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TTC12 Gene

protein-coding   GIFtS: 49
GCID: GC11P113185

Tetratricopeptide Repeat Domain 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetratricopeptide Repeat Domain 121 2
TPR Repeat Protein 122 3
TPARM2 5
Tetratricopeptide Repeat Protein 122
Tetratricopeptide Repeat Protein 12 Variant 12
Tetratricopeptide Repeat Protein 12 Variant 22

External Ids:    HGNC: 237001   Entrez Gene: 549702   Ensembl: ENSG000001492927   OMIM: 6107325   UniProtKB: Q9H8923   

Export aliases for TTC12 gene to outside databases

Previous GC identifers: GC11P112722 GC11P112690 GC11P109112


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTC12 Gene:
TTC12 (tetratricopeptide repeat domain 12) is a protein-coding gene. Diseases associated with TTC12 include drug dependence, and heroin dependence. An important paralog of this gene is RPAP3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTC12 gene promoter:
         ISGF-3   E47   HNF-4alpha1   SRY   POU2F1   POU2F1a   Hand1   TGIF   ATF   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTC12 promoter sequence
   Search Chromatin IP Primers for TTC12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTC12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.2

TTC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC12 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P113185:  view genomic region     (about GC identifiers)

Start:
113,185,251 bp from pter      End:
113,254,266 bp from pter
Size:
69,016 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TTC12_HUMAN, Q9H892 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 12  
Size: 705 amino acids; 78756 Da
Sequence caution: Sequence=BAA91242.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8N5H9 Q9NWY3
Alternative splicing: 2 isoforms:  Q9H892-1   Q9H892-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TTC12: NX_Q9H892

Explore proteomics data for TTC12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TTC12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060338.3  
    ENSEMBL proteins: 
     ENSP00000433757   ENSP00000413335   ENSP00000400039   ENSP00000433916   ENSP00000431806  
     ENSP00000435308   ENSP00000437030   ENSP00000435291   ENSP00000376743   ENSP00000402004  
     ENSP00000436677   ENSP00000419652   ENSP00000433274   ENSP00000435730   ENSP00000315160  

    TTC12 Human Recombinant Protein Products:

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    Novus Biologicals TTC12 Protein
    Novus Biologicals TTC12 Lysates
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    Cloud-Clone Corp. Proteins for TTC12

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    ThermoFisher Antibody for TTC12
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    TTC12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TTC12
    Cloud-Clone Corp. CLIAs for TTC12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR011990 TPR-like_helical
     IPR011989 ARM-like
     IPR013105 TPR_2
     IPR016024 ARM-type_fold
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9H892

    ProtoNet protein and cluster: Q9H892

    UniProtKB/Swiss-Prot: TTC12_HUMAN, Q9H892
    Similarity: Contains 3 TPR repeats


    TTC12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    TTC12 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTC12
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTC12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTC12

    miRNA
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    miRTarBase miRNAs that target TTC12:
    hsa-mir-296-3p (MIRT038355)

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    Search for qRT-PCR Assays for microRNAs that regulate TTC12
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TTC12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TTC12

    Clone
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    OriGene clones in human, mouse for TTC12 (see all 6)
    OriGene ORF clones in mouse, rat for TTC12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTC12 (NM_017868)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTC12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC12

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TTC12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTC12
    Interactions:

        GeneGlobe Interaction Network for TTC12

    1 Interacting protein for TTC12 (Q9H8923) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTC12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TTC12 gene: 
    NM_017868.3  

    Unigene Cluster for TTC12:

    Tetratricopeptide repeat domain 12
    Hs.288772  [show with all ESTs]
    Unigene Representative Sequence: AK125909
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000529221(uc001pnu.3 uc001pnv.3) ENST00000429951 ENST00000442859
    ENST00000531164 ENST00000529850 ENST00000525965 ENST00000464224(uc001pnx.3)
    ENST00000494714(uc001pnw.3) ENST00000393020 ENST00000455306 ENST00000524580
    ENST00000489064 ENST00000527781 ENST00000483239 ENST00000527362 ENST00000525989
    ENST00000534793 ENST00000478125
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TTC12 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TTC12
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TTC12
    Predesigned siRNA for gene silencing in human, mouse, rat TTC12
    Clone
    Products:
         
    OriGene clones in human, mouse for TTC12 (see all 6)
    OriGene ORF clones in mouse, rat for TTC12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTC12 (NM_017868)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTC12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC12
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TTC12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTC12
      QuantiTect SYBR Green Assays in human, mouse, rat TTC12
      QuantiFast Probe-based Assays in human, mouse, rat TTC12

    Additional mRNA sequence: 

    AK000542.1 AK023921.1 AK027161.1 AK091887.1 AK125909.1 AK223117.1 AK292331.1 BC011546.1 
    BC019086.2 

    17 DOTS entries:

    DT.99961473  DT.100020560  DT.108310  DT.100020559  DT.120720437  DT.97779874  DT.91955198  DT.100030480 
    DT.92424750  DT.95269636  DT.65287571  DT.95257432  DT.40307708  DT.97854427  DT.91820313  DT.91840354 
    DT.91853573 

    Selected AceView cDNA sequences (see all 111):

    BM473638 BE261724 AI586953 CN478998 AK000542 AW513387 AK027161 AA399653 
    CD628682 BQ218129 BC032355 BC011546 CR597551 AK125909 BU684868 BM992919 
    BC019086 BM698700 AK023921 BF725316 AK091887 CF132464 AU124478 BX421378 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TTC12 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                      -                                                                                                                     

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for TTC12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTC12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTAGAAAT
    TTC12 Expression
    About this image


    TTC12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Choroid Plexus
     
     Heart (Cardiovascular System)
    TTC12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTC12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288772
        Custom PCR Arrays for TTC12
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TTC12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTC12
    QuantiTect SYBR Green Assays in human, mouse, rat TTC12
    QuantiFast Probe-based Assays in human, mouse, rat TTC12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TTC12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc121 , 5 tetratricopeptide repeat domain 121, 5 80.59(n)1
    75.14(a)1
      9 (26.83 cM)5
    2353301  NM_172770.31  NP_766358.11 
     494369635 
    chicken
    (Gallus gallus)
    Aves TTC121 tetratricopeptide repeat domain 12 60.19(n)
    50.29(a)
      770784  XM_003642610.2  XP_003642658.2 
    lizard
    (Anolis carolinensis)
    Reptilia TTC126
    tetratricopeptide repeat domain 12
    44(a)
    1 ↔ 1
    GL343354.1(553247-590124)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ttc121 tetratricopeptide repeat domain 12 57.15(n)
    46.38(a)
      101732246  XM_004916092.1  XP_004916149.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ttc121 tetratricopeptide repeat domain 12 53.49(n)
    44.4(a)
      563791  NM_001202496.1  NP_001189425.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG342976
    CG69806
    (see all 4)
    --
    22(a)
    22(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    3R(2572814-2573685)
    3R(20633343-20634399)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SGT26
    Glutamine-rich cytoplasmic protein that serves as ...
    15(a)
    1 → many
    XV(338938-339978) YOR007C


    ENSEMBL Gene Tree for TTC12 (if available)
    TreeFam Gene Tree for TTC12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTC12 gene
    RPAP32  SGTB2  SGTA2  
    1 SIMAP similar gene for TTC12 using alignment to 16 protein entries:     TTC12_HUMAN (see all proteins):
    STIP1

    TTC12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTC12 (see all 1163)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769753081,2
    F--113183313(+) AGTACC/GCTATA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1884440871,2
    --113183460(+) GGATCC/TCCAGG 1 -- us2k10--------
    rs1416001441,2
    --113183471(+) TCTCCC/TGCTGC 1 -- us2k10--------
    rs1915766071,2
    --113183546(+) ACATCC/TGTGGC 1 -- us2k10--------
    rs1448352291,2
    C--113183557(+) CCCTT-/TGTGTTA 1 -- us2k10--------
    rs1143465521,2
    C,F--113183676(+) ATGGGG/ACCTAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1147979781,2
    F--113183759(+) CCTCTG/AGCGAA 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs455038941,2
    C,F--113183779(+) TAGGGG/TCTCCT 1 -- us2k11Minor allele frequency- T:0.05NS 38
    rs1825455121,2
    --113183792(+) TTCCCG/TGCCAA 1 -- us2k10--------
    rs8850541,2
    C,F,A,H--113183802(+) AACAGG/ATTTCC 1 -- us2k112Minor allele frequency- A:0.02NA EA NS 1346

    HapMap Linkage Disequilibrium report for TTC12 (113185251 - 113254266 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TTC12: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTC12
    DNA2.0 Custom Variant and Variant Library Synthesis for TTC12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610732    OMIM disorders: --

    8 diseases for TTC12:    
    About MalaCards
    drug dependence    heroin dependence    nicotine dependence    alcohol dependence
    lymphoblastic leukemia    choroiditis    leukemia    malaria


    TTC12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TTC12
    Human Genome Epidemiology (HuGE) Navigator: TTC12 (6 documents)

    Export disorders for TTC12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTC12 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with TTC12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of TPARM gene in silico. (PubMed id 12964006)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    2. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. (PubMed id 18828801)1, 4 Yang B.Z....Gelernter J. (Alcohol. Clin. Exp. Res. 2008)
    3. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (PubMed id 17761687)1, 4 Yang B.Z....Gelernter J. (Hum. Mol. Genet. 2007)
    4. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. (PubMed id 17085484)1, 4 Gelernter J....Farrer L. (Hum. Mol. Genet. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. (PubMed id 23303482)1 Nelson E.C....Montgomery G.W. (JAMA Psychiatry 2013)
    8. TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. (PubMed id 21168125)1 Ducci F....JAorvelin M.R. (Biol. Psychiatry 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans. (PubMed id 20133381)1 David S.P....Eaton W.W. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54970 HGNC: 23700 AceView: TTC12 Ensembl:ENSG00000149292 euGenes: HUgn54970
    ECgene: TTC12 H-InvDB: TTC12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTC12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTC12 gene:
    Search GeneIP for patents involving TTC12

    GeneCards and IP:
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