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TST Gene

protein-coding   GIFtS: 69
GCID: GC22M037408

Thiosulfate Sulfurtransferase (Rhodanese)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thiosulfate Sulfurtransferase (Rhodanese)1 2
EC 2.8.1.13 8
RDS2 5
Thiosulfate Sulfurtransferase2
Rhodanese3
EC 2.8.18

External Ids:    HGNC: 123881   Entrez Gene: 72632   Ensembl: ENSG000001283117   OMIM: 1803705   UniProtKB: Q167623   

Export aliases for TST gene to outside databases

Previous GC identifers: GC22M034021 GC22M035649 GC22M035731 GC22M020372


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TST Gene:
This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The
encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to
thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into
the mitochondria. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2012)

GeneCards Summary for TST Gene:
TST (thiosulfate sulfurtransferase (rhodanese)) is a protein-coding gene. Diseases associated with TST include staphyloenterotoxemia, and mastitis. GO annotations related to this gene include 5S rRNA binding and thiosulfate sulfurtransferase activity. An important paralog of this gene is MPST.

UniProtKB/Swiss-Prot: THTR_HUMAN, Q16762
Function: Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes.
Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate
sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for
the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA

Gene Wiki entry for TST Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TST gene promoter:
         RFX1   USF1   AML1a   HNF-4alpha2   HNF-4alpha1   POU2F1   POU2F1a   USF-1   ZID   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTST promoter sequence
   Search Chromatin IP Primers for TST

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

TST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TST gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037408:  view genomic region     (about GC identifiers)

Start:
37,406,900 bp from pter      End:
37,415,681 bp from pter
Size:
8,782 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: THTR_HUMAN, Q16762 (See protein sequence)
Recommended Name: Thiosulfate sulfurtransferase  
Size: 297 amino acids; 33429 Da
Subunit: Monomer
Secondary accessions: B3KRM1 Q6IB06

Explore the universe of human proteins at neXtProt for TST: NX_Q16762

Explore proteomics data for TST at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TST (Q16762) (see all 5)
     THVVVYDG  APRVWWMFR  SKRFQLVDSR  SPYEMMLPSEA 


    See TST Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257412.1  NP_003303.2  

    ENSEMBL proteins: 
     ENSP00000385828   ENSP00000249042   ENSP00000400764  
    Reactome Protein details: Q16762

    TST Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for TST


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001763 Rhodanese-like_dom
     IPR001307 Thiosulphate_STrfase_CS

    Graphical View of Domain Structure for InterPro Entry Q16762

    ProtoNet protein and cluster: Q16762

    2 Blocks protein domains:
    IPB001307 Thiosulfate sulfurtransferase
    IPB001763 Rhodanese-like


    UniProtKB/Swiss-Prot: THTR_HUMAN, Q16762
    Domain: Contains two rhodanese domains with different primary structures but with near identical secondary
    structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains
    the catalytic cysteine residue (By similarity)
    Similarity: Contains 2 rhodanese domains


    TST for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THTR_HUMAN, Q16762
    Function: Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes.
    Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate
    sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for
    the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA
    Catalytic activity: Thiosulfate + cyanide = sulfite + thiocyanate

         Genatlas biochemistry entry for TST:
    thiosulfate

         Enzyme Numbers (IUBMB): EC 2.8.1.11 2 EC 2.8.12

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004792thiosulfate sulfurtransferase activity IEA--
    GO:00080975S rRNA binding IDA--
         
    TST for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TST:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TST
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TST
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TST

    miRNA
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    miRTarBase miRNAs that target TST:
    hsa-let-7d-5p (MIRT032127), hsa-let-7b-5p (MIRT032251), hsa-mir-548b-3p (MIRT016237)

    Block miRNA regulation of human, mouse, rat TST using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TST:
    hsa-miR-199a-5p hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidTST 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TST

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TST (NM_003312)
    Sino Biological Human cDNA Clone for TST
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TST

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TST


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THTR_HUMAN, Q16762: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane4
    cytosol3
    chloroplast1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix TAS--
    GO:0005886plasma membrane ----

    TST for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TST About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sulfur amino acid metabolism
    Sulfur amino acid metabolism0.35
    Degradation of cysteine and homocysteine0.00
    Cysteine and methionine metabolism0.35
    Sulfide oxidation to sulfate0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Sulfur relay system
    Sulfur relay system
    4Sulfur metabolism
    Sulfur metabolism
    5Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TST
        Sulfide oxidation to sulfate


    4 Kegg Pathways  (Kegg details for TST):
        Cysteine and methionine metabolism
    Sulfur metabolism
    Metabolic pathways
    Sulfur relay system


    TST for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TST: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for TST (Q167622, 3 ENSP000002490424) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MT-ND1P038863, ENSP000003546874I2D: score=1 STRING: ENSP00000354687
    PRSS1P074773, ENSP000003087204I2D: score=1 STRING: ENSP00000308720
    CTHENSP000003599764STRING: ENSP00000359976
    ETHE1ENSP000002921474STRING: ENSP00000292147
    GOT1ENSP000003595394STRING: ENSP00000359539
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0000098sulfur amino acid catabolic process TAS--
    GO:0009440cyanate catabolic process TAS9070219
    GO:0030855epithelial cell differentiation IDA--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    TST for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TST (THTR)

    5 HMDB Compounds for TST    About this table
    CompoundSynonyms CAS #PubMed Ids
    CyanideCarbon nitride ion (see all 9)57-12-5--
    IronArmco iron (see all 19)7439-89-6--
    SulfiteSulfite ion (see all 10)14265-45-3--
    ThiocyanateAmmonium rhodanate (see all 15)302-04-5--
    ThiosulfateHyposulfite (see all 14)14383-50-7--

    1 DrugBank Compound for TST    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-Mercaptocysteine-- 5652-32-4target--10592235

    3 Novoseek inferred chemical compound relationships for TST gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thiosulfate 91 22 1483467 (6), 16790311 (2), 19695240 (2), 8404072 (1) (see all 10)
    2-mercaptoethanol 56.4 1 1483467 (1)
    cyanide 51.8 3 16790311 (2)



    TST for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TST gene (2 alternative transcripts): 
    NM_001270483.1  NM_003312.5  

    Unigene Cluster for TST:

    Thiosulfate sulfurtransferase (rhodanese)
    Hs.474783  [show with all ESTs]
    Unigene Representative Sequence: AK091874
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403892(uc003aqg.3) ENST00000249042(uc003aqh.3) ENST00000438203

    miRNA
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    Block miRNA regulation of human, mouse, rat TST using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TST:
    hsa-miR-199a-5p hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidTST 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TST (NM_003312)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TST
      QuantiTect SYBR Green Assays in human, mouse, rat TST
      QuantiFast Probe-based Assays in human, mouse, rat TST

    Additional mRNA sequence: 

    AK000862.1 AK091874.1 AK223521.1 AK301300.1 BC010148.2 CR456598.1 CR456998.1 D87292.1 

    7 DOTS entries:

    DT.314036  DT.100680843  DT.100703517  DT.92422301  DT.100648802  DT.100798154  DT.120664564 

    Selected AceView cDNA sequences (see all 201):

    AK091874 BM714519 BM740333 BM766744 CB250636 CB241700 BM765179 CB528543 
    BM764615 BM839651 CD616837 BM757266 BM920277 CN484786 CR594857 CB128463 
    BI523933 CD616838 BX398906 BU732819 CB529701 BM740766 BX280585 AK000862 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TST    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for TST

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TST expression in normal human tissues (normalized intensities)      TST embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTAGAAT
    TST Expression
    About this image


    TST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    TST Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TST Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474783
        Pathway & Disease-focused RT2 Profiler PCR Array including TST: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TST
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TST gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tst1 , 5 thiosulfate sulfurtransferase, mitochondrial1, 5 85.75(n)1
    90.91(a)1
      15 (37.47 cM)5
    221171  NM_009437.41  NP_033463.11 
     783995565 
    chicken
    (Gallus gallus)
    Aves TST1 thiosulfate sulfurtransferase (rhodanese) 72.7(n)
    72.01(a)
      418049  NM_001167731.1  NP_001161203.1 
    lizard
    (Anolis carolinensis)
    Reptilia TST6
    thiosulfate sulfurtransferase (rhodanese)
    76(a)
    1 ↔ 1
    5(22665627-22676373)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004928581 thiosulfate sulfurtransferase-like 65.72(n)
    61.92(a)
      100492858  XM_002942118.2  XP_002942164.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa96h112 Transcribed sequence with weak similarity to protein more 72.61(n)    57058139 
    worm
    (Caenorhabditis elegans)
    Secernentea mpst-71 mpst-7 45.53(n)
    37.07(a)
      187919  NM_073841.2  NP_506242.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUM16
    Rhodanese domain sulfur transferase, accepts persu...
    23(a)
    1 → many
    XV(802550-803464) YOR251C


    ENSEMBL Gene Tree for TST (if available)
    TreeFam Gene Tree for TST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TST gene
    MPST2  
    1 SIMAP similar gene for TST using alignment to 2 protein entries:     THTR_HUMAN (see all proteins):
    MPST

    TST for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TST (see all 276)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57503661,2
    C,F,A,H--21323430(+) CACCTG/TCCAGA 2 -- ds500131Minor allele frequency- T:0.47NS EA NA WA CSA 2912
    rs1883875631,2
    --21323637(+) CCCTCC/TGCCCC 2 -- ds50010--------
    rs1817340291,2
    --21323665(+) CTACAA/GCAGCT 2 -- ds50010--------
    rs798398761,2
    C,F--21323807(+) GTGTCC/TTCGGT 2 -- ds50011Minor allele frequency- T:0.07WA 118
    rs560111911,2
    C,F--21323884(+) AGATGG/AAAGTT 2 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1436654351,2
    C--21323919(+) AGAGGC/TAGGCA 2 -- ds50010--------
    rs1123076861,2
    C--21323934(+) CACTAC/G/TTCAGA 4 -- ut311CSA 1
    rs1457170211,2
    C--21324049(+) GTCATC/GGGGTC 2 -- ut310--------
    rs1871678001,2
    C--21324063(+) AAACCA/GGCCGC 2 -- ut310--------
    rs10492801,2
    C,F--21324093(-) GAGCCG/ATGACC 2 -- ut31 ese36Minor allele frequency- A:0.03MN NA CSA EU 1614

    HapMap Linkage Disequilibrium report for TST (37406900 - 37415681 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TST:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661268CNV Deletion23128226
    nsv3622CNV Insertion18451855
    esv34015CNV Loss18971310
    dgv4960n71CNV Loss21882294
    nsv829203CNV Loss20364138
    nsv834187CNV Loss17160897
    nsv459882CNV Gain19166990

    Human Gene Mutation Database (HGMD): TST
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TST
    DNA2.0 Custom Variant and Variant Library Synthesis for TST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180370    OMIM disorders: --

    11 diseases for TST:    About MalaCards
    staphyloenterotoxemia    mastitis    toxic shock syndrome    optic atrophy
    peritonitis    myopathy    tuberculosis    crohn's disease
    cerebritis    adenocarcinoma    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for TST:
    Optic atrophy

    TST for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TST gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 16500920 (1)

    Genetic Association Database (GAD): TST
    Human Genome Epidemiology (HuGE) Navigator: TST (7 documents)

    Export disorders for TST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TST gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with TST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18. (PubMed id 21685364)1, 2 Smirnov A.... Tarassov I. (Genes Dev. 2011)
    2. Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria. (PubMed id 20663881)1, 2 Smirnov A.... Tarassov I. (J. Biol. Chem. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    9. Cloning and expression of human liver rhodanese cDNA. (PubMed id 9070219)1, 2 Aita N.... Tanabe S. (Biochem. Biophys. Res. Commun. 1997)
    10. Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. (PubMed id 16500920)1, 9 Ramasamy S....Eggo M.C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7263 HGNC: 12388 AceView: TST Ensembl:ENSG00000128311 euGenes: HUgn7263
    ECgene: TST Kegg: 7263 H-InvDB: TST

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TST Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TST gene:
    Search GeneIP for patents involving TST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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