TSTD1 Gene
protein-coding GIFtS: 39
GCID: GC01M161007
|
|
thiosulfate sulfurtransferase (rhodanese)-like domain containing...
| |
Aliases
for TSTD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 11 2 | | KAT1 2 3 | | Putative Thiosulfate Sulfurtransferase KAT2 | | Thiosulfate Sulfurtransferase KAT, Putative2 | | Thiosulfate Sulfurtransferase/Rhodanese-Like Domain-Containing Protein 12 |
Export aliases for TSTD1 gene to outside databasesPrevious GC identifers: GC01M159280 GC01M132365 |
Summaries
for TSTD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSTD1_HUMAN, Q8NFU3Function: Possible role in tumorigenesis
|
Genomic Views
for TSTD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TSTD1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSTD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSTD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3TSTD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M161007: view genomic region
(about GC identifiers)
Start:
|
161,007,421 bp from pter |
End:
|
161,008,780 bp from pter |
Size:
|
1,360 bases |
Orientation:
|
minus strand |
|
Proteins
for TSTD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSTD1_HUMAN, Q8NFU3 (See
protein sequence)Recommended Name: Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 Size: 115 amino acids; 12530 Da
Subcellular location: Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes
Sequence caution: Sequence=AAH01699.1; Type=Erroneous initiation; Sequence=CAI15368.1; Type=Erroneous gene modelprediction; Sequence=CAI15369.1; Type=Erroneous initiation;
Secondary accessions: Q5SY48 Q5SY49 Q5SY50 Q5SY51 Q8NFU2 Q9BV22Alternative splicing: 4 isoforms: Q8NFU3-1 Q8NFU3-2 Q8NFU3-3 Q8NFU3-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TSTD1: NX_Q8NFU3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NFU3
TSTD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001106676.1 NP_001106677.1 NP_001106678.1
ENSEMBL proteins: ENSP00000325518 ENSP00000357002 ENSP00000357003 ENSP00000388293
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TSTD1 for ontologies About GeneDecksing
TSTD1 Antibody Products:
Assay Products for TSTD1: |
Protein
Domains /
Families
for TSTD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSTD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NFU3ProtoNet protein and cluster: Q8NFU3 1 Blocks protein family: IPB001763 Rhodanese-like
UniProtKB/Swiss-Prot: TSTD1_HUMAN, Q8NFU3Similarity: Contains 1 rhodanese domain |
Function
for TSTD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSTD1_HUMAN, Q8NFU3Function: Possible role in tumorigenesis
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSTD1 |
|
Pathways & Interactions
for TSTD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSTD1
|
Drugs & Compounds
for TSTD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSTD1
4 HMDB Compounds for TSTD1 About this table
Search CenterWatch for drugs/clinical trials and news about TSTD1 
|
Transcripts
for TSTD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSTD1 gene (3 alternative transcripts): NM_001113205.1 NM_001113206.1 NM_001113207.1 Unigene Cluster for TSTD1: Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 Hs.720030 [show with all ESTs]Unigene Representative Sequence: BG2918577 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000462952 ENST00000318289(uc001fxh.4) ENST00000368023 ENST00000368024
ENST00000423014(uc010pjx.2 uc009wtw.3) ENST00000466967 ENST00000486084
Additional cDNA sequence: BC001699.1 BC038219.1 11 DOTS entries: DT.91852005 DT.100821658 DT.86847063 DT.91770313 DT.121464007 DT.91770316 DT.100821659 DT.97821514 DT.100821656 DT.101980729 DT.91775010
GeneLoc Exon Structure
|
Expression
for TSTD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSTD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGAGCGC
About this image
See TSTD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSTD1
SOURCE GeneReport for Unigene cluster: Hs.720030
UniProtKB/Swiss-Prot: TSTD1_HUMAN, Q8NFU3Tissue specificity: Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon,thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes.Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breastcarcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. Noexpression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected ininvasive ductal carcinoma, but not in the adjacent tissues
SABiosciences Custom PCR Arrays for TSTD1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSTD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSTD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSTD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSTD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSTD1 |
Orthologs
for TSTD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSTD1 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for TSTD1 (if available)
TreeFam Gene Tree for TSTD1 (if available) |
Paralogs
for TSTD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSTD1 gene
TSTD1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TSTD1
PGOHUM00000235591
|
Genomic Variants
for TSTD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSTD1 (161007421 - 161008780 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSTD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSTD1 |
|
Disorders
/ Diseases
for TSTD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSTD1 for disorders About GeneDecksing
5  diseases for TSTD1: About MalaCardscolon carcinoma hepatocellular carcinoma carcinoma lung carcinoma
breast carcinoma
Human Genome Epidemiology (HuGE) Navigator: TSTD1 (3 documents)
Export disorders for TSTD1 gene to outside databases
|
Publications
for TSTD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSTD1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TSTD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. (PubMed id 12817473)1, 2, 3 Wenzel K....Hoehe M.R. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Presence of L-kynurenine aminotransferase III in reti nal ganglion cells and corpora amylacea in the human retina and optic nerve. (PubMed id 21845542)1 Rejdak R....Junemann A.G. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Genomic structure, organization and promoter analysis of the human F11R/F11 receptor/junctional adhesion molecule-1/JAM-A. (PubMed id 16337094)1 Sobocki T....Kornecki E. (2006)
- Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)1 Wistow G.... Peterson K. (2002)
|
External Searches for TSTD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSTD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSTD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSTD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSTD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSTD1 gene:
Search GeneIP for patents involving TSTD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSTD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSTD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSTD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSTD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSTD1 | | OriGene 3'-UTR Clone for TSTD1 | | | Browse OriGene untagged cDNA clones in CMV expression vector | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSTD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSTD1 | | OriGene Custom Protein Services for TSTD1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSTD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSTD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSTD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSTD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSTD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSTD1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TSTD1 |
| |  |  |  |  | | | | | | Recombinant Protein for TSTD1 |
|
 |
 |
 |
 | | | TSTD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSTD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSTD1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TSTD1 |
|
|
|
|
