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Aliases for TSTA3 Gene

Aliases for TSTA3 Gene

  • Tissue Specific Transplantation Antigen P35B 2 3
  • GDP-4-Keto-6-Deoxy-D-Mannose-3,5-Epimerase-4-Reductase 3 4
  • Red Cell NADP(H)-Binding Protein 3 4
  • GDP-L-Fucose Synthase 2 3
  • EC 1.1.1.271 4 63
  • SDR4E1 3 4
  • Short Chain Dehydrogenase/Reductase Family 4E, Member 1 3
  • Short-Chain Dehydrogenase/Reductase Family 4E Member 1 4
  • GDP-4-Keto-6-Deoxy-D-Mannose Epimerase-Reductase 3
  • Short Chain Dehydrogenase/Reductase Family 4E 2
  • Tissue Specific Transplantation Antigen 3 3
  • 3-5 Epimerase/4-Reductase 3
  • Protein FX 4
  • Member 1 2
  • P35B 3
  • FX 3

External Ids for TSTA3 Gene

Summaries for TSTA3 Gene

Entrez Gene Summary for TSTA3 Gene

  • Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSTA3 Gene

TSTA3 (Tissue Specific Transplantation Antigen P35B) is a Protein Coding gene. Diseases associated with TSTA3 include mast cell neoplasm and leukocyte adhesion deficiency. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include electron carrier activity and isomerase activity.

UniProtKB/Swiss-Prot for TSTA3 Gene

  • Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Gene Wiki entry for TSTA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSTA3 Gene

Genomics for TSTA3 Gene

Genomic Location for TSTA3 Gene

Start:
143,612,618 bp from pter
End:
143,618,155 bp from pter
Size:
5,538 bases
Orientation:
Minus strand

Genomic View for TSTA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSTA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSTA3 Gene

Regulatory Elements for TSTA3 Gene

Proteins for TSTA3 Gene

  • Protein details for TSTA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13630-FCL_HUMAN
    Recommended name:
    GDP-L-fucose synthase
    Protein Accession:
    Q13630
    Secondary Accessions:
    • B2R8Y7
    • D3DWK5
    • Q567Q9
    • Q9UDG7

    Protein attributes for TSTA3 Gene

    Size:
    321 amino acids
    Molecular mass:
    35893 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for TSTA3 Gene

neXtProt entry for TSTA3 Gene

Proteomics data for TSTA3 Gene at MOPED

Selected DME Specific Peptides for TSTA3 Gene

Post-translational modifications for TSTA3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21

Domains for TSTA3 Gene

Gene Families for TSTA3 Gene

HGNC:
  • SDRE :Short chain dehydrogenase/reductase superfamily / Extended SDR fold

Protein Domains for TSTA3 Gene

Suggested Antigen Peptide Sequences for TSTA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13630

UniProtKB/Swiss-Prot:

FCL_HUMAN
Family:
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.:
    • Q13630
genes like me logo Genes that share domains with TSTA3: view

Function for TSTA3 Gene

Molecular function for TSTA3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH
UniProtKB/Swiss-Prot Function: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Enzyme Numbers (IUBMB) for TSTA3 Gene

Gene Ontology (GO) - Molecular Function for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0009055 electron carrier activity TAS 8910301
GO:0016853 isomerase activity IEA --
GO:0042356 GDP-4-dehydro-D-rhamnose reductase activity TAS 11698403
GO:0050577 GDP-L-fucose synthase activity IDA 9525924
genes like me logo Genes that share ontologies with TSTA3: view
genes like me logo Genes that share phenotypes with TSTA3: view

Animal Models for TSTA3 Gene

MGI Knock Outs for TSTA3:

miRNA for TSTA3 Gene

miRTarBase miRNAs that target TSTA3

No data available for Transcription Factor Targeting and HOMER Transcription for TSTA3 Gene

Localization for TSTA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSTA3 Gene COMPARTMENTS Subcellular localization image for TSTA3 gene
Compartment Confidence
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 11698403
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TSTA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSTA3 Gene

Pathways for TSTA3 Gene

genes like me logo Genes that share pathways with TSTA3: view

UniProtKB/Swiss-Prot Q13630-FCL_HUMAN

  • Pathway: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2

Interacting Proteins for TSTA3 Gene

Gene Ontology (GO) - Biological Process for TSTA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007159 leukocyte cell-cell adhesion NAS 11698403
GO:0008152 metabolic process --
GO:0019673 GDP-mannose metabolic process IDA 9525924
GO:0019835 cytolysis IEA --
GO:0042351 de novo GDP-L-fucose biosynthetic process TAS 11698403
genes like me logo Genes that share ontologies with TSTA3: view

Compounds for TSTA3 Gene

(5) HMDB Compounds for TSTA3 Gene

Compound Synonyms Cas Number PubMed IDs
GDP-4-Dehydro-6-deoxy-D-mannose
  • GDP-4-dehydro-6-deoxy-D-mannose
18186-48-6
GDP-L-fucose
  • GDP-beta-L-fucose
15839-70-0
Guanosine diphosphate
  • 5'-GDP
146-91-8
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6

(1) Drugbank Compounds for TSTA3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target

(2) Novoseek inferred chemical compound relationships for TSTA3 Gene

Compound -log(P) Hits PubMed IDs
gdpmannose 88 4
polysaccharide 30.9 1
genes like me logo Genes that share compounds with TSTA3: view

Transcripts for TSTA3 Gene

Unigene Clusters for TSTA3 Gene

Tissue specific transplantation antigen P35B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSTA3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - -
SP11: - -
SP12: -

ExUns: 11 ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TSTA3 Gene

GeneLoc Exon Structure for
TSTA3
ECgene alternative splicing isoforms for
TSTA3

Expression for TSTA3 Gene

mRNA expression in normal human tissues for TSTA3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSTA3 Gene

SOURCE GeneReport for Unigene cluster for TSTA3 Gene Hs.404119

genes like me logo Genes that share expressions with TSTA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSTA3 Gene

Orthologs for TSTA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSTA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSTA3 35
  • 99.07 (n)
  • 98.75 (a)
TSTA3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSTA3 35
  • 90.13 (n)
  • 92.52 (a)
TSTA3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSTA3 35
  • 89.41 (n)
  • 95.64 (a)
TSTA3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tsta3 35
  • 88.16 (n)
  • 93.77 (a)
Tsta3 16
Tsta3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSTA3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSTA3 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsta3 35
  • 88.58 (n)
  • 93.46 (a)
chicken
(Gallus gallus)
Aves TSTA3 35
  • 78.49 (n)
  • 82.75 (a)
TSTA3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSTA3 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398450 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394680 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12412 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18707 35
tsta3 35
  • 70.36 (n)
  • 74.37 (a)
tsta3 36
  • 74 (a)
OneToMany
TSTA3 (2 of 3) 36
  • 67 (a)
OneToMany
TSTA3 (3 of 3) 36
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008092 35
  • 63.48 (n)
  • 64.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gmer 35
  • 65.92 (n)
  • 60.58 (a)
Gmer 36
  • 59 (a)
OneToOne
Gmer 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea ger-1 35
  • 60.04 (n)
  • 65.06 (a)
ger-1 36
  • 64 (a)
OneToOne
R01H2.5 37
  • 64 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GER1 35
  • 46.89 (n)
  • 36.33 (a)
rice
(Oryza sativa)
Liliopsida Os06g0652400 35
  • 50.27 (n)
  • 36.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9630 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1309 36
  • 67 (a)
OneToMany
CSA.4654 36
  • 69 (a)
OneToMany
Species with no ortholog for TSTA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSTA3 Gene

ENSEMBL:
Gene Tree for TSTA3 (if available)
TreeFam:
Gene Tree for TSTA3 (if available)

Paralogs for TSTA3 Gene

No data available for Paralogs for TSTA3 Gene

Variants for TSTA3 Gene

Sequence variations from dbSNP and Humsavar for TSTA3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2978 -- 143,612,720(-) GGTCC(C/G)GGGCA utr-variant-3-prime
rs896938 -- 143,633,436(-) TAATA(A/T)TATCT upstream-variant-2KB
rs1049832 -- 143,614,871(-) GCCTT(C/T)GAGGT synonymous-codon, reference
rs1049876 -- 143,612,786(-) CCGCT(C/T)TGCAG utr-variant-3-prime
rs1049886 -- 143,612,680(-) CCCTG(C/G)GCGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TSTA3 Gene

Variant ID Type Subtype PubMed ID
nsv470247 CNV Loss 18288195
nsv891676 CNV Loss 21882294
dgv7928n71 CNV Loss 21882294
dgv7932n71 CNV Loss 21882294
dgv7934n71 CNV Loss 21882294
nsv516210 CNV Loss 19592680
dgv7935n71 CNV Loss 21882294
dgv7936n71 CNV Loss 21882294
dgv7937n71 CNV Loss 21882294
nsv891737 CNV Gain 21882294
nsv466004 CNV Loss 19166990
nsv831488 CNV Loss 17160897
nsv6439 CNV Loss 18451855
nsv42 CNV Loss 15895083
dgv1314e199 CNV Deletion 23128226
dgv132n16 CNV Deletion 17901297
dgv59n50 CNV Loss 21212237

Relevant External Links for TSTA3 Gene

HapMap Linkage Disequilibrium report
TSTA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSTA3 Gene

Disorders for TSTA3 Gene

(1) University of Copenhagen DISEASES for TSTA3 Gene

(2) Novoseek inferred disease relationships for TSTA3 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 23.2 1
tumors 22.3 1
genes like me logo Genes that share disorders with TSTA3: view

No data available for UniProtKB/Swiss-Prot for TSTA3 Gene

Publications for TSTA3 Gene

  1. Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum-transplantation antigen P35B. (PMID: 7803801) Camardella L. … De Flora A. (Blood 1995) 2 3 4 23
  2. Synthesis of GDP-L-fucose by the human FX protein. (PMID: 8910301) Tonetti M. … De Flora A. (J. Biol. Chem. 1996) 3 4 23
  3. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. (PMID: 9525924) Sullivan F.X. … Cumming D.A. (J. Biol. Chem. 1998) 3 23
  4. Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. (PMID: 1348494) Dyson P.J. … Boon T. (Immunogenetics 1992) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TSTA3 Gene

Sources for TSTA3 Gene

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