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Aliases for TTC14 Gene

Aliases for TTC14 Gene

  • Tetratricopeptide Repeat Domain 14 2 3 5
  • TPR Repeat Protein 14 3 4
  • Tetratricopeptide Repeat Protein 14 3
  • DRDL5813 3
  • PRO19630 3
  • KIAA1980 4

External Ids for TTC14 Gene

Previous GeneCards Identifiers for TTC14 Gene

  • GC03P181640
  • GC03P181802
  • GC03P180319
  • GC03P177724

Summaries for TTC14 Gene

GeneCards Summary for TTC14 Gene

TTC14 (Tetratricopeptide Repeat Domain 14) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. GO annotations related to this gene include nucleic acid binding and RNA binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC14 Gene

Genomics for TTC14 Gene

Regulatory Elements for TTC14 Gene

Enhancers for TTC14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G179810 1 Ensembl ENCODE 13.7 -790.7 -790704 1.5 RING1 CTCF ZNF654 RNF2 TRIM22 REST DPF2 TBX21 RAD21 CBX8 TTC14 PEX5L-AS1 ZNF639 ENSG00000270178
GH03G180601 1.1 ENCODE 12.1 +0.1 106 2.3 PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 TTC14 GC03M180608
GH03G180430 0.4 dbSUPER 10.5 -170.8 -170843 1.4 ATF2 TTC14 LINC02053 GC03P180543
GH03G180408 0.6 dbSUPER 5 -192.6 -192623 2.9 JUND GATA2 JUNB NFE2 FOS MNT MAFK NFE2L2 TTC14 LINC02053 LOC131054
GH03G180296 0.6 ENCODE 4.8 -305.0 -305014 1.8 ZNF217 GATA3 ZNF687 ZHX2 RAD21 ZBTB7B TTC14 CCDC39 LOC131054 GAPDHP36
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC14 on UCSC Golden Path with GeneCards custom track

Promoters for TTC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000162635 171 2200 PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5

Genomic Location for TTC14 Gene

Chromosome:
3
Start:
180,602,130 bp from pter
End:
180,618,347 bp from pter
Size:
16,218 bases
Orientation:
Plus strand

Genomic View for TTC14 Gene

Genes around TTC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC14 Gene

Proteins for TTC14 Gene

  • Protein details for TTC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N46-TTC14_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 14
    Protein Accession:
    Q96N46
    Secondary Accessions:
    • G5E9X0
    • Q6UWJ7
    • Q8TF22

    Protein attributes for TTC14 Gene

    Size:
    770 amino acids
    Molecular mass:
    88319 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC14 Gene

Post-translational modifications for TTC14 Gene

  • Ubiquitination at posLast=287287
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TTC14 Gene

Domains & Families for TTC14 Gene

Gene Families for TTC14 Gene

Suggested Antigen Peptide Sequences for TTC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96N46

UniProtKB/Swiss-Prot:

TTC14_HUMAN :
  • Belongs to the TTC14 family.
Family:
  • Belongs to the TTC14 family.
genes like me logo Genes that share domains with TTC14: view

Function for TTC14 Gene

Gene Ontology (GO) - Molecular Function for TTC14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with TTC14: view
genes like me logo Genes that share phenotypes with TTC14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC14 Gene

Localization for TTC14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC14 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC14 Gene

Pathways & Interactions for TTC14 Gene

SuperPathways for TTC14 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with TTC14: view

Pathways by source for TTC14 Gene

1 BioSystems pathway for TTC14 Gene

Gene Ontology (GO) - Biological Process for TTC14 Gene

None

No data available for SIGNOR curated interactions for TTC14 Gene

Drugs & Compounds for TTC14 Gene

No Compound Related Data Available

Transcripts for TTC14 Gene

Unigene Clusters for TTC14 Gene

Tetratricopeptide repeat domain 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: -
SP5: - -
SP6: -
SP7:

Relevant External Links for TTC14 Gene

GeneLoc Exon Structure for
TTC14
ECgene alternative splicing isoforms for
TTC14

Expression for TTC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TTC14 Gene

This gene is overexpressed in Blymphocyte (34.3), Fetal gut (20.4), and Fetal heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC14 Gene



Protein tissue co-expression partners for TTC14 Gene

NURSA nuclear receptor signaling pathways regulating expression of TTC14 Gene:

TTC14

SOURCE GeneReport for Unigene cluster for TTC14 Gene:

Hs.43213

Evidence on tissue expression from TISSUES for TTC14 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with TTC14: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC14 Gene

Orthologs for TTC14 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTC14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC14 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia TTC14 34 35
  • 91.45 (n)
dog
(Canis familiaris)
Mammalia TTC14 34 35
  • 90.08 (n)
mouse
(Mus musculus)
Mammalia Ttc14 34 16 35
  • 87.91 (n)
rat
(Rattus norvegicus)
Mammalia Ttc14 34
  • 86.4 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC14 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC14 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TTC14 34 35
  • 68.46 (n)
lizard
(Anolis carolinensis)
Reptilia TTC14 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc14 34
  • 69.42 (n)
zebrafish
(Danio rerio)
Actinopterygii ttc14 34 35
  • 55.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6621 35
  • 21 (a)
OneToOne
Species where no ortholog for TTC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC14 Gene

ENSEMBL:
Gene Tree for TTC14 (if available)
TreeFam:
Gene Tree for TTC14 (if available)

Paralogs for TTC14 Gene

(3) SIMAP similar genes for TTC14 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for TTC14 Gene

genes like me logo Genes that share paralogs with TTC14: view

No data available for Paralogs for TTC14 Gene

Variants for TTC14 Gene

Sequence variations from dbSNP and Humsavar for TTC14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs587778821 Pathogenic 180,616,873(-) ACTAA(GTA/T)AAGAA intron-variant, reference, frameshift-variant
rs113696248 Likely benign 180,614,788(+) TTTTT(A/T)AAAAC intron-variant, utr-variant-3-prime
rs11914833 Likely benign 180,616,931(+) TTTGC(C/T)AAATG intron-variant, reference, synonymous-codon
rs141409397 Likely benign 180,614,375(+) TTTTT(G/T)GGGGG intron-variant, utr-variant-3-prime
rs201806641 Likely benign 180,616,865(+) TCCTC(C/T)GTTTC intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TTC14 Gene

Variant ID Type Subtype PubMed ID
nsv509869 OTHER sequence alteration 20534489

Variation tolerance for TTC14 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC14 Gene

Disorders for TTC14 Gene

Relevant External Links for TTC14

Genetic Association Database (GAD)
TTC14
Human Genome Epidemiology (HuGE) Navigator
TTC14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC14

No disorders were found for TTC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC14 Gene

Publications for TTC14 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for TTC14 Gene

Sources for TTC14 Gene

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