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TSSK6 Gene

protein-coding   GIFtS: 49
GCID: GC19M019623

Testis-Specific Serine Kinase 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis-Specific Serine Kinase 61 2     Serine/Threonine Protein Kinase SSTK2
Cancer/Testis Antigen 721 2 3     Testis-Specific Serine/Threonine-Protein Kinase 62
SSTK2 3 5     EC 2.7.11.13
Small Serine/Threonine Kinase2 3     TSSK-63
CT722 3     Serine/Threonine-Protein Kinase SSTK3
TSK-62 3     Testis-Specific Kinase 63
TSSK42 5     

External Ids:    HGNC: 304101   Entrez Gene: 839832   Ensembl: ENSG000001780937   OMIM: 6107125   UniProtKB: Q9BXA63   

Export aliases for TSSK6 gene to outside databases

Previous GC identifers: GC19M019485 GC19M019187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSSK6 Gene:
This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase
family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on
fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically
abnormal sperm. (provided by RefSeq, Jan 2012)

GeneCards Summary for TSSK6 Gene:
TSSK6 (testis-specific serine kinase 6) is a protein-coding gene. Diseases associated with TSSK6 include oligospermia, and azoospermia. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is TSSK3.

UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6
Function: Required for sperm production and function. Plays a role in DNA condensation during postmeiotic
chromatin remodeling (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSSK6 gene promoter:
         ER-alpha   STAT1   PPAR-gamma1   E2F-1   CP2   E2F   STAT3   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TSSK6 promoter sequence
   Search Chromatin IP Primers for TSSK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSSK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

TSSK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSSK6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019623:  view genomic region     (about GC identifiers)

Start:
19,623,227 bp from pter      End:
19,626,838 bp from pter
Size:
3,612 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6 (See protein sequence)
Recommended Name: Testis-specific serine/threonine-protein kinase 6  
Size: 273 amino acids; 30331 Da
Cofactor: Magnesium
Subunit: Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required
for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is
essential for kinase activity
Sequence caution: Sequence=BAB71697.1; Type=Frameshift; Positions=104, 169; Sequence=BAD18805.1; Type=Frameshift;
Positions=247;
Secondary accessions: B2R9F8 Q6ZMC4 Q96LJ4

Explore the universe of human proteins at neXtProt for TSSK6: NX_Q9BXA6

Explore proteomics data for TSSK6 at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Modification sites at neXtProt

  • See TSSK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114426.1  
    ENSEMBL proteins: 
     ENSP00000466056   ENSP00000473413   ENSP00000466477   ENSP00000354168  

    TSSK6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TSSK6

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    LSBio Antibodies in human, mouse, rat for TSSK6

    TSSK6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific serine kinase 6
    Testis specific kinase (TSSK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9BXA6

    ProtoNet protein and cluster: Q9BXA6

    UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    TSSK6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSSK6_HUMAN, Q9BXA6
    Function: Required for sperm production and function. Plays a role in DNA condensation during postmeiotic
    chromatin remodeling (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA15870294
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15870294
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15870294
         
    TSSK6 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TSSK6:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tssk6):
     reproductive system 

    TSSK6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tssk6tm1Grj for TSSK6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSSK6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSSK6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSSK6

    miRNA
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    Block miRNA regulation of human, mouse, rat TSSK6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TSSK6:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidTSSK6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSSK6
    Predesigned siRNA for gene silencing in human, mouse, rat TSSK6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TSSK6 (NM_032037)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----

    TSSK6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TSSK6
        Sperm Motility



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSSK6
    Interactions:

        Search GeneGlobe Interaction Network for TSSK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TSSK6 (Q9BXA61, 3 ENSP000003541684) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA15870294
    GO:0007275multicellular organismal development IEA--
    GO:0009103lipopolysaccharide biosynthetic process ----
    GO:0035092sperm chromatin condensation ISS--

    TSSK6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSSK6

    3 HMDB Compounds for TSSK6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSSK6 gene: 
    NM_032037.3  

    Unigene Cluster for TSSK6:

    Testis-specific serine kinase 6
    Hs.532711  [show with all ESTs]
    Unigene Representative Sequence: NM_032037
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587522 ENST00000602623 ENST00000585580 ENST00000360913
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSSK6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TSSK6:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidTSSK6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSSK6
    Predesigned siRNA for gene silencing in human, mouse, rat TSSK6
    Clone
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    OriGene clones in human, mouse for TSSK6 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSSK6 (NM_032037)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSSK6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSSK6
    OriGene qSTAR qPCR primer pairs in human, mouse for TSSK6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSSK6
      QuantiTect SYBR Green Assays in human, mouse, rat TSSK6
      QuantiFast Probe-based Assays in human, mouse, rat TSSK6

    Additional mRNA sequence: 

    AK313767.1 BC014611.2 

    5 DOTS entries:

    DT.85104105  DT.87014811  DT.97837253  DT.436021  DT.452763 

    13 AceView cDNA sequences:

    NM_032037 AF348077 AF329483 BC014611 AW662022 AI150036 AI025487 AA948538 
    AI827749 AA913074 AA608857 AI024234 T84347 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSSK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSSK6 Expression
    About this image


    TSSK6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Testis (Reproductive System)
    TSSK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSSK6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532711

    UniProtKB/Swiss-Prot: TSSK6_HUMAN, Q9BXA6
    Tissue specificity: Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary,
    prostate, thymus, spleen and peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSSK6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tssk61 , 5 testis-specific serine kinase 61, 5 90.23(n)1
    97.07(a)1
      8 (34.05 cM)5
    839841  NM_032004.11  NP_114393.11 
     699022155 
    chicken
    (Gallus gallus)
    Aves LOC1017484261 testis-specific serine/threonine-protein kinase 6-like 72.91(n)
    72.66(a)
      101748426  XM_004942581.1  XP_004942638.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    77(a)
    74(a)
    1 ↔ many
    1 ↔ many
    2(133903917-133904741)
    2(133849409-133850221)
    zebrafish
    (Danio rerio)
    Actinopterygii tssk61 testis-specific serine kinase 6 57.21(n)
    51.49(a)
      557915  NM_001044845.1  NP_001038310.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W02B12.126
    Protein W02B12.12, isoform a (W02B12.12) mRNA, com...
    25(a)
    many ↔ many
    II(11476755-11479161) WBGene00012207
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PTK1(YKL198C)4 Putative serine/threonine protein kinase that regulates more   --   11(70220-68232) 853635  NP_012723.2 


    ENSEMBL Gene Tree for TSSK6 (if available)
    TreeFam Gene Tree for TSSK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSSK6 gene
    TSSK32  TSSK1B2  TSSK22  TSSK42  
    Selected SIMAP similar genes for TSSK6 using alignment to 2 protein entries:     TSSK6_HUMAN (see all proteins) (see all similar genes):
    TSSK2    TSSK3    MARK4    TSSK1    TSSK1B    TSSK4
    MKNK1    MARK1    MARK2    Par1b    SIK1    SIK3
    BRSK2    BRSK1    KIAA0999    NIM1K    PRKAA1    PRKAA2

    TSSK6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    6 SNPs for TSSK6    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813071411,2
    --19624529(+) GAGATG/TAGGTC 1 -- ds50010--------
    rs1861545791,2
    --19624598(+) GGACTC/TGCAGT 1 -- ds50010--------
    rs1881811971,2
    --19624724(+) GGCCAA/CCCTCG 1 -- ds50010--------
    rs3704656541,2
    ----19624741(+) CCCTGC/GTGTTC 1 -- ds50010--------
    rs2014461951,2
    ----19624634(+) GCGCCC/TGGCCC 1 -- ds50010--------
    rs3753573281,2
    ----19624820(+) CATCAC/GACCCG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TSSK6 (19623227 - 19626838 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TSSK6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911305CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TSSK6
    DNA2.0 Custom Variant and Variant Library Synthesis for TSSK6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610712    OMIM disorders: --

    3 diseases for TSSK6:    
    About MalaCards
    oligospermia    azoospermia    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for TSSK6:
    Oligospermia     Azoospermia

    TSSK6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TSSK6
    Human Genome Epidemiology (HuGE) Navigator: TSSK6 (1 document)

    Export disorders for TSSK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSSK6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TSSK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. c.822+126T&gt;G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese population. (PubMed id 20037600)1, 4 Su D....Zhang S.Z. (Asian J. Androl. 2010)
    2. Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. (PubMed id 15870294)1, 2 Spiridonov N.A.... Johnson G.R. (Mol. Cell. Biol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 3 Hao Z....Visconti P.E. (Mol. Hum. Reprod. 2004)
    6. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    7. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. (PubMed id 20829357)2 Jha K.N.... Johnson G.R. (J. Biol. Chem. 2010)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83983 HGNC: 30410 AceView: SSTK Ensembl:ENSG00000178093 euGenes: HUgn83983
    ECgene: TSSK6 H-InvDB: TSSK6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSSK6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSSK6 gene:
    Search GeneIP for patents involving TSSK6

    GeneCards and IP:
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