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Aliases for TST Gene

Aliases for TST Gene

  • Thiosulfate Sulfurtransferase (Rhodanese) 2 3
  • EC 2.8.1.1 4 63
  • RDS 3 6
  • Thiosulfate Sulfurtransferase 3
  • Rhodanese 4
  • EC 2.8.1 63

External Ids for TST Gene

Previous GeneCards Identifiers for TST Gene

  • GC22M034021
  • GC22M035649
  • GC22M035731
  • GC22M037408
  • GC22M020372

Summaries for TST Gene

Entrez Gene Summary for TST Gene

  • This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for TST Gene

TST (Thiosulfate Sulfurtransferase (Rhodanese)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include thiosulfate sulfurtransferase activity and 5S rRNA binding.

UniProtKB/Swiss-Prot for TST Gene

  • Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.

Gene Wiki entry for TST Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TST Gene

Genomics for TST Gene

Regulatory Elements for TST Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TST Gene

Start:
37,010,859 bp from pter
End:
37,020,183 bp from pter
Size:
9,325 bases
Orientation:
Minus strand

Genomic View for TST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TST Gene

Proteins for TST Gene

  • Protein details for TST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16762-THTR_HUMAN
    Recommended name:
    Thiosulfate sulfurtransferase
    Protein Accession:
    Q16762
    Secondary Accessions:
    • B3KRM1
    • Q6IB06

    Protein attributes for TST Gene

    Size:
    297 amino acids
    Molecular mass:
    33429 Da
    Quaternary structure:
    • Monomer

neXtProt entry for TST Gene

Proteomics data for TST Gene at MOPED

Selected DME Specific Peptides for TST Gene

Post-translational modifications for TST Gene

  • Ubiquitination at Lys14
  • Modification sites at PhosphoSitePlus

Other Protein References for TST Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for TST Gene

Protein Domains for TST Gene

Suggested Antigen Peptide Sequences for TST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16762

UniProtKB/Swiss-Prot:

THTR_HUMAN :
  • Q16762
Domain:
  • Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
  • Contains 2 rhodanese domains.
genes like me logo Genes that share domains with TST: view

No data available for Gene Families for TST Gene

Function for TST Gene

Molecular function for TST Gene

GENATLAS Biochemistry:
thiosulfate
UniProtKB/Swiss-Prot CatalyticActivity:
Thiosulfate + cyanide = sulfite + thiocyanate
UniProtKB/Swiss-Prot Function:
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.

Enzyme Numbers (IUBMB) for TST Gene

Gene Ontology (GO) - Molecular Function for TST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004792 thiosulfate sulfurtransferase activity IEA --
GO:0008097 5S rRNA binding IDA 20663881
genes like me logo Genes that share ontologies with TST: view

Phenotypes for TST Gene

GenomeRNAi human phenotypes for TST:
genes like me logo Genes that share phenotypes with TST: view

Animal Model Products

miRNA for TST Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TST

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TST Gene

Localization for TST Gene

Subcellular locations from UniProtKB/Swiss-Prot for TST Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TST Gene COMPARTMENTS Subcellular localization image for TST gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
cytosol 3
chloroplast 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TST: view

Pathways for TST Gene

genes like me logo Genes that share pathways with TST: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0000098 sulfur amino acid catabolic process TAS --
GO:0008152 metabolic process --
GO:0009440 cyanate catabolic process TAS 9070219
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with TST: view

Compounds for TST Gene

(5) HMDB Compounds for TST Gene

Compound Synonyms Cas Number PubMed IDs
Cyanide
  • Carbon nitride ion
57-12-5
Iron
  • Armco iron
7439-89-6
Sulfite
  • Sulfite ion
14265-45-3
Thiocyanate
  • Ammonium rhodanate
302-04-5
Thiosulfate
  • Hyposulfite
14383-50-7

(1) Drugbank Compounds for TST Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-Mercaptocysteine
5652-32-4 target

(3) Novoseek inferred chemical compound relationships for TST Gene

Compound -log(P) Hits PubMed IDs
thiosulfate 91 17
2-mercaptoethanol 56.4 1
cyanide 51.8 2
genes like me logo Genes that share compounds with TST: view

Transcripts for TST Gene

Unigene Clusters for TST Gene

Thiosulfate sulfurtransferase (rhodanese):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TST

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TST Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for TST Gene

GeneLoc Exon Structure for
TST
ECgene alternative splicing isoforms for
TST

Expression for TST Gene

mRNA expression in normal human tissues for TST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TST Gene

This gene is overexpressed in Liver (10.0) and Colon - Transverse (5.9).

Protein differential expression in normal tissues for TST Gene

This gene is overexpressed in Liver, secretome (12.3) and Liver (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TST Gene

SOURCE GeneReport for Unigene cluster for TST Gene Hs.474783

genes like me logo Genes that share expressions with TST: view

Expression partners for TST Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TST Gene

Orthologs for TST Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TST Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TST 35
  • 88.89 (n)
  • 89.56 (a)
TST 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TST 35
  • 90.01 (n)
  • 91.58 (a)
TST 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tst 35
  • 85.75 (n)
  • 90.91 (a)
Tst 16
Tst 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TST 35
  • 99.21 (n)
  • 99.33 (a)
TST 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tst 35
  • 85.97 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia TST 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TST 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TST 35
  • 72.7 (n)
  • 72.01 (a)
TST 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TST 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492858 35
  • 65.72 (n)
  • 61.92 (a)
zebrafish
(Danio rerio)
Actinopterygii wufa96h11 35
MPST 36
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mpst-7 35
  • 45.53 (n)
  • 37.07 (a)
mpst-1 36
  • 23 (a)
ManyToMany
mpst-2 36
  • 22 (a)
ManyToMany
mpst-3 36
  • 21 (a)
ManyToMany
mpst-4 36
  • 26 (a)
ManyToMany
mpst-5 36
  • 27 (a)
ManyToMany
mpst-6 36
  • 27 (a)
ManyToMany
mpst-7 36
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUM1 36
  • 23 (a)
OneToMany
Species with no ortholog for TST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TST Gene

ENSEMBL:
Gene Tree for TST (if available)
TreeFam:
Gene Tree for TST (if available)

Paralogs for TST Gene

Selected SIMAP similar genes for TST Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TST: view

No data available for Paralogs for TST Gene

Variants for TST Gene

Sequence variations from dbSNP and Humsavar for TST Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4764 -- 37,011,153(-) TGCCA(C/T)GTGGC reference, synonymous-codon
rs16363 -- 37,013,844(+) AATCC(-/TGTTT)TGTTT intron-variant
rs130598 -- 37,012,094(+) CACTG(C/T)GTATT intron-variant
rs130599 -- 37,012,678(+) AGGCA(C/T)ATACT intron-variant
rs130600 -- 37,013,057(+) AAAAA(-/A)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TST Gene

Variant ID Type Subtype PubMed ID
nsv834187 CNV Loss 17160897
esv34015 CNV Loss 18971310
nsv459882 CNV Gain 19166990
nsv829203 CNV Loss 20364138
dgv4960n71 CNV Loss 21882294
nsv3622 CNV Insertion 18451855
esv2661268 CNV Deletion 23128226

Relevant External Links for TST Gene

HapMap Linkage Disequilibrium report
TST
Human Gene Mutation Database (HGMD)
TST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TST Gene

Disorders for TST Gene

(1) University of Copenhagen DISEASES for TST Gene

(1) Novoseek inferred disease relationships for TST Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for TST

Genetic Association Database (GAD)
TST
Human Genome Epidemiology (HuGE) Navigator
TST
genes like me logo Genes that share disorders with TST: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for TST Gene

Publications for TST Gene

  1. Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients. (PMID: 19695240) Krueger K. … Scholze A. (Clin. Biochem. 2010) 3 23
  2. Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. (PMID: 16500920) Ramasamy S. … Eggo M.C. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006) 3 23
  3. Evidence for a functional genetic polymorphism of the human thiosulfate sulfurtransferase (Rhodanese), a cyanide and H2S detoxification enzyme. (PMID: 16790311) Billaut-Laden I. … Broly F. (Toxicology 2006) 3 23
  4. Cloning and expression of human liver rhodanese cDNA. (PMID: 9070219) Aita N. … Tanabe S. (Biochem. Biophys. Res. Commun. 1997) 3 4
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for TST Gene

Sources for TST Gene

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