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Aliases for TSSK6 Gene

Aliases for TSSK6 Gene

  • Testis Specific Serine Kinase 6 2 3 5
  • Cancer/Testis Antigen 72 2 3 4
  • Small Serine/Threonine Kinase 3 4
  • TSK-6 3 4
  • CT72 3 4
  • SSTK 3 4
  • Testis-Specific Serine/Threonine-Protein Kinase 6 3
  • Testis Secretory Sperm-Binding Protein Li 205a 3
  • Serine/Threonine Protein Kinase SSTK 3
  • Serine/Threonine-Protein Kinase SSTK 4
  • Testis-Specific Kinase 6 4
  • EC 4
  • FKSG82 3
  • TSSK-6 4
  • TSSK4 3

External Ids for TSSK6 Gene

Previous GeneCards Identifiers for TSSK6 Gene

  • GC19M019485
  • GC19M019623
  • GC19M019187

Summaries for TSSK6 Gene

Entrez Gene Summary for TSSK6 Gene

  • This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012]

GeneCards Summary for TSSK6 Gene

TSSK6 (Testis Specific Serine Kinase 6) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK3.

UniProtKB/Swiss-Prot for TSSK6 Gene

  • Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).

Additional gene information for TSSK6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK6 Gene

Genomics for TSSK6 Gene

GeneHancer (GH) Regulatory Elements for TSSK6 Gene

Promoters and enhancers for TSSK6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I019515 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.7 -747 2 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 NDUFA13 ENSG00000258674 PIR50534 TSSK6 GATAD2A YJEFN3
GH19I019514 Enhancer 0.4 ENCODE 550.8 +1.0 1018 0.2 MAX ZBTB33 SETDB1 NDUFA13 PIR50534 TSSK6 ENSG00000258674 GATAD2A GC19M019509
GH19I019516 Enhancer 0.4 ENCODE 550.8 +1.2 1218 0.2 MAX ZBTB33 NDUFA13 PIR50534 TSSK6 ENSG00000258674 GC19M019509
GH19I019517 Enhancer 0.4 ENCODE 550.8 +0.8 775 0.1 ZBTB33 MLLT1 SETDB1 NDUFA13 PIR50534 TSSK6 ENSG00000258674 GC19M019509
GH19I018587 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.4 +926.2 926245 3.6 CLOCK MLX DMAP1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 REX1BD ENSG00000268030 UPF1 ENSG00000268938 NR2C2AP ENSG00000269191 MAU2 IQCN MEF2B ELL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSSK6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSSK6 gene promoter:

Genomic Locations for TSSK6 Gene

Genomic Locations for TSSK6 Gene
3,268 bases
Minus strand

Genomic View for TSSK6 Gene

Genes around TSSK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK6 Gene

Proteins for TSSK6 Gene

  • Protein details for TSSK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific serine/threonine-protein kinase 6
    Protein Accession:
    Secondary Accessions:
    • B2R9F8
    • Q6ZMC4
    • Q96LJ4

    Protein attributes for TSSK6 Gene

    273 amino acids
    Molecular mass:
    30331 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with the heat shock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.
    • Sequence=BAB71697.1; Type=Frameshift; Positions=104, 169; Evidence={ECO:0000305}; Sequence=BAD18805.1; Type=Frameshift; Positions=247; Evidence={ECO:0000305};

neXtProt entry for TSSK6 Gene

Post-translational modifications for TSSK6 Gene

Other Protein References for TSSK6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSSK6 Gene

Domains & Families for TSSK6 Gene

Gene Families for TSSK6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TSSK6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK6: view

Function for TSSK6 Gene

Molecular function for TSSK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).

Enzyme Numbers (IUBMB) for TSSK6 Gene

Gene Ontology (GO) - Molecular Function for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15870294
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 15870294
GO:0005515 protein binding IPI 15870294
GO:0005524 ATP binding IDA 15870294
genes like me logo Genes that share ontologies with TSSK6: view
genes like me logo Genes that share phenotypes with TSSK6: view

Animal Models for TSSK6 Gene

MGI Knock Outs for TSSK6:

Animal Model Products

miRNA for TSSK6 Gene

miRTarBase miRNAs that target TSSK6

Clone Products

  • Addgene plasmids for TSSK6

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSSK6 Gene

Localization for TSSK6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSSK6 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSSK6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TSSK6 Gene

Pathways & Interactions for TSSK6 Gene

SuperPathways for TSSK6 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK6: view

Pathways by source for TSSK6 Gene

1 Qiagen pathway for TSSK6 Gene

Interacting Proteins for TSSK6 Gene

Gene Ontology (GO) - Biological Process for TSSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 15870294
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSSK6: view

No data available for SIGNOR curated interactions for TSSK6 Gene

Drugs & Compounds for TSSK6 Gene

(2) Drugs for TSSK6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for TSSK6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TSSK6: view

Transcripts for TSSK6 Gene

mRNA/cDNA for TSSK6 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSSK6 Gene

Testis-specific serine kinase 6:
Representative Sequences:

Clone Products

  • Addgene plasmids for TSSK6

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK6 Gene

No ASD Table

Relevant External Links for TSSK6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSSK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSSK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSSK6 Gene

This gene is overexpressed in Testis (x13.7).

Protein differential expression in normal tissues from HIPED for TSSK6 Gene

This gene is overexpressed in Pancreatic juice (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSSK6 Gene

Protein tissue co-expression partners for TSSK6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSSK6 Gene:


SOURCE GeneReport for Unigene cluster for TSSK6 Gene:


mRNA Expression by UniProt/SwissProt for TSSK6 Gene:

Tissue specificity: Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TSSK6: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSSK6 Gene

Orthologs for TSSK6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSSK6 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia TSSK6 33 34
  • 90.84 (n)
(Bos Taurus)
Mammalia TSSK6 33 34
  • 90.6 (n)
(Mus musculus)
Mammalia Tssk6 33 16 34
  • 90.23 (n)
(Rattus norvegicus)
Mammalia Tssk6 33
  • 89.62 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 84 (a)
-- 34
  • 56 (a)
(Monodelphis domestica)
Mammalia TSSK6 34
  • 82 (a)
(Gallus gallus)
Aves LOC101748426 33
  • 72.91 (n)
-- 34
  • 71 (a)
-- 34
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
-- 34
  • 74 (a)
(Danio rerio)
Actinopterygii tssk6 33 34
  • 57.21 (n)
(Caenorhabditis elegans)
Secernentea W02B12.12 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN4 34
  • 12 (a)
FRK1 34
  • 11 (a)
-- 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for TSSK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSSK6 Gene

Gene Tree for TSSK6 (if available)
Gene Tree for TSSK6 (if available)

Paralogs for TSSK6 Gene

Variants for TSSK6 Gene

Sequence variations from dbSNP and Humsavar for TSSK6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs137852869 pathogenic, Hurthle cell carcinoma of thyroid 19,516,253(-) G/A/C upstream_transcript_variant
rs183288709 uncertain-significance, not specified 19,516,283(-) C/A/T upstream_transcript_variant
rs1001298943 -- 19,514,495(-) T/C 3_prime_UTR_variant
rs1001708485 -- 19,515,179(-) G/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs1001916701 -- 19,517,372(-) G/C upstream_transcript_variant

Variation tolerance for TSSK6 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSSK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSSK6 Gene

Disorders for TSSK6 Gene

Additional Disease Information for TSSK6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TSSK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSSK6 Gene

Publications for TSSK6 Gene

  1. c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese population. (PMID: 20037600) Su D … Zhang SZ (Asian journal of andrology 2010) 3 44 58
  2. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. (PMID: 20829357) Jha KN … Johnson GR (The Journal of biological chemistry 2010) 3 4 58
  3. Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. (PMID: 15870294) Spiridonov NA … Johnson GR (Molecular and cellular biology 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TSSK6 Gene

Sources for TSSK6 Gene

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