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Aliases for TTC12 Gene

Aliases for TTC12 Gene

  • Tetratricopeptide Repeat Domain 12 2 3
  • TPR Repeat Protein 12 3 4
  • Tetratricopeptide Repeat Protein 12 Variant 1 3
  • Tetratricopeptide Repeat Protein 12 Variant 2 3
  • TPARM 3

External Ids for TTC12 Gene

Previous GeneCards Identifiers for TTC12 Gene

  • GC11P112722
  • GC11P112690
  • GC11P113185
  • GC11P109112

Summaries for TTC12 Gene

GeneCards Summary for TTC12 Gene

TTC12 (Tetratricopeptide Repeat Domain 12) is a Protein Coding gene. Diseases associated with TTC12 include nicotine dependence, protection against. GO annotations related to this gene include binding. An important paralog of this gene is SGTB.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC12 Gene

Genomics for TTC12 Gene

Regulatory Elements for TTC12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTC12 Gene

113,314,529 bp from pter
113,385,952 bp from pter
71,424 bases
Plus strand

Genomic View for TTC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC12 Gene

Proteins for TTC12 Gene

  • Protein details for TTC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 12
    Protein Accession:
    Secondary Accessions:
    • Q8N5H9
    • Q9NWY3

    Protein attributes for TTC12 Gene

    705 amino acids
    Molecular mass:
    78756 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91242.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC12 Gene


neXtProt entry for TTC12 Gene

Proteomics data for TTC12 Gene at MOPED

Post-translational modifications for TTC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC12 Gene

Domains & Families for TTC12 Gene

Gene Families for TTC12 Gene

Protein Domains for TTC12 Gene

Suggested Antigen Peptide Sequences for TTC12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 TPR repeats.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC12: view

Function for TTC12 Gene

Gene Ontology (GO) - Molecular Function for TTC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC12: view

Phenotypes for TTC12 Gene

genes like me logo Genes that share phenotypes with TTC12: view

Animal Model Products

miRNA for TTC12 Gene

miRTarBase miRNAs that target TTC12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC12 Gene

Localization for TTC12 Gene

Subcellular locations from

Jensen Localization Image for TTC12 Gene COMPARTMENTS Subcellular localization image for TTC12 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC12 Gene

Pathways & Interactions for TTC12 Gene

SuperPathways for TTC12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC12 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC12 Gene

Drugs & Compounds for TTC12 Gene

No Compound Related Data Available

Transcripts for TTC12 Gene

Unigene Clusters for TTC12 Gene

Tetratricopeptide repeat domain 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTC12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTC12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP5: -
SP7: - - - -
SP8: - -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24

Relevant External Links for TTC12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC12 Gene

mRNA expression in normal human tissues for TTC12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC12 Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for TTC12 Gene

This gene is overexpressed in Bone (23.9), Ovary (14.2), Plasma (12.8), and Rectum (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC12 Gene

SOURCE GeneReport for Unigene cluster for TTC12 Gene Hs.288772

genes like me logo Genes that share expression patterns with TTC12: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTC12 Gene

Orthologs for TTC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC12 35
  • 84.17 (n)
  • 81.03 (a)
TTC12 36
  • 81 (a)
(Canis familiaris)
Mammalia TTC12 35
  • 83.93 (n)
  • 78.83 (a)
TTC12 36
  • 78 (a)
(Mus musculus)
Mammalia Ttc12 35
  • 80.59 (n)
  • 75.14 (a)
Ttc12 16
Ttc12 36
  • 75 (a)
(Pan troglodytes)
Mammalia TTC12 35
  • 99.1 (n)
  • 98.72 (a)
TTC12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ttc12 35
  • 81.16 (n)
  • 77.27 (a)
(Monodelphis domestica)
Mammalia TTC12 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
-- 36
  • 52 (a)
(Gallus gallus)
Aves TTC12 35
  • 60.19 (n)
  • 50.29 (a)
TTC12 36
  • 48 (a)
(Anolis carolinensis)
Reptilia TTC12 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc12 35
  • 57.15 (n)
  • 46.38 (a)
(Danio rerio)
Actinopterygii ttc12 35
  • 53.49 (n)
  • 44.4 (a)
ttc12 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31294 36
  • 20 (a)
CG34274 36
  • 17 (a)
CG34297 36
  • 22 (a)
CG6980 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for TTC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC12 Gene

Gene Tree for TTC12 (if available)
Gene Tree for TTC12 (if available)

Paralogs for TTC12 Gene

Paralogs for TTC12 Gene

genes like me logo Genes that share paralogs with TTC12: view

Variants for TTC12 Gene

Sequence variations from dbSNP and Humsavar for TTC12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1078 -- 113,371,155(-) GATTA(A/G)ATGAT intron-variant
rs635358 -- 113,326,521(-) CTTAA(A/T)CTCGA intron-variant
rs713233 -- 113,363,744(+) CTAGC(A/C/G)CTATA intron-variant
rs719802 -- 113,363,957(+) GCCCT(C/G/T)GTCCC intron-variant
rs719803 -- 113,363,749(+) GCTAT(A/G)ATAAC intron-variant

Variation tolerance for TTC12 Gene

Residual Variation Intolerance Score: 72.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TTC12 Gene

Disorders for TTC12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nicotine dependence, protection against
  • nicotine dependence
- elite association
Search TTC12 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTC12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTC12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC12 Gene

Publications for TTC12 Gene

  1. Identification and characterization of TPARM gene in silico. (PMID: 12964006) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 23 67
  2. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 23 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. (PMID: 23303482) Nelson E.C. … Montgomery G.W. (JAMA Psychiatry 2013) 67
  5. TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. (PMID: 21168125) Ducci F. … JAorvelin M.R. (Biol. Psychiatry 2011) 67

Products for TTC12 Gene

Sources for TTC12 Gene

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