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Aliases for TTC1 Gene

Aliases for TTC1 Gene

  • Tetratricopeptide Repeat Domain 1 2 3 5
  • TPR Repeat Protein 1 3 4
  • TPR1 3 4

External Ids for TTC1 Gene

Previous GeneCards Identifiers for TTC1 Gene

  • GC05P159553
  • GC05P159945
  • GC05P159371
  • GC05P159417
  • GC05P159368
  • GC05P154530
  • GC05P159436

Summaries for TTC1 Gene

Entrez Gene Summary for TTC1 Gene

  • This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for TTC1 Gene

TTC1 (Tetratricopeptide Repeat Domain 1) is a Protein Coding gene. Diseases associated with TTC1 include Dysthymic Disorder and Tricuspid Valve Insufficiency. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is UNC45B.

Gene Wiki entry for TTC1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTC1 Gene

Genomics for TTC1 Gene

Regulatory Elements for TTC1 Gene

Enhancers for TTC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TTC1 on UCSC Golden Path with GeneCards custom track

Promoters for TTC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TTC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TTC1 Gene

160,009,100 bp from pter
160,065,545 bp from pter
56,446 bases
Plus strand

Genomic View for TTC1 Gene

Genes around TTC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTC1 Gene

Proteins for TTC1 Gene

  • Protein details for TTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tetratricopeptide repeat protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RCT2
    • D3DQJ8
    • Q9BVT3

    Protein attributes for TTC1 Gene

    292 amino acids
    Molecular mass:
    33526 Da
    Quaternary structure:
    • Interacts with the GAP domain of NF1.

neXtProt entry for TTC1 Gene

Proteomics data for TTC1 Gene at MOPED

Post-translational modifications for TTC1 Gene

  • Ubiquitination at Lys 152
  • Modification sites at PhosphoSitePlus

Other Protein References for TTC1 Gene

No data available for DME Specific Peptides for TTC1 Gene

Domains & Families for TTC1 Gene

Gene Families for TTC1 Gene

Protein Domains for TTC1 Gene

Suggested Antigen Peptide Sequences for TTC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 TPR repeats.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TTC1: view

Function for TTC1 Gene

Molecular function for TTC1 Gene

GENATLAS Biochemistry:
tetratricopeptide-repeat containing gene 1,ubiquitously expressed,predominantly expressed in the brain

Gene Ontology (GO) - Molecular Function for TTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding NAS 8836031
genes like me logo Genes that share ontologies with TTC1: view

Phenotypes for TTC1 Gene

genes like me logo Genes that share phenotypes with TTC1: view

Animal Model Products

miRNA for TTC1 Gene

miRTarBase miRNAs that target TTC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTC1 Gene

Localization for TTC1 Gene

Subcellular locations from

Jensen Localization Image for TTC1 Gene COMPARTMENTS Subcellular localization image for TTC1 gene
Compartment Confidence
cytosol 5
peroxisome 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TTC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTC1 Gene

Pathways & Interactions for TTC1 Gene

SuperPathways for TTC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TTC1 Gene

Drugs & Compounds for TTC1 Gene

No Compound Related Data Available

Transcripts for TTC1 Gene

Unigene Clusters for TTC1 Gene

Tetratricopeptide repeat domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TTC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8

Relevant External Links for TTC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTC1 Gene

mRNA expression in normal human tissues for TTC1 Gene

Protein differential expression in normal tissues from HIPED for TTC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.6) and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TTC1 Gene

SOURCE GeneReport for Unigene cluster for TTC1 Gene Hs.519718

genes like me logo Genes that share expression patterns with TTC1: view

Protein tissue co-expression partners for TTC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TTC1 Gene

Orthologs for TTC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TTC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TTC1 35
  • 88.55 (n)
  • 87.63 (a)
TTC1 36
  • 87 (a)
(Canis familiaris)
Mammalia TTC1 35
  • 89.5 (n)
  • 88.01 (a)
TTC1 36
  • 87 (a)
(Mus musculus)
Mammalia Ttc1 35
  • 84.99 (n)
  • 83.85 (a)
Ttc1 16
Ttc1 36
  • 83 (a)
(Pan troglodytes)
Mammalia TTC1 35
  • 99.77 (n)
  • 99.32 (a)
TTC1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ttc1 35
  • 84.42 (n)
  • 84.54 (a)
(Monodelphis domestica)
Mammalia TTC1 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia TTC1 36
  • 72 (a)
(Gallus gallus)
Aves TTC1 35
  • 71.92 (n)
  • 68.49 (a)
TTC1 36
  • 66 (a)
(Anolis carolinensis)
Reptilia TTC1 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487316 35
  • 69.7 (n)
  • 72.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15001 35
(Danio rerio)
Actinopterygii ttc1 35
  • 67.15 (n)
  • 72.46 (a)
ttc1 36
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8492 35
fruit fly
(Drosophila melanogaster)
Insecta CG14894 37
  • 45 (a)
CG14894 35
  • 56.2 (n)
  • 54.59 (a)
CG14894 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003336 35
  • 52.99 (n)
  • 50.43 (a)
(Caenorhabditis elegans)
Secernentea C34B2.5 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 36
  • 8 (a)
TOM71 36
  • 7 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G30480 35
  • 50.48 (n)
  • 44.57 (a)
(Oryza sativa)
Liliopsida Os10g0486900 35
  • 49.2 (n)
  • 45.99 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4424 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6035 36
  • 42 (a)
Species with no ortholog for TTC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TTC1 Gene

Gene Tree for TTC1 (if available)
Gene Tree for TTC1 (if available)

Paralogs for TTC1 Gene

Paralogs for TTC1 Gene

genes like me logo Genes that share paralogs with TTC1: view

Variants for TTC1 Gene

Sequence variations from dbSNP and Humsavar for TTC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs961265 -- 160,010,459(+) AAATA(C/T)AAGCA intron-variant
rs6864045 -- 160,036,199(+) AATGT(C/G)TCTCT intron-variant
rs6866671 -- 160,009,816(+) AGCTG(A/C)GTGGG intron-variant
rs3941840 -- 160,037,743(-) TAAAT(A/C)GGAAA intron-variant
rs1568398 -- 160,013,010(-) TGAAT(A/T)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTC1 Gene

Variant ID Type Subtype PubMed ID
nsv830531 CNV Loss 17160897
nsv528868 CNV Loss 19592680
esv2662749 CNV Deletion 23128226
esv2730972 CNV Deletion 23290073

Variation tolerance for TTC1 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TTC1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTC1 Gene

Disorders for TTC1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TTC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dysthymic disorder
  • dysthymia
tricuspid valve insufficiency
  • tricuspid incompetence
tricuspid valve disease
  • disease of tricuspid valve
  • deerfly fever
major depressive disorder and accelerated response to antidepressant drug treatment
  • unipolar depression
- elite association - COSMIC cancer census association via MalaCards
Search TTC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TTC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TTC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TTC1 Gene

Publications for TTC1 Gene

  1. Identification and characterization of two novel tetratricopeptide repeat-containing genes. (PMID: 8836031) Murthy A.E. … Gusella J.F. (DNA Cell Biol. 1996) 2 3 4 23 67
  2. Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. (PMID: 14503850) Oh W.K. … Song J. (Mol. Cells 2003) 3 23
  3. Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. (PMID: 9383998) Zhao S. … Sancar A. (Photochem. Photobiol. 1997) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for TTC1 Gene

Sources for TTC1 Gene