TSSK3 Gene
protein-coding GIFtS: 48
GCID: GC01P032827
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testis-specific serine kinase 3(Previous name: serine/threonine kinase 22C (spermiogenesis associated)...)
(Previous symbol: STK22C)
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Aliases
for TSSK3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis-Specific Serine Kinase 31 2 | | Serine/Threonine Kinase 22C (Spermiogenesis Associated)1 | | STK22C1 2 3 5 | | TSK32 | | SPOGA31 2 3 | | Spermiogenesis Associated 32 | | Serine/Threonine-Protein Kinase 22C2 3 | | Testis-Specific Serine/Threonine Kinase 22C2 | | Testis-Specific Kinase 32 3 | | Testis-Specific Serine/Threonine-Protein Kinase 32 | | TSK-32 3 | | EC 2.7.11.13 | | TSSK-32 3 | | EC 2.7.118 | | STK22D2 5 | | |
Export aliases for TSSK3 gene to outside databasesPrevious GC identifers: GC01P032497 GC01P032600 GC01P030943 |
Summaries
for TSSK3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSSK3:
This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ celldifferentiation or mature sperm function. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8Function: May be involved in a signaling pathway during male germ cell development or mature sperm function
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Genomic Views
for TSSK3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSSK3 gene promoter:
STAT1 AP-1 ATF-2 IRF-1 AP-2gamma STAT1alpha AP-2beta c-Jun AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSSK3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSK3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35-p34 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35-p34TSSK3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P032827: view genomic region
(about GC identifiers)
Start:
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32,817,122 bp from pter |
End:
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32,829,926 bp from pter |
Size:
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12,805 bases |
Orientation:
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plus strand |
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Proteins
for TSSK3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8 (See
protein sequence)Recommended Name: Testis-specific serine/threonine-protein kinase 3 Size: 268 amino acids; 30102 Da
Cofactor: Magnesium (By similarity)
Miscellaneous: The mouse homolog is Stk22d
Secondary accessions: Q5TEE5Explore the universe of human proteins at neXtProt for TSSK3: NX_Q96PN8
Post-translational modifications:
Autophosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PN8
2 DME Specific Peptides for TSSK3 (Q96PN8)
TSSK3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443073.1
ENSEMBL proteins: ENSP00000459187 ENSP00000362634
Human Recombinant Protein Products:
TSSK3 Antibody Products:
Assay Products for TSSK3: |
Protein
Domains /
Families
for TSSK3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSSK3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96PN8ProtoNet protein and cluster: Q96PN8 UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for TSSK3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8Function: May be involved in a signaling pathway during male germ cell development or mature sperm functionCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation on Thr-168, potentially by autophosphorylation (By similarity)Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK3 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000287 | magnesium ion binding |
ISS | -- | | GO:0004674 | protein serine/threonine kinase activity |
ISS | -- | | GO:0005524 | ATP binding |
ISS | -- |
TSSK3 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for TSSK3:
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Pathways & Interactions
for TSSK3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSSK3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for TSSK3 (Q96PN83 ENSP000003626344) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TSSK3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSSK3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSSK3
3 HMDB Compounds for TSSK3 About this table
Search CenterWatch for drugs/clinical trials and news about TSSK3
|
Transcripts
for TSSK3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSSK3 gene: NM_052841.3 Unigene Cluster for TSSK3: Testis-specific serine kinase 3 Hs.512763 [show with all ESTs]Unigene Representative Sequence: AK1250954 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000421153 ENST00000574792 ENST00000574315 ENST00000373534(uc001bvf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK3 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSSK3 (NM_052841) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSSK3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK3 |
Additional cDNA sequence: AF296450.1 AK125095.1 AY048701.1 BC035354.1 4 DOTS entries: DT.95154096 DT.304604 DT.95368355 DT.40127483 24/41 AceView cDNA sequences (see all 41): CD635280 CD635260 CD635291 CD635245 BX280647 NM_052841 BC035354 CD635267 CD635241 AL706924 CD635272 CD635278 CD635300 AL704437 CD635288 CD635294 CD635297 CD635273 CD635252 CD635275 CD635296 CD635282 AF296450 CD635285
GeneLoc Exon Structure
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Expression
for TSSK3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSSK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TSSK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSSK3
SOURCE GeneReport for Unigene cluster: Hs.512763
SABiosciences Custom PCR Arrays for TSSK3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSSK3
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK3 |
Orthologs
for TSSK3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSSK3 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for TSSK3 (if available)
TreeFam Gene Tree for TSSK3 (if available) |
Paralogs
for TSSK3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSSK3 gene
- TSSK1B2 PRKAA22 HUNK2 TSSK62 PRKAA12 MELK2 TSSK22 TSSK42
- STK112
18/92 SIMAP similar genes for TSSK3 using alignment to 2 protein entries: TSSK3_HUMAN (see all proteins)
(see all similar genes):TSSK2 TSSK1 TSSK1B TSSK6 TSSK4 MARK2
KIAA0999 SIK3 MARK1 MARK4 NUAK1 Par1b
SIK1 C14orf20 PRKAA1 BRSK2 NUAK2 BRSK1
TSSK3 for paralogs About GeneDecksing
|
Genomic Variants
for TSSK3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSSK3 (32817122 - 32829926 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSSK3: --
Human Gene Mutation Database (HGMD): TSSK3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSSK3 |
|
Disorders
/ Diseases
for TSSK3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TSSK3 for disorders About MalaCards
TSSK3 for disorders About GeneDecksing
OMIM gene information: 607660
OMIM disorders: --
Export disorders for TSSK3 gene to outside databases
|
Publications
for TSSK3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSSK3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSSK3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. (PubMed id 11597141)1, 2, 3, 9 Visconti P.E.... Kopf G.S. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. (PubMed id 16336268)1 Bucko-Justyna M....Trzeciak L. (2005)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TSSK3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TSSK3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSSK3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSSK3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSSK3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TSSK3 gene:
Search GeneIP for patents involving TSSK3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSSK3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TSSK3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK3 |
|  |  |  | | | | ThermoFisher Antibodies for TSSK3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK3 |
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