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Aliases for TSTA3 Gene

Aliases for TSTA3 Gene

  • Tissue Specific Transplantation Antigen P35B 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 4E, Member 1 2 3
  • GDP-4-Keto-6-Deoxy-D-Mannose-3,5-Epimerase-4-Reductase 3 4
  • Red Cell NADP(H)-Binding Protein 3 4
  • GDP-L-Fucose Synthase 2 3
  • EC 1.1.1.271 4 61
  • SDR4E1 3 4
  • Short-Chain Dehydrogenase/Reductase Family 4E Member 1 4
  • GDP-4-Keto-6-Deoxy-D-Mannose Epimerase-Reductase 3
  • Testis Tissue Sperm-Binding Protein Li 45a 3
  • Tissue Specific Transplantation Antigen 3 3
  • 3-5 Epimerase/4-Reductase 3
  • Protein FX 4
  • P35B 3
  • FX 3

External Ids for TSTA3 Gene

Previous GeneCards Identifiers for TSTA3 Gene

  • GC08M142739
  • GC08M144922
  • GC08M144469
  • GC08M144799
  • GC08M144765
  • GC08M144694
  • GC08M139946

Summaries for TSTA3 Gene

Entrez Gene Summary for TSTA3 Gene

  • Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSTA3 Gene

TSTA3 (Tissue Specific Transplantation Antigen P35B) is a Protein Coding gene. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Transport to the Golgi and subsequent modification. GO annotations related to this gene include electron carrier activity and isomerase activity.

UniProtKB/Swiss-Prot for TSTA3 Gene

  • Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Gene Wiki entry for TSTA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTA3 Gene

Genomics for TSTA3 Gene

Regulatory Elements for TSTA3 Gene

Enhancers for TSTA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G142776 0.9 ENCODE 5.3 +840.5 840528 2.1 KLF17 DEAF1 SIN3A DMAP1 ZNF48 RAD21 RARA YY1 EGR1 ZNF143 LYNX1 THEM6 TSTA3 SLURP2
GH08G143275 1.8 FANTOM5 ENCODE dbSUPER 1.9 +339.0 338974 6.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MINCR ZFP41 ZNF623 RHPN1 HGH1 FAM83H-AS1 TOP1MT ZC3H3 TIGD5 GLI4
GH08G143615 1.1 ENCODE 0.7 +1.1 1083 3.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF207 LOC105375798 NAPRT TSSK5P GSDMD MROH6 TSTA3 PYCR3
GH08G143632 0.9 Ensembl ENCODE 0.4 -14.7 -14722 0.5 POLR2A IKZF1 HMBOX1 KDM5B ZBTB40 RBFOX2 MGA SUPT5H ZNF592 LOC105375798 TSTA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSTA3 on UCSC Golden Path with GeneCards custom track

Promoters for TSTA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232121 248 1601 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B ZNF766 ZNF207 ZNF143 KLF13

Genomic Location for TSTA3 Gene

Chromosome:
8
Start:
143,612,618 bp from pter
End:
143,618,048 bp from pter
Size:
5,431 bases
Orientation:
Minus strand

Genomic View for TSTA3 Gene

Genes around TSTA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSTA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTA3 Gene

Proteins for TSTA3 Gene

  • Protein details for TSTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13630-FCL_HUMAN
    Recommended name:
    GDP-L-fucose synthase
    Protein Accession:
    Q13630
    Secondary Accessions:
    • B2R8Y7
    • D3DWK5
    • Q567Q9
    • Q9UDG7

    Protein attributes for TSTA3 Gene

    Size:
    321 amino acids
    Molecular mass:
    35893 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for TSTA3 Gene

neXtProt entry for TSTA3 Gene

Selected DME Specific Peptides for TSTA3 Gene

Q13630:
  • KVVSCLSTCIFPDKT
  • YPIDETM
  • PTHVIHLAAMVGGLF
  • YLPDFRFTPFKQAVKETC

Post-translational modifications for TSTA3 Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

Domains & Families for TSTA3 Gene

Gene Families for TSTA3 Gene

Suggested Antigen Peptide Sequences for TSTA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13630

UniProtKB/Swiss-Prot:

FCL_HUMAN :
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
Family:
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
genes like me logo Genes that share domains with TSTA3: view

Function for TSTA3 Gene

Molecular function for TSTA3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Enzyme Numbers (IUBMB) for TSTA3 Gene

Gene Ontology (GO) - Molecular Function for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009055 electron carrier activity TAS 8910301
GO:0016491 oxidoreductase activity IEA --
GO:0016853 isomerase activity TAS --
GO:0042356 GDP-4-dehydro-D-rhamnose reductase activity TAS 11698403
GO:0042802 identical protein binding IPI 23774504
genes like me logo Genes that share ontologies with TSTA3: view
genes like me logo Genes that share phenotypes with TSTA3: view

Animal Models for TSTA3 Gene

MGI Knock Outs for TSTA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TSTA3

CRISPR Products

miRNA for TSTA3 Gene

miRTarBase miRNAs that target TSTA3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TSTA3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSTA3 Gene

Localization for TSTA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSTA3 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 11698403
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TSTA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSTA3 Gene

Pathways & Interactions for TSTA3 Gene

genes like me logo Genes that share pathways with TSTA3: view

UniProtKB/Swiss-Prot Q13630-FCL_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.

Gene Ontology (GO) - Biological Process for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007159 leukocyte cell-cell adhesion NAS 11698403
GO:0008152 metabolic process IEA --
GO:0009226 nucleotide-sugar biosynthetic process IEA --
GO:0019673 GDP-mannose metabolic process IDA 9525924
GO:0019835 cytolysis IEA --
genes like me logo Genes that share ontologies with TSTA3: view

No data available for SIGNOR curated interactions for TSTA3 Gene

Drugs & Compounds for TSTA3 Gene

(2) Drugs for TSTA3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
NADH Nutra Target 0

(7) Additional Compounds for TSTA3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-4-Dehydro-6-deoxy-D-mannose
  • GDP-4-Dehydro-6-deoxy-D-mannose
  • GDP-4-Dehydro-6-deoxy-D-talose
  • GDP-4-Dehydro-D-rhamnose
  • GDP-4-Keto-6-D-deoxymannose
  • GDP-4-Keto-6-deoxy-D-mannose
18186-48-6
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with TSTA3: view

Transcripts for TSTA3 Gene

Unigene Clusters for TSTA3 Gene

Tissue specific transplantation antigen P35B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TSTA3

Alternative Splicing Database (ASD) splice patterns (SP) for TSTA3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - -
SP11: - -
SP12: -

ExUns: 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TSTA3 Gene

GeneLoc Exon Structure for
TSTA3
ECgene alternative splicing isoforms for
TSTA3

Expression for TSTA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSTA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSTA3 Gene

This gene is overexpressed in Oral epithelium (9.9) and Breast (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSTA3 Gene



Protein tissue co-expression partners for TSTA3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSTA3 Gene:

TSTA3

SOURCE GeneReport for Unigene cluster for TSTA3 Gene:

Hs.404119

Evidence on tissue expression from TISSUES for TSTA3 Gene

  • Lung(4.5)
  • Blood(4.3)
  • Skin(4.3)
  • Liver(4.2)
  • Nervous system(3.1)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with TSTA3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSTA3 Gene

Orthologs for TSTA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSTA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSTA3 34 35
  • 99.07 (n)
cow
(Bos Taurus)
Mammalia TSTA3 34 35
  • 90.13 (n)
dog
(Canis familiaris)
Mammalia TSTA3 34 35
  • 89.41 (n)
rat
(Rattus norvegicus)
Mammalia Tsta3 34
  • 88.58 (n)
mouse
(Mus musculus)
Mammalia Tsta3 34 16 35
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia TSTA3 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSTA3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSTA3 34 35
  • 78.49 (n)
lizard
(Anolis carolinensis)
Reptilia TSTA3 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394680 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398450 34
zebrafish
(Danio rerio)
Actinopterygii tsta3 34 35
  • 70.36 (n)
TSTA3 (2 of 3) 35
  • 67 (a)
OneToMany
TSTA3 (3 of 3) 35
  • 65 (a)
OneToMany
Dr.18707 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12412 34
fruit fly
(Drosophila melanogaster)
Insecta Gmer 36 34 35
  • 65.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008092 34
  • 63.48 (n)
worm
(Caenorhabditis elegans)
Secernentea R01H2.5 36
  • 64 (a)
ger-1 34 35
  • 60.04 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GER1 34
  • 46.89 (n)
rice
(Oryza sativa)
Liliopsida Os06g0652400 34
  • 50.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4654 35
  • 69 (a)
OneToMany
CSA.1309 35
  • 67 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9630 34
Species where no ortholog for TSTA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSTA3 Gene

ENSEMBL:
Gene Tree for TSTA3 (if available)
TreeFam:
Gene Tree for TSTA3 (if available)

Paralogs for TSTA3 Gene

No data available for Paralogs for TSTA3 Gene

Variants for TSTA3 Gene

Sequence variations from dbSNP and Humsavar for TSTA3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000195461 -- 143,615,782(+) AGGCC(C/G)TGGGG intron-variant
rs1000358430 -- 143,612,194(+) GGGGA(A/C)GCCCG downstream-variant-500B
rs1000987962 -- 143,633,220(+) GGTTA(C/T)GGCAA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001210038 -- 143,617,278(+) CCAGG(A/G)CCAGC intron-variant, upstream-variant-2KB
rs1001310924 -- 143,612,992(+) GGCCA(C/T)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSTA3 Gene

Variant ID Type Subtype PubMed ID
dgv12419n54 CNV loss 21841781
dgv12427n54 CNV loss 21841781
dgv12428n54 CNV loss 21841781
dgv1314e199 CNV deletion 23128226
dgv132n16 CNV deletion 17901297
dgv2118e212 CNV loss 25503493
dgv271n111 CNV deletion 26073780
dgv59n50 CNV loss 21212237
dgv7336n100 CNV gain 25217958
esv3544391 CNV deletion 23714750
esv3573032 CNV loss 25503493
esv3584899 CNV loss 24956385
nsv1161810 CNV deletion 26073780
nsv1161814 CNV deletion 26073780
nsv42 CNV deletion 15895083
nsv466004 CNV loss 19166990
nsv470247 CNV loss 18288195
nsv516210 CNV loss 19592680
nsv612777 CNV gain 21841781
nsv612793 CNV loss 21841781
nsv6439 CNV deletion 18451855
nsv831488 CNV loss 17160897
nsv950013 CNV deletion 24416366

Variation tolerance for TSTA3 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSTA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSTA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTA3 Gene

Disorders for TSTA3 Gene

Relevant External Links for TSTA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSTA3

No disorders were found for TSTA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSTA3 Gene

Publications for TSTA3 Gene

  1. Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum-transplantation antigen P35B. (PMID: 7803801) Camardella L. … De Flora A. (Blood 1995) 2 3 4 22 64
  2. Synthesis of GDP-L-fucose by the human FX protein. (PMID: 8910301) Tonetti M. … De Flora A. (J. Biol. Chem. 1996) 3 4 22 64
  3. The crystal structure of human GDP-L-fucose synthase. (PMID: 23774504) Zhou H. … He J. (Acta Biochim. Biophys. Sin. 2013) 3 4 64
  4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TSTA3 Gene

  • Addgene plasmids for TSTA3

Sources for TSTA3 Gene

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