Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TTC1 Gene

Aliases for TTC1 Gene

  • Tetratricopeptide Repeat Domain 1 2 3
  • TPR1 3 4 6
  • TPR Repeat Protein 1 3 4
  • Tetratricopeptide Repeat Protein 1 3

External Ids for TTC1 Gene

Summaries for TTC1 Gene

Entrez Gene Summary for TTC1 Gene

  • This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for TTC1 Gene

TTC1 (Tetratricopeptide Repeat Domain 1) is a Protein Coding gene. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is SPAG1.

Gene Wiki entry for TTC1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC1 Gene

Genomics for TTC1 Gene

Genomic Location for TTC1 Gene

Start:
160,009,100 bp from pter
End:
160,065,545 bp from pter
Size:
56,446 bases
Orientation:
Plus strand

Genomic View for TTC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC1 Gene

Regulatory Elements for TTC1 Gene

Proteins for TTC1 Gene

  • Protein details for TTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99614-TTC1_HUMAN
    Recommended name:
    Tetratricopeptide repeat protein 1
    Protein Accession:
    Q99614
    Secondary Accessions:
    • B2RCT2
    • D3DQJ8
    • Q9BVT3

    Protein attributes for TTC1 Gene

    Size:
    292 amino acids
    Molecular mass:
    33526 Da
    Quaternary structure:
    • Interacts with the GAP domain of NF1.

neXtProt entry for TTC1 Gene

Proteomics data for TTC1 Gene at MOPED

Post-translational modifications for TTC1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys152

Other Protein References for TTC1 Gene

No data available for DME Specific Peptides for TTC1 Gene

Domains for TTC1 Gene

Gene Families for TTC1 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TTC1 Gene

Suggested Antigen Peptide Sequences for TTC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99614

UniProtKB/Swiss-Prot:

TTC1_HUMAN
Similarity:
  • Contains 3 TPR repeats.:
    • Q99614
genes like me logo Genes that share domains with TTC1: view

Function for TTC1 Gene

Molecular function for TTC1 Gene

GENATLAS Biochemistry: tetratricopeptide-repeat containing gene 1,ubiquitously expressed,predominantly expressed in the brain

Gene Ontology (GO) - Molecular Function for TTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14985359
GO:0051082 unfolded protein binding NAS 8836031
genes like me logo Genes that share ontologies with TTC1: view

Phenotypes for TTC1 Gene

GenomeRNAi human phenotypes for TTC1:
genes like me logo Genes that share phenotypes with TTC1: view

miRNA for TTC1 Gene

miRTarBase miRNAs that target TTC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TTC1 Gene

Localization for TTC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TTC1 Gene COMPARTMENTS Subcellular localization image for TTC1 gene
Compartment Confidence
peroxisome 5
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005778 peroxisomal membrane IDA 21525035
genes like me logo Genes that share ontologies with TTC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC1 Gene

Pathways for TTC1 Gene

SuperPathways for TTC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 8836031
genes like me logo Genes that share ontologies with TTC1: view

No data available for Pathways by source for TTC1 Gene

Transcripts for TTC1 Gene

Unigene Clusters for TTC1 Gene

Tetratricopeptide repeat domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for TTC1 Gene

GeneLoc Exon Structure for
TTC1
ECgene alternative splicing isoforms for
TTC1

Expression for TTC1 Gene

mRNA expression in normal human tissues for TTC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC1 Gene

SOURCE GeneReport for Unigene cluster for TTC1 Gene Hs.519718

genes like me logo Genes that share expressions with TTC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC1 Gene

Orthologs for TTC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC1 35
  • 99.77 (n)
  • 99.32 (a)
TTC1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC1 35
  • 88.55 (n)
  • 87.63 (a)
TTC1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TTC1 35
  • 89.5 (n)
  • 88.01 (a)
TTC1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc1 35
  • 84.99 (n)
  • 83.85 (a)
Ttc1 16
Ttc1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TTC1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TTC1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc1 35
  • 84.42 (n)
  • 84.54 (a)
chicken
(Gallus gallus)
Aves TTC1 35
  • 71.92 (n)
  • 68.49 (a)
TTC1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC1 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15001 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487316 35
  • 69.7 (n)
  • 72.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8492 35
zebrafish
(Danio rerio)
Actinopterygii ttc1 35
  • 67.15 (n)
  • 72.46 (a)
ttc1 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003336 35
  • 52.99 (n)
  • 50.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14894 35
  • 56.2 (n)
  • 54.59 (a)
CG14894 36
  • 44 (a)
OneToOne
CG14894 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea C34B2.5 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 36
  • 8 (a)
ManyToMany
TOM71 36
  • 7 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30480 35
  • 50.48 (n)
  • 44.57 (a)
rice
(Oryza sativa)
Liliopsida Os10g0486900 35
  • 49.2 (n)
  • 45.99 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4424 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6035 36
  • 42 (a)
OneToOne
Species with no ortholog for TTC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC1 Gene

ENSEMBL:
Gene Tree for TTC1 (if available)
TreeFam:
Gene Tree for TTC1 (if available)

Paralogs for TTC1 Gene

Paralogs for TTC1 Gene

genes like me logo Genes that share paralogs with TTC1: view

Variants for TTC1 Gene

Sequence variations from dbSNP and Humsavar for TTC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs14653 -- 160,065,388(+) AAAGC(C/T)TCTCC utr-variant-3-prime
rs961265 -- 160,010,459(+) AAATA(C/T)AAGCA intron-variant
rs1065118 -- 160,061,921(-) AAAAC(G/T)TCCCC intron-variant
rs1065119 -- 160,061,915(-) TCCCC(C/G)CTCCC intron-variant
rs1106055 -- 160,064,513(+) GAGAG(A/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC1 Gene

Variant ID Type Subtype PubMed ID
nsv830531 CNV Loss 17160897
nsv528868 CNV Loss 19592680
esv2662749 CNV Deletion 23128226
esv2730972 CNV Deletion 23290073

Relevant External Links for TTC1 Gene

HapMap Linkage Disequilibrium report
TTC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC1 Gene

Disorders for TTC1 Gene

No disorders were found for TTC1 Gene.

No data available for UniProtKB/Swiss-Prot for TTC1 Gene

Publications for TTC1 Gene

  1. Identification and characterization of two novel tetratricopeptide repeat-containing genes. (PMID: 8836031) Murthy A.E. … Gusella J.F. (DNA Cell Biol. 1996) 2 3 4 23
  2. Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. (PMID: 9383998) Zhao S. … Sancar A. (Photochem. Photobiol. 1997) 3 23
  3. Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. (PMID: 14503850) Oh W.K. … Song J. (Mol. Cells 2003) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3

Products for TTC1 Gene

Sources for TTC1 Gene

Back to Top

Content