TTC13 Gene
protein-coding GIFtS: 39
GCID: GC01M231041
|
|
tetratricopeptide repeat domain 13
| |
Aliases
for TTC13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 131 2 | | TPR Repeat Protein 132 3 | | FLJ225841 | | Tetratricopeptide Repeat Protein 132 |
Export aliases for TTC13 gene to outside databasesPrevious GC identifers: GC01M228076 GC01M227348 GC01M229108 GC01M201526 |
Summaries
for TTC13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TTC13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC13 gene promoter:
MEF-2 Lmo2 FOXO3 E47 FOXO3b Evi-1 MEF-2A Hand1 FOXO3a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.2 Ensembl cytogenetic band: 1q42.2 HGNC cytogenetic band: 1q42.2TTC13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M231041: view genomic region
(about GC identifiers)
Start:
|
231,041,987 bp from pter |
End:
|
231,114,621 bp from pter |
Size:
|
72,635 bases |
Orientation:
|
minus strand |
|
Proteins
for TTC13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC13_HUMAN, Q8NBP0 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 13 Size: 860 amino acids; 96813 Da
Secondary accessions: B1AQI1 B1AQI2 Q8IVP8 Q8NBI0 Q8ND20Alternative splicing: 2 isoforms: Q8NBP0-1 Q8NBP0-2 Explore the universe of human proteins at neXtProt for TTC13: NX_Q8NBP0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NBP0
TTC13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001116307.2 NP_078801.3
ENSEMBL proteins: ENSP00000355621 ENSP00000355622 ENSP00000428447 ENSP00000430280 ENSP00000430385 ENSP00000428622 ENSP00000431120 ENSP00000416631
Human Recombinant Protein Products:
TTC13 Antibody Products:
Assay Products for TTC13: |
Protein
Domains /
Families
for TTC13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC13 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NBP0ProtoNet protein and cluster: Q8NBP0 UniProtKB/Swiss-Prot: TTC13_HUMAN, Q8NBP0Similarity: Contains 7 TPR repeats |
Function
for TTC13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC13 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC13 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TTC13 (NM_024525) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC13 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TTC13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC13 |
1 GenomeRNAi human phenotype for TTC13:
|
Pathways & Interactions
for TTC13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTC13
1 Interacting protein for TTC13 (Q8NBP03) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TTC13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC13
Search CenterWatch for drugs/clinical trials and news about TTC13
|
Transcripts
for TTC13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC13 gene (2 alternative transcripts): NM_001122835.2 NM_024525.4 Unigene Cluster for TTC13: Tetratricopeptide repeat domain 13 Hs.424788 [show with all ESTs]Unigene Representative Sequence: NM_02452510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366661(uc001huf.4 uc009xfj.3) ENST00000366662 ENST00000471302
ENST00000486879 ENST00000481976 ENST00000522821 ENST00000519379 ENST00000522399
ENST00000466507 ENST00000414259(uc001hug.4 uc009xfk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC13 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC13 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TTC13 (NM_024525) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC13 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TTC13 |
Additional cDNA sequence: AK026237.1 AK074365.1 AK075386.1 AK075561.1 AK093564.1 AK309725.1 AL832286.1 AL834453.1 BC042683.1 BC047662.1 BC110880.1 11 DOTS entries: DT.312493 DT.99989162 DT.439253 DT.101973532 DT.100777313 DT.100740081 DT.100765986 DT.121331655 DT.456394 DT.75144126 DT.99971064 24/95 AceView cDNA sequences (see all 95): AW613930 BX100099 AW157022 AI081003 AA482141 AI142520 AL832286 AA759272 BM069688 BC042683 BG680345 BM693681 AL110452 AW294123 AA331847 AA101644 CK905700 AK075561 AA485084 AL834453 AA491277 AW161528 AA279077 BM054864
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TTC13 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | |
ECgene alternative splicing isoforms for TTC13
|
Expression
for TTC13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTTTTTC
About this image
See TTC13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC13
SOURCE GeneReport for Unigene cluster: Hs.424788
SABiosciences Custom PCR Arrays for TTC13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC13 |
Orthologs
for TTC13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TTC13 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TTC131 |
tetratricopeptide repeat domain 13 |
80.45(n)
89.49(a) |
|
421545 XM_419586.3 XP_419586.2 |
lizard
(Anolis carolinensis) |
Reptilia |
TTC136 |
-- |
80(a) |
1 ↔ 1 |
1(222940637-222963142) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.151502 |
Xenopus laevis transcribed sequence with weak similarity to protein spP14922 (S. cerevisiae) SSN6_YEAST GLUCOSE REPRESSION MEDIATOR PROTEIN less |
75.77(n) |
|
CA791282.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.174262 |
Transcribed sequence with moderate similarity to protein refNP_078801.1 (H.sapiens) hypothetical protein FLJ22584 [Homo sapiens] less |
77.46(n) |
|
57063212 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SRFR11 |
suppressor of RPS4-RLD 1 / tetratricopeptide repeat domain-containing protein less |
44(n)
30.79(a) |
|
829901 NM_119910.3 NP_195462.3 |
rice
(Oryza sativa) |
Liliopsida |
Os07g01137001 |
hypothetical protein |
43.41(n)
30.08(a) |
|
4342244 NM_001065284.1 NP_001058749.1 |
ENSEMBL Gene Tree for TTC13 (if available)
TreeFam Gene Tree for TTC13 (if available) |
Paralogs
for TTC13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTC13 gene
- TTC62
1 SIMAP similar gene for TTC13 using alignment to 7 protein entries: TTC13_HUMAN (see all proteins):DKFZp667K0918
TTC13 for paralogs About GeneDecksing
|
Genomic Variants
for TTC13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC13 (231041987 - 231114621 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TTC13: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC13 |
|
Disorders
/ Diseases
for TTC13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TTC13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TTC13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TTC13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTC13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTC13 gene:
Search GeneIP for patents involving TTC13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TTC13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC13 | | | OriGene Protein Over-expression Lysate for TTC13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC13 | | OriGene 3'-UTR Clone for TTC13 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC13 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TTC13 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TTC13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC13 |
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| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TTC13 |
|
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