TTC1 Gene
protein-coding GIFtS: 52
GCID: GC05P159436
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|
tetratricopeptide repeat domain 1
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Aliases
for TTC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat Domain 11 2 | | TPR11 2 3 5 | | TPR Repeat Protein 12 3 | | Tetratricopeptide Repeat Protein 12 |
Export aliases for TTC1 gene to outside databasesPrevious GC identifers: GC05P159553 GC05P159945 GC05P159371 GC05P159417 GC05P159368 GC05P154530 |
Summaries
for TTC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for TTC1
|
Genomic Views
for TTC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTC1 gene promoter:
AREB6 SRF AP-1 NRF-2 SRF (504 AA) FOXO4 POU6F1 (c2) GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q32-q33.2TTC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P159436: view genomic region
(about GC identifiers)
Start:
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159,436,120 bp from pter |
End:
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159,492,550 bp from pter |
Size:
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56,431 bases |
Orientation:
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plus strand |
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Proteins
for TTC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTC1_HUMAN, Q99614 (See
protein sequence)Recommended Name: Tetratricopeptide repeat protein 1 Size: 292 amino acids; 33526 Da
Subunit: Interacts with the GAP domain of NF1
Secondary accessions: B2RCT2 D3DQJ8 Q9BVT3Explore the universe of human proteins at neXtProt for TTC1: NX_Q99614
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99614
TTC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003305.1
ENSEMBL proteins: ENSP00000231238 ENSP00000429225 ENSP00000428613
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005778 | peroxisomal membrane |
IDA | -- |
TTC1 for ontologies About GeneDecksing
TTC1 Antibody Products:
Assay Products for TTC1: |
Protein
Domains /
Families
for TTC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTC1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99614ProtoNet protein and cluster: Q99614 UniProtKB/Swiss-Prot: TTC1_HUMAN, Q99614Similarity: Contains 3 TPR repeats |
Function
for TTC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for TTC1:tetratricopeptide-repeat containing gene 1,ubiquitously expressed,predominantly expressed in the brain
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TTC1 (NM_003314) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TTC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TTC1:
|
Pathways & Interactions
for TTC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TTC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/29 Interacting proteins for TTC1 (Q996142, 3 ENSP000002312384) via UniProtKB, MINT, STRING, and/or I2D (see all 29)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
TTC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TTC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTC1
Search CenterWatch for drugs/clinical trials and news about TTC1
|
Transcripts
for TTC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTC1 gene: NM_003314.1 Unigene Cluster for TTC1: Tetratricopeptide repeat domain 1 Hs.519718 [show with all ESTs]Unigene Representative Sequence: AK1288405 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000231238(uc003lxu.3) ENST00000522793 ENST00000522073 ENST00000520274
ENST00000518560
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTC1 (NM_003314) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC1 |
Additional cDNA sequence: AK128840.1 AK222641.1 AK222984.1 AK315262.1 BC000942.3 U46570.1 14 DOTS entries: DT.100703382 DT.446779 DT.95276381 DT.40248412 DT.306372 DT.120849335 DT.120849299 DT.87016230 DT.100841605 DT.91737576 DT.100841602 DT.120849304 DT.92438061 DT.87046581 24/390 AceView cDNA sequences (see all 390): CA944598 BU625562 CA442591 AA642000 CB141835 BQ004892 CA437501 AV709435 AA159905 T16296 CR625510 CK826224 BQ232086 AA356382 BU173120 BM753892 CA441202 H53645 CA427834 BQ575556 BM975552 AI160222 AA283938 BI871514
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TTC1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TTC1
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Expression
for TTC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGATGACG
About this image
See TTC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTC1
SOURCE GeneReport for Unigene cluster: Hs.519718
SABiosciences Custom PCR Arrays for TTC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC1 |
Orthologs
for TTC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TTC1 gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for TTC1 (if available)
TreeFam Gene Tree for TTC1 (if available) |
Paralogs
for TTC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTC1 gene
- RPAP32 TOMM342 STIP12 SPAG12
TTC1 for paralogs About GeneDecksing
|
Genomic Variants
for TTC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTC1 (159436120 - 159492550 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TTC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC1 |
|
Disorders
/ Diseases
for TTC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TTC1 for disorders About GeneDecksing
OMIM gene information: 601963
OMIM disorders: --
2  diseases for TTC1: About MalaCardspancreatic cancer pancreatitis
Export disorders for TTC1 gene to outside databases
|
Publications
for TTC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTC1 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with TTC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of two novel tetratricopeptide repeat-containing genes. (PubMed id 8836031)1, 2, 3, 9 Murthy A.E.... Gusella J.F. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. (PubMed id 14503850)1, 9 Oh W.K. and Song J. (2003)
- Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity. (PubMed id 9383998)1, 9 Zhao S. and Sancar A. (1997)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Activation of Ras-dependent signaling pathways by G(14 ) -coupled receptors requires the adaptor protein TPR1. (PubMed id 22711498)1 Kwan D.H....Wong Y.H. (2012)
- Structural and functional insights into the role of th e N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). (PubMed id 23067341)1 Thebault P....Bolanos-Garcia V.M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)
|
External Searches for TTC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TTC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TTC1 gene:
Search GeneIP for patents involving TTC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TTC1 | | OriGene shRNA RFP for TTC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TTC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTC1 | | | OriGene Protein Over-expression Lysate for TTC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TTC1 | | OriGene 3'-UTR Clone for TTC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TTC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TTC1 | | OriGene Custom Protein Services for TTC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTC1 |
| |
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| | | | Search Tocris compounds for TTC1 |
| |  |  |  |  | | | | | | Recombinant Protein for TTC1 |
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 | | | TTC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTC1 |
|  |  |  | | | | ThermoFisher Antibodies for TTC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTC1 |
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