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Aliases for TSTD2 Gene

Aliases for TSTD2 Gene

  • Thiosulfate Sulfurtransferase Like Domain Containing 2 2 3 5
  • Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 2 2 3
  • Rhodanese Domain-Containing Protein 2 3 4
  • Rhodanese Like Domain Containing 2 2 3
  • C9orf97 3 4
  • Thiosulfate Sulfurtransferase/Rhodanese-Like Domain-Containing Protein 2 3
  • Chromosome 9 Open Reading Frame 97 2
  • PP4189 3

External Ids for TSTD2 Gene

Previous HGNC Symbols for TSTD2 Gene

  • C9orf97

Previous GeneCards Identifiers for TSTD2 Gene

  • GC09M099403
  • GC09M100363
  • GC09M069963

Summaries for TSTD2 Gene

GeneCards Summary for TSTD2 Gene

TSTD2 (Thiosulfate Sulfurtransferase Like Domain Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTD2 Gene

Genomics for TSTD2 Gene

Regulatory Elements for TSTD2 Gene

Enhancers for TSTD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F097710 1.1 Ensembl ENCODE 8.5 -77.3 -77326 1.4 ARID4B SIN3A RAD21 RFX5 ZNF335 GLIS2 ZNF143 MIXL1 EGR2 ZNF654 KRT18P13 TSTD2 ENSG00000260677
GH09F097695 1 ENCODE 8.3 -63.5 -63496 2.8 HDGF ATF1 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2 YY1 ZNF322P1 ZNF510 XPA NCBP1 CCDC180 ZNF782 KRT18P13 TSTD2 GC09M097677
GH09F097703 1.2 Ensembl ENCODE 6.8 -70.4 -70405 2.0 TBP PKNOX1 WRNIP1 BMI1 FEZF1 THRB RARA ZNF366 SCRT2 FOS TMOD1 FOXE1 KRT18P13 TRMO TSTD2 ENSG00000260677
GH09F097597 1 Ensembl ENCODE 7.3 +34.7 34701 2.2 HDGF CTCF ETV1 KLF17 ARID4B RAD21 PATZ1 ZNF143 SMC3 NR2F6 KRT18P13 TSTD2 PIR41890 PIR34153
GH09F098034 1.1 Ensembl ENCODE 4.6 -402.6 -402566 3.5 ARID4B RAD21 ZNF121 ZNF143 FOS CREM EGR2 ZNF263 ZNF654 HCFC1 NANS TRMO LOC101928408 ANP32B ENSG00000201830 TBC1D2 TSTD2 RNU6-918P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSTD2 on UCSC Golden Path with GeneCards custom track

Promoters for TSTD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001309489 80 3201 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207

Genomic Location for TSTD2 Gene

Chromosome:
9
Start:
97,600,080 bp from pter
End:
97,633,680 bp from pter
Size:
33,601 bases
Orientation:
Minus strand

Genomic View for TSTD2 Gene

Genes around TSTD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSTD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTD2 Gene

Proteins for TSTD2 Gene

  • Protein details for TSTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7W7-TSTD2_HUMAN
    Recommended name:
    Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
    Protein Accession:
    Q5T7W7
    Secondary Accessions:
    • A6NMJ4
    • A8K584
    • Q6ZQZ6
    • Q8IYM3
    • Q8WY73
    • Q96ML6
    • Q96MU1

    Protein attributes for TSTD2 Gene

    Size:
    516 amino acids
    Molecular mass:
    58263 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35604.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71188.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71271.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSTD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSTD2 Gene

Post-translational modifications for TSTD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSTD2 Gene

No data available for DME Specific Peptides for TSTD2 Gene

Domains & Families for TSTD2 Gene

Protein Domains for TSTD2 Gene

Suggested Antigen Peptide Sequences for TSTD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T7W7

UniProtKB/Swiss-Prot:

TSTD2_HUMAN :
  • Contains 1 rhodanese domain.
Domain:
  • Contains 1 rhodanese domain.
genes like me logo Genes that share domains with TSTD2: view

No data available for Gene Families for TSTD2 Gene

Function for TSTD2 Gene

Gene Ontology (GO) - Molecular Function for TSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TSTD2: view
genes like me logo Genes that share phenotypes with TSTD2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSTD2 Gene

Localization for TSTD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSTD2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with TSTD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSTD2 Gene

Pathways & Interactions for TSTD2 Gene

SuperPathways for TSTD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TSTD2: view

No data available for Pathways by source and SIGNOR curated interactions for TSTD2 Gene

Transcripts for TSTD2 Gene

Unigene Clusters for TSTD2 Gene

Thiosulfate sulfurtransferase (rhodanese)-like domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSTD2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: -
SP7:
SP8: - - - -
SP9: - - -
SP10: -

Relevant External Links for TSTD2 Gene

GeneLoc Exon Structure for
TSTD2
ECgene alternative splicing isoforms for
TSTD2

Expression for TSTD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSTD2 Gene

Protein differential expression in normal tissues from HIPED for TSTD2 Gene

This gene is overexpressed in Plasma (37.7) and Pancreatic juice (31.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSTD2 Gene



Protein tissue co-expression partners for TSTD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSTD2 Gene:

TSTD2

SOURCE GeneReport for Unigene cluster for TSTD2 Gene:

Hs.723236
genes like me logo Genes that share expression patterns with TSTD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSTD2 Gene

Orthologs for TSTD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSTD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSTD2 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia TSTD2 34 35
  • 88.13 (n)
cow
(Bos Taurus)
Mammalia TSTD2 34 35
  • 87.34 (n)
mouse
(Mus musculus)
Mammalia Tstd2 34 16 35
  • 84.08 (n)
rat
(Rattus norvegicus)
Mammalia Tstd2 34
  • 83.06 (n)
oppossum
(Monodelphis domestica)
Mammalia TSTD2 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSTD2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSTD2 34 35
  • 65.88 (n)
lizard
(Anolis carolinensis)
Reptilia TSTD2 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tstd2 34
  • 63.55 (n)
Str.13632 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6725 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7313 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
Species where no ortholog for TSTD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSTD2 Gene

ENSEMBL:
Gene Tree for TSTD2 (if available)
TreeFam:
Gene Tree for TSTD2 (if available)

Paralogs for TSTD2 Gene

(1) SIMAP similar genes for TSTD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TSTD2: view

No data available for Paralogs for TSTD2 Gene

Variants for TSTD2 Gene

Sequence variations from dbSNP and Humsavar for TSTD2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1034097 -- 97,624,164(-) ACAGT(C/G)TAGGA intron-variant
rs1034098 -- 97,603,734(-) tgaca(A/C)agcaa intron-variant
rs1034099 -- 97,603,191(-) TGTTC(A/C)CTGTA intron-variant
rs1034100 -- 97,603,149(-) TCCCC(A/C)CTGGA intron-variant
rs10817858 -- 97,625,837(+) TAGAA(G/T)CTGTC nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TSTD2 Gene

Variant ID Type Subtype PubMed ID
nsv819796 CNV loss 19587683
esv3621190 CNV gain 21293372
esv2738815 CNV deletion 23290073
dgv1494e214 CNV gain 21293372

Variation tolerance for TSTD2 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.98; 74.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSTD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTD2 Gene

Disorders for TSTD2 Gene

Relevant External Links for TSTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSTD2

No disorders were found for TSTD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSTD2 Gene

Publications for TSTD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for TSTD2 Gene

Sources for TSTD2 Gene

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