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Aliases for TTC12 Gene

Aliases for TTC12 Gene

  • Tetratricopeptide Repeat Domain 12 2 3 5
  • TPR Repeat Protein 12 3 4
  • Tetratricopeptide Repeat Protein 12 3
  • TPARM 3

External Ids for TTC12 Gene

Previous GeneCards Identifiers for TTC12 Gene

  • GC11P112722
  • GC11P112690
  • GC11P113185
  • GC11P109112

Summaries for TTC12 Gene

GeneCards Summary for TTC12 Gene

TTC12 (Tetratricopeptide Repeat Domain 12) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is SGTB.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC12 Gene

Genomics for TTC12 Gene

Regulatory Elements for TTC12 Gene

Enhancers for TTC12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G113312 1 ENCODE 55.9 -0.1 -107 3.6 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS SP3 TTC12 DRD2 ENSG00000256757 ANKK1 LOC105369499 GC11M113268
GH11G113383 0.9 Ensembl ENCODE 29.2 +70.4 70426 2.3 JUN BHLHE40 OSR2 CTBP1 JUND ZFHX2 GATA2 SCRT2 ZNF600 FOS TTC12 ANKK1 ENSG00000270179
GH11G113286 0.9 ENCODE dbSUPER 22.9 -27.0 -26959 2.6 FOXA2 ZMYM3 NR3C1 ATF2 RARA ZNF664 HNF1A POLR2A SMARCA4 TCF7 TTC12 LOC105369499 GC11M113268
GH11G113372 0.7 ENCODE 23.3 +59.0 58957 1.3 HDAC1 IRF2 TAL1 ETV1 TCF12 GATA2 NCOR1 STAT2 HES1 STAT1 TTC12 ENSG00000270179 ANKK1
GH11G113680 1.5 FANTOM5 ENCODE dbSUPER 10.1 +367.1 367121 1.5 PKNOX1 CBX3 FEZF1 ZBTB40 TCF12 TSHZ1 ZNF488 ZNF398 HDAC8 ZNF843 DRD2 LRRC37A13P TTC12 LOC105369499 TMPRSS5 MTRF1LP1 LOC105369501
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TTC12 on UCSC Golden Path with GeneCards custom track

Promoters for TTC12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045120 271 1201 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 TCF12 GLIS2 ZNF143

Genomic Location for TTC12 Gene

Chromosome:
11
Start:
113,314,529 bp from pter
End:
113,385,952 bp from pter
Size:
71,424 bases
Orientation:
Plus strand

Genomic View for TTC12 Gene

Genes around TTC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC12 Gene

Proteins for TTC12 Gene

  • Protein details for TTC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H892-TTC12_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 12
    Protein Accession:
    Q9H892
    Secondary Accessions:
    • Q8N5H9
    • Q9NWY3

    Protein attributes for TTC12 Gene

    Size:
    705 amino acids
    Molecular mass:
    78756 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91242.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC12 Gene

Post-translational modifications for TTC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC12 Gene

Domains & Families for TTC12 Gene

Gene Families for TTC12 Gene

Suggested Antigen Peptide Sequences for TTC12 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTC12: view

No data available for UniProtKB/Swiss-Prot for TTC12 Gene

Function for TTC12 Gene

genes like me logo Genes that share phenotypes with TTC12: view

Animal Model Products

CRISPR Products

miRNA for TTC12 Gene

miRTarBase miRNAs that target TTC12

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC12 Gene

Localization for TTC12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTC12 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for TTC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 23300604
genes like me logo Genes that share ontologies with TTC12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC12 Gene

Pathways & Interactions for TTC12 Gene

SuperPathways for TTC12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC12 Gene

Drugs & Compounds for TTC12 Gene

No Compound Related Data Available

Transcripts for TTC12 Gene

Unigene Clusters for TTC12 Gene

Tetratricopeptide repeat domain 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7: - - - -
SP8: - -
SP9:
SP10:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TTC12 Gene

GeneLoc Exon Structure for
TTC12
ECgene alternative splicing isoforms for
TTC12

Expression for TTC12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTC12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC12 Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for TTC12 Gene

This gene is overexpressed in Bone (23.9), Ovary (14.2), Plasma (12.8), and Rectum (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC12 Gene



NURSA nuclear receptor signaling pathways regulating expression of TTC12 Gene:

TTC12

SOURCE GeneReport for Unigene cluster for TTC12 Gene:

Hs.288772

Evidence on tissue expression from TISSUES for TTC12 Gene

  • Thyroid gland(4.2)
  • Blood(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with TTC12: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTC12 Gene

Orthologs for TTC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC12 34 35
  • 99.1 (n)
cow
(Bos Taurus)
Mammalia TTC12 34 35
  • 84.17 (n)
dog
(Canis familiaris)
Mammalia TTC12 34 35
  • 83.93 (n)
rat
(Rattus norvegicus)
Mammalia Ttc12 34
  • 81.16 (n)
mouse
(Mus musculus)
Mammalia Ttc12 34 16 35
  • 80.59 (n)
oppossum
(Monodelphis domestica)
Mammalia TTC12 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves TTC12 34 35
  • 60.19 (n)
lizard
(Anolis carolinensis)
Reptilia TTC12 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc12 34
  • 57.15 (n)
zebrafish
(Danio rerio)
Actinopterygii ttc12 34 35
  • 53.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34297 35
  • 22 (a)
OneToMany
CG6980 35
  • 22 (a)
OneToMany
CG31294 35
  • 20 (a)
OneToMany
CG34274 35
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 35
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToOne
Species where no ortholog for TTC12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC12 Gene

ENSEMBL:
Gene Tree for TTC12 (if available)
TreeFam:
Gene Tree for TTC12 (if available)

Paralogs for TTC12 Gene

Paralogs for TTC12 Gene

genes like me logo Genes that share paralogs with TTC12: view

Variants for TTC12 Gene

Sequence variations from dbSNP and Humsavar for TTC12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000000503 -- 113,353,288(+) TCATG(C/T)CCTTT intron-variant
rs1000094930 -- 113,374,339(+) ACTTG(A/G)ATGAC intron-variant
rs1000103544 -- 113,382,553(+) TTAGG(-/A)AGGAA intron-variant
rs1000124285 -- 113,347,413(+) AATCT(C/G)CATTT intron-variant
rs1000265034 -- 113,383,303(+) TTTTG(C/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC12 Gene

Variant ID Type Subtype PubMed ID
nsv483080 CNV loss 15286789
nsv556444 CNV gain 21841781

Variation tolerance for TTC12 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TTC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC12 Gene

Disorders for TTC12 Gene

Relevant External Links for TTC12

Genetic Association Database (GAD)
TTC12
Human Genome Epidemiology (HuGE) Navigator
TTC12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC12

No disorders were found for TTC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTC12 Gene

Publications for TTC12 Gene

  1. Identification and characterization of TPARM gene in silico. (PMID: 12964006) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 22 64
  2. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. (PMID: 18828801) Yang B.Z. … Gelernter J. (Alcohol. Clin. Exp. Res. 2008) 3 46 64
  3. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (PMID: 17761687) Yang B.Z. … Gelernter J. (Hum. Mol. Genet. 2007) 3 46 64
  4. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. (PMID: 17085484) Gelernter J. … Farrer L. (Hum. Mol. Genet. 2006) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TTC12 Gene

Sources for TTC12 Gene

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