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Aliases for TSTD1 Gene

Aliases for TSTD1 Gene

  • Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 1 2 3
  • KAT 3 4
  • Thiosulfate Sulfurtransferase KAT, Putative 3
  • Putative Thiosulfate Sulfurtransferase KAT 3

External Ids for TSTD1 Gene

Previous GeneCards Identifiers for TSTD1 Gene

  • GC01M159280
  • GC01M132365

Summaries for TSTD1 Gene

GeneCards Summary for TSTD1 Gene

TSTD1 (Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TSTD1 Gene

  • Possible role in tumorigenesis

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTD1 Gene

Genomics for TSTD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSTD1 Gene

161,037,631 bp from pter
161,038,990 bp from pter
1,360 bases
Minus strand

Genomic View for TSTD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTD1 Gene

No data available for Regulatory Elements for TSTD1 Gene

Proteins for TSTD1 Gene

  • Protein details for TSTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5SY48
    • Q5SY49
    • Q5SY50
    • Q5SY51
    • Q8NFU2
    • Q9BV22

    Protein attributes for TSTD1 Gene

    115 amino acids
    Molecular mass:
    12530 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15368.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSTD1 Gene


neXtProt entry for TSTD1 Gene

Proteomics data for TSTD1 Gene at MOPED

Post-translational modifications for TSTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSTD1 Gene

No data available for DME Specific Peptides for TSTD1 Gene

Domains & Families for TSTD1 Gene

Protein Domains for TSTD1 Gene


Suggested Antigen Peptide Sequences for TSTD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 rhodanese domain.
  • Contains 1 rhodanese domain.
genes like me logo Genes that share domains with TSTD1: view

No data available for Gene Families for TSTD1 Gene

Function for TSTD1 Gene

Molecular function for TSTD1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in tumorigenesis

Phenotypes for TSTD1 Gene

GenomeRNAi human phenotypes for TSTD1:
genes like me logo Genes that share phenotypes with TSTD1: view

Animal Model Products

CRISPR Products

miRNA for TSTD1 Gene

miRTarBase miRNAs that target TSTD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TSTD1 Gene

Localization for TSTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSTD1 Gene

Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes.

Subcellular locations from

Jensen Localization Image for TSTD1 Gene COMPARTMENTS Subcellular localization image for TSTD1 gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TSTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12817473
GO:0005739 mitochondrion IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TSTD1: view

Pathways & Interactions for TSTD1 Gene

SuperPathways for TSTD1 Gene

No Data Available

Interacting Proteins for TSTD1 Gene

Gene Ontology (GO) - Biological Process for TSTD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSTD1 Gene

Drugs & Compounds for TSTD1 Gene

(4) Additional Compounds for TSTD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Carbon nitride ion
  • Chuck Norrisium
  • Cyanide
  • Cyanide ion
  • Cyanide(1-) ion
  • Bisulfite
  • Sulfite dianion
  • Sulfite ion
  • Sulfite ions
  • Sulfonate
  • Rhodanide
  • SCN
  • Ammonium sulfocyanate
  • HSCN
  • Hydrogen thiocyanate
  • Hyposulfite
  • S-Hydril
  • Sodium hyposulfite
  • Sodium oxide sulfide (Na2S2O3)
  • Sodium thiosulfate
genes like me logo Genes that share compounds with TSTD1: view

Transcripts for TSTD1 Gene

mRNA/cDNA for TSTD1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSTD1 Gene

Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSTD1 Gene

No ASD Table

Relevant External Links for TSTD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSTD1 Gene

mRNA expression in normal human tissues for TSTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSTD1 Gene

This gene is overexpressed in Salivary gland (9.9), Skin (7.5), and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSTD1 Gene

SOURCE GeneReport for Unigene cluster for TSTD1 Gene Hs.720030

mRNA Expression by UniProt/SwissProt for TSTD1 Gene

Tissue specificity: Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.
genes like me logo Genes that share expression patterns with TSTD1: view

Protein tissue co-expression partners for TSTD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TSTD1 Gene

Orthologs for TSTD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSTD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSTD1 35
  • 86.43 (n)
  • 89.38 (a)
TSTD1 36
  • 88 (a)
(Canis familiaris)
Mammalia TSTD1 35
  • 85.96 (n)
  • 88.6 (a)
TSTD1 36
  • 85 (a)
(Mus musculus)
Mammalia Tstd1 35
  • 80.99 (n)
  • 84.21 (a)
Tstd1 16
Tstd1 36
  • 72 (a)
(Pan troglodytes)
Mammalia TSTD1 35
  • 99.11 (n)
  • 99.11 (a)
TSTD1 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Tstd1 35
  • 82.46 (n)
  • 84.21 (a)
(Monodelphis domestica)
Mammalia TSTD1 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia TSTD1 36
  • 31 (a)
(Gallus gallus)
Aves TSTD1 36
  • 28 (a)
(Anolis carolinensis)
Reptilia TSTD1 36
  • 32 (a)
(Danio rerio)
Actinopterygii LOC563265 35
  • 56.79 (n)
  • 52.78 (a)
TSTD1 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12279 36
  • 37 (a)
CG6000 36
  • 26 (a)
Hsp67Bb 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDL1 36
  • 22 (a)
RDL2 36
  • 23 (a)
RDL2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for TSTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSTD1 Gene

Gene Tree for TSTD1 (if available)
Gene Tree for TSTD1 (if available)

Paralogs for TSTD1 Gene Pseudogenes for TSTD1 Gene

genes like me logo Genes that share paralogs with TSTD1: view

No data available for Paralogs for TSTD1 Gene

Variants for TSTD1 Gene

Sequence variations from dbSNP and Humsavar for TSTD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4339888 -- 161,037,536(+) CAGAT(C/G)AATGC downstream-variant-500B
rs10908821 -- 161,038,745(+) CTCAC(C/G)TGGCA intron-variant
rs17175568 -- 161,038,638(-) CACTC(C/T)TAGCC reference, synonymous-codon, intron-variant
rs17181967 -- 161,037,533(-) TTCAT(C/T)TGCTT downstream-variant-500B
rs17181988 -- 161,038,634(-) CCTAG(C/T)CTCCG reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSTD1 Gene

Variant ID Type Subtype PubMed ID
nsv3221 CNV Loss 18451855

Variation tolerance for TSTD1 Gene

Gene Damage Index Score: 1.06; 21.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSTD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTD1 Gene

Disorders for TSTD1 Gene

Relevant External Links for TSTD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSTD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSTD1 Gene

Publications for TSTD1 Gene

  1. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. (PMID: 12817473) Wenzel K. … Hoehe M.R. (Biol. Chem. 2003) 2 67
  2. Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog. (PMID: 24981631) Melideo S.L. … Jorns M.S. (Biochemistry 2014) 67
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67
  5. Presence of L-kynurenine aminotransferase III in retinal ganglion cells and corpora amylacea in the human retina and optic nerve. (PMID: 21845542) Rejdak R. … Junemann A.G. (Folia Neuropathol 2011) 67

Products for TSTD1 Gene

Sources for TSTD1 Gene

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