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Aliases for TSTD1 Gene

Aliases for TSTD1 Gene

  • Thiosulfate Sulfurtransferase Like Domain Containing 1 2 3 5
  • Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 1 2 3
  • KAT 3 4
  • Thiosulfate Sulfurtransferase/Rhodanese-Like Domain-Containing Protein 1 3
  • Putative Thiosulfate Sulfurtransferase KAT 3

External Ids for TSTD1 Gene

Previous GeneCards Identifiers for TSTD1 Gene

  • GC01M159280
  • GC01M132365

Summaries for TSTD1 Gene

GeneCards Summary for TSTD1 Gene

TSTD1 (Thiosulfate Sulfurtransferase Like Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TSTD3.

UniProtKB/Swiss-Prot for TSTD1 Gene

  • Possible role in tumorigenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTD1 Gene

Genomics for TSTD1 Gene

Regulatory Elements for TSTD1 Gene

Enhancers for TSTD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G161011 1.9 FANTOM5 ENCODE dbSUPER 33.2 +21.8 21777 11.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TSTD1 ARHGAP30 KLHDC9 FCGR2A USF1 RPSAP18 DEDD LOC105371471 NECTIN4 F11R
GH01G161066 1.7 FANTOM5 ENCODE dbSUPER 31.5 -29.6 -29625 5.1 HDGF PKNOX1 AGO1 WRNIP1 SIN3A YY1 GLIS2 ELK1 ZNF143 ZNF207 FCGR2A TSTD1 ARHGAP30 F11R DUSP12 DEDD NECTIN4 ENSG00000232879 KLHDC9 USF1
GH01G161073 1.3 Ensembl ENCODE 30.1 -35.5 -35505 2.2 HDGF ATF1 PKNOX1 CREB3L1 SIN3A ARID4B ZNF48 GLIS2 GATA2 DEK TSTD1 GC01P161070 LOC105371471
GH01G160980 1 Ensembl ENCODE 33.3 +57.0 57011 2.0 CTCF RB1 TEAD4 RBBP5 ZNF48 RAD21 GATA3 GATA2 POLR2A SMC3 TSTD1 LY9 ITLN1 SLAMF7 SLAMF1 ENSG00000228863 F11R GC01M160999 PIR56289 ITLN2
GH01G161050 1.1 dbSUPER 25.1 -14.2 -14152 4.9 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 TSTD1 F11R LOC105371471 NECTIN4 ENSG00000228606 KLHDC9 DEDD GC01P161046 ARHGAP30
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSTD1 on UCSC Golden Path with GeneCards custom track

Promoters for TSTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014624 290 601 HDGF AGO1 SIN3A ZNF2 YY1 GLIS2 ELK1 ZNF143 SP3 REST

Genomic Location for TSTD1 Gene

Chromosome:
1
Start:
161,037,631 bp from pter
End:
161,038,990 bp from pter
Size:
1,360 bases
Orientation:
Minus strand

Genomic View for TSTD1 Gene

Genes around TSTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTD1 Gene

Proteins for TSTD1 Gene

  • Protein details for TSTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFU3-TSTD1_HUMAN
    Recommended name:
    Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
    Protein Accession:
    Q8NFU3
    Secondary Accessions:
    • Q5SY48
    • Q5SY49
    • Q5SY50
    • Q5SY51
    • Q8NFU2
    • Q9BV22

    Protein attributes for TSTD1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12530 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH01699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15368.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSTD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSTD1 Gene

Post-translational modifications for TSTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSTD1 Gene

No data available for DME Specific Peptides for TSTD1 Gene

Domains & Families for TSTD1 Gene

Protein Domains for TSTD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TSTD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSTD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TSTD1 Gene

Function for TSTD1 Gene

Molecular function for TSTD1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in tumorigenesis.

Phenotypes for TSTD1 Gene

GenomeRNAi human phenotypes for TSTD1:
genes like me logo Genes that share phenotypes with TSTD1: view

Animal Model Products

CRISPR Products

miRNA for TSTD1 Gene

miRTarBase miRNAs that target TSTD1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSTD1 Gene

Localization for TSTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSTD1 Gene

Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSTD1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TSTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA --
GO:0005737 cytoplasm IEA,IDA 12817473
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TSTD1: view

Pathways & Interactions for TSTD1 Gene

SuperPathways for TSTD1 Gene

No Data Available

Interacting Proteins for TSTD1 Gene

Gene Ontology (GO) - Biological Process for TSTD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TSTD1 Gene

Drugs & Compounds for TSTD1 Gene

(4) Additional Compounds for TSTD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cyanide
  • Carbon nitride ion
  • Chuck Norrisium
  • Cyanide
  • Cyanide ion
  • Cyanide(1-) ion
57-12-5
Sulfite
  • Bisulfite
  • Sulfite dianion
  • Sulfite ion
  • Sulfite ions
  • Sulfonate
14265-45-3
thiocyanate
  • Rhodanide
  • SCN
  • Ammonium sulfocyanate
  • HSCN
  • Hydrogen thiocyanate
302-04-5
thiosulfate
  • Hyposulfite
  • S-Hydril
  • Sodium hyposulfite
  • Sodium oxide sulfide (Na2S2O3)
  • Sodium thiosulfate
14383-50-7
genes like me logo Genes that share compounds with TSTD1: view

Transcripts for TSTD1 Gene

mRNA/cDNA for TSTD1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSTD1 Gene

Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSTD1 Gene

No ASD Table

Relevant External Links for TSTD1 Gene

GeneLoc Exon Structure for
TSTD1
ECgene alternative splicing isoforms for
TSTD1

Expression for TSTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSTD1 Gene

This gene is overexpressed in Salivary gland (9.9), Skin (7.5), and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSTD1 Gene



Protein tissue co-expression partners for TSTD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSTD1 Gene:

TSTD1

SOURCE GeneReport for Unigene cluster for TSTD1 Gene:

Hs.720030

mRNA Expression by UniProt/SwissProt for TSTD1 Gene:

Q8NFU3-TSTD1_HUMAN
Tissue specificity: Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.
genes like me logo Genes that share expression patterns with TSTD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSTD1 Gene

Orthologs for TSTD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSTD1 34 35
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia TSTD1 34 35
  • 86.43 (n)
dog
(Canis familiaris)
Mammalia TSTD1 34 35
  • 85.96 (n)
rat
(Rattus norvegicus)
Mammalia Tstd1 34
  • 82.46 (n)
mouse
(Mus musculus)
Mammalia Tstd1 34 16 35
  • 80.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TSTD1 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSTD1 35
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSTD1 35
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSTD1 35
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC563265 34
  • 56.79 (n)
TSTD1 35
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12279 35
  • 37 (a)
OneToMany
Hsp67Bb 35
  • 33 (a)
OneToMany
CG6000 35
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDL2 35 37
  • 23 (a)
OneToMany
RDL1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for TSTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSTD1 Gene

ENSEMBL:
Gene Tree for TSTD1 (if available)
TreeFam:
Gene Tree for TSTD1 (if available)

Paralogs for TSTD1 Gene

Paralogs for TSTD1 Gene

Pseudogenes.org Pseudogenes for TSTD1 Gene

genes like me logo Genes that share paralogs with TSTD1: view

Variants for TSTD1 Gene

Sequence variations from dbSNP and Humsavar for TSTD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2073658 other 161,040,972(-) CATAA(A/G)TGGTC intron-variant, upstream-variant-2KB
rs3737787 other 161,039,733(-) GTGGA(C/T)GTGCA upstream-variant-2KB, utr-variant-3-prime
rs1000010156 -- 161,040,145(+) TGTCA(A/G)ACTGG intron-variant, upstream-variant-2KB
rs1000080464 -- 161,038,710(+) AGGGG(A/G)CCTAG intron-variant
rs1000550967 -- 161,040,479(+) ATAAG(A/G)CTACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSTD1 Gene

Variant ID Type Subtype PubMed ID
nsv3221 CNV deletion 18451855
nsv548059 CNV gain 21841781

Variation tolerance for TSTD1 Gene

Gene Damage Index Score: 1.06; 21.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTD1 Gene

Disorders for TSTD1 Gene

Relevant External Links for TSTD1

Genetic Association Database (GAD)
TSTD1
Human Genome Epidemiology (HuGE) Navigator
TSTD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSTD1

No disorders were found for TSTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSTD1 Gene

Publications for TSTD1 Gene

  1. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. (PMID: 12817473) Wenzel K. … Hoehe M.R. (Biol. Chem. 2003) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64

Products for TSTD1 Gene

Sources for TSTD1 Gene

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