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TTBK1 Gene

protein-coding   GIFtS: 51
GCID: GC06P043259

Tau Tubulin Kinase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tau Tubulin Kinase 11 2     EC 2.7.11.13
Brain-Derived Tau Kinase2 3     KIAA18553
BDTK2 3     EC 2.7.118
Tau-Tubulin Kinase 12     

External Ids:    HGNC: 191401   Entrez Gene: 846302   Ensembl: ENSG000001462167   UniProtKB: Q5TCY13   

Export aliases for TTBK1 gene to outside databases

Previous GC identifers: GC06P043221 GC06P043319 GC06P042933


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TTBK1 Gene:
TTBK1 (tau tubulin kinase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is VRK3.

UniProtKB/Swiss-Prot: TTBK1_HUMAN, Q5TCY1
Function: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues.
Induces aggregation of TAU




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TTBK1 gene promoter:
         ISGF-3   AML1a   SREBP-1c   HNF-4alpha2   HNF-4alpha1   SREBP-1b   HEN1   SREBP-1a   ZIC2/Zic2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTTBK1 promoter sequence
   Search Chromatin IP Primers for TTBK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TTBK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TTBK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTBK1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043259:  view genomic region     (about GC identifiers)

Start:
43,211,222 bp from pter      End:
43,255,997 bp from pter
Size:
44,776 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TTBK1_HUMAN, Q5TCY1 (See protein sequence)
Recommended Name: Tau-tubulin kinase 1  
Size: 1321 amino acids; 142737 Da
Cofactor: Divalent cations. Magnesium or, to a lesser extent, manganese, but not calcium or zinc
Caution: It is uncertain whether Met-1 or Met-14 is the initiator
3 PDB 3D structures from and Proteopedia for TTBK1:
4BTJ (3D)        4BTK (3D)        4BTM (3D)    
Secondary accessions: A2A2U5 Q2L6C6 Q6ZNH0 Q8N444 Q96JH2
Alternative splicing: 2 isoforms:  Q5TCY1-1   Q5TCY1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TTBK1: NX_Q5TCY1

Explore proteomics data for TTBK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for TTBK1 (Q5TCY1)
     LDFGLAR  FLHRDIK 


    See TTBK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115927.1  
    ENSEMBL proteins: 
     ENSP00000259750   ENSP00000307357  

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: tau tubulin kinase 1
    Tau tubulin kinase (TTBK) family

    3 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q5TCY1

    ProtoNet protein and cluster: Q5TCY1

    UniProtKB/Swiss-Prot: TTBK1_HUMAN, Q5TCY1
    Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TTBK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TTBK1_HUMAN, Q5TCY1
    Function: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues.
    Induces aggregation of TAU
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with TTBK1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TTBK1:
     Decreased substrate adherent c  PARP inhibitor sensitization  Upregulation of Wnt/beta-caten 

    Animal Models:
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    hsa-miR-134 hsa-miR-30d hsa-miR-219-5p hsa-miR-1304 hsa-miR-30a hsa-miR-3622b-3p hsa-miR-509-3-5p hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidTTBK1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TTBK1_HUMAN, Q5TCY1: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0030054cell junction ----

    Find genes that share ontologies with TTBK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TTBK1
    Interactions:

        Search GeneGlobe Interaction Network for TTBK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TTBK1 (Q5TCY13 ENSP000002597504) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK5R1Q150783, ENSP000003184864I2D: score=1 STRING: ENSP00000318486
    CSN1S1P477103, ENSP000002468914I2D: score=1 STRING: ENSP00000246891
    TUBB2AQ138853, ENSP000003697034I2D: score=1 STRING: ENSP00000369703
    TTBK2Q6IQ553, ENSP000002678904I2D: score=1 STRING: ENSP00000267890
    HEATR1Q9H5833, ENSP000003555414I2D: score=2 STRING: ENSP00000355541
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0021762substantia nigra development IEP--

    Find genes that share ontologies with TTBK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TTBK1

    5 HMDB Compounds for TTBK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TTBK1 gene: 
    NM_032538.1  

    Unigene Cluster for TTBK1:

    Tau tubulin kinase 1
    Hs.485436  [show with all ESTs]
    Unigene Representative Sequence: NM_032538
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259750(uc003ouq.1 uc021yzs.1) ENST00000304139(uc011dvg.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TTBK1 (see all 69):
    hsa-miR-134 hsa-miR-30d hsa-miR-219-5p hsa-miR-1304 hsa-miR-30a hsa-miR-3622b-3p hsa-miR-509-3-5p hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidTTBK1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB058758.1 AB218664.1 AK055425.1 AK131217.1 AL833256.1 BC036764.1 

    3 DOTS entries:

    DT.207973  DT.102824744  DT.91702916 

    Selected AceView cDNA sequences (see all 32):

    AL833256 CD673585 T04842 BE220853 AK131217 AI364124 AB058758 CD674750 
    BC036764 AK055425 BI769489 AI827963 AW016334 H40039 AI197837 AI869980 
    AI680639 Z42763 BG912008 N67991 BF345682 CD673584 AA321860 AI765713 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TTBK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCTGCCC
    TTBK1 Expression
    About this image

    TTBK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TTBK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485436

    UniProtKB/Swiss-Prot: TTBK1_HUMAN, Q5TCY1
    Tissue specificity: Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in
    spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver,
    lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TTBK1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ttbk11 , 5 tau tubulin kinase 11, 5 85.9(n)1
    90.02(a)1
      17 (22.90 cM)5
    1067631  NM_001162864.11  NP_001156336.11 
     464424485 
    chicken
    (Gallus gallus)
    Aves TTBK11 tau tubulin kinase 1 69.84(n)
    75.36(a)
      416713  NM_001199439.1  NP_001186368.1 
    lizard
    (Anolis carolinensis)
    Reptilia TTBK16
    tau tubulin kinase 1
    66(a)
    1 ↔ 1
    2(143639280-143764895)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159752 Xenopus laevis transcribed sequences 77.55(n)    BJ042311.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003321251 tau-tubulin kinase 1-like 63.59(n)
    65.93(a)
      100332125  XM_002663801.3  XP_002663847.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Asator6
    Asator
    26(a)
    1 → many
    4(490035-506659)
    worm
    (Caenorhabditis elegans)
    Secernentea R90.16
    Protein R90.1 (R90.1) mRNA, complete cds
    35(a)
    1 → many
    V(12891527-12895872) WBGene00011283


    ENSEMBL Gene Tree for TTBK1 (if available)
    TreeFam Gene Tree for TTBK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TTBK1 gene
    VRK32  VRK12  CSNK1G32  VRK22  CSNK1D2  ENSG000002593162  CSNK1A12  CSNK1G22  
    CSNK1A1L2  CSNK1E2  CSNK1G12  TTBK22  
    5 SIMAP similar genes for TTBK1 using alignment to 2 protein entries:     TTBK1_HUMAN (see all proteins):
    CSNK1A1    CSNK1E    CSNK1D    CSNK1G2    TTBK2

    Find genes that share paralogs with TTBK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TTBK1 (see all 935)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412584
    A metastatic melanoma sample4--see VAR_0412582 P S mis40--------
    VAR_0412574
    A lung large cell carcinoma sample4--see VAR_0412572 S F mis40--------
    rs719018101,2
    C--43209343(+) TCTAA-/TCTTCTTA 1 -- us2k11Minor allele frequency- TCT:0.00CSA 2
    rs30789541,2
    C--43209344(+) ATCTT-/CTTAGCAC 1 -- us2k11Minor allele frequency- CTT:0.00CSA 2
    rs728675711,2
    C,F--43209386(+) CACACG/ACCCGC 1 -- us2k12Minor allele frequency- A:0.05NA EA 240
    rs1511231561,2
    --43209389(+) ACGCCC/TGCCCC 1 -- us2k10--------
    rs1809743141,2
    --43209428(+) TGGAAG/TTCTCT 1 -- us2k10--------
    rs1853851901,2
    --43209554(+) AGGCTA/CAATGA 1 -- us2k10--------
    rs1410200211,2
    --43209571(+) CTCCCA/TATGTG 1 -- us2k10--------
    rs1902941681,2
    --43209729(+) ATAGGG/TTTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TTBK1 (43211222 - 43255997 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TTBK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517442CNV Loss19592680
    nsv525187CNV Loss19592680
    dgv6839n71CNV Loss21882294
    dgv6840n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TTBK1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: TTBK1 (2 documents)

    Export disorders for TTBK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TTBK1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TTBK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. (PubMed id 19118186)1, 9 Sato S....Ikezu T. (J. Neurosci. 2008)
    6. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. (PubMed id 16923168)2, 9 Sato S.... Ikezu T. (J. Neurochem. 2006)
    7. Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain. (PubMed id 23088643)1 Lund H....Sunnemark D. (Brain Pathol. 2013)
    8. Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort. (PubMed id 20096481)1 VA!zquez-Higuera J.L....Combarros O. (Neurobiol. Aging 2011)
    9. Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese. (PubMed id 21219968)1 Yu N.N....Tan L. (Neurosci. Lett. 2011)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84630 HGNC: 19140 AceView: TTBK1 Ensembl:ENSG00000146216 euGenes: HUgn84630
    ECgene: TTBK1 H-InvDB: TTBK1

    (According to HUGE)
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    HUGE: KIAA1855

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TTBK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TTBK1 gene:
    Search GeneIP for patents involving TTBK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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