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Aliases for TTC14 Gene

Aliases for TTC14 Gene

  • Tetratricopeptide Repeat Domain 14 2 3 5
  • TPR Repeat Protein 14 3 4
  • DRDL5813 3
  • PRO19630 3
  • KIAA1980 4

External Ids for TTC14 Gene

Previous GeneCards Identifiers for TTC14 Gene

  • GC03P181640
  • GC03P181802
  • GC03P180319
  • GC03P177724

Summaries for TTC14 Gene

GeneCards Summary for TTC14 Gene

TTC14 (Tetratricopeptide Repeat Domain 14) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC14 Gene

Genomics for TTC14 Gene

Regulatory Elements for TTC14 Gene

Enhancers for TTC14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC14 on UCSC Golden Path with GeneCards custom track

Promoters for TTC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC14 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC14 Gene

180,602,130 bp from pter
180,618,347 bp from pter
16,218 bases
Plus strand

Genomic View for TTC14 Gene

Genes around TTC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC14 Gene

Proteins for TTC14 Gene

  • Protein details for TTC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 14
    Protein Accession:
    Secondary Accessions:
    • G5E9X0
    • Q6UWJ7
    • Q8TF22

    Protein attributes for TTC14 Gene

    770 amino acids
    Molecular mass:
    88319 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC14 Gene


neXtProt entry for TTC14 Gene

Proteomics data for TTC14 Gene at MOPED

Post-translational modifications for TTC14 Gene

  • Ubiquitination at Lys 287
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC14 Gene

Domains & Families for TTC14 Gene

Gene Families for TTC14 Gene

Protein Domains for TTC14 Gene

Suggested Antigen Peptide Sequences for TTC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 S1 motif domain.
  • Belongs to the TTC14 family.
  • Contains 4 TPR repeats.
  • Contains 1 S1 motif domain.
  • Belongs to the TTC14 family.
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with TTC14: view

Function for TTC14 Gene

Gene Ontology (GO) - Molecular Function for TTC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with TTC14: view
genes like me logo Genes that share phenotypes with TTC14: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC14 Gene

Localization for TTC14 Gene

Subcellular locations from

Jensen Localization Image for TTC14 Gene COMPARTMENTS Subcellular localization image for TTC14 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC14 Gene

Pathways & Interactions for TTC14 Gene

SuperPathways for TTC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC14 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC14 Gene

Drugs & Compounds for TTC14 Gene

No Compound Related Data Available

Transcripts for TTC14 Gene

Unigene Clusters for TTC14 Gene

Tetratricopeptide repeat domain 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - -
SP6: -

Relevant External Links for TTC14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC14 Gene

mRNA expression in normal human tissues for TTC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTC14 Gene

This gene is overexpressed in Blymphocyte (34.3), Fetal gut (20.4), and Fetal heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC14 Gene

SOURCE GeneReport for Unigene cluster for TTC14 Gene Hs.43213

genes like me logo Genes that share expression patterns with TTC14: view

Protein tissue co-expression partners for TTC14 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC14 Gene

Orthologs for TTC14 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC14 35
  • 91.45 (n)
  • 93.53 (a)
TTC14 36
  • 93 (a)
(Canis familiaris)
Mammalia TTC14 35
  • 90.08 (n)
  • 88.9 (a)
TTC14 36
  • 89 (a)
(Mus musculus)
Mammalia Ttc14 35
  • 87.91 (n)
  • 88.44 (a)
Ttc14 16
Ttc14 36
  • 88 (a)
(Pan troglodytes)
Mammalia TTC14 35
  • 99.57 (n)
  • 99.48 (a)
TTC14 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ttc14 35
  • 86.4 (n)
  • 85.83 (a)
(Monodelphis domestica)
Mammalia TTC14 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia TTC14 36
  • 75 (a)
(Gallus gallus)
Aves TTC14 35
  • 68.46 (n)
  • 64.09 (a)
TTC14 36
  • 63 (a)
(Anolis carolinensis)
Reptilia TTC14 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc14 35
  • 69.42 (n)
  • 69.27 (a)
(Danio rerio)
Actinopterygii ttc14 35
  • 55.83 (n)
  • 55.33 (a)
ttc14 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6621 36
  • 21 (a)
Species with no ortholog for TTC14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC14 Gene

Gene Tree for TTC14 (if available)
Gene Tree for TTC14 (if available)

Paralogs for TTC14 Gene

(3) SIMAP similar genes for TTC14 Gene using alignment to 6 proteins: Pseudogenes for TTC14 Gene

genes like me logo Genes that share paralogs with TTC14: view

No data available for Paralogs for TTC14 Gene

Variants for TTC14 Gene

Sequence variations from dbSNP and Humsavar for TTC14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2338574 -- 180,606,802(-) ATAGT(A/G)TAGTC intron-variant
rs960780 -- 180,612,549(-) agcct(C/T)aagca intron-variant
rs58296954 -- 180,609,461(+) CCCCA(-/A)AAAAG intron-variant, utr-variant-3-prime
rs58349211 -- 180,612,666(+) AGGAG(-/GAG)TTCGA intron-variant
rs11544675 -- 180,609,975(+) TCATC(A/T)TCACT downstream-variant-500B, reference, synonymous-codon, utr-variant-3-prime

Variation tolerance for TTC14 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TTC14 Gene

Disorders for TTC14 Gene

Relevant External Links for TTC14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TTC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC14 Gene

Publications for TTC14 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A. … Stelzl U. (Mol. Cell 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TTC14 Gene

Sources for TTC14 Gene