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Aliases for TSSK3 Gene

Aliases for TSSK3 Gene

  • Testis Specific Serine Kinase 3 2 3 5
  • Serine/Threonine-Protein Kinase 22C 3 4
  • Testis-Specific Kinase 3 3 4
  • STK22C 3 4
  • SPOGA3 3 4
  • TSSK-3 3 4
  • TSK-3 3 4
  • Serine/Threonine Kinase 22C (Spermiogenesis Associated) 2
  • Testis-Specific Serine/Threonine-Protein Kinase 3 3
  • Testis-Specific Serine/Threonine Kinase 22C 3
  • Spermiogenesis Associated 3 3
  • EC 4
  • EC 2.7.11 61
  • STK22D 3
  • TSK3 3

External Ids for TSSK3 Gene

Previous HGNC Symbols for TSSK3 Gene

  • STK22C

Previous GeneCards Identifiers for TSSK3 Gene

  • GC01P032497
  • GC01P032600
  • GC01P032827
  • GC01P030943

Summaries for TSSK3 Gene

Entrez Gene Summary for TSSK3 Gene

  • This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSSK3 Gene

TSSK3 (Testis Specific Serine Kinase 3) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot for TSSK3 Gene

  • May be involved in a signaling pathway during male germ cell development or mature sperm function.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK3 Gene

Genomics for TSSK3 Gene

Regulatory Elements for TSSK3 Gene

Enhancers for TSSK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G031924 2.1 FANTOM5 Ensembl ENCODE dbSUPER 31.4 -415.7 -415689 22.1 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 SNRNP40 ENSG00000229447 TSSK3 LOC105378626 EIF3I MTMR9LP KHDRBS1 HDAC1 ENSG00000224066 ENSG00000203325
GH01G031815 1.6 Ensembl ENCODE dbSUPER 22.1 -535.5 -535463 1.2 HDGF PKNOX1 MLX ARNT ARID4B CBX5 ZNF207 ZNF143 KLF13 ZNF263 SNRNP40 TSSK3 ZBTB8B ADGRB2 EIF3I ENSG00000229447 SPOCD1 ENSG00000203620
GH01G031795 1.5 FANTOM5 ENCODE dbSUPER 22.9 -553.6 -553599 4.5 ATF1 ZNF493 ZFP64 TCF12 GTF3C2 GLIS2 FOS ZNF263 REST ZNF623 SNRNP40 ENSG00000229447 EIF3I TSSK3 COL16A1 ZBTB8B KPNA6 MTMR9LP PEF1 KHDRBS1
GH01G031825 1.7 Ensembl ENCODE dbSUPER 19.7 -524.3 -524260 2.8 CREB3L1 DMAP1 YY1 ZNF143 ZNF416 ZNF548 ZNF263 SP3 NFYC TBX21 SNRNP40 ENSG00000229447 TSSK3 LOC105378626 HDAC1 ENSG00000235790 KPNA6 SPOCD1 ENSG00000203620
GH01G032350 1.5 ENCODE dbSUPER 22.2 +1.2 1210 4.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 TSSK3 EIF3I KPNA6 ENSG00000224066 DCDC2B IQCC ENSG00000235790 LOC105378629 FAM229A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSSK3 on UCSC Golden Path with GeneCards custom track

Promoters for TSSK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004350 79 1201 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for TSSK3 Gene

32,351,521 bp from pter
32,364,325 bp from pter
12,805 bases
Plus strand

Genomic View for TSSK3 Gene

Genes around TSSK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK3 Gene

Proteins for TSSK3 Gene

  • Protein details for TSSK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific serine/threonine-protein kinase 3
    Protein Accession:
    Secondary Accessions:
    • Q5TEE5

    Protein attributes for TSSK3 Gene

    268 amino acids
    Molecular mass:
    30102 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • The mouse homolog is Stk22d.

neXtProt entry for TSSK3 Gene

Selected DME Specific Peptides for TSSK3 Gene


Post-translational modifications for TSSK3 Gene

Other Protein References for TSSK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TSSK3 Gene

Gene Families for TSSK3 Gene

Protein Domains for TSSK3 Gene

Suggested Antigen Peptide Sequences for TSSK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK3: view

Function for TSSK3 Gene

Molecular function for TSSK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-168, potentially by autophosphorylation.
UniProtKB/Swiss-Prot Function:
May be involved in a signaling pathway during male germ cell development or mature sperm function.

Enzyme Numbers (IUBMB) for TSSK3 Gene

Gene Ontology (GO) - Molecular Function for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity ISS,IBA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding ISS --
genes like me logo Genes that share ontologies with TSSK3: view
genes like me logo Genes that share phenotypes with TSSK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSSK3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TSSK3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSSK3 Gene

Localization for TSSK3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSSK3 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSSK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSSK3 Gene

Pathways & Interactions for TSSK3 Gene

SuperPathways for TSSK3 Gene

SuperPathway Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK3: view

Pathways by source for TSSK3 Gene

1 Qiagen pathway for TSSK3 Gene

Gene Ontology (GO) - Biological Process for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS,IBA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis ISS --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSSK3: view

No data available for SIGNOR curated interactions for TSSK3 Gene

Drugs & Compounds for TSSK3 Gene

(2) Drugs for TSSK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for TSSK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TSSK3: view

Transcripts for TSSK3 Gene

Unigene Clusters for TSSK3 Gene

Testis-specific serine kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TSSK3

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK3 Gene

No ASD Table

Relevant External Links for TSSK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSSK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSSK3 Gene

mRNA differential expression in normal tissues according to GTEx for TSSK3 Gene

This gene is overexpressed in Testis (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of TSSK3 Gene:


SOURCE GeneReport for Unigene cluster for TSSK3 Gene:


Evidence on tissue expression from TISSUES for TSSK3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TSSK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSSK3 Gene

Orthologs for TSSK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSSK3 34 35
  • 99.63 (n)
(Monodelphis domestica)
Mammalia TSSK3 35
  • 95 (a)
(Canis familiaris)
Mammalia TSSK3 34 35
  • 94.78 (n)
(Bos Taurus)
Mammalia TSSK3 34 35
  • 94.65 (n)
(Mus musculus)
Mammalia Tssk3 34 16 35
  • 92.79 (n)
(Rattus norvegicus)
Mammalia Tssk3 34
  • 92.66 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 24 (a)
(Gallus gallus)
Aves TSSK3 34 35
  • 75.06 (n)
(Anolis carolinensis)
Reptilia TSSK3 35
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14305 35
  • 37 (a)
(Caenorhabditis elegans)
Secernentea Y38H8A.4 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN4 35
  • 12 (a)
FRK1 35
  • 11 (a)
-- 35
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
-- 35
  • 30 (a)
Species where no ortholog for TSSK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TSSK3 Gene

Gene Tree for TSSK3 (if available)
Gene Tree for TSSK3 (if available)

Paralogs for TSSK3 Gene

Variants for TSSK3 Gene

Sequence variations from dbSNP and Humsavar for TSSK3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000068694 -- 32,362,322(+) CGCGC(A/G)TTCCC upstream-variant-2KB, utr-variant-5-prime
rs1000652777 -- 32,361,200(+) GGAAG(A/G)GAAAG intron-variant, upstream-variant-2KB
rs1000982482 -- 32,360,986(+) TGTTC(C/T)CCGCT intron-variant, upstream-variant-2KB
rs1001722336 -- 32,360,696(+) GAGAG(A/G)ATTAA upstream-variant-2KB
rs1002459355 -- 32,361,849(+) TCCTG(A/G)GCGCT upstream-variant-2KB, reference, synonymous-codon

Variation tolerance for TSSK3 Gene

Residual Variation Intolerance Score: 53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSSK3 Gene

Disorders for TSSK3 Gene

Relevant External Links for TSSK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSSK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSSK3 Gene

Publications for TSSK3 Gene

  1. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. (PMID: 11597141) Visconti P.E. … Kopf G.S. (Genomics 2001) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3 64

Products for TSSK3 Gene

  • Addgene plasmids for TSSK3

Sources for TSSK3 Gene

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