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Aliases for TSSK6 Gene

Aliases for TSSK6 Gene

  • Testis Specific Serine Kinase 6 2 3 5
  • Cancer/Testis Antigen 72 2 3 4
  • Small Serine/Threonine Kinase 3 4
  • TSK-6 3 4
  • CT72 3 4
  • SSTK 3 4
  • Testis-Specific Serine/Threonine-Protein Kinase 6 3
  • Testis Secretory Sperm-Binding Protein Li 205a 3
  • Serine/Threonine Protein Kinase SSTK 3
  • Serine/Threonine-Protein Kinase SSTK 4
  • Testis-Specific Kinase 6 4
  • EC 4
  • FKSG82 3
  • TSSK-6 4
  • TSSK4 3

External Ids for TSSK6 Gene

Previous GeneCards Identifiers for TSSK6 Gene

  • GC19M019485
  • GC19M019623
  • GC19M019187

Summaries for TSSK6 Gene

Entrez Gene Summary for TSSK6 Gene

  • This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]

GeneCards Summary for TSSK6 Gene

TSSK6 (Testis Specific Serine Kinase 6) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK3.

UniProtKB/Swiss-Prot for TSSK6 Gene

  • Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK6 Gene

Genomics for TSSK6 Gene

Regulatory Elements for TSSK6 Gene

Enhancers for TSSK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F020000 0.4 FANTOM5 18.2 -484.5 -484534 0.1 ATF3 TSSK6 GC19M021744 VN1R77P
GH19F019755 0.4 FANTOM5 5.9 -239.8 -239798 0.4 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF766 CBX5 TSSK6 GC19M021621 GC19M021693 PIR31947 PIR51069
GH19F019514 0.4 ENCODE 0.8 +1.0 1019 0.2 MAX ZBTB33 SETDB1 GATAD2A GC19M019509 TSSK6
GH19F019516 0.5 ENCODE 0.8 +1.2 1219 0.2 MAX ZBTB33 GC19M019509 TSSK6
GH19F019517 0.6 ENCODE 0.8 +0.8 775 0.1 POLR2A ZBTB33 MLLT1 SETDB1 TSSK6 GC19M019509
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TSSK6 on UCSC Golden Path with GeneCards custom track

Promoters for TSSK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001816696 385 201 ZBTB33 MLLT1
ENSR00001418394 -815 1801 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ZNF263
ENSR00001816695 1285 401 MAX ZBTB33

Genomic Location for TSSK6 Gene

19,512,418 bp from pter
19,515,685 bp from pter
3,268 bases
Minus strand

Genomic View for TSSK6 Gene

Genes around TSSK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK6 Gene

Proteins for TSSK6 Gene

  • Protein details for TSSK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific serine/threonine-protein kinase 6
    Protein Accession:
    Secondary Accessions:
    • B2R9F8
    • Q6ZMC4
    • Q96LJ4

    Protein attributes for TSSK6 Gene

    273 amino acids
    Molecular mass:
    30331 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.
    • Sequence=BAB71697.1; Type=Frameshift; Positions=104, 169; Evidence={ECO:0000305}; Sequence=BAD18805.1; Type=Frameshift; Positions=247; Evidence={ECO:0000305};

neXtProt entry for TSSK6 Gene

Post-translational modifications for TSSK6 Gene

Other Protein References for TSSK6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSSK6 Gene

Domains & Families for TSSK6 Gene

Gene Families for TSSK6 Gene

Protein Domains for TSSK6 Gene

Suggested Antigen Peptide Sequences for TSSK6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK6: view

Function for TSSK6 Gene

Molecular function for TSSK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).

Enzyme Numbers (IUBMB) for TSSK6 Gene

Gene Ontology (GO) - Molecular Function for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15870294
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 15870294
GO:0005515 protein binding IPI 15870294
GO:0005524 ATP binding IDA 15870294
genes like me logo Genes that share ontologies with TSSK6: view
genes like me logo Genes that share phenotypes with TSSK6: view

Animal Models for TSSK6 Gene

MGI Knock Outs for TSSK6:

Animal Model Products

  • Taconic Biosciences Mouse Models for TSSK6

miRNA for TSSK6 Gene

miRTarBase miRNAs that target TSSK6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TSSK6

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSSK6 Gene

Localization for TSSK6 Gene

Subcellular locations from

Jensen Localization Image for TSSK6 Gene COMPARTMENTS Subcellular localization image for TSSK6 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSSK6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSSK6 Gene

Pathways & Interactions for TSSK6 Gene

SuperPathways for TSSK6 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK6: view

Pathways by source for TSSK6 Gene

1 Qiagen pathway for TSSK6 Gene

Interacting Proteins for TSSK6 Gene

Gene Ontology (GO) - Biological Process for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 15870294
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSSK6: view

No data available for SIGNOR curated interactions for TSSK6 Gene

Drugs & Compounds for TSSK6 Gene

(2) Drugs for TSSK6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for TSSK6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TSSK6: view

Transcripts for TSSK6 Gene

mRNA/cDNA for TSSK6 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSSK6 Gene

Testis-specific serine kinase 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TSSK6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK6 Gene

No ASD Table

Relevant External Links for TSSK6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSSK6 Gene

mRNA expression in normal human tissues for TSSK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSSK6 Gene

This gene is overexpressed in Testis (x13.7).

Protein differential expression in normal tissues from HIPED for TSSK6 Gene

This gene is overexpressed in Pancreatic juice (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSSK6 Gene

Protein tissue co-expression partners for TSSK6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSSK6 Gene:


SOURCE GeneReport for Unigene cluster for TSSK6 Gene:


mRNA Expression by UniProt/SwissProt for TSSK6 Gene:

Tissue specificity: Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TSSK6: view

Primer Products

Orthologs for TSSK6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSSK6 34 35
  • 99.51 (n)
(Canis familiaris)
Mammalia TSSK6 34 35
  • 90.84 (n)
(Bos Taurus)
Mammalia TSSK6 34 35
  • 90.6 (n)
(Mus musculus)
Mammalia Tssk6 34 16 35
  • 90.23 (n)
(Rattus norvegicus)
Mammalia Tssk6 34
  • 89.62 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
-- 35
  • 56 (a)
(Monodelphis domestica)
Mammalia TSSK6 35
  • 82 (a)
(Gallus gallus)
Aves LOC101748426 34
  • 72.91 (n)
-- 35
  • 71 (a)
-- 35
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 77 (a)
-- 35
  • 74 (a)
(Danio rerio)
Actinopterygii tssk6 34 35
  • 57.21 (n)
(Caenorhabditis elegans)
Secernentea W02B12.12 35
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN4 35
  • 12 (a)
FRK1 35
  • 11 (a)
-- 35
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
Species where no ortholog for TSSK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSSK6 Gene

Gene Tree for TSSK6 (if available)
Gene Tree for TSSK6 (if available)

Paralogs for TSSK6 Gene

Variants for TSSK6 Gene

Sequence variations from dbSNP and Humsavar for TSSK6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs137852869 Pathogenic 19,516,253(+) TCAAA(C/G)GTGAA upstream-variant-2KB, reference, missense
rs11399431 -- 19,517,251(+) TTTTT(-/T)TTTTT intron-variant, upstream-variant-2KB
rs11552886 -- 19,516,274(+) CTCCA(A/C/G)CCGGG upstream-variant-2KB, reference, synonymous-codon
rs138118121 -- 19,516,145(+) GCCGT(A/G)CCGCG upstream-variant-2KB
rs138193947 -- 19,516,848(+) AATGG(C/T)GCCAT intron-variant, upstream-variant-2KB

Variation tolerance for TSSK6 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSSK6 Gene

Disorders for TSSK6 Gene

Relevant External Links for TSSK6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSSK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSSK6 Gene

Publications for TSSK6 Gene

  1. c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese population. (PMID: 20037600) Su D. … Zhang S.Z. (Asian J. Androl. 2010) 3 46 64
  2. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. (PMID: 20829357) Jha K.N. … Johnson G.R. (J. Biol. Chem. 2010) 3 4 64
  3. Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. (PMID: 15870294) Spiridonov N.A. … Johnson G.R. (Mol. Cell. Biol. 2005) 3 4 64
  4. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PMID: 15044604) Hao Z. … Visconti P.E. (Mol. Hum. Reprod. 2004) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TSSK6 Gene

Sources for TSSK6 Gene

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