TTC12 Gene
protein-coding GIFtS : 46
GCID: GC11 P113185
tetratricopeptide repeat domain 12
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Aliasesfor TTC12 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tetratricopeptide Repeat Domain 12 1 2 FLJ205351 TPARM1 2 5 Tetratricopeptide Repeat Protein 122 TPR Repeat Protein 122 3 Tetratricopeptide Repeat Protein 12 Variant 12 FLJ138591 Tetratricopeptide Repeat Protein 12 Variant 22
Export aliases for TTC12 gene to outside databases Previous GC identifers: GC11P112722 GC11P112690 GC11P109112
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Summariesfor TTC12 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TTC12 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_033899.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TTC12 gene promoter: ISGF-3 E47 HNF-4alpha1 SRY POU2F1 POU2F1a Hand1 TGIF ATF En-1 Other transcription factors Search SABiosciences Chromatin IP Primers for TTC12 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TTC12
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q23.2 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23.2 TTC12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P113185: view genomic region
(about GC identifiers )
Start:
113,185,251 bp from pter
End:
113,254,266 bp from pter
Size:
69,016 bases
Orientation:
plus strand
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Proteinsfor TTC12 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TTC12_HUMAN, Q9H892 (See
protein sequence )Recommended Name: Tetratricopeptide repeat protein 12 Size : 705 amino acids; 78756 Da
Sequence caution : Sequence=BAA91242.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions : Q8N5H9 Q9NWY3Alternative splicing : 2 isoforms : Q9H892-1 Q9H892-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for TTC12: NX_Q9H892 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H892 TTC12 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060338.3 ENSEMBL proteins: ENSP00000433757 ENSP00000413335 ENSP00000400039 ENSP00000433916 ENSP00000431806 ENSP00000435308 ENSP00000437030 ENSP00000435291 ENSP00000376743 ENSP00000402004 ENSP00000419652 ENSP00000436677 ENSP00000433274 ENSP00000435730 ENSP00000315160 Human Recombinant Protein Products: TTC12 Antibody Products: Assay Products for TTC12:
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Protein
Domains / Familiesfor TTC12 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TTC12 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q9H892 ProtoNet protein and cluster: Q9H892
UniProtKB/Swiss-Prot: TTC12_HUMAN, Q9H892 Similarity : Contains 3 TPR repeats
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Functionfor TTC12 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC12 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC12OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TTC12 (NM_017868 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC12 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC12
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC12
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Pathways & Interactionsfor TTC12 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TTC12 1 Interacting protein for TTC12 (Q9H892 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table
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Drugs & Compoundsfor TTC12 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TTC12 Search CenterWatch for drugs/clinical trials and news about TTC12
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Transcriptsfor TTC12 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TTC12 gene: NM_017868.3 Unigene Cluster for TTC12:
Tetratricopeptide repeat domain 12 Hs.288772 [show with all ESTs ] Unigene Representative Sequence: AK125909 18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22 ): ENST00000529221 (uc001pnu.3 uc001pnv.3 ) ENST00000429951 ENST00000442859 ENST00000531164 ENST00000529850 ENST00000525965 ENST00000464224 (uc001pnx.3 )ENST00000494714 (uc001pnw.3 ) ENST00000393020 ENST00000455306 ENST00000489064 ENST00000527781 ENST00000483239 ENST00000524580 ENST00000527362 ENST00000525989 ENST00000534793 ENST00000478125 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC12 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC12OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TTC12 (NM_017868 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC12 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC12
Additional cDNA sequence: AK000542.1 AK023921.1 AK027161.1 AK091887.1 AK125909.1 AK223117.1 AK292331.1 BC011546.1 BC019086.2
17 DOTS entries : DT.99961473 DT.100020560
DT.108310 DT.100020559 DT.120720437 DT.97779874 DT.91955198 DT.100030480 DT.92424750 DT.95269636 DT.65287571 DT.95257432 DT.40307708 DT.97854427 DT.91820313 DT.91840354 DT.91853573 24/111 AceView cDNA sequences (see all 111 ):
BC019086 CR597551 CN478998 AW513387 BU684868 BC032355 BC011546 AI586953 AK000542 AK125909 BE261724 AA809070 AK027161 BM992919 BX421378 AA399653 AK023921 BM698700 BF725316 BM473638 CF132464 AK091887 BQ218129 AU124478 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TTC12 (see all 10 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ SP1 :                           -                           SP2 :                                                     SP3 :                                                     SP4 :                                                     SP5 :             -                                        
ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 SP1 :               SP2 :               SP3 :               SP4 :               SP5 :              
ECgene alternative splicing isoforms for TTC12
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Expression for TTC12 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TTC12 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCTAGAAAT
About this image TTC12 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Brain Choroid Plexus Brain Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TTC12 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TTC12 SOURCE GeneReport for Unigene cluster: Hs.288772 SABiosciences Custom PCR Arrays for TTC12 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TTC12Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TTC12 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TTC12 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TTC12 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC12
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Orthologsfor TTC12 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TTC12 gene from 5/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for TTC12 (if available)TreeFam Gene Tree for TTC12 (if available)
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Paralogsfor TTC12 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TTC12 gene SGTB 2 STUB1 2 SGTA 2 1 SIMAP similar gene for TTC12 using alignment to 16 protein entries: TTC12_HUMAN (see all proteins ):STIP1
TTC12 for paralogs About GeneDecksing
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Genomic Variantsfor TTC12 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TTC12 (113185251 - 113254266 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TTC12: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TTC12
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Disorders
/ Diseasesfor TTC12 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TTC12 for disorders About GeneDecksing
OMIM gene information: 610732
OMIM disorders : --7 diseases for TTC12 : About MalaCards nicotine dependence drug dependence alcohol dependence acute lymphoblastic leukemia lymphoblastic leukemia alcoholism leukemia Human Genome Epidemiology (HuGE) Navigator: TTC12 (6 documents) Export disorders for TTC12 gene to outside databases
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Publicationsfor TTC12 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TTC12 gene, integrated from 9 sources (see all 16 ): (articles sorted by number of sources associating them with TTC12) Utopia : connect your pdf to the dynamic world of online information
Identification and characterization of TPARM gene in silico. (PubMed id 12964006) 1 , 3, 9 Katoh M. and Katoh M. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence d ifferent pathways leading to smoking behavior from adolescence to mid-adulthood . (PubMed id 21168125) 1 Ducci F....JAorvelin M.R. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans. (PubMed id 20133381) 1 David S.P....Eaton W.W. (2010) Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence. (PubMed id 18828801) 1 Yang B.Z....Gelernter J. (2008) Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (PubMed id 17761687) 1 Yang B.Z....Gelernter J. (2007) Hypermethylation of TTC12 gene in acute lymphoblastic leukemia. (PubMed id 17657212) 1 Wattanawaraporn R....Mutirangura A. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006)
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External Searches for TTC12 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TTC12 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TTC12 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TTC12 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TTC12 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TTC12 gene: Search GeneIP for patents involving TTC12 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TTC12 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TTC12 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TTC12 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TTC12 OriGene Protein Over-expression Lysate for TTC12 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TTC12 OriGene 3'-UTR Clone for TTC12 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TTC12 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TTC12 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TTC12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TTC12 OriGene Custom Protein Services for TTC12 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC12 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TTC12 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TTC12 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TTC12 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TTC12 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TTC12
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TTC12 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC12
ThermoFisher Antibody for TTC12
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TTC12
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Aliases for TTC12
Databases for TTC12
Disorders / Diseases for TTC12
Domains / Families for TTC12
Drugs / Compounds for TTC12
Expression for TTC12
Function for TTC12
Genomic Views for TTC12
Intellectual Property for TTC12
Orthologs for TTC12
Paralogs for TTC12
Pathways / Interactions for TTC12
Products for TTC12
Proteins for TTC12
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Summaries for TTC12
Transcripts for TTC12
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