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Aliases for TTBK1 Gene

Aliases for TTBK1 Gene

  • Tau Tubulin Kinase 1 2 3
  • Brain-Derived Tau Kinase 3 4
  • BDTK 3 4
  • Tau-Tubulin Kinase 1 3
  • EC 4
  • EC 2.7.11 63
  • KIAA1855 4

External Ids for TTBK1 Gene

Previous GeneCards Identifiers for TTBK1 Gene

  • GC06P043221
  • GC06P043259
  • GC06P043319
  • GC06P042933

Summaries for TTBK1 Gene

GeneCards Summary for TTBK1 Gene

TTBK1 (Tau Tubulin Kinase 1) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is CSNK1G2.

UniProtKB/Swiss-Prot for TTBK1 Gene

  • Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTBK1 Gene

Genomics for TTBK1 Gene

Regulatory Elements for TTBK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TTBK1 Gene

43,243,484 bp from pter
43,288,259 bp from pter
44,776 bases
Plus strand

Genomic View for TTBK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TTBK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTBK1 Gene

Proteins for TTBK1 Gene

  • Protein details for TTBK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tau-tubulin kinase 1
    Protein Accession:
    Secondary Accessions:
    • A2A2U5
    • Q2L6C6
    • Q6ZNH0
    • Q8N444
    • Q96JH2

    Protein attributes for TTBK1 Gene

    1321 amino acids
    Molecular mass:
    142737 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Divalent metal cations. Mg(2+) or, to a lesser extent, Mn(2+), but not Ca(2+) or Zn(2+).;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TTBK1 Gene

    Alternative splice isoforms for TTBK1 Gene


neXtProt entry for TTBK1 Gene

Proteomics data for TTBK1 Gene at MOPED

Selected DME Specific Peptides for TTBK1 Gene

Post-translational modifications for TTBK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TTBK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for TTBK1 Gene

Gene Families for TTBK1 Gene

Protein Domains for TTBK1 Gene

Suggested Antigen Peptide Sequences for TTBK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5TCY1
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TTBK1: view

Function for TTBK1 Gene

Molecular function for TTBK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.

Enzyme Numbers (IUBMB) for TTBK1 Gene

Gene Ontology (GO) - Molecular Function for TTBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with TTBK1: view
genes like me logo Genes that share phenotypes with TTBK1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTBK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TTBK1 Gene

Localization for TTBK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TTBK1 Gene


Subcellular locations from

Jensen Localization Image for TTBK1 Gene COMPARTMENTS Subcellular localization image for TTBK1 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TTBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TTBK1: view

Pathways for TTBK1 Gene

SuperPathways for TTBK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0008360 regulation of cell shape IBA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with TTBK1: view

No data available for Pathways by source for TTBK1 Gene

Compounds for TTBK1 Gene

(5) HMDB Compounds for TTBK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Ca
  • Magnesium
  • manganese
genes like me logo Genes that share compounds with TTBK1: view

Transcripts for TTBK1 Gene

Unigene Clusters for TTBK1 Gene

Tau tubulin kinase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TTBK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTBK1 Gene

No ASD Table

Relevant External Links for TTBK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTBK1 Gene

mRNA expression in normal human tissues for TTBK1 Gene

mRNA differential expression in normal tissues according to GTEx for TTBK1 Gene

This gene is overexpressed in Brain - Cortex (5.5), Brain - Frontal Cortex (BA9) (4.9), Brain - Cerebellum (4.4), Brain - Anterior cingulate cortex (BA24) (4.4), and Brain - Cerebellar Hemisphere (4.1).

Protein differential expression in normal tissues for TTBK1 Gene

This gene is overexpressed in Fetal Brain (19.8), Pancreatic juice (15.7), Tlymphocyte (12.2), Heart (8.6), and Frontal cortex (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TTBK1 Gene

SOURCE GeneReport for Unigene cluster for TTBK1 Gene Hs.485436

mRNA Expression by UniProt/SwissProt for TTBK1 Gene

Tissue specificity: Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.
genes like me logo Genes that share expressions with TTBK1: view

Expression partners for TTBK1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TTBK1 Gene

Orthologs for TTBK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TTBK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TTBK1 35
  • 89.3 (n)
  • 91.39 (a)
TTBK1 36
  • 85 (a)
(Mus musculus)
Mammalia Ttbk1 35
  • 85.9 (n)
  • 90.02 (a)
Ttbk1 16
Ttbk1 36
  • 90 (a)
(Pan troglodytes)
Mammalia TTBK1 35
  • 99.2 (n)
  • 98.91 (a)
TTBK1 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Ttbk1 35
  • 85.37 (n)
  • 89.09 (a)
(Monodelphis domestica)
Mammalia TTBK1 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia TTBK1 36
  • 88 (a)
(Gallus gallus)
Aves TTBK1 35
  • 69.84 (n)
  • 75.36 (a)
TTBK1 36
  • 68 (a)
(Anolis carolinensis)
Reptilia TTBK1 36
  • 66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15975 35
(Danio rerio)
Actinopterygii LOC100332125 35
  • 63.59 (n)
  • 65.93 (a)
TTBK1 (1 of 2) 36
  • 57 (a)
ttbk1b 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Asator 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea R90.1 36
  • 35 (a)
Species with no ortholog for TTBK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TTBK1 Gene

Gene Tree for TTBK1 (if available)
Gene Tree for TTBK1 (if available)

Paralogs for TTBK1 Gene

Selected SIMAP similar genes for TTBK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TTBK1: view

Variants for TTBK1 Gene

Sequence variations from dbSNP and Humsavar for TTBK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14245 -- 43,288,223(-) GGCTA(A/C)TTCCC utr-variant-3-prime
rs732691 -- 43,272,652(-) ACCCC(A/G)AAAAG intron-variant, downstream-variant-500B
rs732692 -- 43,272,200(+) CAAGG(A/G)CCCCC intron-variant, utr-variant-3-prime
rs751775 -- 43,260,183(+) GGACC(A/G)GCGGG intron-variant
rs754421 -- 43,265,528(+) AGTCA(A/C)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TTBK1 Gene

Variant ID Type Subtype PubMed ID
dgv6839n71 CNV Loss 21882294
dgv6840n71 CNV Loss 21882294
nsv517442 CNV Loss 19592680
nsv525187 CNV Loss 19592680

Relevant External Links for TTBK1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTBK1 Gene

Disorders for TTBK1 Gene

Relevant External Links for TTBK1

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TTBK1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TTBK1 Gene

Publications for TTBK1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. (PMID: 16923168) Sato S. … Ikezu T. (J. Neurochem. 2006) 4 23
  3. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. (PMID: 19118186) Sato S. … Ikezu T. (J. Neurosci. 2008) 3 23
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TTBK1 Gene

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