Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSSK6 Gene

Aliases for TSSK6 Gene

  • Testis-Specific Serine Kinase 6 2 3
  • Cancer/Testis Antigen 72 2 3 4
  • SSTK 3 4 6
  • Small Serine/Threonine Kinase 3 4
  • TSSK4 3 6
  • TSK-6 3 4
  • CT72 3 4
  • Testis-Specific Serine/Threonine-Protein Kinase 6 3
  • Serine/Threonine Protein Kinase SSTK 3
  • Serine/Threonine-Protein Kinase SSTK 4
  • Testis-Specific Kinase 6 4
  • EC 2.7.11.1 4
  • FKSG82 3
  • TSSK-6 4

External Ids for TSSK6 Gene

Summaries for TSSK6 Gene

Entrez Gene Summary for TSSK6 Gene

  • This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]

GeneCards Summary for TSSK6 Gene

TSSK6 (Testis-Specific Serine Kinase 6) is a Protein Coding gene. Diseases associated with TSSK6 include oligospermia. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is TSSK4.

UniProtKB/Swiss-Prot for TSSK6 Gene

  • Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK6 Gene

Genomics for TSSK6 Gene

Genomic Location for TSSK6 Gene

Start:
19,512,418 bp from pter
End:
19,515,685 bp from pter
Size:
3,268 bases
Orientation:
Minus strand

Genomic View for TSSK6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSSK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK6 Gene

Regulatory Elements for TSSK6 Gene

Proteins for TSSK6 Gene

  • Protein details for TSSK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXA6-TSSK6_HUMAN
    Recommended name:
    Testis-specific serine/threonine-protein kinase 6
    Protein Accession:
    Q9BXA6
    Secondary Accessions:
    • B2R9F8
    • Q6ZMC4
    • Q96LJ4

    Protein attributes for TSSK6 Gene

    Size:
    273 amino acids
    Molecular mass:
    30331 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.
    SequenceCaution:
    • Sequence=BAB71697.1; Type=Frameshift; Positions=104, 169; Evidence={ECO:0000305}; Sequence=BAD18805.1; Type=Frameshift; Positions=247; Evidence={ECO:0000305};

neXtProt entry for TSSK6 Gene

Proteomics data for TSSK6 Gene at MOPED

Post-translational modifications for TSSK6 Gene

Other Protein References for TSSK6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSSK6 Gene

Domains for TSSK6 Gene

UniProtKB/Swiss-Prot:

TSSK6_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9BXA6
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.:
    • Q9BXA6
genes like me logo Genes that share domains with TSSK6: view

Function for TSSK6 Gene

Molecular function for TSSK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).

Enzyme Numbers (IUBMB) for TSSK6 Gene

Gene Ontology (GO) - Molecular Function for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15870294
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 15870294
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15870294
genes like me logo Genes that share ontologies with TSSK6: view
genes like me logo Genes that share phenotypes with TSSK6: view

Animal Models for TSSK6 Gene

MGI Knock Outs for TSSK6:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TSSK6 Gene

Localization for TSSK6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSSK6 Gene COMPARTMENTS Subcellular localization image for TSSK6 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TSSK6: view

Pathways for TSSK6 Gene

SuperPathways for TSSK6 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK6: view

Pathways by source for TSSK6 Gene

1 Qiagen pathway for TSSK6 Gene

Interacting Proteins for TSSK6 Gene

Gene Ontology (GO) - Biological Process for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 15870294
GO:0007275 multicellular organismal development IEA --
GO:0009103 lipopolysaccharide biosynthetic process --
GO:0009966 regulation of signal transduction IEA --
GO:0035092 sperm chromatin condensation ISS --
genes like me logo Genes that share ontologies with TSSK6: view

Compounds for TSSK6 Gene

(3) HMDB Compounds for TSSK6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with TSSK6: view

Transcripts for TSSK6 Gene

mRNA/cDNA for TSSK6 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSSK6 Gene

Testis-specific serine kinase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK6 Gene

No ASD Table

Relevant External Links for TSSK6 Gene

GeneLoc Exon Structure for
TSSK6
ECgene alternative splicing isoforms for
TSSK6

Expression for TSSK6 Gene

mRNA expression in normal human tissues for TSSK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSSK6 Gene

This gene is overexpressed in Testis (13.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TSSK6 Gene

SOURCE GeneReport for Unigene cluster for TSSK6 Gene Hs.532711

mRNA Expression by UniProt/SwissProt for TSSK6 Gene

Q9BXA6-TSSK6_HUMAN
Tissue specificity: Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes.
genes like me logo Genes that share expressions with TSSK6: view

Orthologs for TSSK6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSSK6 36
  • 99.51 (n)
  • 99.63 (a)
TSSK6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSSK6 36
  • 90.6 (n)
  • 98.53 (a)
TSSK6 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSSK6 36
  • 90.84 (n)
  • 97.8 (a)
TSSK6 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tssk6 36
  • 90.23 (n)
  • 97.07 (a)
Tssk6 16
Tssk6 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSSK6 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tssk6 36
  • 89.62 (n)
  • 97.44 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 55 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
LOC101748426 36
  • 72.91 (n)
  • 72.66 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 74 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tssk6 36
  • 57.21 (n)
  • 51.49 (a)
tssk6 37
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W02B12.12 37
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 10 (a)
ManyToMany
FRK1 37
  • 11 (a)
ManyToMany
KIN4 37
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
ManyToMany
Species with no ortholog for TSSK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSSK6 Gene

ENSEMBL:
Gene Tree for TSSK6 (if available)
TreeFam:
Gene Tree for TSSK6 (if available)

Paralogs for TSSK6 Gene

Paralogs for TSSK6 Gene

genes like me logo Genes that share paralogs with TSSK6: view

Variants for TSSK6 Gene

Sequence variations from dbSNP and Humsavar for TSSK6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs181307141 -- 19,513,720(+) GAGAT(G/T)AGGTC downstream-variant-500B
rs186154579 -- 19,513,789(+) GGACT(C/T)GCAGT downstream-variant-500B
rs188181197 -- 19,513,915(+) GGCCA(A/C)CCTCG downstream-variant-500B
rs201446195 -- 19,513,825(+) GCGCC(C/T)GGCCC downstream-variant-500B
rs370465654 -- 19,513,932(+) CCCTG(C/G)CTGTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TSSK6 Gene

Variant ID Type Subtype PubMed ID
nsv911305 CNV Loss 21882294

Relevant External Links for TSSK6 Gene

HapMap Linkage Disequilibrium report
TSSK6

Disorders for TSSK6 Gene

(1) MalaCards Diseases for TSSK6 Gene

Search for TSSK6 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TSSK6 Gene

Relevant External Links for TSSK6

Genetic Association Database (GAD)
TSSK6
Human Genome Epidemiology (HuGE) Navigator
TSSK6
genes like me logo Genes that share disorders with TSSK6: view

No data available for UniProtKB/Swiss-Prot for TSSK6 Gene

Publications for TSSK6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PMID: 15044604) Hao Z. … Visconti P.E. (Mol. Hum. Reprod. 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. (PMID: 15870294) Spiridonov N.A. … Johnson G.R. (Mol. Cell. Biol. 2005) 3 4
  5. c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese population. (PMID: 20037600) Su D. … Zhang S.Z. (Asian J. Androl. 2010) 3 49

Products for TSSK6 Gene

Sources for TSSK6 Gene

Back to Top

Content