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Aliases for TSTA3 Gene

Aliases for TSTA3 Gene

  • Tissue Specific Transplantation Antigen P35B 2 3 5
  • GDP-4-Keto-6-Deoxy-D-Mannose-3,5-Epimerase-4-Reductase 3 4
  • Red Cell NADP(H)-Binding Protein 3 4
  • EC 1.1.1.271 4 63
  • SDR4E1 3 4
  • Short Chain Dehydrogenase/Reductase Family 4E, Member 1 3
  • Short-Chain Dehydrogenase/Reductase Family 4E Member 1 4
  • GDP-4-Keto-6-Deoxy-D-Mannose Epimerase-Reductase 3
  • Short Chain Dehydrogenase/Reductase Family 4E 2
  • Testis Tissue Sperm-Binding Protein Li 45a 3
  • Tissue Specific Transplantation Antigen 3 3
  • 3-5 Epimerase/4-Reductase 3
  • GDP-L-Fucose Synthase 2
  • Protein FX 4
  • Member 1 2
  • P35B 3
  • FX 3

External Ids for TSTA3 Gene

Previous GeneCards Identifiers for TSTA3 Gene

  • GC08M142739
  • GC08M144922
  • GC08M144469
  • GC08M144799
  • GC08M144765
  • GC08M144694
  • GC08M139946

Summaries for TSTA3 Gene

Entrez Gene Summary for TSTA3 Gene

  • Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSTA3 Gene

TSTA3 (Tissue Specific Transplantation Antigen P35B) is a Protein Coding gene. Among its related pathways are Amino sugar and nucleotide sugar metabolism and Fructose and mannose metabolism. GO annotations related to this gene include electron carrier activity and isomerase activity.

UniProtKB/Swiss-Prot for TSTA3 Gene

  • Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Gene Wiki entry for TSTA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTA3 Gene

Genomics for TSTA3 Gene

Regulatory Elements for TSTA3 Gene

Enhancers for TSTA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSTA3 on UCSC Golden Path with GeneCards custom track

Promoters for TSTA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSTA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSTA3 Gene

Chromosome:
8
Start:
143,612,618 bp from pter
End:
143,618,048 bp from pter
Size:
5,431 bases
Orientation:
Minus strand

Genomic View for TSTA3 Gene

Genes around TSTA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSTA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTA3 Gene

Proteins for TSTA3 Gene

  • Protein details for TSTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13630-FCL_HUMAN
    Recommended name:
    GDP-L-fucose synthase
    Protein Accession:
    Q13630
    Secondary Accessions:
    • B2R8Y7
    • D3DWK5
    • Q567Q9
    • Q9UDG7

    Protein attributes for TSTA3 Gene

    Size:
    321 amino acids
    Molecular mass:
    35893 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for TSTA3 Gene

neXtProt entry for TSTA3 Gene

Proteomics data for TSTA3 Gene at MOPED

Selected DME Specific Peptides for TSTA3 Gene

Post-translational modifications for TSTA3 Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for TSTA3 Gene

Gene Families for TSTA3 Gene

Protein Domains for TSTA3 Gene

Suggested Antigen Peptide Sequences for TSTA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13630

UniProtKB/Swiss-Prot:

FCL_HUMAN :
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
Family:
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
genes like me logo Genes that share domains with TSTA3: view

Function for TSTA3 Gene

Molecular function for TSTA3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Enzyme Numbers (IUBMB) for TSTA3 Gene

Gene Ontology (GO) - Molecular Function for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042356 GDP-4-dehydro-D-rhamnose reductase activity TAS 11698403
genes like me logo Genes that share ontologies with TSTA3: view
genes like me logo Genes that share phenotypes with TSTA3: view

Animal Models for TSTA3 Gene

MGI Knock Outs for TSTA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for TSTA3

CRISPR Products

miRNA for TSTA3 Gene

miRTarBase miRNAs that target TSTA3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSTA3 Gene

Localization for TSTA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSTA3 Gene COMPARTMENTS Subcellular localization image for TSTA3 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 11698403
genes like me logo Genes that share ontologies with TSTA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSTA3 Gene

Pathways & Interactions for TSTA3 Gene

genes like me logo Genes that share pathways with TSTA3: view

UniProtKB/Swiss-Prot Q13630-FCL_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.

Interacting Proteins for TSTA3 Gene

Gene Ontology (GO) - Biological Process for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007159 leukocyte cell-cell adhesion NAS 11698403
GO:0008152 metabolic process IEA --
GO:0042351 de novo GDP-L-fucose biosynthetic process TAS 11698403
genes like me logo Genes that share ontologies with TSTA3: view

No data available for SIGNOR curated interactions for TSTA3 Gene

Drugs & Compounds for TSTA3 Gene

(2) Drugs for TSTA3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
NADH Nutra Target 0

(7) Additional Compounds for TSTA3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-4-Dehydro-6-deoxy-D-mannose
  • GDP-4-Dehydro-6-deoxy-D-mannose
  • GDP-4-Dehydro-6-deoxy-D-talose
  • GDP-4-Dehydro-D-rhamnose
  • GDP-4-Keto-6-D-deoxymannose
  • GDP-4-Keto-6-deoxy-D-mannose
18186-48-6
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with TSTA3: view

Transcripts for TSTA3 Gene

Unigene Clusters for TSTA3 Gene

Tissue specific transplantation antigen P35B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSTA3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - -
SP11: - -
SP12: -

ExUns: 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TSTA3 Gene

GeneLoc Exon Structure for
TSTA3
ECgene alternative splicing isoforms for
TSTA3

Expression for TSTA3 Gene

mRNA expression in normal human tissues for TSTA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSTA3 Gene

This gene is overexpressed in Oral epithelium (9.9) and Breast (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSTA3 Gene



SOURCE GeneReport for Unigene cluster for TSTA3 Gene Hs.404119

genes like me logo Genes that share expression patterns with TSTA3: view

Protein tissue co-expression partners for TSTA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSTA3 Gene

Orthologs for TSTA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSTA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSTA3 35
  • 90.13 (n)
  • 92.52 (a)
TSTA3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSTA3 35
  • 89.41 (n)
  • 95.64 (a)
TSTA3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsta3 35
  • 88.16 (n)
  • 93.77 (a)
Tsta3 16
Tsta3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSTA3 35
  • 99.07 (n)
  • 98.75 (a)
TSTA3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsta3 35
  • 88.58 (n)
  • 93.46 (a)
oppossum
(Monodelphis domestica)
Mammalia TSTA3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSTA3 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSTA3 35
  • 78.49 (n)
  • 82.75 (a)
TSTA3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSTA3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394680 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398450 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18707 35
tsta3 35
  • 70.36 (n)
  • 74.37 (a)
tsta3 36
  • 74 (a)
OneToMany
TSTA3 (2 of 3) 36
  • 67 (a)
OneToMany
TSTA3 (3 of 3) 36
  • 65 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12412 35
fruit fly
(Drosophila melanogaster)
Insecta Gmer 37
  • 60 (a)
Gmer 35
  • 65.92 (n)
  • 60.58 (a)
Gmer 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008092 35
  • 63.48 (n)
  • 64.97 (a)
worm
(Caenorhabditis elegans)
Secernentea R01H2.5 37
  • 64 (a)
ger-1 35
  • 60.04 (n)
  • 65.06 (a)
ger-1 36
  • 64 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons GER1 35
  • 46.89 (n)
  • 36.33 (a)
rice
(Oryza sativa)
Liliopsida Os06g0652400 35
  • 50.27 (n)
  • 36.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9630 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1309 36
  • 67 (a)
OneToMany
CSA.4654 36
  • 69 (a)
OneToMany
Species with no ortholog for TSTA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSTA3 Gene

ENSEMBL:
Gene Tree for TSTA3 (if available)
TreeFam:
Gene Tree for TSTA3 (if available)

Paralogs for TSTA3 Gene

No data available for Paralogs for TSTA3 Gene

Variants for TSTA3 Gene

Sequence variations from dbSNP and Humsavar for TSTA3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2242085 -- 143,617,254(-) GAGCC(C/G)GAGCA intron-variant, upstream-variant-2KB
rs2242086 -- 143,613,329(-) GAGGT(G/T)CTCTT intron-variant
rs2242087 -- 143,613,006(-) GCCCC(A/G)ACCCT intron-variant
rs7844633 -- 143,615,296(+) CCCAC(A/C/T)CTGGA intron-variant
rs3812446 -- 143,617,922(+) AATAC(C/G)CAGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSTA3 Gene

Variant ID Type Subtype PubMed ID
nsv470247 CNV Loss 18288195
nsv891676 CNV Loss 21882294
dgv7928n71 CNV Loss 21882294
dgv7932n71 CNV Loss 21882294
dgv7934n71 CNV Loss 21882294
nsv516210 CNV Loss 19592680
dgv7935n71 CNV Loss 21882294
dgv7936n71 CNV Loss 21882294
dgv7937n71 CNV Loss 21882294
nsv891737 CNV Gain 21882294
nsv466004 CNV Loss 19166990
nsv831488 CNV Loss 17160897
nsv6439 CNV Loss 18451855
nsv42 CNV Loss 15895083
dgv1314e199 CNV Deletion 23128226
dgv132n16 CNV Deletion 17901297
dgv59n50 CNV Loss 21212237

Variation tolerance for TSTA3 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSTA3 Gene

HapMap Linkage Disequilibrium report
TSTA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTA3 Gene

Disorders for TSTA3 Gene

Relevant External Links for TSTA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSTA3

No disorders were found for TSTA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSTA3 Gene

Publications for TSTA3 Gene

  1. Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum-transplantation antigen P35B. (PMID: 7803801) Camardella L. … De Flora A. (Blood 1995) 2 3 4 23 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. (PMID: 9525924) Sullivan F.X. … Cumming D.A. (J. Biol. Chem. 1998) 3 23
  4. Synthesis of GDP-L-fucose by the human FX protein. (PMID: 8910301) Tonetti M. … De Flora A. (J. Biol. Chem. 1996) 3 23
  5. Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. (PMID: 1348494) Dyson P.J. … Boon T. (Immunogenetics 1992) 2 3

Products for TSTA3 Gene

Sources for TSTA3 Gene

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