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Aliases for TTC12 Gene

Aliases for TTC12 Gene

  • Tetratricopeptide Repeat Domain 12 2 3
  • TPR Repeat Protein 12 3 4
  • TPARM 3 6
  • Tetratricopeptide Repeat Protein 12 Variant 1 3
  • Tetratricopeptide Repeat Protein 12 Variant 2 3
  • Tetratricopeptide Repeat Protein 12 3

External Ids for TTC12 Gene

Summaries for TTC12 Gene

GeneCards Summary for TTC12 Gene

TTC12 (Tetratricopeptide Repeat Domain 12) is a Protein Coding gene. An important paralog of this gene is SGTB.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC12 Gene

Genomics for TTC12 Gene

Genomic Location for TTC12 Gene

Start:
113,314,529 bp from pter
End:
113,383,544 bp from pter
Size:
69,016 bases
Orientation:
Plus strand

Genomic View for TTC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC12 Gene

Regulatory Elements for TTC12 Gene

Proteins for TTC12 Gene

  • Protein details for TTC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H892-TTC12_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 12
    Protein Accession:
    Q9H892
    Secondary Accessions:
    • Q8N5H9
    • Q9NWY3

    Protein attributes for TTC12 Gene

    Size:
    705 amino acids
    Molecular mass:
    78756 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91242.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC12 Gene

Proteomics data for TTC12 Gene at MOPED

Post-translational modifications for TTC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC12 Gene

Domains for TTC12 Gene

Gene Families for TTC12 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC12 Gene

UniProtKB/Swiss-Prot:

TTC12_HUMAN
Similarity:
  • Contains 3 TPR repeats.:
    • Q9H892
genes like me logo Genes that share domains with TTC12: view

Function for TTC12 Gene

Gene Ontology (GO) - Molecular Function for TTC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TTC12: view

miRNA for TTC12 Gene

miRTarBase miRNAs that target TTC12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTC12 Gene

Localization for TTC12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC12 Gene COMPARTMENTS Subcellular localization image for TTC12 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TTC12 Gene

Pathways for TTC12 Gene

SuperPathways for TTC12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC12 Gene

None

No data available for Pathways by source for TTC12 Gene

Transcripts for TTC12 Gene

Unigene Clusters for TTC12 Gene

Tetratricopeptide repeat domain 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7: - - - -
SP8: - -
SP9:
SP10:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TTC12 Gene

GeneLoc Exon Structure for
TTC12
ECgene alternative splicing isoforms for
TTC12

Expression for TTC12 Gene

mRNA expression in normal human tissues for TTC12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC12 Gene

This gene is overexpressed in Testis (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTC12 Gene

SOURCE GeneReport for Unigene cluster for TTC12 Gene Hs.288772

genes like me logo Genes that share expressions with TTC12: view

Orthologs for TTC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC12 36
  • 99.1 (n)
  • 98.72 (a)
TTC12 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC12 36
  • 84.17 (n)
  • 81.03 (a)
TTC12 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC12 36
  • 83.93 (n)
  • 78.83 (a)
TTC12 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc12 36
  • 80.59 (n)
  • 75.14 (a)
Ttc12 16
Ttc12 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC12 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 58 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ttc12 36
  • 81.16 (n)
  • 77.27 (a)
chicken
(Gallus gallus)
Aves TTC12 36
  • 60.19 (n)
  • 50.29 (a)
TTC12 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC12 37
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc12 36
  • 57.15 (n)
  • 46.38 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc12 36
  • 53.49 (n)
  • 44.4 (a)
ttc12 37
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31294 37
  • 20 (a)
OneToMany
CG34274 37
  • 17 (a)
OneToMany
CG34297 37
  • 22 (a)
OneToMany
CG6980 37
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 37
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToOne
Species with no ortholog for TTC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC12 Gene

ENSEMBL:
Gene Tree for TTC12 (if available)
TreeFam:
Gene Tree for TTC12 (if available)

Paralogs for TTC12 Gene

Paralogs for TTC12 Gene

genes like me logo Genes that share paralogs with TTC12: view

Variants for TTC12 Gene

Sequence variations from dbSNP and Humsavar for TTC12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1078 -- 113,371,155(-) GATTA(A/G)ATGAT intron-variant
rs587290 -- 113,315,509(+) tctgg(C/G)caatg intron-variant
rs589453 -- 113,327,674(+) GAAAT(G/T)GTTGG intron-variant
rs589454 -- 113,327,677(+) ATTGT(G/T)GGAAC intron-variant
rs626505 -- 113,319,770(-) ccttt(C/T)cagca intron-variant

Relevant External Links for TTC12 Gene

HapMap Linkage Disequilibrium report
TTC12

No data available for Structural Variations from Database of Genomic Variants (DGV) for TTC12 Gene

Disorders for TTC12 Gene

Relevant External Links for TTC12

Genetic Association Database (GAD)
TTC12
Human Genome Epidemiology (HuGE) Navigator
TTC12
genes like me logo Genes that share disorders with TTC12: view

No data available for UniProtKB/Swiss-Prot for TTC12 Gene

Publications for TTC12 Gene

  1. Identification and characterization of TPARM gene in silico. (PMID: 12964006) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (PMID: 17761687) Yang B.Z. … Gelernter J. (Hum. Mol. Genet. 2007) 3 49
  5. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. (PMID: 18828801) Yang B.Z. … Gelernter J. (Alcohol. Clin. Exp. Res. 2008) 3 49

Products for TTC12 Gene

Sources for TTC12 Gene

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