Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TSSK3 Gene

protein-coding   GIFtS: 48
GCID: GC01P032827

Testis-Specific Serine Kinase 3

(Previous name: serine/threonine kinase 22C (spermiogenesis associated))
(Previous symbol: STK22C)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Testis-Specific Serine Kinase 31 2     Serine/Threonine Kinase 22C (Spermiogenesis Associated)1
STK22C1 2 3 5     TSK32
Serine/Threonine-Protein Kinase 22C2 3     Spermiogenesis Associated 32
Testis-Specific Kinase 32 3     Testis-Specific Serine/Threonine Kinase 22C2
SPOGA32 3     Testis-Specific Serine/Threonine-Protein Kinase 32
TSK-32 3     EC 2.7.11.13
TSSK-32 3     EC 2.7.118
STK22D2 5     

External Ids:    HGNC: 154731   Entrez Gene: 816292   Ensembl: ENSG000001625267   OMIM: 6076605   UniProtKB: Q96PN83   
ORGUL members:         

Export aliases for TSSK3 gene to outside databases

Previous GC identifers: GC01P032497 GC01P032600 GC01P030943


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TSSK3 Gene:
This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell
differentiation or mature sperm function. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSSK3 Gene:
TSSK3 (testis-specific serine kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8
Function: May be involved in a signaling pathway during male germ cell development or mature sperm function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSSK3 gene promoter:
         STAT1   AP-1   ATF-2   IRF-1   AP-2gamma   STAT1alpha   AP-2beta   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSSK3 promoter sequence
   Search Chromatin IP Primers for TSSK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSSK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p34   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35-p34

TSSK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSSK3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032827:  view genomic region     (about GC identifiers)

Start:
32,817,122 bp from pter      End:
32,829,926 bp from pter
Size:
12,805 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8 (See protein sequence)
Recommended Name: Testis-specific serine/threonine-protein kinase 3  
Size: 268 amino acids; 30102 Da
Cofactor: Magnesium (By similarity)
Miscellaneous: The mouse homolog is Stk22d
Secondary accessions: Q5TEE5

Explore the universe of human proteins at neXtProt for TSSK3: NX_Q96PN8

Explore proteomics data for TSSK3 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for TSSK3 (Q96PN8)
     TDFGFAK  VAIKVIDK 


    See TSSK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443073.1  
    ENSEMBL proteins: 
     ENSP00000459187   ENSP00000362634  

    TSSK3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TSSK3
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for TSSK3
    OriGene Custom Protein Services for TSSK3
    GenScript Custom Purified and Recombinant Proteins Services for TSSK3
    Novus Biologicals TSSK3 Proteins
    Novus Biologicals TSSK3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSSK3

     
    Search eBioscience for Proteins for TSSK3 

     
    antibodies-online proteins for TSSK3 (6 products) 

     
    antibodies-online peptides for TSSK3

    TSSK3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSSK3
    Novus Biologicals TSSK3 Antibodies
    Search for Antibodies for TSSK3 at Abcam
    Cloud-Clone Corp. Antibodies for TSSK3
    ThermoFisher Antibodies for TSSK3
    antibodies-online antibodies for TSSK3 (17 products) 

    TSSK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSSK3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSSK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TSSK3
    Cloud-Clone Corp. CLIAs for TSSK3
    Search eBioscience for ELISAs for TSSK3 
    antibodies-online kits for TSSK3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific serine kinase 3
    Testis specific kinase (TSSK) family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96PN8

    ProtoNet protein and cluster: Q96PN8

    UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TSSK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSSK3_HUMAN, Q96PN8
    Function: May be involved in a signaling pathway during male germ cell development or mature sperm function
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-168, potentially by autophosphorylation (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding ISS--
         
    Find genes that share ontologies with TSSK3           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TSSK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased gamma-H2AX phosphory 
     PARP inhibitor sensitization  Paclitaxel antagonistic effect 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TSSK3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TSSK3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TSSK3:
    hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSSK3
    Predesigned siRNA for gene silencing in human, mouse, rat TSSK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSSK3

    Clone
    Products:
         
    OriGene clones in human, mouse for TSSK3 (see all 8)
    OriGene ORF clones in mouse, rat for TSSK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSSK3 (NM_052841)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSSK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK3
    Addgene plasmids for TSSK3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSSK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TSSK3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TSSK3
        Sperm Motility


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSSK3
    Interactions:

        Search GeneGlobe Interaction Network for TSSK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TSSK3 (Q96PN83 ENSP000003626344) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134853, ENSP000003415514I2D: score=4 STRING: ENSP00000341551
    C15orf48ENSP000003416104STRING: ENSP00000341610
    FUT9ENSP000003025994STRING: ENSP00000302599
    GP2ENSP000003707674STRING: ENSP00000370767
    OIP5ENSP000002205144STRING: ENSP00000220514
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis ISS--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with TSSK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSSK3

    3 HMDB Compounds for TSSK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TSSK3 gene: 
    NM_052841.3  

    Unigene Cluster for TSSK3:

    Testis-specific serine kinase 3
    Hs.512763  [show with all ESTs]
    Unigene Representative Sequence: AK125095
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421153 ENST00000574792 ENST00000574315 ENST00000373534(uc001bvf.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSSK3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TSSK3:
    hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSSK3
    Predesigned siRNA for gene silencing in human, mouse, rat TSSK3
    Clone
    Products:
         
    OriGene clones in human, mouse for TSSK3 (see all 8)
    OriGene ORF clones in mouse, rat for TSSK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSSK3 (NM_052841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSSK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK3
    Addgene plasmids for TSSK3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSSK3
    OriGene qSTAR qPCR primer pairs in human, mouse for TSSK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSSK3
      QuantiTect SYBR Green Assays in human, mouse, rat TSSK3
      QuantiFast Probe-based Assays in human, mouse, rat TSSK3

    Additional mRNA sequence: 

    AF296450.1 AK125095.1 AY048701.1 BC035354.1 

    4 DOTS entries:

    DT.95154096  DT.304604  DT.95368355  DT.40127483 

    Selected AceView cDNA sequences (see all 41):

    CD635280 CD635245 NM_052841 BC035354 CD635260 CD635291 BX280647 CD635267 
    AL706924 CD635252 CD635284 CD635282 CD635263 AL704437 CD635241 CD635290 
    BI829825 CD635278 CD635301 CD635273 CD635288 CD635294 CD635285 CD635272 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TSSK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSSK3 Expression
    About this image

    TSSK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSSK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512763
        Custom PCR Arrays for TSSK3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TSSK3
    OriGene qSTAR qPCR primer pairs in human, mouse for TSSK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSSK3
    QuantiTect SYBR Green Assays in human, mouse, rat TSSK3
    QuantiFast Probe-based Assays in human, mouse, rat TSSK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSSK3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tssk31 , 5 testis-specific serine kinase 31, 5 92.79(n)1
    97.76(a)1
      4 (63.26 cM)5
    588641  NM_080442.21  NP_536690.11 
     1294890145 
    chicken
    (Gallus gallus)
    Aves TSSK31 testis-specific serine kinase 3 75.06(n)
    78.2(a)
      771376  XM_001233431.2  XP_001233432.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSSK36
    testis-specific serine kinase 3
    85(a)
    1 ↔ 1
    GL343706.1(213608-215898)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG143056
    --
    37(a)
    many ↔ many
    3R(14424478-14425819)
    worm
    (Caenorhabditis elegans)
    Secernentea Y38H8A.46
    Protein Y38H8A.4 (Y38H8A.4) mRNA, complete cds
    30(a)
    many ↔ many
    IV(13470562-13472263) WBGene00012638
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN46
    FRK16
    (see all 3)
    Serine/threonine protein kinase that inhibits the ...
    Putative protein kinase; similar to Kin4p; green f...
    (see all 3)
    12(a)
    11(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XV(775846-778248) YOR233W
    XVI(283464-286061) YPL141C


    ENSEMBL Gene Tree for TSSK3 (if available)
    TreeFam Gene Tree for TSSK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TSSK3 gene
    TSSK62  TSSK1B2  TSSK22  TSSK42  
    Selected SIMAP similar genes for TSSK3 using alignment to 2 protein entries:     TSSK3_HUMAN (see all proteins) (see all similar genes):
    TSSK2    TSSK1    TSSK1B    TSSK6    TSSK4    MARK2
    KIAA0999    SIK3    MARK1    MARK4    NUAK1    Par1b
    SIK1    C14orf20    PRKAA1    BRSK2    NUAK2    BRSK1

    Find genes that share paralogs with TSSK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TSSK3 (see all 20)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430575731,2
    --32825929(+) TCTCCC/TGCCTC 1 -- us2k10--------
    rs1909754891,2
    C--32826068(+) GCCTCA/GGTCTC 1 -- us2k10--------
    rs127569791,2
    C,H--32826261(+) GCAAGT/GCGCAG 1 -- us2k15Minor allele frequency- G:0.00NS EA NA 420
    rs783453701,2
    C--32829888(+) ATAAAG/ATAGGG 1 -- ut312Minor allele frequency- A:0.07CSA WA 119
    rs1140914591,2
    C,F--32829933(+) GGTGAT/CATATA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1441849731,2
    --32829984(+) TCTACC/TCCAGC 1 -- ds50010--------
    rs351689751,2
    C--32830063(+) TTTTTT/-AAGAG 1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1861864651,2
    --32830104(+) TGGCAC/TGATTC 1 -- ds50010--------
    rs1131565271,2
    C,F--32830198(+) ACCACA/GCCTGG 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs355082551,2,4
    ----see VAR_0516782 mis40--------

    HapMap Linkage Disequilibrium report for TSSK3 (32817122 - 32829926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TSSK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv211n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): TSSK3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSSK3
    DNA2.0 Custom Variant and Variant Library Synthesis for TSSK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607660    OMIM disorders: --


    Find genes that share disorders with TSSK3           About GenesLikeMe


    Export disorders for TSSK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TSSK3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TSSK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. (PubMed id 11597141)1, 2, 3, 9 Visconti P.E.... Kopf G.S. (Genomics 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    5. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
    8. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. (PubMed id 16336268)1 Bucko-Justyna M....Trzeciak L. (FEBS J. 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 81629 HGNC: 15473 AceView: STK22C Ensembl:ENSG00000162526 euGenes: HUgn81629
    ECgene: TSSK3 H-InvDB: TSSK3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TSSK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TSSK3 gene:
    Search GeneIP for patents involving TSSK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSSK3  
     OriGene qPCR primer pairs and template standards for TSSK3   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec for TSSK3   OriGene clones in human, mouse for TSSK3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSSK3   OriGene Purified Protein for TSSK3  
     OriGene ORF clones in mouse, rat for TSSK3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSSK3   OriGene Custom Protein Services for TSSK3  

     
     
     Block miRNA regulation of human, mouse, rat TSSK3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TSSK3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSSK3 Predesigned siRNA for gene silencing in human, mouse, rat TSSK3
     QuantiFast Probe-based Assays in human, mouse, rat TSSK3 QuantiTect SYBR Green Assays in human, mouse, rat TSSK3
     Custom PCR Arrays for TSSK3 Search Chromatin IP Primers for TSSK3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSSK3  Search GeneGlobe Interaction Network for TSSK3
     Regulatory tfbs in TSSK3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TSSK3 GenScript cDNA clones with any tag delivered in your preferred vector for TSSK3
     GenScript Custom Assay Services for TSSK3 GenScript Custom overexpressing Cell Line Services for TSSK3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TSSK3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TSSK3 antibodies
     TSSK3 proteins
     TSSK3 lysates
     Search for Antibodies for TSSK3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TSSK3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TSSK3
     Antibodies for TSSK3
     ELISAs for TSSK3
     CLIAs for TSSK3



     Browse ESI BIO Cell Lines and PureStem Progenitors for TSSK3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TSSK3
     SwitchGear Promoter luciferase reporter plasmids for TSSK3
     ThermoFisher Antibodies for TSSK3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK3
     Browse compounds at ApexBio
     Addgene plasmids for TSSK3
      Search eBioscience for proteins for TSSK3
      Search eBioscience for elisas for TSSK3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TSSK3
     antibodies-online antibodies for TSSK3 (17 products)
     antibodies-online kits for TSSK3 (4 products)
     antibodies-online peptides for TSSK3
     antibodies-online proteins for TSSK3 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSSK3 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4