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Aliases for TTC13 Gene

Aliases for TTC13 Gene

  • Tetratricopeptide Repeat Domain 13 2 3 5
  • TPR Repeat Protein 13 4

External Ids for TTC13 Gene

Previous GeneCards Identifiers for TTC13 Gene

  • GC01M228076
  • GC01M227348
  • GC01M229108
  • GC01M231041
  • GC01M201526

Summaries for TTC13 Gene

GeneCards Summary for TTC13 Gene

TTC13 (Tetratricopeptide Repeat Domain 13) is a Protein Coding gene. An important paralog of this gene is TTC6.

Additional gene information for TTC13 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC13 Gene

Genomics for TTC13 Gene

GeneHancer (GH) Regulatory Elements for TTC13 Gene

Promoters and enhancers for TTC13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I230976 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 564.7 +0.2 248 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TTC13 ARV1 C1orf131 EXOC8 FAM89A LOC101927604 SPRTN GC01P230904
GH01I230985 Enhancer 0.9 ENCODE 11.4 -6.4 -6421 0.6 HDGF ATF1 ARNT TCF12 GATA2 ATF7 NCOA1 ZNF592 GMEB1 SMARCA4 TTC13 ARV1 MIR1182
GH01I230971 Enhancer 0.9 Ensembl ENCODE 9.1 +6.0 6001 2.2 HDAC1 MEIS2 ATF1 LEF1 TEAD4 EBF1 BATF GATA3 POLR2A ATF7 C1orf131 FAM89A ARV1 COG2 TTC13 C1orf198 GC01P230904
GH01I231013 Enhancer 0.4 ENCODE 8.8 -35.0 -35017 0.5 FOS EGR2 FAM89A ARV1 TTC13 MIR1182
GH01I231026 Enhancer 0.6 ENCODE 5.8 -48.4 -48386 0.7 ZNF146 HLF RARA NFIL3 ZFHX2 CEBPA ZBTB33 ZNF600 EGR2 TTC13 LOC644006 FAM89A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TTC13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTC13 gene promoter:

Genomic Locations for TTC13 Gene

Genomic Locations for TTC13 Gene
chr1:230,906,241-230,978,875
(GRCh38/hg38)
Size:
72,635 bases
Orientation:
Minus strand
chr1:231,041,987-231,114,621
(GRCh37/hg19)

Genomic View for TTC13 Gene

Genes around TTC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC13 Gene

Proteins for TTC13 Gene

  • Protein details for TTC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBP0-TTC13_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 13
    Protein Accession:
    Q8NBP0
    Secondary Accessions:
    • B1AQI1
    • B1AQI2
    • Q8IVP8
    • Q8NBI0
    • Q8ND20

    Protein attributes for TTC13 Gene

    Size:
    860 amino acids
    Molecular mass:
    96813 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TTC13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC13 Gene

Post-translational modifications for TTC13 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TTC13 Gene

Domains & Families for TTC13 Gene

Gene Families for TTC13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TTC13 Gene

Suggested Antigen Peptide Sequences for TTC13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC13: view

No data available for UniProtKB/Swiss-Prot for TTC13 Gene

Function for TTC13 Gene

genes like me logo Genes that share phenotypes with TTC13: view

Animal Model Products

miRNA for TTC13 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC13 Gene

Localization for TTC13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC13 gene
Compartment Confidence
extracellular 2
nucleus 2
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC13 Gene

Pathways & Interactions for TTC13 Gene

SuperPathways for TTC13 Gene

No Data Available

Interacting Proteins for TTC13 Gene

Gene Ontology (GO) - Biological Process for TTC13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC13 Gene

Drugs & Compounds for TTC13 Gene

No Compound Related Data Available

Transcripts for TTC13 Gene

Unigene Clusters for TTC13 Gene

Tetratricopeptide repeat domain 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP1: - -
SP2: - - - -
SP3:
SP4:

ExUns: 24
SP1:
SP2:
SP3:
SP4:

Relevant External Links for TTC13 Gene

GeneLoc Exon Structure for
TTC13
ECgene alternative splicing isoforms for
TTC13

Expression for TTC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC13 Gene

Protein differential expression in normal tissues from HIPED for TTC13 Gene

This gene is overexpressed in Placenta (50.6) and Adipocyte (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TTC13 Gene



Protein tissue co-expression partners for TTC13 Gene

NURSA nuclear receptor signaling pathways regulating expression of TTC13 Gene:

TTC13

SOURCE GeneReport for Unigene cluster for TTC13 Gene:

Hs.424788

Evidence on tissue expression from TISSUES for TTC13 Gene

  • Nervous system(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TTC13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC13 Gene

Orthologs for TTC13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC13 33 34
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia TTC13 33 34
  • 93.29 (n)
cow
(Bos Taurus)
Mammalia TTC13 33 34
  • 93.04 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC13 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC13 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc13 33
  • 86.07 (n)
mouse
(Mus musculus)
Mammalia Ttc13 33 16 34
  • 85.67 (n)
chicken
(Gallus gallus)
Aves TTC13 33 34
  • 81.36 (n)
lizard
(Anolis carolinensis)
Reptilia TTC13 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc13 33
  • 75.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15150 33
zebrafish
(Danio rerio)
Actinopterygii ttc13 33 34
  • 72.4 (n)
Dr.17426 33
thale cress
(Arabidopsis thaliana)
eudicotyledons SRFR1 33
  • 44.15 (n)
rice
(Oryza sativa)
Liliopsida Os07g0113700 33
  • 43.96 (n)
Species where no ortholog for TTC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC13 Gene

ENSEMBL:
Gene Tree for TTC13 (if available)
TreeFam:
Gene Tree for TTC13 (if available)

Paralogs for TTC13 Gene

Paralogs for TTC13 Gene

(1) SIMAP similar genes for TTC13 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TTC13: view

Variants for TTC13 Gene

Sequence variations from dbSNP and Humsavar for TTC13 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs34745784 likely-benign, not provided 230,979,199(-) T/C upstream_transcript_variant
rs1000019673 -- 230,921,926(-) C/T intron_variant
rs1000023806 -- 230,969,247(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000033650 -- 230,969,479(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000060217 -- 230,928,066(-) G/A intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TTC13 Gene

Variant ID Type Subtype PubMed ID
esv3589093 CNV gain 21293372
esv3589103 CNV loss 21293372
nsv1000488 CNV gain 25217958
nsv1011066 CNV gain 25217958

Variation tolerance for TTC13 Gene

Residual Variation Intolerance Score: 8.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC13 Gene

Disorders for TTC13 Gene

Additional Disease Information for TTC13

No disorders were found for TTC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC13 Gene

Publications for TTC13 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. HIV-host interactome revealed directly from infected cells. (PMID: 27375898) Luo Y … Muesing MA (Nature microbiology 2016) 3 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B … Wang LS (Journal of proteome research 2012) 3 58

Products for TTC13 Gene

Sources for TTC13 Gene

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