TTBK2 Gene
protein-coding GIFtS: 55
GCID: GC15M043030
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|
tau tubulin kinase 2(Previous name: spinocerebellar ataxia 11 )
(Previous symbol: SCA11)
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Aliases
for TTBK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tau Tubulin Kinase 21 2 | | TTBK2 | | SCA111 2 5 | | Tau-Tubulin Kinase 22 | | KIAA08471 3 | | EC 2.7.11.13 | | Spinocerebellar Ataxia 111 | | EC 2.7.118 |
Export aliases for TTBK2 gene to outside databasesPrevious GC identifers: GC15M040615 GC15M040753 GC15M040752 GC15M040825 GC15M043036 GC15M019885 |
Summaries
for TTBK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TTBK2:
This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in thisgene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia andatrophy of the cerebellum and brainstem. (provided by RefSeq, Aug 2009)
UniProtKB/Swiss-Prot: TTBK2_HUMAN, Q6IQ55Function: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesisby binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole,leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference forproteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site.Able to phosphorylate tau on serines in vitro
|
Genomic Views
for TTBK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TTBK2 gene promoter:
Nkx3-1 c-Fos AP-1 Nkx3-1 v1 AP-2gamma Nkx3-1 v2 AP-2beta c-Jun AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for TTBK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTBK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.2 Ensembl cytogenetic band: 15q15.2 HGNC cytogenetic band: 15q15.2TTBK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M043030: view genomic region
(about GC identifiers)
Start:
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43,030,932 bp from pter |
End:
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43,213,007 bp from pter |
Size:
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182,076 bases |
Orientation:
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minus strand |
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Proteins
for TTBK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TTBK2_HUMAN, Q6IQ55 (See
protein sequence)Recommended Name: Tau-tubulin kinase 2 Size: 1244 amino acids; 137412 Da
Subunit: Interacts with CEP164
Subcellular location: Cell projection, cilium (By similarity). Cytoplasm, cytoskeleton, cilium basal body (Bysimilarity). Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to thetransition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May alsobe present in cytosol and, at lower level in the nucleus
Secondary accessions: O94932 Q6ZN52 Q8IVV1Alternative splicing: 3 isoforms: Q6IQ55-1 Q6IQ55-2 Q6IQ55-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TTBK2: NX_Q6IQ55
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IQ55
2 DME Specific Peptides for TTBK2 (Q6IQ55)
TTBK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775771.3
ENSEMBL proteins: ENSP00000267890 ENSP00000455734 ENSP00000457489 ENSP00000455574 ENSP00000457385 ENSP00000454605
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TTBK2 for ontologies About GeneDecksing
TTBK2 Antibody Products:
Assay Products for TTBK2: |
Protein
Domains /
Families
for TTBK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TTBK2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6IQ55ProtoNet protein and cluster: Q6IQ55 UniProtKB/Swiss-Prot: TTBK2_HUMAN, Q6IQ55Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for TTBK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TTBK2_HUMAN, Q6IQ55Function: Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesisby binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole,leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference forproteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site.Able to phosphorylate tau on serines in vitroCatalytic activity: ATP + a protein = ADP + a phosphoproteinBiophysicochemical properties: Kinetic parameters: KM=18 uM for RRKDLHDDEEDEAMSIYpA peptide; KM=141 uM forRRKDLHDDEEDEAMSIYA peptide; Vmax=76 umol/min/mg enzyme with RRKDLHDDEEDEAMSIYpA peptide as substrate; Vmax=66umol/min/mg enzyme with RRKDLHDDEEDEAMSIYA peptide as substrate;Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTBK2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TTBK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTBK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTBK2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TTBK2 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for TTBK2:
Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ttbk2):
TTBK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TTBK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTBK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/10 Interacting proteins for TTBK2 (Q6IQ551, 3 ENSP000002678904) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TTBK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TTBK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TTBK2
2 HMDB Compounds for TTBK2 About this table
Search CenterWatch for drugs/clinical trials and news about TTBK2
|
Transcripts
for TTBK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TTBK2 gene: NM_173500.3 Unigene Cluster for TTBK2: Tau tubulin kinase 2 Hs.646511 [show with all ESTs]Unigene Representative Sequence: NM_1735007 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000267890(uc001zqo.2 uc010bcy.2) ENST00000567840(uc001zqp.3)
ENST00000567274 ENST00000564431 ENST00000562880 ENST00000566931 ENST00000567485
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TTBK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TTBK2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TTBK2 (NM_173500) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TTBK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTBK2 |
Additional cDNA sequence: AB020654.1 AF525400.1 AK131372.1 BC041876.1 BC071556.1 10 DOTS entries: DT.91856557 DT.100813216 DT.97835428 DT.92040193 DT.100726914 DT.91729590 DT.121018306 DT.95349013 DT.40274210 DT.92415918 24/151 AceView cDNA sequences (see all 151): BU685813 BE669454 AW269801 BE222107 BX390074 BC041876 AI131106 BG150399 AW298697 BG150292 BX117998 N23323 AL698196 AI286085 AF525400 AA810495 CR611465 BF433088 BF433920 BE221530 BU501589 BM511674 NM_173500 CD557495
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TTBK2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TTBK2
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Expression
for TTBK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TTBK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTCCCTG
About this image
See TTBK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TTBK2
SOURCE GeneReport for Unigene cluster: Hs.646511
SABiosciences Custom PCR Arrays for TTBK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TTBK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TTBK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTBK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTBK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTBK2 |
Orthologs
for TTBK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TTBK2 gene from 5/22 species (see all 22) About this table
ENSEMBL Gene Tree for TTBK2 (if available)
TreeFam Gene Tree for TTBK2 (if available) |
Paralogs
for TTBK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TTBK2 gene
- VRK32 VRK12 CSNK1G32 VRK22 CSNK1D2 CSNK1G22 CSNK1A12 CSNK1A1L2
- TTBK12 CSNK1G12 CSNK1E2
18/21 SIMAP similar genes for TTBK2 using alignment to 5 protein entries: TTBK2_HUMAN (see all proteins)
(see all similar genes):KRT8 KRT5 KRT7 CSNK1A1 KRT1 KRT4
KRT74 KRT79 KRT71 CSNK1D CSNK1E KRT6A
KRT72 KRT84 KRTHB1 KRT85 MAP3K3 KRT82
TTBK2 for paralogs About GeneDecksing
|
Genomic Variants
for TTBK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TTBK2 (43030932 - 43213007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TTBK2
2 CNVs: 76957 87663
1 Indel: 11790
Human Gene Mutation Database (HGMD): TTBK2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTBK2 |
|
Disorders
/ Diseases
for TTBK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TTBK2 for disorders About GeneDecksing
OMIM gene information: 611695
OMIM disorders: 604432
UniProtKB/Swiss-Prot: TTBK2_HUMAN, Q6IQ55
Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11) [MIM:604432]. Spinocerebellar ataxiais a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordinationof gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum withvariable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It isa relatively benign, late-onset, slowly progressive neurologic disorder
10  diseases for TTBK2: About MalaCardsspinocerebellar ataxia spinocerebellar ataxia type 11 ataxia congenital dyserythropoietic anemia type i
spinocerebellar ataxia type11 congenital dyserythropoietic anemia dyserythropoietic anemia neurodegenerative disease
cerebellar ataxia anemia
3 diseases from the University of Copenhagen DISEASES database for TTBK2:Spinocerebellar ataxia dentatorubral-pallidoluysian atrophy Cerebellar ataxia GeneTests: TTBK2
Spinocerebellar Ataxia Type11
Human Genome Epidemiology (HuGE) Navigator: TTBK2 (3 documents)
Export disorders for TTBK2 gene to outside databases
|
Publications
for TTBK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TTBK2 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with TTBK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- Missense exchanges in the TTBK2 gene mutated in SCA11 . (PubMed id 19533200)1, 2, 9 Edener U....ZA1hlke C. (2009)
- Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. (PubMed id 18037885)1, 2, 9 Houlden H.... Wood N.W. (2007)
- The spinocerebellar ataxia-associated gene tau tubulin kinase 2 controls the initiation of ciliogenesis. (PubMed id 23141541)1, 2 Goetz S.C.... Anderson K.V. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein. (PubMed id 17620722)1, 9 Kitano-Takahashi M....Kohno T. (2007)
- Upregulation of Na-coupled glucose transporter SGLT1 b y Tau tubulin kinase 2. (PubMed id 22814243)1 Alesutan I....Lang F. (2012)
- PRKX, TTBK2 and RSK4 expression causes Sunitinib resis tance in kidney carcinoma- and melanoma-cell lines. (PubMed id 22020623)1 Bender C. and Ullrich A. (2012)
- Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. (PubMed id 22863007)2 Chaki M....Hildebrandt F. (2012)
|
External Searches for TTBK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TTBK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TTBK2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TTBK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TTBK2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TTBK2 |
|
| | |
About This Section
| Patent Information for TTBK2 gene:
Search GeneIP for patents involving TTBK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TTBK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TTBK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TTBK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TTBK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TTBK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TTBK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TTBK2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TTBK2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TTBK2 |
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