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Aliases for TST Gene

Aliases for TST Gene

  • Thiosulfate Sulfurtransferase 2 3
  • Thiosulfate Sulfurtransferase (Rhodanese) 2 3 5
  • EC 2.8.1.1 4 63
  • Rhodanese 2 4
  • EC 2.8.1 63
  • RDS 3

External Ids for TST Gene

Previous GeneCards Identifiers for TST Gene

  • GC22M034021
  • GC22M035649
  • GC22M035731
  • GC22M037408
  • GC22M020372

Summaries for TST Gene

Entrez Gene Summary for TST Gene

  • This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for TST Gene

TST (Thiosulfate Sulfurtransferase) is a Protein Coding gene. Diseases associated with TST include Commensal Bacterial Infectious Disease and Staphyloenterotoxemia. Among its related pathways are Sulfur metabolism and Metabolism. GO annotations related to this gene include thiosulfate sulfurtransferase activity and 5S rRNA binding. An important paralog of this gene is MPST.

UniProtKB/Swiss-Prot for TST Gene

  • Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.

Gene Wiki entry for TST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TST Gene

Genomics for TST Gene

Regulatory Elements for TST Gene

Enhancers for TST Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TST on UCSC Golden Path with GeneCards custom track

Promoters for TST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TST on UCSC Golden Path with GeneCards custom track

Genomic Location for TST Gene

Chromosome:
22
Start:
37,010,859 bp from pter
End:
37,020,183 bp from pter
Size:
9,325 bases
Orientation:
Minus strand

Genomic View for TST Gene

Genes around TST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TST Gene

Proteins for TST Gene

  • Protein details for TST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16762-THTR_HUMAN
    Recommended name:
    Thiosulfate sulfurtransferase
    Protein Accession:
    Q16762
    Secondary Accessions:
    • B3KRM1
    • Q6IB06

    Protein attributes for TST Gene

    Size:
    297 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for TST Gene

Proteomics data for TST Gene at MOPED

Selected DME Specific Peptides for TST Gene

Post-translational modifications for TST Gene

Other Protein References for TST Gene

Domains & Families for TST Gene

Protein Domains for TST Gene

Suggested Antigen Peptide Sequences for TST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16762

UniProtKB/Swiss-Prot:

THTR_HUMAN :
  • Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
Domain:
  • Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
  • Contains 2 rhodanese domains.
genes like me logo Genes that share domains with TST: view

No data available for Gene Families for TST Gene

Function for TST Gene

Molecular function for TST Gene

GENATLAS Biochemistry:
thiosulfate
UniProtKB/Swiss-Prot CatalyticActivity:
Thiosulfate + cyanide = sulfite + thiocyanate.
UniProtKB/Swiss-Prot Function:
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.

Enzyme Numbers (IUBMB) for TST Gene

genes like me logo Genes that share phenotypes with TST: view

Animal Model Products

miRNA for TST Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TST Gene

Localization for TST Gene

Subcellular locations from UniProtKB/Swiss-Prot for TST Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TST Gene COMPARTMENTS Subcellular localization image for TST gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 3
chloroplast 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TST Gene

Pathways & Interactions for TST Gene

genes like me logo Genes that share pathways with TST: view

Gene Ontology (GO) - Biological Process for TST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0030855 epithelial cell differentiation IDA 21492153
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase TAS --
genes like me logo Genes that share ontologies with TST: view

No data available for SIGNOR curated interactions for TST Gene

Drugs & Compounds for TST Gene

(10) Drugs for TST Gene - From: DrugBank, ClinicalTrials, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoniazid Approved Pharma 144
Zaleplon Approved, Illicit, Investigational Pharma Full agonist, Allosteric regulator 15
Pyruvic acid Approved Nutra 0
S-Mercaptocysteine Experimental Pharma Target 0
Anticonvulsants Pharma 2521

(9) Additional Compounds for TST Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cyanide
  • Carbon nitride ion
  • Chuck Norrisium
  • Cyanide
  • Cyanide ion
  • Cyanide(1-) ion
57-12-5
thiosulfate
  • Hyposulfite
  • S-Hydril
  • Sodium hyposulfite
  • Sodium oxide sulfide (Na2S2O3)
  • Sodium thiosulfate
14383-50-7
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
2464-23-5
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Hydrogen cyanide
genes like me logo Genes that share compounds with TST: view

Transcripts for TST Gene

Unigene Clusters for TST Gene

Thiosulfate sulfurtransferase (rhodanese):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TST Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for TST Gene

GeneLoc Exon Structure for
TST
ECgene alternative splicing isoforms for
TST

Expression for TST Gene

mRNA expression in normal human tissues for TST Gene

mRNA differential expression in normal tissues according to GTEx for TST Gene

This gene is overexpressed in Liver (x10.0) and Colon - Transverse (x5.9).

Protein differential expression in normal tissues from HIPED for TST Gene

This gene is overexpressed in Liver, secretome (12.3) and Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TST Gene



SOURCE GeneReport for Unigene cluster for TST Gene Hs.474783

genes like me logo Genes that share expression patterns with TST: view

Protein tissue co-expression partners for TST Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TST Gene

Orthologs for TST Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TST Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TST 35
  • 88.89 (n)
  • 89.56 (a)
TST 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TST 35
  • 90.01 (n)
  • 91.58 (a)
TST 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tst 35
  • 85.75 (n)
  • 90.91 (a)
Tst 16
Tst 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TST 35
  • 99.21 (n)
  • 99.33 (a)
TST 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tst 35
  • 85.97 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia TST 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TST 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TST 35
  • 72.7 (n)
  • 72.01 (a)
TST 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TST 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492858 35
  • 65.72 (n)
  • 61.92 (a)
zebrafish
(Danio rerio)
Actinopterygii wufa96h11 35
MPST 36
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mpst-7 35
  • 45.53 (n)
  • 37.07 (a)
mpst-1 36
  • 23 (a)
ManyToMany
mpst-2 36
  • 22 (a)
ManyToMany
mpst-3 36
  • 21 (a)
ManyToMany
mpst-4 36
  • 26 (a)
ManyToMany
mpst-5 36
  • 27 (a)
ManyToMany
mpst-6 36
  • 27 (a)
ManyToMany
mpst-7 36
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUM1 36
  • 23 (a)
OneToMany
Species with no ortholog for TST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TST Gene

ENSEMBL:
Gene Tree for TST (if available)
TreeFam:
Gene Tree for TST (if available)

Paralogs for TST Gene

Paralogs for TST Gene

(1) SIMAP similar genes for TST Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TST: view

Variants for TST Gene

Sequence variations from dbSNP and Humsavar for TST Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_051799 -
rs1049270 - 37,011,238(-) AGAAG(A/G)GCTCC reference, missense
rs4764 -- 37,011,153(-) TGCCA(C/T)GTGGC reference, synonymous-codon
rs16363 -- 37,013,844(+) AATCC(-/TGTTT)TGTTT intron-variant
rs130598 -- 37,012,094(+) CACTG(C/T)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TST Gene

Variant ID Type Subtype PubMed ID
nsv834187 CNV Loss 17160897
esv34015 CNV Loss 18971310
nsv459882 CNV Gain 19166990
nsv829203 CNV Loss 20364138
dgv4960n71 CNV Loss 21882294
nsv3622 CNV Insertion 18451855
esv2661268 CNV Deletion 23128226

Variation tolerance for TST Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TST Gene

Human Gene Mutation Database (HGMD)
TST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TST Gene

Disorders for TST Gene

MalaCards: The human disease database

(4) MalaCards diseases for TST Gene - From: DISEASES

Disorder Aliases PubMed IDs
commensal bacterial infectious disease
staphyloenterotoxemia
  • staphylococcal food poisoning
ritter's disease
  • dermatitis exfoliativa neonatorum
necrotizing fasciitis
  • fasciitis, necrotizing
- elite association - COSMIC cancer census association via MalaCards
Search TST in MalaCards View complete list of genes associated with diseases

Relevant External Links for TST

Genetic Association Database (GAD)
TST
Human Genome Epidemiology (HuGE) Navigator
TST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TST
genes like me logo Genes that share disorders with TST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TST Gene

Publications for TST Gene

  1. Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18. (PMID: 21685364) Smirnov A. … Tarassov I. (Genes Dev. 2011) 3 4 67
  2. Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients. (PMID: 19695240) Krueger K. … Scholze A. (Clin. Biochem. 2010) 3 23
  3. Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. (PMID: 16500920) Ramasamy S. … Eggo M.C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006) 3 23
  4. Evidence for a functional genetic polymorphism of the human thiosulfate sulfurtransferase (Rhodanese), a cyanide and H2S detoxification enzyme. (PMID: 16790311) Billaut-Laden I. … Broly F. (Toxicology 2006) 3 23
  5. Chromosome assignment of human brain expressed sequence tags (ESTs) by analyzing fluorescently labeled PCR products from hybrid cell panels. (PMID: 8404072) Durkin A.S. … Maglott D.R. (Cytogenet. Cell Genet. 1994) 3 23

Products for TST Gene

Sources for TST Gene

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