Hs.43213

genes like me logo Genes that share expressions with TTC14: view

Expression partners for TTC14 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC14 Gene

Orthologs for TTC14 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC14 35
  • 91.45 (n)
  • 93.53 (a)
TTC14 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC14 35
  • 90.08 (n)
  • 88.9 (a)
TTC14 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc14 35
  • 87.91 (n)
  • 88.44 (a)
Ttc14 16
Ttc14 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC14 35
  • 99.57 (n)
  • 99.48 (a)
TTC14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc14 35
  • 86.4 (n)
  • 85.83 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC14 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC14 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC14 35
  • 68.46 (n)
  • 64.09 (a)
TTC14 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC14 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc14 35
  • 69.42 (n)
  • 69.27 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc14 35
  • 55.83 (n)
  • 55.33 (a)
ttc14 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6621 36
  • 21 (a)
OneToOne
Species with no ortholog for TTC14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC14 Gene

ENSEMBL:
Gene Tree for TTC14 (if available)
TreeFam:
Gene Tree for TTC14 (if available)

Paralogs for TTC14 Gene

Selected SIMAP similar genes for TTC14 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TTC14 Gene

genes like me logo Genes that share paralogs with TTC14: view

No data available for Paralogs for TTC14 Gene

Variants for TTC14 Gene

Sequence variations from dbSNP and Humsavar for TTC14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs960780 -- 180,612,549(-) agcct(C/T)aagca intron-variant
rs1532485 -- 180,602,193(+) CACCC(G/T)GCTCA utr-variant-5-prime, nc-transcript-variant
rs2338574 -- 180,606,802(-) ATAGT(A/G)TAGTC intron-variant, upstream-variant-2KB
rs3810763 -- 180,610,961(+) AAATC(A/G)TCAGC utr-variant-3-prime, intron-variant
rs5854876 -- 180,602,058(+) GCTCG(-/G)TTTCG upstream-variant-2KB

Relevant External Links for TTC14 Gene

HapMap Linkage Disequilibrium report
TTC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTC14 Gene

Disorders for TTC14 Gene

Relevant External Links for TTC14

Genetic Association Database (GAD)
TTC14
Human Genome Epidemiology (HuGE) Navigator
TTC14

No disorders were found for TTC14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TTC14 Gene

Publications for TTC14 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for TTC14 Gene

Sources for TTC14 Gene

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