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Aliases for TTC12 Gene

Aliases for TTC12 Gene

  • Tetratricopeptide Repeat Domain 12 2 3 5
  • TPR Repeat Protein 12 3 4
  • TPARM 3

External Ids for TTC12 Gene

Previous GeneCards Identifiers for TTC12 Gene

  • GC11P112722
  • GC11P112690
  • GC11P113185
  • GC11P109112

Summaries for TTC12 Gene

GeneCards Summary for TTC12 Gene

TTC12 (Tetratricopeptide Repeat Domain 12) is a Protein Coding gene. Diseases associated with TTC12 include Nicotine Dependence, Protection Against. GO annotations related to this gene include binding. An important paralog of this gene is SGTB.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC12 Gene

Genomics for TTC12 Gene

Regulatory Elements for TTC12 Gene

Enhancers for TTC12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC12 on UCSC Golden Path with GeneCards custom track

Promoters for TTC12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC12 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC12 Gene

Chromosome:
11
Start:
113,314,529 bp from pter
End:
113,385,952 bp from pter
Size:
71,424 bases
Orientation:
Plus strand

Genomic View for TTC12 Gene

Genes around TTC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC12 Gene

Proteins for TTC12 Gene

  • Protein details for TTC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H892-TTC12_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 12
    Protein Accession:
    Q9H892
    Secondary Accessions:
    • Q8N5H9
    • Q9NWY3

    Protein attributes for TTC12 Gene

    Size:
    705 amino acids
    Molecular mass:
    78756 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91242.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TTC12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TTC12 Gene

Proteomics data for TTC12 Gene at MOPED

Post-translational modifications for TTC12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTC12 Gene

Domains & Families for TTC12 Gene

Gene Families for TTC12 Gene

Protein Domains for TTC12 Gene

Suggested Antigen Peptide Sequences for TTC12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H892

UniProtKB/Swiss-Prot:

TTC12_HUMAN :
  • Contains 3 TPR repeats.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC12: view

Function for TTC12 Gene

genes like me logo Genes that share phenotypes with TTC12: view

Animal Model Products

miRNA for TTC12 Gene

miRTarBase miRNAs that target TTC12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC12 Gene

Localization for TTC12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC12 Gene COMPARTMENTS Subcellular localization image for TTC12 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TTC12 Gene

Pathways & Interactions for TTC12 Gene

SuperPathways for TTC12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TTC12 Gene

Drugs & Compounds for TTC12 Gene

No Compound Related Data Available

Transcripts for TTC12 Gene

Unigene Clusters for TTC12 Gene

Tetratricopeptide repeat domain 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7: - - - -
SP8: - -
SP9:
SP10:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TTC12 Gene

GeneLoc Exon Structure for
TTC12
ECgene alternative splicing isoforms for
TTC12

Expression for TTC12 Gene

mRNA expression in normal human tissues for TTC12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TTC12 Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for TTC12 Gene

This gene is overexpressed in Bone (23.9), Ovary (14.2), Plasma (12.8), and Rectum (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TTC12 Gene



SOURCE GeneReport for Unigene cluster for TTC12 Gene Hs.288772

genes like me logo Genes that share expression patterns with TTC12: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TTC12 Gene

Orthologs for TTC12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TTC12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC12 35
  • 84.17 (n)
  • 81.03 (a)
TTC12 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC12 35
  • 83.93 (n)
  • 78.83 (a)
TTC12 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc12 35
  • 80.59 (n)
  • 75.14 (a)
Ttc12 16
Ttc12 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC12 35
  • 99.1 (n)
  • 98.72 (a)
TTC12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc12 35
  • 81.16 (n)
  • 77.27 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC12 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves TTC12 35
  • 60.19 (n)
  • 50.29 (a)
TTC12 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC12 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ttc12 35
  • 57.15 (n)
  • 46.38 (a)
zebrafish
(Danio rerio)
Actinopterygii ttc12 35
  • 53.49 (n)
  • 44.4 (a)
ttc12 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31294 36
  • 20 (a)
OneToMany
CG34274 36
  • 17 (a)
OneToMany
CG34297 36
  • 22 (a)
OneToMany
CG6980 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for TTC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTC12 Gene

ENSEMBL:
Gene Tree for TTC12 (if available)
TreeFam:
Gene Tree for TTC12 (if available)

Paralogs for TTC12 Gene

Paralogs for TTC12 Gene

genes like me logo Genes that share paralogs with TTC12: view

Variants for TTC12 Gene

Sequence variations from dbSNP and Humsavar for TTC12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs723077 - 113,323,446(+) CTGCT(A/C)TGAAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs35852218 - 113,352,163(+) GACAC(A/T)TGGCG nc-transcript-variant, reference, missense
rs35303225 - 113,362,474(+) AGGAG(C/T)GGTAA nc-transcript-variant, reference, missense
rs589453 -- 113,327,674(+) GAAAT(G/T)GTTGG intron-variant
rs589454 -- 113,327,677(+) ATTGT(G/T)GGAAC intron-variant

Variation tolerance for TTC12 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TTC12 Gene

Disorders for TTC12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TTC12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nicotine dependence, protection against
  • nicotine dependence
- elite association - COSMIC cancer census association via MalaCards
Search TTC12 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTC12

Genetic Association Database (GAD)
TTC12
Human Genome Epidemiology (HuGE) Navigator
TTC12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TTC12
genes like me logo Genes that share disorders with TTC12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC12 Gene

Publications for TTC12 Gene

  1. Identification and characterization of TPARM gene in silico. (PMID: 12964006) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23 67
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. (PMID: 23303482) Nelson E.C. … Montgomery G.W. (JAMA Psychiatry 2013) 3
  5. Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. (PMID: 23300604) Hoh R.A. … Stearns T. (PLoS ONE 2012) 3

Products for TTC12 Gene

Sources for TTC12 Gene

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