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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSTA3 Gene

protein-coding   GIFtS: 59
GCID: GC08M144694

tissue specific transplantation antigen P35B

 Explore 8 diseases affiliated with
TSTA3 via our new
 Human Malady Compendium 
Biological research products
for TSTA3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tissue Specific Transplantation Antigen P35B1 2     3-5 Epimerase/4-Reductase2
SDR4E11 2 3     GDP-4-Keto-6-Deoxy-D-Mannose Epimerase-Reductase2
FX1 2     GDP-L-Fucose Synthase2
P35B1 2     Short Chain Dehydrogenase/Reductase Family 4E, Member 12
Red Cell NADP(H)-Binding Protein2 3     Tissue Specific Transplantation Antigen 32
GDP-4-Keto-6-Deoxy-D-Mannose-3,5-Epimerase-4-Reductase1     Protein FX3
EC 1.1.1.2713 8     Short-Chain Dehydrogenase/Reductase Family 4E Member 13

External Ids:    HGNC: 123901   Entrez Gene: 72642   Ensembl: ENSG000001045227   OMIM: 1370205   UniProtKB: Q136303   

Export aliases for TSTA3 gene to outside databases

Previous GC identifers: GC08M142739 GC08M144922 GC08M144469 GC08M144799 GC08M144765 GC08M139946


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSTA3:
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the
reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose
is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood
group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion
deficiency, type II. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FCL_HUMAN, Q13630
Function: Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase
and a reductase reaction

Gene Wiki entry for TSTA3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSTA3 gene promoter:
         MyoD   STAT5A   NF-kappaB   Nkx6-1   NF-kappaB2   COMP1   STAT3   NF-kappaB1   En-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSTA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSTA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSTA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

TSTA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSTA3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M144694:  view genomic region     (about GC identifiers)

Start:
144,694,788 bp from pter      End:
144,700,218 bp from pter
Size:
5,431 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FCL_HUMAN, Q13630 (See protein sequence)
Recommended Name: GDP-L-fucose synthase  
Size: 321 amino acids; 35893 Da
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for TSTA3:
4B8W (3D)        4B8Z (3D)    
Secondary accessions: B2R8Y7 D3DWK5 Q567Q9 Q9UDG7

Explore the universe of human proteins at neXtProt for TSTA3: NX_Q13630

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13630

  • 4 DME Specific Peptides for TSTA3 (Q13630)
     YPIDETM  KVVSCLSTCIFPDKT  PTHVIHLAAMVGGLF  YLPDFRFTPFKQAVKETC 

    TSTA3 Protein expression data from MOPED and PaxDb:    About this image 
    TSTA3 Protein Expression
    REFSEQ proteins: NP_003304.1  
    ENSEMBL proteins: 
     ENSP00000432088   ENSP00000435386   ENSP00000398803   ENSP00000431587   ENSP00000437012  
     ENSP00000436405   ENSP00000433331   ENSP00000435240  

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    ProSpec Recombinant Protein for TSTA3
    Uscn Proteins for TSTA3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IC11698403

    TSTA3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TSTA3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001509 Epimerase_deHydtase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q13630

    ProtoNet protein and cluster: Q13630

    1 Blocks protein family: IPB001509 NAD-dependent epimerase/dehydratase

    UniProtKB/Swiss-Prot: FCL_HUMAN, Q13630
    Similarity: Belongs to the fucose synthase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FCL_HUMAN, Q13630
    Function: Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase
    and a reductase reaction
    Catalytic activity: GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH

         Enzyme Number (IUBMB): EC 1.1.1.2711 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0009055electron carrier activity TAS8910301
    GO:0016853isomerase activity IEA--
    GO:0042356GDP-4-dehydro-D-rhamnose reductase activity TAS11698403
         
    TSTA3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSTA3:
     Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tsta3):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  reproductive system 

    TSTA3 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Tsta3tm1Jbl for TSTA3
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TSTA3 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GDP-L-fucose biosynthesis I (from GDP-D-mannose)
    GDP-L-fucose biosynthesis I (from GDP-D-mannose)1.00
    2Amino sugar and nucleotide sugar metabolism
    Amino sugar and nucleotide sugar metabolism1.00
    3Fructose and mannose metabolism
    Fructose and mannose metabolism1.00
    4Metabolism
    Metabolic pathways0.38
    5GDP-mannose biosynthesis
    colanic acid building blocks biosynthesis0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for TSTA3 
        colanic acid building blocks biosynthesis
    GDP-L-fucose biosynthesis I (from GDP-D-mannose)


    3         Kegg Pathways  (Kegg details for TSTA3):
        Fructose and mannose metabolism
    Amino sugar and nucleotide sugar metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: FCL_HUMAN, Q13630
    Pathway: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from
    GDP-alpha-D-mannose: step 2/2


    TSTA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSTA3

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007159leukocyte cell-cell adhesion NAS11698403
    GO:0019673GDP-mannose metabolic process IDA9525924
    GO:0019835cytolysis IEA--
    GO:0042351'de novo' GDP-L-fucose biosynthetic process TAS11698403
    GO:0044237cellular metabolic process ----

    TSTA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TSTA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TSTA3

    5 HMDB Compounds for TSTA3    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-4-Dehydro-6-deoxy-D-mannoseGDP-4-dehydro-6-deoxy-D-mannose (see all 9)18186-48-6--
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--

    1 DrugBank Compound for TSTA3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    2 Novoseek chemical compound relationships for TSTA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdpmannose 88 5 10410995 (2), 9603974 (1), 9525924 (1)
    polysaccharide 30.9 1 10777581 (1)

    Search CenterWatch for drugs/clinical trials and news about TSTA3 / FCL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSTA3 gene: 
    NM_003313.3  

    Unigene Cluster for TSTA3:

    Tissue specific transplantation antigen P35B
    Hs.404119  [show with all ESTs]
    Unigene Representative Sequence: NM_003313
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524719 ENST00000528920 ENST00000529064(uc003yza.2) ENST00000531473
    ENST00000425753(uc003yzb.2) ENST00000527677 ENST00000529048 ENST00000532308
    ENST00000533817 ENST00000530474 ENST00000525274 ENST00000527549(uc011lko.1)
    ENST00000526290 ENST00000527006 ENST00000529899 ENST00000531006

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    hsa-miR-125a-5p hsa-miR-544b hsa-miR-670 hsa-miR-125b hsa-miR-3647-3p hsa-miR-1224-5p hsa-miR-4319
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    Additional cDNA sequence: 

    AK303125.1 AK313560.1 BC001941.1 BC093061.1 U58766.1 

    16 DOTS entries:

    DT.100815155  DT.100815159  DT.95371933  DT.100815157  DT.100815156  DT.100815160  DT.121492444  DT.95371926 
    DT.100044616  DT.102836313  DT.121492423  DT.121492429  DT.316195  DT.95371874  DT.95371895  DT.97790931 

    24/351 AceView cDNA sequences (see all 351):

    BQ959713 BM694890 BI823794 T30220 BC001941 CF528158 BQ447366 CR615707 
    CR594900 CA423846 BQ957529 BU682713 BU741614 BM819793 BQ921484 BQ690350 
    BQ689180 BQ217661 AW247296 BQ067832 BM915330 CA435511 BQ009612 AA377941 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TSTA3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
    SP1:                                      -     -                 -     -                 -                             -                                   -   
    SP2:                                                              -     -                 -                                                                 -   
    SP3:                                            -                 -     -                 -                             -                                       
    SP4:                                                              -     -                 -                 -     -     -                                       
    SP5:                                      -     -                 -     -                 -                                                                     

    ExUns: 11 ^ 12 ^ 13a · 13b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for TSTA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSTA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGAAGTCAC
    TSTA3 Expression
    About this image
    See TSTA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSTA3

    SOURCE GeneReport for Unigene cluster: Hs.404119
        SABiosciences Custom PCR Arrays for TSTA3

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for TSTA3 gene from 10/32 species (see all 32)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsta31 , 5 tissue specific transplantation antigen P35B1, 5 88.16(n)1
    93.77(a)1
      15 (35.10 cM)5
    221221  NM_031201.11  NP_112478.11 
     759246845 
    chicken
    (Gallus gallus)
    Aves TSTA31 tissue specific transplantation antigen P35B 78.49(n)
    82.75(a)
      420292  XM_418405.3  XP_418405.3 
    lizard
    (Anolis carolinensis)
    Reptilia TSTA36
    --
    82(a)
    1 ↔ 1
    GL343511.1(154902-179279)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984502 similar to tissue specific transplantation antigen more 77.08(n)    BC043886.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187072 Transcribed sequence with moderate similarity to protein more 79.39(n)    BQ481263.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gmer1 , 3 GDP-L-fucose biosynthesis, de novo pathway
    GDP-4-dehydro-D-rhamnose more3
    GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase1
    60(a)3
    65.92(n)1
    60.58(a)1
      59B43
    376381  NM_137890.21  NP_611734.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R01H2.53
    ger-11
    Protein GER-11 64(a)3
    60.04(n)1
    65.06(a)1
      III(7137313-7139190)3
    1875121  NM_066139.31  NP_498540.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GER11 GDP-L-fucose synthase 46.89(n)
    36.33(a)
      843659  NM_105984.3  NP_177468.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g06524001 hypothetical protein 50.27(n)
    36.72(a)
      4341699  NM_001064770.1  NP_001058235.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria fcl6
    bifunctional GDP-fucose synthetase: GDP-4-dehydro-...
    28(a)
    1 ↔ 1
    Chromosome(2124249-2125214)


    ENSEMBL Gene Tree for TSTA3 (if available)
    TreeFam Gene Tree for TSTA3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/165 NCBI SNPs in TSTA3 are shown (see all 165    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929658991,2
    --144694338(+) AGCCAC/GAGAGA 1 -- ds50010--------
    rs593444961,2
    C--144694361(+) CCAGGG/AGAAGC 1 -- ds50012Minor allele frequency- A:0.07WA 120
    rs1455648231,2
    --144694421(+) CTCGG-/CTGGCTCA
    CTAGACGTTT
    CTGGC
    1 -- ds50010--------
    rs794502331,2
    F--144694622(+) GCCCAC/TGTGTG 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs774480261,2
    --144694649(+) CTCTGC/TGGCCT 1 -- ds50010--------
    rs1836099191,2
    --144694877(+) AAAGCA/GCCGGG 1 -- ut310--------
    rs29781,2
    C,F,A,H--144694890(-) GGTCCC/GGGGCA 1 -- ut31 ese313Minor allele frequency- G:0.37MN NS EA NA CSA 845
    rs1883049121,2
    --144694947(+) TGCTTC/GGGGCT 1 -- ut310--------
    rs759002601,2
    C,F--144695004(+) GCTCCT/CGGCAG 1 -- ut311Minor allele frequency- C:0.06WA 118
    rs119872091,2
    C,F,H--144695053(+) GGTCCG/ACTGGC 1 -- ut31 ese314Minor allele frequency- A:0.10NS EA NA WA EU 1741

    HapMap Linkage Disequilibrium report for TSTA3 (144694788 - 144700218 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for TSTA3
         7 CNVs: 4612 22871 36778 0648 30297 36777 52422

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSTA3
    DNA2.0 Custom Variant and Variant Library Synthesis for TSTA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TSTA3 for disorders           About GeneDecksing

    OMIM gene information: 137020    OMIM disorders: --

    8 diseases for TSTA3:    About MalaCards
    mast cell neoplasm    intrahepatic cholangiocarcinoma    cholangiocarcinoma    hepatocellular carcinoma
    carcinoma    tuberculosis    malaria    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for TSTA3:
    Mast cell neoplasm

    2 Novoseek disease relationships for TSTA3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 23.2 1 10777581 (1)
    tumors 22.3 1 10762016 (1)


    Export disorders for TSTA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSTA3 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with TSTA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum-transplantation antigen P35B. (PubMed id 7803801)1, 2, 3, 9 Camardella L....De Flora A. (1995)
    2. Synthesis of GDP-L-fucose by the human FX protein. (PubMed id 8910301)1, 2, 9 Tonetti M.... De Flora A. (1996)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198. (PubMed id 1348494)1, 3 Dyson P.J....Boon T. (1992)
    7. Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. (PubMed id 9525924)1, 9 Sullivan F.X.... Cumming D.A. (1998)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Tissue-specific transplantation antigen P35B (TSTA3) i mmune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by bioco mputation. (PubMed id 22528125)1 Wang L....Lin H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7264 HGNC: 12390 AceView: TSTA3 Ensembl:ENSG00000104522 euGenes: HUgn7264
    ECgene: TSTA3 Kegg: 7264 H-InvDB: TSTA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSTA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSTA3 gene:
    Search GeneIP for patents involving TSTA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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