TSSK6 Gene
protein-coding GIFtS: 45
GCID: GC19M019623
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testis-specific serine kinase 6
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Aliases
for TSSK6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis-Specific Serine Kinase 61 2 | | FLJ240021 | | SSTK1 2 3 5 | | Serine/Threonine Protein Kinase SSTK2 | | CT721 2 3 | | Testis-Specific Serine/Threonine-Protein Kinase 62 | | Cancer/Testis Antigen 722 3 | | EC 2.7.11.13 | | Small Serine/Threonine Kinase2 3 | | TSSK-63 | | TSK-62 3 | | Serine/Threonine-Protein Kinase SSTK3 | | TSSK42 5 | | Testis-Specific Kinase 63 |
Export aliases for TSSK6 gene to outside databasesPrevious GC identifers: GC19M019485 GC19M019187 |
Summaries
for TSSK6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSSK6:
This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinasefamily. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects onfertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologicallyabnormal sperm. (provided by RefSeq, Jan 2012)
UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6Function: Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatinremodeling (By similarity)
|
Genomic Views
for TSSK6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSSK6 gene promoter:
ER-alpha STAT1 PPAR-gamma1 E2F-1 CP2 E2F STAT3 PPAR-gamma2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSSK6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSK6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11TSSK6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M019623: view genomic region
(about GC identifiers)
Start:
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19,623,219 bp from pter |
End:
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19,627,004 bp from pter |
Size:
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3,786 bases |
Orientation:
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minus strand |
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Proteins
for TSSK6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6 (See
protein sequence)Recommended Name: Testis-specific serine/threonine-protein kinase 6 Size: 273 amino acids; 30331 Da
Cofactor: Magnesium
Subunit: Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required forTSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which isessential for kinase activity
Sequence caution: Sequence=BAB71697.1; Type=Frameshift; Positions=104, 169; Sequence=BAD18805.1; Type=Frameshift;Positions=247;
Secondary accessions: B2R9F8 Q6ZMC4 Q96LJ4Explore the universe of human proteins at neXtProt for TSSK6: NX_Q9BXA6
Post-translational modifications:
Autophosphorylated1
View neXtProt modification sites for NX_Q9BXA6
TSSK6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114426.1
ENSEMBL proteins: ENSP00000466056 ENSP00000466477 ENSP00000354168
Human Recombinant Protein Products:
TSSK6 Antibody Products:
Assay Products for TSSK6: |
Protein
Domains /
Families
for TSSK6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSSK6 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXA6ProtoNet protein and cluster: Q9BXA6 UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for TSSK6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6Function: Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatinremodeling (By similarity)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.11
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK6 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TSSK6 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for TSSK6:
Animal Models:
Mouse knock-out Tssk6tm1Grj for TSSK6
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tssk6):
TSSK6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TSSK6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSSK6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/20 Interacting proteins for TSSK6 (Q9BXA61, 3 ENSP000003541684) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TSSK6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSSK6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSSK6
3 HMDB Compounds for TSSK6 About this table
Search CenterWatch for drugs/clinical trials and news about TSSK6
|
Transcripts
for TSSK6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSSK6 gene: NM_032037.3 Unigene Clusters for TSSK6: Testis-specific serine kinase 6 Hs.532711 [show with all ESTs], Hs.666780 [show with all ESTs]Unigene Representative Sequences: NM_032037, AK1728413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587522 ENST00000585580 ENST00000360913
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSSK6 (NM_032037) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSSK6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK6 |
Additional cDNA sequence: AF348077.1 AK058166.1 AK172841.1 6 DOTS entries: DT.87014811 DT.85104105 DT.97837253 DT.452763 DT.436021 DT.100749736 13 AceView cDNA sequences: AF348077 AF329483 NM_032037 BC014611 AI025487 AW662022 AI150036 AA948538 AI827749 AA913074 AA608857 AI024234 T84347
GeneLoc Exon Structure
|
Expression
for TSSK6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSSK6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TSSK6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSSK6
SOURCE GeneReport for Unigene clusters: Hs.532711 Hs.666780
UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6Tissue specificity: Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate,thymus, spleen and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for TSSK6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSSK6
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK6 |
Orthologs
for TSSK6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSSK6 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for TSSK6 (if available)
TreeFam Gene Tree for TSSK6 (if available) |
Paralogs
for TSSK6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSSK6 gene
- TSSK1B2 PRKAA22 HUNK2 TSSK32 PRKAA12 MELK2 TSSK22 TSSK42
- STK112
18/64 SIMAP similar genes for TSSK6 using alignment to 1 protein entry: TSSK6_HUMAN(see all similar genes):TSSK2 TSSK3 TSSK1 TSSK1B TSSK4 MARK1
MARK2 MARK4 Par1b SIK1 SIK3 BRSK2
AURKC BRSK1 KIAA0999 NIM1 PRKAA1 PRKAA2
TSSK6 for paralogs About GeneDecksing
|
Genomic Variants
for TSSK6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSSK6 (19623219 - 19627004 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSSK6: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TSSK6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSSK6 for disorders About GeneDecksing
OMIM gene information: 610712
OMIM disorders: --
4  diseases for TSSK6: About MalaCardsoligospermia azoospermia prostatitis alcoholism
2 diseases from the University of Copenhagen DISEASES database for TSSK6:Oligospermia Azoospermia Human Genome Epidemiology (HuGE) Navigator: TSSK6 (1 document)
Export disorders for TSSK6 gene to outside databases
|
Publications
for TSSK6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSSK6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSSK6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. (PubMed id 15870294)1, 2 Spiridonov N.A.... Johnson G.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 3 Hao Z....Visconti P.E. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Identification of a novel HSP70-binding cochaperone c ritical to HSP90-mediated activation of small serine/threonine kinase. (PubMed id 20829357)2 Jha K.N....Johnson G.R. (2010)
- c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese populatio n. (PubMed id 20037600)1 Su D....Zhang S.Z. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TSSK6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSSK6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSSK6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSSK6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSSK6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSSK6 gene:
Search GeneIP for patents involving TSSK6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSSK6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TSSK6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK6 |
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