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TSTA3 Gene

protein-coding   GIFtS: 59
GCID: GC08M144694

Tissue Specific Transplantation Antigen P35B

  See TSTA3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tissue Specific Transplantation Antigen P35B1 2     3-5 Epimerase/4-Reductase2
GDP-L-Fucose Synthase1 2     FX2
Red Cell NADP(H)-Binding Protein2 3     P35B2
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase2 3     GDP-4-Keto-6-Deoxy-D-Mannose Epimerase-Reductase2
SDR4E12 3     Short Chain Dehydrogenase/Reductase Family 4E, Member 12
EC 1.1.1.2713 8     Tissue Specific Transplantation Antigen 32
Member 11     Protein FX3
Short Chain Dehydrogenase/Reductase Family 4E1     Short-Chain Dehydrogenase/Reductase Family 4E Member 13

External Ids:    HGNC: 123901   Entrez Gene: 72642   Ensembl: ENSG000001045227   OMIM: 1370205   UniProtKB: Q136303   

Export aliases for TSTA3 gene to outside databases

Previous GC identifers: GC08M142739 GC08M144922 GC08M144469 GC08M144799 GC08M144765 GC08M139946


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSTA3 Gene:
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and
the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose.
GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates,
including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause
leukocyte adhesion deficiency, type II. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSTA3 Gene:
TSTA3 (tissue specific transplantation antigen P35B) is a protein-coding gene. Diseases associated with TSTA3 include mast cell neoplasm, and leukocyte adhesion deficiency. GO annotations related to this gene include isomerase activity and electron carrier activity.

UniProtKB/Swiss-Prot: FCL_HUMAN, Q13630
Function: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose,
involving an epimerase and a reductase reaction

Gene Wiki entry for TSTA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NT_187571.1  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSTA3 gene promoter:
         MyoD   STAT5A   NF-kappaB   Nkx6-1   NF-kappaB2   COMP1   STAT3   NF-kappaB1   En-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSTA3 promoter sequence
   Search Chromatin IP Primers for TSTA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSTA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

TSTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSTA3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M144694:  view genomic region     (about GC identifiers)

Start:
144,694,788 bp from pter      End:
144,700,218 bp from pter
Size:
5,431 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FCL_HUMAN, Q13630 (See protein sequence)
Recommended Name: GDP-L-fucose synthase  
Size: 321 amino acids; 35893 Da
Subunit: Homodimer
4 PDB 3D structures from and Proteopedia for TSTA3:
4B8W (3D)        4B8Z (3D)        4BKP (3D)        4E5Y (3D)    
Secondary accessions: B2R8Y7 D3DWK5 Q567Q9 Q9UDG7

Explore the universe of human proteins at neXtProt for TSTA3: NX_Q13630

Explore proteomics data for TSTA3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for TSTA3 (Q13630)
     YPIDETM  KVVSCLSTCIFPDKT  PTHVIHLAAMVGGLF  YLPDFRFTPFKQAVKETC 


    See TSTA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003304.1  
    ENSEMBL proteins: 
     ENSP00000432088   ENSP00000435386   ENSP00000398803   ENSP00000431587   ENSP00000437012  
     ENSP00000436405   ENSP00000433331   ENSP00000435240  

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    antibodies-online proteins for TSTA3 (24 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRE: Short chain dehydrogenase/reductase superfamily / Extended SDR fold

    3 InterPro protein domains:
     IPR028614 GDP_fucose_synth
     IPR001509 Epimerase_deHydtase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13630

    ProtoNet protein and cluster: Q13630

    1 Blocks protein domain: IPB001509 NAD-dependent epimerase/dehydratase

    UniProtKB/Swiss-Prot: FCL_HUMAN, Q13630
    Similarity: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily


    Find genes that share domains with TSTA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCL_HUMAN, Q13630
    Function: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose,
    involving an epimerase and a reductase reaction
    Catalytic activity: GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH

         Enzyme Number (IUBMB): EC 1.1.1.2711 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008831dTDP-4-dehydrorhamnose reductase activity ----
    GO:0009055electron carrier activity TAS8910301
    GO:0016853isomerase activity IEA--
    GO:0042356GDP-4-dehydro-D-rhamnose reductase activity TAS11698403
         
    Find genes that share ontologies with TSTA3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TSTA3:
     Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tsta3):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with TSTA3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tsta3tm1Jbl for TSTA3

       genOway: Develop your customized and physiologically relevant rodent model for TSTA3

    miRNA
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    miRTarBase miRNAs that target TSTA3:
    hsa-mir-26b-5p (MIRT030034), hsa-mir-346 (MIRT004227)

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    7 qRT-PCR Assays for microRNAs that regulate TSTA3:
    hsa-miR-125a-5p hsa-miR-544b hsa-miR-670 hsa-miR-125b hsa-miR-3647-3p hsa-miR-1224-5p hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidTSTA3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IC11698403
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with TSTA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TSTA3 About    
    See pathways by source

    SuperPathContained pathways About
    1Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism
    GDP-L-fucose biosynthesis I (from GDP-D-mannose)0.00
    colanic acid building blocks biosynthesis0.00
    2Metabolism
    Metabolic pathways0.38
    3Fructose and mannose metabolism
    Fructose and mannose metabolism


    Find genes that share SuperPaths with TSTA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TSTA3
        colanic acid building blocks biosynthesis
    GDP-L-fucose biosynthesis I (from GDP-D-mannose)


    3 Kegg Pathways  (Kegg details for TSTA3):
        Fructose and mannose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: FCL_HUMAN, Q13630
    Pathway: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from
    GDP-alpha-D-mannose: step 2/2

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSTA3
    Interactions:

        Search GeneGlobe Interaction Network for TSTA3

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007159leukocyte cell-cell adhesion NAS11698403
    GO:0019673GDP-mannose metabolic process IDA9525924
    GO:0019835cytolysis IEA--
    GO:0042351'de novo' GDP-L-fucose biosynthetic process TAS11698403
    GO:0044237cellular metabolic process ----

    Find genes that share ontologies with TSTA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TSTA3 (FCL)

    5 HMDB Compounds for TSTA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-4-Dehydro-6-deoxy-D-mannoseGDP-4-dehydro-6-deoxy-D-mannose (see all 9)18186-48-6--
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for TSTA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    2 Novoseek inferred chemical compound relationships for TSTA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdpmannose 88 5 10410995 (2), 9603974 (1), 9525924 (1)
    polysaccharide 30.9 1 10777581 (1)



    Find genes that share compounds with TSTA3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSTA3 gene: 
    NM_003313.3  

    Unigene Cluster for TSTA3:

    Tissue specific transplantation antigen P35B
    Hs.404119  [show with all ESTs]
    Unigene Representative Sequence: NM_003313
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524719 ENST00000528920 ENST00000529064(uc003yza.2) ENST00000531473
    ENST00000425753(uc003yzb.2) ENST00000527677 ENST00000529048 ENST00000532308
    ENST00000533817 ENST00000530474 ENST00000525274 ENST00000527549(uc011lko.1)
    ENST00000526290 ENST00000527006 ENST00000529899 ENST00000531006
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    hsa-miR-125a-5p hsa-miR-544b hsa-miR-670 hsa-miR-125b hsa-miR-3647-3p hsa-miR-1224-5p hsa-miR-4319
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    Additional mRNA sequence: 

    AK303125.1 AK313560.1 BC001941.1 BC093061.1 U58766.1 

    16 DOTS entries:

    DT.100815155  DT.100815159  DT.95371933  DT.100815157  DT.100815156  DT.100815160  DT.121492444  DT.95371926 
    DT.100044616  DT.102836313  DT.121492423  DT.121492429  DT.316195  DT.95371874  DT.95371895  DT.97790931 

    Selected AceView cDNA sequences (see all 351):

    BM987355 BM553381 CB128420 T34726 AL548615 AV684480 AW605254 CR624941 
    BG282607 CR617801 AA300000 BF334638 BX092406 BQ446341 BU500859 BU172407 
    BM559065 BM825801 AW247440 AA377941 BM915330 BQ009612 CA435511 BQ067832 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TSTA3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
    SP1:                                      -     -                 -     -                 -                             -                                   -   
    SP2:                                                              -     -                 -                                                                 -   
    SP3:                                            -                 -     -                 -                             -                                       
    SP4:                                                              -     -                 -                 -     -     -                                       
    SP5:                                      -     -                 -     -                 -                                                                     

    ExUns: 11 ^ 12 ^ 13a · 13b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for TSTA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSTA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGTCAC
    TSTA3 Expression
    About this image

    TSTA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSTA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.404119
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSTA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TSTA3 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsta31 , 5 tissue specific transplantation antigen P35B1, 5 88.16(n)1
    93.77(a)1
      15 (35.10 cM)5
    221221  NM_031201.11  NP_112478.11 
     759246845 
    chicken
    (Gallus gallus)
    Aves TSTA31 tissue specific transplantation antigen P35B 78.49(n)
    82.75(a)
      420292  NM_001277448.1  NP_001264377.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSTA36
    tissue specific transplantation antigen P35B
    83(a)
    1 ↔ 1
    GL343511.1(153731-179342)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984502 similar to tissue specific transplantation antigen more 77.08(n)    BC043886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187072 Transcribed sequence with moderate similarity to protein more 79.39(n)    BQ481263.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gmer1 , 3 GDP-L-fucose biosynthesis, de novo
    pathway GDP-4-dehydro-D-rhamnose
    more3
    GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase1
    60(a)3
    65.92(n)1
    60.58(a)1
      59B43
    376381  NM_137890.31  NP_611734.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R01H2.53
    ger-11
    ger-11 64(a)3
    60.04(n)1
    65.06(a)1
      III(7137313-7139190)3
    1875121  NM_066139.41  NP_498540.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GER11 GER1 46.89(n)
    36.33(a)
      843659  NM_105984.3  NP_177468.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g06524001 Os06g0652400 50.27(n)
    36.72(a)
      4341699  NM_001064770.1  NP_001058235.1 


    ENSEMBL Gene Tree for TSTA3 (if available)
    TreeFam Gene Tree for TSTA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TSTA3 (see all 271)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473682051,2
    C,Funtested1144696996(+) GGGAAG/AATACA 2 /I syn11Minor allele frequency- A:0.00NA 4542
    rs1929658991,2
    --144694338(+) AGCCAC/GAGAGA 1 -- ds50010--------
    rs593444961,2
    C,F--144694361(+) CCAGGG/AGAAGC 1 -- ds50012Minor allele frequency- A:0.07WA 120
    rs1455648231,2
    C--144694421(+) CTCGG-/CTGGCTCA
    CTAGACGTTT
    CTGGC
    1 -- ds50010--------
    rs794502331,2
    F--144694622(+) GCCCAC/TGTGTG 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs774480261,2
    C--144694649(+) CTCTGC/TGGCCT 1 -- ds50010--------
    rs1836099191,2
    --144694877(+) AAAGCA/GCCGGG 1 -- ut310--------
    rs29781,2
    C,F,A,H--144694890(-) GGTCCC/GGGGCA 1 -- ut31 ese313Minor allele frequency- G:0.37MN NS EA NA CSA 845
    rs1883049121,2
    C--144694947(+) TGCTTC/GGGGCT 1 -- ut310--------
    rs759002601,2
    C,F--144695004(+) GCTCCT/CGGCAG 1 -- ut311Minor allele frequency- C:0.06WA 118

    HapMap Linkage Disequilibrium report for TSTA3 (144694788 - 144700218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TSTA3 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1314e199CNV Deletion23128226
    dgv132n16CNV Deletion17901297
    nsv466004CNV Loss19166990
    dgv7932n71CNV Loss21882294
    nsv516210CNV Loss19592680
    dgv7936n71CNV Loss21882294
    nsv42CNV Loss15895083
    dgv7928n71CNV Loss21882294
    dgv7934n71CNV Loss21882294
    dgv59n50CNV Loss21212237

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSTA3
    DNA2.0 Custom Variant and Variant Library Synthesis for TSTA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 137020    OMIM disorders: --

    2 diseases for TSTA3:    
    About MalaCards
    mast cell neoplasm    leukocyte adhesion deficiency

    1 disease from the University of Copenhagen DISEASES database for TSTA3:
    Mast cell neoplasm

    Find genes that share disorders with TSTA3           About GenesLikeMe

    2 Novoseek inferred disease relationships for TSTA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 23.2 1 10777581 (1)
    tumors 22.3 1 10762016 (1)


    Export disorders for TSTA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSTA3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with TSTA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum-transplantation antigen P35B. (PubMed id 7803801)1, 2, 3, 9 Camardella L....De Flora A. (Blood 1995)
    2. Synthesis of GDP-L-fucose by the human FX protein. (PubMed id 8910301)1, 2, 9 Tonetti M.... De Flora A. (J. Biol. Chem. 1996)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. (PubMed id 1348494)1, 3 Dyson P.J....Boon T. (Immunogenetics 1992)
    7. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. (PubMed id 9525924)1, 9 Sullivan F.X.... Cumming D.A. (J. Biol. Chem. 1998)
    8. The crystal structure of human GDP-L-fucose synthase. (PubMed id 23774504)2 Zhou H.... He J. (Acta Biochim. Biophys. Sin. 2013)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7264 HGNC: 12390 AceView: TSTA3 Ensembl:ENSG00000104522 euGenes: HUgn7264
    ECgene: TSTA3 Kegg: 7264 H-InvDB: TSTA3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TSTA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TSTA3 gene:
    Search GeneIP for patents involving TSTA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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