Aliases for TTBK1 Gene
External Ids for TTBK1 Gene
Previous GeneCards Identifiers for TTBK1 Gene
Summary:This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease. [provided by RefSeq, Jul 2016]
GeneCards Summary for TTBK1 Gene
TTBK1 (Tau Tubulin Kinase 1) is a Protein Coding gene. Diseases associated with TTBK1 include Childhood-Onset Schizophrenia and Alzheimer Disease. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TTBK2.
UniProtKB/Swiss-Prot for TTBK1 Gene
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.