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TSSK4 Gene

protein-coding   GIFtS: 51
GCID: GC14P024674

Testis-Specific Serine Kinase 4

(Previous name: serine/threonine kinase 22E)
(Previous symbols: C14orf20, STK22E)
  See TSSK4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis-Specific Serine Kinase 41 2     Chromosome 14 Open Reading Frame 201
C14orf201 2 3     TSK42
STK22E1 2 3     Testis-Specific Serine/Threonine-Protein Kinase 42
TSSK52 3 5     EC 2.7.11.13
Serine/Threonine Kinase 22E1 2     TSSK-43
Serine/Threonine-Protein Kinase 22E2 3     Testis-Specific Kinase 43
TSK-42 3     EC 2.7.118

External Ids:    HGNC: 198251   Entrez Gene: 2836292   Ensembl: ENSG000001399087   OMIM: 6107115   UniProtKB: Q6SA083   

Export aliases for TSSK4 gene to outside databases

Previous GC identifers: GC14P023745 GC14P004789


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSSK4 Gene:
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought
to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of
the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple
transcript variants.(provided by RefSeq, May 2010)

GeneCards Summary for TSSK4 Gene:
TSSK4 (testis-specific serine kinase 4) is a protein-coding gene. Diseases associated with TSSK4 include spondylosis, and spondylolisthesis. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot: TSSK4_HUMAN, Q6SA08
Function: May be involved in a signaling pathway during male germ cell development or mature sperm function (By
similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSSK4 gene promoter:
         RFX1   Lmo2   RelA   Nkx2-5   Nkx5-1   GATA-1   c-Ets-1   PPAR-gamma1   deltaCREB   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSSK4 promoter sequence
   Search Chromatin IP Primers for TSSK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSSK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

TSSK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSSK4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024674:  view genomic region     (about GC identifiers)

Start:
24,674,903 bp from pter      End:
24,677,568 bp from pter
Size:
2,666 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSSK4_HUMAN, Q6SA08 (See protein sequence)
Recommended Name: Testis-specific serine/threonine-protein kinase 4  
Size: 328 amino acids; 37454 Da
Cofactor: Magnesium
Secondary accessions: Q2TA60 Q6ZNM2
Alternative splicing: 3 isoforms:  Q6SA08-1   Q6SA08-2   Q6SA08-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSSK4: NX_Q6SA08

Explore proteomics data for TSSK4 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for TSSK4 (Q6SA08)
     RDLKLEN  IVHRDLK 


    See TSSK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171668.1  NP_777604.2  

    ENSEMBL proteins: 
     ENSP00000339179   ENSP00000452054   ENSP00000287913   ENSP00000412180   ENSP00000451121  
     ENSP00000450752  

    TSSK4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific serine kinase 4
    Testis specific kinase (TSSK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q6SA08

    ProtoNet protein and cluster: Q6SA08

    UniProtKB/Swiss-Prot: TSSK4_HUMAN, Q6SA08
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TSSK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSSK4_HUMAN, Q6SA08
    Function: May be involved in a signaling pathway during male germ cell development or mature sperm function (By
    similarity). Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-197, potentially by autophosphorylation (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15964553
         
    Find genes that share ontologies with TSSK4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSSK4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    peroxisome2
    extracellular1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TSSK4
        Sperm Motility


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSSK4
    Interactions:

        Search GeneGlobe Interaction Network for TSSK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for TSSK4 (Q6SA081, 3 ENSP000002879134) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB1P162201, 3, ENSP000003876994EBI-1202583,EBI-711855 I2D: score=2 STRING: ENSP00000387699
    SMURF2Q9HAU43, ENSP000002624354I2D: score=2 STRING: ENSP00000262435
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    DVL1O146403I2D: score=1 
    HSPA8ENSP000002273784STRING: ENSP00000227378
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--
    GO:0032793positive regulation of CREB transcription factor activity IDA15964553

    Find genes that share ontologies with TSSK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSSK4

    3 HMDB Compounds for TSSK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSSK4 gene (2 alternative transcripts): 
    NM_001184739.1  NM_174944.3  

    Unigene Cluster for TSSK4:

    Testis-specific serine kinase 4
    Hs.314432  [show with all ESTs]
    Unigene Representative Sequence: AK056676
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554420(uc001wne.3 uc001wnf.3) ENST00000339917(uc001wng.3 uc001wnh.3)
    ENST00000556621 ENST00000287913 ENST00000428351 ENST00000555092 ENST00000553766

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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSSK4
      QuantiTect SYBR Green Assays in human, mouse, rat TSSK4
      QuantiFast Probe-based Assays in human, mouse, rat TSSK4

    Additional mRNA sequence: 

    AK056676.1 AK131042.1 AY461663.1 BC111088.1 

    6 DOTS entries:

    DT.40238214  DT.75124437  DT.120777248  DT.209549  DT.100641203  DT.209550 

    22 AceView cDNA sequences:

    AI365148 BI827247 BC029918 NM_174944 AF542390 BE551971 BX279855 AY461663 
    AW296282 AK131042 BX095739 AA781349 AI218614 BF510751 AA399669 AI028618 
    BI825382 AA399596 AA626260 AA725841 AI207132 AI075923 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TSSK4    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c
    SP1:                                                        -               
    SP2:                                -                       -               
    SP3:                    -                                                   
    SP4:                                                        -               
    SP5:                                                                        


    ECgene alternative splicing isoforms for TSSK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSSK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCAGCTCC
    TSSK4 Expression
    About this image

    TSSK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSSK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.314432

    UniProtKB/Swiss-Prot: TSSK4_HUMAN, Q6SA08
    Tissue specificity: Expressed only in the testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSSK4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tssk41 , 5 testis-specific serine kinase 41, 5 88.46(n)1
    85.8(a)1
      14 (28.19 cM)5
    710991  NM_001253888.11  NP_001240817.11 
     556501845 
    lizard
    (Anolis carolinensis)
    Reptilia TSSK46
    testis-specific serine kinase 4
    74(a)
    1 ↔ 1
    GL343400.1(72581-76512)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92221 CG9222 54.06(n)
    42.18(a)
      33867  NM_135155.2  NP_608999.2 
    worm
    (Caenorhabditis elegans)
    Secernentea W02B12.121 W02B12.12 45.07(n)
    37.2(a)
      174755  NM_001027214.1  NP_001022385.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN46
    FRK16
    (see all 3)
    Serine/threonine protein kinase that inhibits the ...
    Putative protein kinase; similar to Kin4p; green f...
    (see all 3)
    11(a)
    11(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XV(775846-778248) YOR233W
    XVI(283464-286061) YPL141C


    ENSEMBL Gene Tree for TSSK4 (if available)
    TreeFam Gene Tree for TSSK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSSK4 gene
    TSSK62  TSSK32  TSSK1B2  TSSK22  
    Selected SIMAP similar genes for TSSK4 using alignment to 4 protein entries:     TSSK4_HUMAN (see all proteins) (see all similar genes):
    C14orf20    TSSK3    TSSK2    TSSK6    TSSK1    TSSK1B
    BRSK2    CDKL3    MARK2    KIAA0999    RPS6KA2    MARK4
    PRKCG    SGK2    MARK3    STK33    BRSK1    MARK1

    Find genes that share paralogs with TSSK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSSK4 (see all 153)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839087671,2
    --24672946(+) TGGGCA/GACAAG 2 -- us2k10--------
    rs1872622001,2
    --24672983(+) CAGACA/GGGGCG 2 -- us2k10--------
    rs12420201,2
    C,F--24673040(-) aggtgG/Atctgc 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs12420191,2
    C,F--24673121(-) caccaT/Cgccta 2 -- us2k19Minor allele frequency- C:0.48NA WA CSA 133
    rs789277351,2
    C--24673132(+) GTGCAC/TGTCTG 2 -- us2k10--------
    rs1425959061,2
    C--24673174(+) AGAATC/TGCTTG 2 -- us2k10--------
    rs1135322091,2
    C,F--24673247(+) AAGAGC/TGAAAC 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs776754431,2
    --24673274(+) AAAAAG/AAGAAA 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs354336071,2
    C,F--24673537(+) CTGGCA/G/TGGGGC 2 -- us2k16NA WA EA 364
    rs726943111,2
    C,F--24673627(+) ATCAGG/TAGGTA 2 -- us2k15Minor allele frequency- T:0.16WA NA EA 362

    HapMap Linkage Disequilibrium report for TSSK4 (24674903 - 24677568 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSSK4: --
    Human Gene Mutation Database (HGMD): TSSK4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSSK4
    DNA2.0 Custom Variant and Variant Library Synthesis for TSSK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610711    OMIM disorders: --

    3 diseases for TSSK4:    
    About MalaCards
    spondylosis    spondylolisthesis    spinal stenosis

    3 diseases from the University of Copenhagen DISEASES database for TSSK4:
    Spondylolisthesis     Spondylosis     Spinal stenosis

    Find genes that share disorders with TSSK4           About GenesLikeMe

    Genetic Association Database (GAD): TSSK4
    Human Genome Epidemiology (HuGE) Navigator: TSSK4 (4 documents)

    Export disorders for TSSK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSSK4 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TSSK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    2. Mutation screening and association study of the TSSK4 Gene in Chinese infertile men with impaired spermatogenesis. (PubMed id 18390560)1, 4 Su D....Zhang S. (J. Androl. 2008)
    3. TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway. (PubMed id 15964553)1, 2 Chen X.... Yu L. (Biochem. Biophys. Res. Commun. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    8. DAZL binds to the transcripts of several Tssk genes in germ cells. (PubMed id 18452650)1 Zeng M....Ma Y. (BMB Rep 2008)
    9. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    10. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283629 HGNC: 19825 AceView: C14orf20 Ensembl:ENSG00000139908 euGenes: HUgn283629
    ECgene: TSSK4 H-InvDB: TSSK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSSK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSSK4 gene:
    Search GeneIP for patents involving TSSK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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