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Aliases for TSTD1 Gene

Aliases for TSTD1 Gene

  • Thiosulfate Sulfurtransferase Like Domain Containing 1 2 3 5
  • Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 1 2 3
  • KAT 3 4
  • Thiosulfate Sulfurtransferase/Rhodanese-Like Domain-Containing Protein 1 3
  • Putative Thiosulfate Sulfurtransferase KAT 3

External Ids for TSTD1 Gene

Previous GeneCards Identifiers for TSTD1 Gene

  • GC01M159280
  • GC01M132365

Summaries for TSTD1 Gene

GeneCards Summary for TSTD1 Gene

TSTD1 (Thiosulfate Sulfurtransferase Like Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TSTD3.

UniProtKB/Swiss-Prot for TSTD1 Gene

  • Possible role in tumorigenesis.

Additional gene information for TSTD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTD1 Gene

Genomics for TSTD1 Gene

Regulatory Elements for TSTD1 Gene

Enhancers for TSTD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H161011 1.8 FANTOM5 ENCODE dbSUPER 33.2 +21.8 21777 11.7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC DUSP12 USP21 LOC100287049 DEDD TSTD1 LOC148430 PPOX ARHGAP30 KLHDC9 B4GALT3
GH01H161073 1.1 Ensembl ENCODE 30.1 -35.5 -35505 2.2 ATF1 ARID4B ZNF76 KLF17 RAD21 ZEB1 GLIS2 SCRT2 ATF7 CREM TSTD1 GC01P161070 LOC105371471
GH01H161079 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -45.8 -45763 11.2 PKNOX1 ATF1 SIN3A BRCA1 GLIS2 ATF7 FOS SP3 NCOA1 SMARCB1 F11R NECTIN4 TSTD1 NCSTN USF1 LOC105371471
GH01H160980 0.7 Ensembl ENCODE 33.3 +57.0 57011 2 POLR2A POU5F1 EZH2 TSTD1 LY9 ITLN1 SLAMF7 SLAMF1 ENSG00000228863 F11R GC01M160999 PIR56289 ITLN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSTD1 on UCSC Golden Path with GeneCards custom track

Promoters for TSTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014624 290 601 HDGF TBL1XR1 NFIB RB1 SIN3A KLF17 ZNF2 ZBTB40 YY1 GLIS2

Genomic Locations for TSTD1 Gene

Genomic Locations for TSTD1 Gene
1,360 bases
Minus strand

Genomic View for TSTD1 Gene

Genes around TSTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTD1 Gene

Proteins for TSTD1 Gene

  • Protein details for TSTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5SY48
    • Q5SY49
    • Q5SY50
    • Q5SY51
    • Q8NFU2
    • Q9BV22

    Protein attributes for TSTD1 Gene

    115 amino acids
    Molecular mass:
    12530 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15368.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSTD1 Gene


neXtProt entry for TSTD1 Gene

Post-translational modifications for TSTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSTD1 Gene

No data available for DME Specific Peptides for TSTD1 Gene

Domains & Families for TSTD1 Gene

Gene Families for TSTD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSTD1 Gene


Suggested Antigen Peptide Sequences for TSTD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSTD1: view

No data available for UniProtKB/Swiss-Prot for TSTD1 Gene

Function for TSTD1 Gene

Molecular function for TSTD1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in tumorigenesis.

Phenotypes From GWAS Catalog for TSTD1 Gene

Phenotypes for TSTD1 Gene

GenomeRNAi human phenotypes for TSTD1:
genes like me logo Genes that share phenotypes with TSTD1: view

miRNA for TSTD1 Gene

miRTarBase miRNAs that target TSTD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSTD1 Gene

Localization for TSTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSTD1 Gene

Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSTD1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 12817473
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TSTD1: view

Pathways & Interactions for TSTD1 Gene

SuperPathways for TSTD1 Gene

No Data Available

Interacting Proteins for TSTD1 Gene

Gene Ontology (GO) - Biological Process for TSTD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSTD1 Gene

Drugs & Compounds for TSTD1 Gene

(4) Additional Compounds for TSTD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Carbon nitride ion
  • Chuck Norrisium
  • Cyanide
  • Cyanide ion
  • Cyanide(1-) ion
  • Bisulfite
  • Sulfite dianion
  • Sulfite ion
  • Sulfite ions
  • Sulfonate
  • Rhodanide
  • SCN
  • Ammonium sulfocyanate
  • HSCN
  • Hydrogen thiocyanate
  • Hyposulfite
  • S-Hydril
  • Sodium hyposulfite
  • Sodium oxide sulfide (Na2S2O3)
  • Sodium thiosulfate
genes like me logo Genes that share compounds with TSTD1: view

Transcripts for TSTD1 Gene

mRNA/cDNA for TSTD1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSTD1 Gene

Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSTD1 Gene

No ASD Table

Relevant External Links for TSTD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSTD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSTD1 Gene

This gene is overexpressed in Salivary gland (9.9), Skin (7.5), and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSTD1 Gene

Protein tissue co-expression partners for TSTD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSTD1 Gene:


SOURCE GeneReport for Unigene cluster for TSTD1 Gene:


mRNA Expression by UniProt/SwissProt for TSTD1 Gene:

Tissue specificity: Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.
genes like me logo Genes that share expression patterns with TSTD1: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSTD1 Gene

Orthologs for TSTD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSTD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSTD1 33 34
  • 99.11 (n)
(Bos Taurus)
Mammalia TSTD1 33 34
  • 86.43 (n)
(Canis familiaris)
Mammalia TSTD1 33 34
  • 85.96 (n)
(Rattus norvegicus)
Mammalia Tstd1 33
  • 82.46 (n)
(Mus musculus)
Mammalia Tstd1 33 16 34
  • 80.99 (n)
(Monodelphis domestica)
Mammalia TSTD1 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia TSTD1 34
  • 31 (a)
(Gallus gallus)
Aves TSTD1 34
  • 28 (a)
(Anolis carolinensis)
Reptilia TSTD1 34
  • 32 (a)
(Danio rerio)
Actinopterygii LOC563265 33
  • 56.79 (n)
TSTD1 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12279 34
  • 37 (a)
Hsp67Bb 34
  • 33 (a)
CG6000 34
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDL2 34 36
  • 23 (a)
RDL1 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
Species where no ortholog for TSTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSTD1 Gene

Gene Tree for TSTD1 (if available)
Gene Tree for TSTD1 (if available)

Paralogs for TSTD1 Gene

Paralogs for TSTD1 Gene Pseudogenes for TSTD1 Gene

genes like me logo Genes that share paralogs with TSTD1: view

Variants for TSTD1 Gene

Sequence variations from dbSNP and Humsavar for TSTD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2073658 other 161,040,972(-) CATAA(A/G)TGGTC intron-variant, upstream-variant-2KB
rs3737787 other 161,039,733(-) GTGGA(C/T)GTGCA upstream-variant-2KB, utr-variant-3-prime
rs1000010156 -- 161,040,145(+) TGTCA(A/G)ACTGG intron-variant, upstream-variant-2KB
rs1000080464 -- 161,038,710(+) AGGGG(A/G)CCTAG intron-variant
rs1000550967 -- 161,040,479(+) ATAAG(A/G)CTACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSTD1 Gene

Variant ID Type Subtype PubMed ID
nsv548059 CNV gain 21841781
nsv3221 CNV deletion 18451855

Variation tolerance for TSTD1 Gene

Gene Damage Index Score: 1.06; 21.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTD1 Gene

Disorders for TSTD1 Gene

Relevant External Links for TSTD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSTD1 Gene

Publications for TSTD1 Gene

  1. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. (PMID: 12817473) Wenzel K … Hoehe MR (Biological chemistry 2003) 2 3 4 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 60

Products for TSTD1 Gene

Sources for TSTD1 Gene

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