TSTD2 Gene
protein-coding GIFtS: 45
GCID: GC09M100363
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thiosulfate sulfurtransferase (rhodanese)-like domain containing...(Previous name: chromosome 9 open reading frame 97 )
(Previous symbol: C9orf97)
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Aliases
for TSTD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 21 2 | | C9orf971 2 3 | | PP41891 2 | | Rhodanese Domain-Containing Protein 22 3 | | Chromosome 9 Open Reading Frame 971 | | Thiosulfate Sulfurtransferase/Rhodanese-Like Domain-Containing Protein 22 |
Export aliases for TSTD2 gene to outside databasesPrevious GC identifers: GC09M099403 GC09M069963 |
Summaries
for TSTD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TSTD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TSTD2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSTD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSTD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q22.33 Ensembl cytogenetic band: 9q22.33 HGNC chromosome: 9TSTD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M100363: view genomic region
(about GC identifiers)
Start:
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100,362,362 bp from pter |
End:
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100,395,962 bp from pter |
Size:
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33,601 bases |
Orientation:
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minus strand |
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Proteins
for TSTD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSTD2_HUMAN, Q5T7W7 (See
protein sequence)Recommended Name: Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 Size: 516 amino acids; 58263 Da
Sequence caution: Sequence=AAH35604.1; Type=Erroneous initiation; Sequence=BAB71188.1; Type=Erroneous initiation;Sequence=BAB71271.1; Type=Erroneous initiation;
Secondary accessions: A6NMJ4 A8K584 Q6ZQZ6 Q8IYM3 Q8WY73 Q96ML6 Q96MU1Alternative splicing: 2 isoforms: Q5T7W7-1 Q5T7W7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TSTD2: NX_Q5T7W7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T7W7
TSTD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_640339.4
ENSEMBL proteins: ENSP00000364316 ENSP00000364315 ENSP00000342499 ENSP00000364308 ENSP00000364306 ENSP00000346856
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
TSTD2 for ontologies About GeneDecksing
TSTD2 Antibody Products:
Assay Products for TSTD2: |
Protein
Domains /
Families
for TSTD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSTD2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T7W7ProtoNet protein and cluster: Q5T7W7 1 Blocks protein family: IPB001763 Rhodanese-like
UniProtKB/Swiss-Prot: TSTD2_HUMAN, Q5T7W7Similarity: Contains 1 rhodanese domain |
Function
for TSTD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSTD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSTD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSTD2 (NM_139246) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSTD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSTD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSTD2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TSTD2 for ontologies About GeneDecksing
|
Pathways & Interactions
for TSTD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSTD2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TSTD2 (ENSP000003424994) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TSTD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSTD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSTD2
Search CenterWatch for drugs/clinical trials and news about TSTD2
|
Transcripts
for TSTD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSTD2 gene: NM_139246.4 Unigene Cluster for TSTD2: Thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 Hs.723236 [show with all ESTs]Unigene Representative Sequence: NM_1392467 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375173 ENST00000375172 ENST00000341170(uc004axn.3 uc004axo.3)
ENST00000375165(uc004axp.1) ENST00000375163 ENST00000484708 ENST00000354801
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSTD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSTD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSTD2 (NM_139246) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSTD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSTD2 |
Additional cDNA sequence: AF131836.1 AF258575.1 AK056453.1 AK056752.1 AK094043.1 AK122809.1 AK128615.1 AK291199.1 BC022958.1 BC035604.1 BX538308.1 BX648493.1 15 DOTS entries: DT.100786207 DT.95369662 DT.447207 DT.448680 DT.100786210 DT.95084369 DT.121158360 DT.75153479 DT.91740885 DT.121158271 DT.75149024 DT.101961008 DT.121119174 DT.121158298 DT.91879219 24/162 AceView cDNA sequences (see all 162): AK056752 BE645010 AA477609 BM510672 BI962789 BQ130571 BE219525 BE219750 BF969167 AI684242 AA252215 F09707 AW451604 AK122809 BC022958 AI821673 AW872392 AA773651 AI362303 BI962601 BQ954258 AW149071 R96512 CK431028
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TSTD2 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | - | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSTD2
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Expression
for TSTD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSTD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGACTCCTG
About this image
See TSTD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSTD2
SOURCE GeneReport for Unigene cluster: Hs.723236
SABiosciences Custom PCR Arrays for TSTD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSTD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSTD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSTD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSTD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSTD2 |
Orthologs
for TSTD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TSTD2 gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for TSTD2 (if available)
TreeFam Gene Tree for TSTD2 (if available) |
Paralogs
for TSTD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TSTD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSTD2 (100362362 - 100395962 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TSTD2
1 CNV: 59541 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSTD2 |
|
Disorders
/ Diseases
for TSTD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSTD2 for disorders About GeneDecksing
1  disease for TSTD2: About MalaCardspneumonia
Export disorders for TSTD2 gene to outside databases
|
Publications
for TSTD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSTD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSTD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for TSTD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSTD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSTD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSTD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSTD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSTD2 gene:
Search GeneIP for patents involving TSTD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSTD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSTD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSTD2 | | | OriGene Protein Over-expression Lysate for TSTD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSTD2 | | OriGene 3'-UTR Clone for TSTD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSTD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSTD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSTD2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSTD2 | | OriGene Custom Protein Services for TSTD2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSTD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSTD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSTD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSTD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSTD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSTD2 |
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| | | | Search Tocris compounds for TSTD2 |
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 | | | TSTD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSTD2 |
|  |  |  | | | | ThermoFisher Antibody for TSTD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSTD2 |
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