Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TTC1 Gene

protein-coding   GIFtS: 54
GCID: GC05P159436

Tetratricopeptide Repeat Domain 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tetratricopeptide Repeat Domain 11 2
TPR12 3 5
TPR Repeat Protein 12 3
Tetratricopeptide Repeat Protein 12

External Ids:    HGNC: 123911   Entrez Gene: 72652   Ensembl: ENSG000001133127   OMIM: 6019635   UniProtKB: Q996143   

Export aliases for TTC1 gene to outside databases

Previous GC identifers: GC05P159553 GC05P159945 GC05P159371 GC05P159417 GC05P159368 GC05P154530


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TTC1 Gene:
This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded
protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled
receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants.
(provided by RefSeq, Sep 2013)

GeneCards Summary for TTC1 Gene:
TTC1 (tetratricopeptide repeat domain 1) is a protein-coding gene. Diseases associated with TTC1 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is TOMM70A.

Gene Wiki entry for TTC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTC1 gene promoter:
         AREB6   SRF   AP-1   NRF-2   SRF (504 AA)   FOXO4   POU6F1 (c2)   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTC1 promoter sequence
   Search Chromatin IP Primers for TTC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q32-q33.2

TTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTC1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P159436:  view genomic region     (about GC identifiers)

Start:
159,436,120 bp from pter      End:
159,492,550 bp from pter
Size:
56,431 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TTC1_HUMAN, Q99614 (See protein sequence)
Recommended Name: Tetratricopeptide repeat protein 1  
Size: 292 amino acids; 33526 Da
Subunit: Interacts with the GAP domain of NF1
Secondary accessions: B2RCT2 D3DQJ8 Q9BVT3

Explore the universe of human proteins at neXtProt for TTC1: NX_Q99614

Explore proteomics data for TTC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys152
  • Modification sites at PhosphoSitePlus

  • See TTC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269429.1  NP_003305.1  

    ENSEMBL proteins: 
     ENSP00000429225   ENSP00000231238   ENSP00000428613  

    TTC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TTC1
    OriGene Protein Over-expression Lysate for TTC1
    OriGene MassSpec for TTC1
    OriGene Custom Protein Services for TTC1
    GenScript Custom Purified and Recombinant Proteins Services for TTC1
    Novus Biologicals TTC1 Proteins
    Novus Biologicals TTC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TTC1
    Cloud-Clone Corp. Proteins for TTC1

    TTC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TTC1
    OriGene Custom Antibody Services for TTC1
    Novus Biologicals TTC1 Antibodies
    Abcam antibodies for TTC1
    Cloud-Clone Corp. Antibodies for TTC1
    ThermoFisher Antibodies for TTC1
    LSBio Antibodies in human, mouse, rat for TTC1

    TTC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TTC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TTC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TTC1
    Cloud-Clone Corp. CLIAs for TTC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q99614

    ProtoNet protein and cluster: Q99614

    UniProtKB/Swiss-Prot: TTC1_HUMAN, Q99614
    Similarity: Contains 3 TPR repeats


    TTC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:
         Genatlas biochemistry entry for TTC1:
    tetratricopeptide-repeat containing gene 1,ubiquitously expressed,predominantly expressed in the brain

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14985359
    GO:0051082unfolded protein binding NAS8836031
         
    TTC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TTC1:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TTC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TTC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TTC1:
    hsa-mir-15b-5p (MIRT046424), hsa-mir-16-5p (MIRT031698), hsa-mir-15a-5p (MIRT051350)

    Block miRNA regulation of human, mouse, rat TTC1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TTC1:
    hsa-miR-1321 hsa-miR-556-3p hsa-miR-1207-5p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidTTC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TTC1
    Predesigned siRNA for gene silencing in human, mouse, rat TTC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TTC1

    Clone
    Products:
         
    OriGene clones in human, mouse for TTC1 (see all 7)
    OriGene ORF clones in mouse, rat for TTC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTC1 (NM_003314)
    Sino Biological Human cDNA Clone for TTC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TTC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TTC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005778peroxisomal membrane IDA--

    TTC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTC1
    Interactions:

        GeneGlobe Interaction Network for TTC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for TTC1 (Q996142, 3 ENSP000002312384) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding NAS8836031

    TTC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TTC1 gene (2 alternative transcripts): 
    NM_001282500.1  NM_003314.2  

    Unigene Cluster for TTC1:

    Tetratricopeptide repeat domain 1
    Hs.519718  [show with all ESTs]
    Unigene Representative Sequence: AK128840
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522793 ENST00000231238(uc003lxu.3) ENST00000522073 ENST00000520274
    ENST00000518560
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TTC1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TTC1:
    hsa-miR-1321 hsa-miR-556-3p hsa-miR-1207-5p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidTTC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TTC1
    Predesigned siRNA for gene silencing in human, mouse, rat TTC1
    Clone
    Products:
         
    OriGene clones in human, mouse for TTC1 (see all 7)
    OriGene ORF clones in mouse, rat for TTC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TTC1 (NM_003314)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TTC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TTC1
    OriGene qSTAR qPCR primer pairs in human, mouse for TTC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTC1
      QuantiTect SYBR Green Assays in human, mouse, rat TTC1
      QuantiFast Probe-based Assays in human, mouse, rat TTC1

    Additional mRNA sequence: 

    AK128840.1 AK222641.1 AK222984.1 AK315262.1 BC000942.3 U46570.1 

    14 DOTS entries:

    DT.100703382  DT.446779  DT.95276381  DT.40248412  DT.306372  DT.120849335  DT.120849299  DT.87016230 
    DT.100841605  DT.91737576  DT.100841602  DT.120849304  DT.92438061  DT.87046581 

    Selected AceView cDNA sequences (see all 390):

    CB109993 BM999473 AI493533 BU173120 BM981495 AI804675 BU607629 AI371789 
    BG113973 BM550620 BM789226 CB125070 CR609532 BQ932769 BE298935 CB107110 
    BU688024 AA642000 AL559114 AI753387 BG057277 BQ052782 BP373080 AV682832 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TTC1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                      
    SP2:                                                      


    ECgene alternative splicing isoforms for TTC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TTC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGATGACG
    TTC1 Expression
    About this image

    TTC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519718
        Custom PCR Arrays for TTC1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TTC1
    OriGene qSTAR qPCR primer pairs in human, mouse for TTC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTC1
    QuantiTect SYBR Green Assays in human, mouse, rat TTC1
    QuantiFast Probe-based Assays in human, mouse, rat TTC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TTC1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttc11 , 5 tetratricopeptide repeat domain 11, 5 84.99(n)1
    83.85(a)1
      11 (25.81 cM)5
    668271  NM_133795.11  NP_598556.11 
     437295125 
    chicken
    (Gallus gallus)
    Aves TTC11 tetratricopeptide repeat domain 1 71.92(n)
    68.49(a)
      416152  XM_004944814.1  XP_004944871.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTC16
    tetratricopeptide repeat domain 1
    64(a)
    1 ↔ 1
    GL343286.1(1060681-1075565)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.150012 Xenopus laevis transcribed sequence with weak similarity more 73.25(n)    BX843124.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ttc11 tetratricopeptide repeat domain 1 67.15(n)
    72.46(a)
      492510  NM_001007382.1  NP_001007383.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG148941 , 3 CG148941 45(a)3
    56.2(n)1
    54.59(a)1
      89C63
    419931  NM_142286.31  NP_650543.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C34B2.56
    Protein C34B2.5 (C34B2.5) mRNA, complete cds
    32(a)
    1 ↔ 1
    I(10675166-10676811) WBGene00016390
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOM706
    TOM716
    Component of the TOM (translocase of outer membran...
    Mitochondrial outer membrane protein with similari...
    8(a)
    7(a)
    many ↔ many
    many ↔ many
    XIV(398684-400537) YNL121C
    VIII(342349-344268) YHR117W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G304801 AT4G30480 50.48(n)
    44.57(a)
      829171  NM_119194.5  NP_194777.3 
    rice
    (Oryza sativa)
    Liliopsida Os10g04869001 Os10g0486900 49.2(n)
    45.99(a)
      4348950  NM_001071439.1  NP_001064904.1 


    ENSEMBL Gene Tree for TTC1 (if available)
    TreeFam Gene Tree for TTC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TTC1 gene
    TOMM70A2  TOMM342  SPAG12  UNC45A2  UNC45B2  

    TTC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TTC1 (see all 1147)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405208461,2
    --159434389(+) AAAATA/TAAAAC 1 -- us2k10--------
    rs748131391,2
    C,F--159434500(+) ACAGCA/GTGCGG 1 -- us2k11Minor allele frequency- G:0.17WA 118
    rs1504252251,2
    --159434507(+) GCGGTA/GCTTAA 1 -- us2k10--------
    rs1381660601,2
    C--159434588(+) GAGACC/TGTAAC 1 -- us2k10--------
    rs764088681,2
    C,F--159434589(+) AGACCG/ATAACT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs767432631,2
    C--159434618(+) TTACTA/TATTTA 1 -- us2k10--------
    rs746796861,2
    C--159434619(+) TACTTA/CTTTAT 1 -- us2k10--------
    rs758473751,2
    C--159434621(+) CTTATG/TTATTT 1 -- us2k10--------
    rs802958261,2
    C--159434623(+) TATTTA/TTTTAG 1 -- us2k10--------
    rs126596561,2
    C,H--159434671(+) AATTAA/CCAGGG 1 -- us2k14Minor allele frequency- C:0.00NS EA 420

    HapMap Linkage Disequilibrium report for TTC1 (159436120 - 159492550 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TTC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730972CNV Deletion23290073
    esv2662749CNV Deletion23128226
    nsv528868CNV Loss19592680
    nsv830531CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TTC1
    DNA2.0 Custom Variant and Variant Library Synthesis for TTC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601963    OMIM disorders: --

    3 diseases for TTC1:    
    About MalaCards
    pancreatic cancer    pancreatitis    malaria


    TTC1 for disorders           About GeneDecksing


    Export disorders for TTC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TTC1 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with TTC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of two novel tetratricopeptide repeat-containing genes. (PubMed id 8836031)1, 2, 3, 9 Murthy A.E.... Gusella J.F. (DNA Cell Biol. 1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. (PubMed id 14503850)1, 9 Oh W.K. and Song J. (Mol. Cells 2003)
    4. Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. (PubMed id 9383998)1, 9 Zhao S. and Sancar A. (Photochem. Photobiol. 1997)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1. (PubMed id 22711498)1 Kwan D.H....Wong Y.H. (J. Cell. Biochem. 2012)
    8. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). (PubMed id 23067341)1 Thebault P....Bolanos-Garcia V.M. (Biochem. J. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7265 HGNC: 12391 AceView: TTC1 Ensembl:ENSG00000113312 euGenes: HUgn7265
    ECgene: TTC1 H-InvDB: TTC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TTC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TTC1 gene:
    Search GeneIP for patents involving TTC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TTC1   OriGene RNAi products in human, mouse, rat for TTC1  
     OriGene qPCR primer pairs and template standards for TTC1   OriGene Protein Over-expression Lysate for TTC1  
     OriGene MassSpec something-or-other for TTC1   OriGene clones in human, mouse for TTC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TTC1   OriGene Purified Protein for TTC1  
     OriGene ORF clones in mouse, rat for TTC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TTC1   OriGene Custom Protein Services for TTC1  

     
     
     Block miRNA regulation of human, mouse, rat TTC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TTC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTC1 Predesigned siRNA for gene silencing in human, mouse, rat TTC1
     QuantiFast Probe-based Assays in human, mouse, rat TTC1 QuantiTect SYBR Green Assays in human, mouse, rat TTC1
     Custom PCR Arrays for TTC1 Search Chromatin IP Primers for TTC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TTC1  GeneGlobe Interaction Network for TTC1
     Regulatory tfbs in TTC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TTC1 GenScript cDNA clones with any tag delivered in your preferred vector for TTC1
     GenScript Custom Assay Services for TTC1 GenScript Custom overexpressing Cell Line Services for TTC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TTC1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TTC1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TTC1 antibodies
     TTC1 proteins
     TTC1 lysates
     Antibodies for TTC1
     See all of Abcam's Antibodies, Kits and Proteins for TTC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TTC1
     Proteins for TTC1
     Antibodies for TTC1
     ELISAs for TTC1
     CLIAs for TTC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TTC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC1
     SwitchGear 3'UTR luciferase reporter plasmids for TTC1
     SwitchGear Promoter luciferase reporter plasmids for TTC1
     ThermoFisher Antibodies for TTC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TTC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TTC1
     LSBio Antibodies in human, mouse, rat for TTC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TTC1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4