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Aliases for TSTD1 Gene

Aliases for TSTD1 Gene

  • Thiosulfate Sulfurtransferase Like Domain Containing 1 2 3 5
  • Thiosulfate Sulfurtransferase (Rhodanese)-Like Domain Containing 1 2 3
  • KAT 3 4
  • Thiosulfate Sulfurtransferase/Rhodanese-Like Domain-Containing Protein 1 3
  • Thiosulfate Sulfurtransferase KAT, Putative 3
  • Putative Thiosulfate Sulfurtransferase KAT 3

External Ids for TSTD1 Gene

Previous GeneCards Identifiers for TSTD1 Gene

  • GC01M159280
  • GC01M132365

Summaries for TSTD1 Gene

GeneCards Summary for TSTD1 Gene

TSTD1 (Thiosulfate Sulfurtransferase Like Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TSTD3.

UniProtKB/Swiss-Prot for TSTD1 Gene

  • Possible role in tumorigenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTD1 Gene

Genomics for TSTD1 Gene

Regulatory Elements for TSTD1 Gene

Enhancers for TSTD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F160980 0.8 Ensembl ENCODE 33.3 +57.0 57011 2.0 CTCF TEAD4 RAD21 ZNF48 GATA3 GATA2 POLR2A SMC3 PRDM10 EZH2 TSTD1 LY9 ITLN1 SLAMF7 SLAMF1 ENSG00000228863 F11R PIR56289 GC01M160999 ITLN2
GH01F161011 1.2 FANTOM5 ENCODE 33.1 +21.8 21777 11.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DUSP12 ARHGAP30 TSTD1 ENSG00000228606 FCGR2A USF1 RPSAP18 CD48 DEDD KLHDC9
GH01F161066 1 FANTOM5 ENCODE 31.5 -29.6 -29625 5.1 HDGF PKNOX1 WRNIP1 SIN3A YY1 GLIS2 ELK1 ZNF143 ZNF207 SP3 FCGR2A TSTD1 DUSP12 ENSG00000228606 ARHGAP30 F11R DEDD ATF6 NECTIN4 ENSG00000232879
GH01F161073 1 Ensembl ENCODE 30.1 -35.5 -35505 2.2 HDGF ATF1 PKNOX1 CREB3L1 SIN3A ARID4B ZNF48 GLIS2 GATA2 DEK TSTD1 ATF6 ENSG00000228606 LOC148430 GC01P161070 LOC105371471
GH01F161041 0.2 ENCODE 20.2 -2.7 -2673 1.1 HDGF CTCF ZNF362 JUNB TRIM22 REST ZNF48 RAD21 ATF2 CREB3 TSTD1 F11R KLHDC9 ARHGAP30 LOC105371471 NECTIN4 DEDD PIR33280
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TSTD1 on UCSC Golden Path with GeneCards custom track

Promoters for TSTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167142 290 1001 HDGF TBP TBL1XR1 KLF17 SIN3A ZNF2 ZBTB40 YY1 GLIS2 EGR1

Genomic Location for TSTD1 Gene

161,037,631 bp from pter
161,038,990 bp from pter
1,360 bases
Minus strand

Genomic View for TSTD1 Gene

Genes around TSTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTD1 Gene

Proteins for TSTD1 Gene

  • Protein details for TSTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5SY48
    • Q5SY49
    • Q5SY50
    • Q5SY51
    • Q8NFU2
    • Q9BV22

    Protein attributes for TSTD1 Gene

    115 amino acids
    Molecular mass:
    12530 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH01699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15368.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSTD1 Gene


neXtProt entry for TSTD1 Gene

Post-translational modifications for TSTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSTD1 Gene

No data available for DME Specific Peptides for TSTD1 Gene

Domains & Families for TSTD1 Gene

Protein Domains for TSTD1 Gene


Suggested Antigen Peptide Sequences for TSTD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 rhodanese domain.
  • Contains 1 rhodanese domain.
genes like me logo Genes that share domains with TSTD1: view

No data available for Gene Families for TSTD1 Gene

Function for TSTD1 Gene

Molecular function for TSTD1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in tumorigenesis.

Phenotypes for TSTD1 Gene

GenomeRNAi human phenotypes for TSTD1:
genes like me logo Genes that share phenotypes with TSTD1: view

Animal Model Products

miRNA for TSTD1 Gene

miRTarBase miRNAs that target TSTD1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSTD1 Gene

Localization for TSTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSTD1 Gene

Cytoplasm, perinuclear region. Note=Localized around the nuclear membranes.

Subcellular locations from

Jensen Localization Image for TSTD1 Gene COMPARTMENTS Subcellular localization image for TSTD1 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TSTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12817473
GO:0005739 mitochondrion IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TSTD1: view

Pathways & Interactions for TSTD1 Gene

SuperPathways for TSTD1 Gene

No Data Available

Interacting Proteins for TSTD1 Gene

Gene Ontology (GO) - Biological Process for TSTD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSTD1 Gene

Drugs & Compounds for TSTD1 Gene

(4) Additional Compounds for TSTD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Carbon nitride ion
  • Chuck Norrisium
  • Cyanide
  • Cyanide ion
  • Cyanide(1-) ion
  • Bisulfite
  • Sulfite dianion
  • Sulfite ion
  • Sulfite ions
  • Sulfonate
  • Rhodanide
  • SCN
  • Ammonium sulfocyanate
  • HSCN
  • Hydrogen thiocyanate
  • Hyposulfite
  • S-Hydril
  • Sodium hyposulfite
  • Sodium oxide sulfide (Na2S2O3)
  • Sodium thiosulfate
genes like me logo Genes that share compounds with TSTD1: view

Transcripts for TSTD1 Gene

mRNA/cDNA for TSTD1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSTD1 Gene

Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSTD1 Gene

No ASD Table

Relevant External Links for TSTD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSTD1 Gene

mRNA expression in normal human tissues for TSTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSTD1 Gene

This gene is overexpressed in Salivary gland (9.9), Skin (7.5), and Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSTD1 Gene

Protein tissue co-expression partners for TSTD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSTD1 Gene:


SOURCE GeneReport for Unigene cluster for TSTD1 Gene:


mRNA Expression by UniProt/SwissProt for TSTD1 Gene:

Tissue specificity: Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A-549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues.
genes like me logo Genes that share expression patterns with TSTD1: view

Primer Products

No data available for mRNA differential expression in normal tissues for TSTD1 Gene

Orthologs for TSTD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSTD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSTD1 34 35
  • 99.11 (n)
(Bos Taurus)
Mammalia TSTD1 34 35
  • 86.43 (n)
(Canis familiaris)
Mammalia TSTD1 34 35
  • 85.96 (n)
(Rattus norvegicus)
Mammalia Tstd1 34
  • 82.46 (n)
(Mus musculus)
Mammalia Tstd1 34 16 35
  • 80.99 (n)
(Monodelphis domestica)
Mammalia TSTD1 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia TSTD1 35
  • 31 (a)
(Gallus gallus)
Aves TSTD1 35
  • 28 (a)
(Anolis carolinensis)
Reptilia TSTD1 35
  • 32 (a)
(Danio rerio)
Actinopterygii LOC563265 34
  • 56.79 (n)
TSTD1 35
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12279 35
  • 37 (a)
Hsp67Bb 35
  • 33 (a)
CG6000 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDL2 35 37
  • 23 (a)
RDL1 35
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
Species where no ortholog for TSTD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSTD1 Gene

Gene Tree for TSTD1 (if available)
Gene Tree for TSTD1 (if available)

Paralogs for TSTD1 Gene

Paralogs for TSTD1 Gene Pseudogenes for TSTD1 Gene

genes like me logo Genes that share paralogs with TSTD1: view

Variants for TSTD1 Gene

Sequence variations from dbSNP and Humsavar for TSTD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2073658 other 161,040,972(-) CATAA(A/G)TGGTC intron-variant, upstream-variant-2KB
rs3737787 other 161,039,733(-) GTGGA(C/T)GTGCA upstream-variant-2KB, utr-variant-3-prime
rs10908821 -- 161,038,745(+) CTCAC(C/G)TGGCA intron-variant
rs112080717 -- 161,039,306(+) GAAAA(A/G)AAAAA upstream-variant-2KB, utr-variant-3-prime
rs112811086 -- 161,040,652(+) TCTTG(C/T)CTCGG upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TSTD1 Gene

Variant ID Type Subtype PubMed ID
nsv3221 CNV deletion 18451855
nsv548059 CNV gain 21841781

Variation tolerance for TSTD1 Gene

Gene Damage Index Score: 1.06; 21.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSTD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTD1 Gene

Disorders for TSTD1 Gene

Relevant External Links for TSTD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSTD1 Gene

Publications for TSTD1 Gene

  1. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. (PMID: 12817473) Wenzel K. … Hoehe M.R. (Biol. Chem. 2003) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64

Products for TSTD1 Gene

Sources for TSTD1 Gene

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