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Aliases for TSSK4 Gene

Aliases for TSSK4 Gene

  • Testis Specific Serine Kinase 4 2 3 5
  • Serine/Threonine-Protein Kinase 22E 3 4
  • Serine/Threonine Kinase 22E 2 3
  • C14orf20 3 4
  • STK22E 3 4
  • TSK-4 3 4
  • TSSK5 3 4
  • Testis-Specific Serine/Threonine-Protein Kinase 4 3
  • Chromosome 14 Open Reading Frame 20 2
  • Testis-Specific Kinase 4 4
  • EC 2.7.11.1 4
  • EC 2.7.11 61
  • TSSK-4 4
  • TSK4 3

External Ids for TSSK4 Gene

Previous HGNC Symbols for TSSK4 Gene

  • C14orf20
  • STK22E

Previous GeneCards Identifiers for TSSK4 Gene

  • GC14P023745
  • GC14P024674
  • GC14P004789

Summaries for TSSK4 Gene

Entrez Gene Summary for TSSK4 Gene

  • This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for TSSK4 Gene

TSSK4 (Testis Specific Serine Kinase 4) is a Protein Coding gene. Diseases associated with TSSK4 include Oligospermia. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK1B.

UniProtKB/Swiss-Prot for TSSK4 Gene

  • May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK4 Gene

Genomics for TSSK4 Gene

Regulatory Elements for TSSK4 Gene

Enhancers for TSSK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G024091 1.7 Ensembl ENCODE dbSUPER 9.9 -111.9 -111884 6.5 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 RNA5SP383 KHNYN CARMIL3 C14orf119 NYNRIN NRL DCAF11 TM9SF1 IPO4 IRF9
GH14G024270 1.5 FANTOM5 ENCODE 10.2 +67.3 67296 5.4 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 DHRS1 TINF2 LTB4R KHNYN NEDD8 NEDD8-MDP1 NOP9 GMPR2 MDP1 CHMP4A
GH14G024277 1.4 FANTOM5 Ensembl ENCODE 10.2 +74.1 74071 5.2 CTCF PKNOX1 USF1 NFIB MAX EBF1 RAD21 RELA RFX5 NFYB DHRS1 TINF2 NOP9 LTB4R2 CIDEB LTB4R NEDD8-MDP1 NEDD8 GMPR2 MDP1
GH14G024246 1.2 Ensembl ENCODE dbSUPER 9.8 +41.7 41715 1.7 HDGF PKNOX1 MTA2 ASH2L JUNB RBBP5 DPF2 TBX21 EED IKZF1 CHMP4A RABGGTA NOP9 DHRS1 ENSG00000254692 MDP1 TM9SF1 IPO4 ADCY4 TSSK4
GH14G024113 1.2 ENCODE 9.1 -90.7 -90690 3.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RNA5SP383 KHNYN LOC102724814 NFATC4 HOMEZ EMC9 NOP9 PSME1 PCK2 PSME2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSSK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSSK4 Gene

Chromosome:
14
Start:
24,205,530 bp from pter
End:
24,208,362 bp from pter
Size:
2,833 bases
Orientation:
Plus strand

Genomic View for TSSK4 Gene

Genes around TSSK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK4 Gene

Proteins for TSSK4 Gene

  • Protein details for TSSK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6SA08-TSSK4_HUMAN
    Recommended name:
    Testis-specific serine/threonine-protein kinase 4
    Protein Accession:
    Q6SA08
    Secondary Accessions:
    • Q2TA60
    • Q6ZNM2

    Protein attributes for TSSK4 Gene

    Size:
    328 amino acids
    Molecular mass:
    37454 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSSK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSSK4 Gene

Selected DME Specific Peptides for TSSK4 Gene

Q6SA08:
  • RDLKLEN
  • IVHRDLK

Post-translational modifications for TSSK4 Gene

Domains & Families for TSSK4 Gene

Gene Families for TSSK4 Gene

Protein Domains for TSSK4 Gene

Suggested Antigen Peptide Sequences for TSSK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q6SA08

UniProtKB/Swiss-Prot:

TSSK4_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK4: view

Function for TSSK4 Gene

Molecular function for TSSK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-197, potentially by autophosphorylation.
UniProtKB/Swiss-Prot Function:
May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling.

Enzyme Numbers (IUBMB) for TSSK4 Gene

Gene Ontology (GO) - Molecular Function for TSSK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0005515 protein binding IPI 15964553
GO:0005524 ATP binding ISS,IEA --
genes like me logo Genes that share ontologies with TSSK4: view
genes like me logo Genes that share phenotypes with TSSK4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSSK4

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSSK4 Gene

Localization for TSSK4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSSK4 gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TSSK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSSK4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSSK4 Gene

Pathways & Interactions for TSSK4 Gene

SuperPathways for TSSK4 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK4: view

Pathways by source for TSSK4 Gene

1 Qiagen pathway for TSSK4 Gene

SIGNOR curated interactions for TSSK4 Gene

Activates:

Gene Ontology (GO) - Biological Process for TSSK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS,IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSSK4: view

Drugs & Compounds for TSSK4 Gene

(2) Drugs for TSSK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for TSSK4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TSSK4: view

Transcripts for TSSK4 Gene

Unigene Clusters for TSSK4 Gene

Testis-specific serine kinase 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TSSK4 Gene

GeneLoc Exon Structure for
TSSK4
ECgene alternative splicing isoforms for
TSSK4

Expression for TSSK4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSSK4 Gene

mRNA differential expression in normal tissues according to GTEx for TSSK4 Gene

This gene is overexpressed in Testis (x12.4).

Protein differential expression in normal tissues from HIPED for TSSK4 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSSK4 Gene



Protein tissue co-expression partners for TSSK4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSSK4 Gene:

TSSK4

SOURCE GeneReport for Unigene cluster for TSSK4 Gene:

Hs.314432

mRNA Expression by UniProt/SwissProt for TSSK4 Gene:

Q6SA08-TSSK4_HUMAN
Tissue specificity: Expressed only in the testis.
genes like me logo Genes that share expression patterns with TSSK4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSSK4 Gene

Orthologs for TSSK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSSK4 34 35
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia TSSK4 34 35
  • 90.04 (n)
cow
(Bos Taurus)
Mammalia TSSK4 34 35
  • 89.88 (n)
rat
(Rattus norvegicus)
Mammalia Tssk4 34
  • 89.84 (n)
mouse
(Mus musculus)
Mammalia Tssk4 34 16 35
  • 88.46 (n)
oppossum
(Monodelphis domestica)
Mammalia TSSK4 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSSK4 35
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9222 34 35
  • 54.06 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008735 34
  • 50.52 (n)
worm
(Caenorhabditis elegans)
Secernentea W02B12.12 34
  • 45.07 (n)
F23C8.8 35
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FRK1 35
  • 11 (a)
ManyToMany
KIN4 35
  • 11 (a)
ManyToMany
-- 35
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
ManyToMany
Species where no ortholog for TSSK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TSSK4 Gene

ENSEMBL:
Gene Tree for TSSK4 (if available)
TreeFam:
Gene Tree for TSSK4 (if available)

Paralogs for TSSK4 Gene

Paralogs for TSSK4 Gene

genes like me logo Genes that share paralogs with TSSK4: view

Variants for TSSK4 Gene

Sequence variations from dbSNP and Humsavar for TSSK4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000661628 -- 24,205,644(+) GTGGA(C/T)TGTGA upstream-variant-2KB, utr-variant-5-prime
rs1000730648 -- 24,207,257(+) CCTTC(C/T)TACCG reference, synonymous-codon
rs1000813099 -- 24,205,547(+) CCCGC(C/G)TCGGC upstream-variant-2KB, utr-variant-5-prime
rs1001339053 -- 24,208,738(+) CGGGC(A/C/G)TAGTG downstream-variant-500B
rs1001487624 -- 24,204,831(+) CTGAG(A/G)AGTGA upstream-variant-2KB

Variation tolerance for TSSK4 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSK4 Gene

Human Gene Mutation Database (HGMD)
TSSK4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSSK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSSK4 Gene

Disorders for TSSK4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSSK4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oligospermia
- elite association - COSMIC cancer census association via MalaCards
Search TSSK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSSK4

Genetic Association Database (GAD)
TSSK4
Human Genome Epidemiology (HuGE) Navigator
TSSK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSSK4
genes like me logo Genes that share disorders with TSSK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSSK4 Gene

Publications for TSSK4 Gene

  1. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 46 64
  2. Mutation screening and association study of the TSSK4 Gene in Chinese infertile men with impaired spermatogenesis. (PMID: 18390560) Su D. … Zhang S. (J. Androl. 2008) 3 46 64
  3. TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway. (PMID: 15964553) Chen X. … Yu L. (Biochem. Biophys. Res. Commun. 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TSSK4 Gene

Sources for TSSK4 Gene

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