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Aliases for TSSK3 Gene

Aliases for TSSK3 Gene

  • Testis Specific Serine Kinase 3 2 3 5
  • Serine/Threonine-Protein Kinase 22C 3 4
  • Testis-Specific Kinase 3 3 4
  • STK22C 3 4
  • SPOGA3 3 4
  • TSSK-3 3 4
  • TSK-3 3 4
  • Serine/Threonine Kinase 22C (Spermiogenesis Associated) 2
  • Testis-Specific Serine/Threonine-Protein Kinase 3 3
  • Testis-Specific Serine/Threonine Kinase 22C 3
  • Spermiogenesis Associated 3 3
  • EC 2.7.11.1 4
  • EC 2.7.11 58
  • STK22D 3
  • TSK3 3

External Ids for TSSK3 Gene

Previous HGNC Symbols for TSSK3 Gene

  • STK22C

Previous GeneCards Identifiers for TSSK3 Gene

  • GC01P032497
  • GC01P032600
  • GC01P032827
  • GC01P030943

Summaries for TSSK3 Gene

Entrez Gene Summary for TSSK3 Gene

  • This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSSK3 Gene

TSSK3 (Testis Specific Serine Kinase 3) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot for TSSK3 Gene

  • May be involved in a signaling pathway during male germ cell development or mature sperm function.

Additional gene information for TSSK3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK3 Gene

Genomics for TSSK3 Gene

Regulatory Elements for TSSK3 Gene

Enhancers for TSSK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H031924 2.1 FANTOM5 Ensembl ENCODE dbSUPER 62 -415.7 -415689 22 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B PUM1 EIF3I
GH01H033126 2.1 FANTOM5 Ensembl ENCODE dbSUPER 40.3 +776.3 776294 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TSSK3 TXLNA RBBP4 FAM229A ZBTB8B AZIN2 ZSCAN20 ENSG00000239670 TRIM62 GC01P033128
GH01H032289 1.2 ENCODE 51.3 -60.2 -60202 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SNRNP40 RBBP4 KHDRBS1 TXLNA TSSK3 TMEM39B S100PBP ZBTB8A FAM229A DCDC2B
GH01H032262 1.8 FANTOM5 Ensembl ENCODE dbSUPER 33.7 -86.1 -86134 4 ZNF493 ZFP64 RARA SCRT2 ZNF654 ZNF680 ZC3H11A CEBPB OVOL3 REST TXLNA RBBP4 KHDRBS1 SNRNP40 TMEM39B ZBTB8A ZNF362 DCDC2B TSSK3 S100PBP
GH01H032813 1.7 FANTOM5 ENCODE dbSUPER 28.6 +465.7 465721 7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A RBBP4 KHDRBS1 ZBTB8A TXLNA TMEM39B S100PBP KPNA6 ZSCAN20 TSSK3 FAM229A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSSK3 on UCSC Golden Path with GeneCards custom track

Promoters for TSSK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004350 79 1201 HDGF MLX ARNT SIN3A FEZF1 ZBTB7B SLC30A9 ZNF766 CBX5 ZNF207

Genomic Location for TSSK3 Gene

Chromosome:
1
Start:
32,351,521 bp from pter
End:
32,364,325 bp from pter
Size:
12,805 bases
Orientation:
Plus strand

Genomic View for TSSK3 Gene

Genes around TSSK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK3 Gene

Proteins for TSSK3 Gene

  • Protein details for TSSK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PN8-TSSK3_HUMAN
    Recommended name:
    Testis-specific serine/threonine-protein kinase 3
    Protein Accession:
    Q96PN8
    Secondary Accessions:
    • Q5TEE5

    Protein attributes for TSSK3 Gene

    Size:
    268 amino acids
    Molecular mass:
    30102 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The mouse homolog is Stk22d.

neXtProt entry for TSSK3 Gene

Selected DME Specific Peptides for TSSK3 Gene

Q96PN8:
  • VAIKVIDK
  • TDFGFAK

Post-translational modifications for TSSK3 Gene

Other Protein References for TSSK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TSSK3 Gene

Gene Families for TSSK3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TSSK3 Gene

Suggested Antigen Peptide Sequences for TSSK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PN8

UniProtKB/Swiss-Prot:

TSSK3_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK3: view

Function for TSSK3 Gene

Molecular function for TSSK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-168, potentially by autophosphorylation.
UniProtKB/Swiss-Prot Function:
May be involved in a signaling pathway during male germ cell development or mature sperm function.

Enzyme Numbers (IUBMB) for TSSK3 Gene

Gene Ontology (GO) - Molecular Function for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,ISS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding ISS --
genes like me logo Genes that share ontologies with TSSK3: view
genes like me logo Genes that share phenotypes with TSSK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSSK3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TSSK3
  • Applied Biological Materials Clones for TSSK3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSSK3 Gene

Localization for TSSK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSSK3 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSSK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSSK3 Gene

Pathways & Interactions for TSSK3 Gene

SuperPathways for TSSK3 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK3: view

Pathways by source for TSSK3 Gene

1 Qiagen pathway for TSSK3 Gene

Gene Ontology (GO) - Biological Process for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis ISS --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSSK3: view

No data available for SIGNOR curated interactions for TSSK3 Gene

Drugs & Compounds for TSSK3 Gene

(2) Drugs for TSSK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0
Magnesium Nutra 0

(1) Additional Compounds for TSSK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TSSK3: view

Transcripts for TSSK3 Gene

Unigene Clusters for TSSK3 Gene

Testis-specific serine kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TSSK3
  • Applied Biological Materials Clones for TSSK3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK3 Gene

No ASD Table

Relevant External Links for TSSK3 Gene

GeneLoc Exon Structure for
TSSK3
ECgene alternative splicing isoforms for
TSSK3

Expression for TSSK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSSK3 Gene

mRNA differential expression in normal tissues according to GTEx for TSSK3 Gene

This gene is overexpressed in Testis (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of TSSK3 Gene:

TSSK3

SOURCE GeneReport for Unigene cluster for TSSK3 Gene:

Hs.512763

Evidence on tissue expression from TISSUES for TSSK3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TSSK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSSK3 Gene

Orthologs for TSSK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSSK3 33 34
  • 99.63 (n)
oppossum
(Monodelphis domestica)
Mammalia TSSK3 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSSK3 33 34
  • 94.78 (n)
cow
(Bos Taurus)
Mammalia TSSK3 33 34
  • 94.65 (n)
mouse
(Mus musculus)
Mammalia Tssk3 33 16 34
  • 92.79 (n)
rat
(Rattus norvegicus)
Mammalia Tssk3 33
  • 92.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TSSK3 33 34
  • 75.06 (n)
lizard
(Anolis carolinensis)
Reptilia TSSK3 34
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14305 34
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y38H8A.4 34
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN4 34
  • 12 (a)
ManyToMany
FRK1 34
  • 11 (a)
ManyToMany
-- 34
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Species where no ortholog for TSSK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TSSK3 Gene

ENSEMBL:
Gene Tree for TSSK3 (if available)
TreeFam:
Gene Tree for TSSK3 (if available)

Paralogs for TSSK3 Gene

Variants for TSSK3 Gene

Sequence variations from dbSNP and Humsavar for TSSK3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000068694 -- 32,362,322(+) CGCGC(A/G)TTCCC upstream-variant-2KB, utr-variant-5-prime
rs1000652777 -- 32,361,200(+) GGAAG(A/G)GAAAG intron-variant, upstream-variant-2KB
rs1000982482 -- 32,360,986(+) TGTTC(C/T)CCGCT intron-variant, upstream-variant-2KB
rs1001722336 -- 32,360,696(+) GAGAG(A/G)ATTAA upstream-variant-2KB
rs1002459355 -- 32,361,849(+) TCCTG(A/G)GCGCT upstream-variant-2KB, reference, synonymous-codon

Variation tolerance for TSSK3 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSSK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSSK3 Gene

Disorders for TSSK3 Gene

Relevant External Links for TSSK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSSK3

No disorders were found for TSSK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSSK3 Gene

Publications for TSSK3 Gene

  1. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. (PMID: 11597141) Visconti PE … Kopf GS (Genomics 2001) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M … Lindquist S (Cell 2012) 3 60

Products for TSSK3 Gene

  • Addgene plasmids for TSSK3

Sources for TSSK3 Gene

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