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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSSK3 Gene

protein-coding   GIFtS: 49
GCID: GC01P032827

Testis-Specific Serine Kinase 3

(Previous name: serine/threonine kinase 22C (spermiogenesis associated))
(Previous symbol: STK22C)
  Search for TSSK3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis-Specific Serine Kinase 31 2     Serine/Threonine Kinase 22C (Spermiogenesis Associated)1
STK22C1 2 3 5     TSK32
Serine/Threonine-Protein Kinase 22C2 3     Spermiogenesis Associated 32
Testis-Specific Kinase 32 3     Testis-Specific Serine/Threonine Kinase 22C2
SPOGA32 3     Testis-Specific Serine/Threonine-Protein Kinase 32
TSK-32 3     EC 2.7.11.13
TSSK-32 3     EC 2.7.118
STK22D2 5     

External Ids:    HGNC: 154731   Entrez Gene: 816292   Ensembl: ENSG000001625267   OMIM: 6076605   UniProtKB: Q96PN83   

Export aliases for TSSK3 gene to outside databases

Previous GC identifers: GC01P032497 GC01P032600 GC01P030943


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSSK3 Gene:
This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell
differentiation or mature sperm function. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSSK3 Gene: 
TSSK3 (testis-specific serine kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8
Function: May be involved in a signaling pathway during male germ cell development or mature sperm function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSSK3 gene promoter:
         STAT1   AP-1   ATF-2   IRF-1   AP-2gamma   STAT1alpha   AP-2beta   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSSK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSSK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35-p34   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35-p34

TSSK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSSK3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032827:  view genomic region     (about GC identifiers)

Start:
32,817,122 bp from pter      End:
32,829,926 bp from pter
Size:
12,805 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8 (See protein sequence)
Recommended Name: Testis-specific serine/threonine-protein kinase 3  
Size: 268 amino acids; 30102 Da
Cofactor: Magnesium (By similarity)
Miscellaneous: The mouse homolog is Stk22d
Secondary accessions: Q5TEE5

Explore the universe of human proteins at neXtProt for TSSK3: NX_Q96PN8

Explore proteomics data for TSSK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96PN8

  • 2 DME Specific Peptides for TSSK3 (Q96PN8)
     TDFGFAK  VAIKVIDK 

    TSSK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSSK3 Protein Expression
    REFSEQ proteins: NP_443073.1  
    ENSEMBL proteins: 
     ENSP00000459187   ENSP00000362634  

    Human Recombinant Protein Products for TSSK3: 
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    Novus Biologicals TSSK3 Proteins
    Novus Biologicals TSSK3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSSK3 


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific serine kinase 3 
    Testis specific kinase (TSSK) family

    4 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q96PN8

    ProtoNet protein and cluster: Q96PN8

    UniProtKB/Swiss-Prot: TSSK3_HUMAN, Q96PN8
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    TSSK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSSK3_HUMAN, Q96PN8
    Function: May be involved in a signaling pathway during male germ cell development or mature sperm function
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-168, potentially by autophosphorylation (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding ISS--
         
    TSSK3 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TSSK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased gamma-H2AX phosphory 
     PARP inhibitor sensitization  Paclitaxel antagonistic effect 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSSK3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSSK3 
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSSK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for TSSK3 (Q96PN83 ENSP000003626344) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134853, ENSP000003415514I2D: score=4 STRING: ENSP00000341551
    C15orf48ENSP000003416104STRING: ENSP00000341610
    FUT9ENSP000003025994STRING: ENSP00000302599
    GP2ENSP000003707674STRING: ENSP00000370767
    OIP5ENSP000002205144STRING: ENSP00000220514
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis ISS--
    GO:0030154cell differentiation IEA--

    TSSK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSSK3

    3 HMDB Compounds for TSSK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about TSSK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSSK3 gene: 
    NM_052841.3  

    Unigene Cluster for TSSK3:

    Testis-specific serine kinase 3
    Hs.512763  [show with all ESTs]
    Unigene Representative Sequence: AK125095
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421153 ENST00000574792 ENST00000574315 ENST00000373534(uc001bvf.3)

    miRNA
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    hsa-miR-629*
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of TSSK3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSSK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSSK3

    Additional mRNA sequence: 

    AF296450.1 AK125095.1 AY048701.1 BC035354.1 

    4 DOTS entries:

    DT.95154096  DT.304604  DT.95368355  DT.40127483 

    24/41 AceView cDNA sequences (see all 41):

    NM_052841 CD635280 BC035354 BX280647 CD635245 CD635267 CD635291 CD635260 
    CD635285 CD635296 CD635273 CD635301 CD635275 BI829825 CD635252 CD635300 
    AF296450 CD635288 CD635278 CD635272 CD635247 CD635294 CD635290 CD635241 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSSK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSSK3 Expression
    About this image


    See TSSK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSSK3

    SOURCE GeneReport for Unigene cluster: Hs.512763
        SABiosciences Custom PCR Arrays for TSSK3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSSK3 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tssk31 , 5 testis-specific serine kinase 31, 5 92.79(n)1
    97.76(a)1
      4 (63.26 cM)5
    588641  NM_080442.21  NP_536690.11 
     1294890145 
    chicken
    (Gallus gallus)
    Aves TSSK31 testis-specific serine kinase 3 75.06(n)
    78.2(a)
      771376  XM_001233431.1  XP_001233432.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSSK36
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343706.1(213608-215898)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG143056
    --
    37(a)
    possible ortholog
    3R(14424478-14425819)
    worm
    (Caenorhabditis elegans)
    Secernentea C27D6.116
    Y38H8A.46
    (see all 5)
    Protein Y38H8A.4
    (see all 5)
    30(a)
    29(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    II(5159716-5161130)
    IV(13470562-13472263)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRR16
    Serine/threonine protein kinase that inhibits pher...
    14(a)
    1 → many
    XI(221344-222900)


    ENSEMBL Gene Tree for TSSK3 (if available)
    TreeFam Gene Tree for TSSK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSSK3 gene
    TSSK62  TSSK1B2  MELK2  TSSK22  TSSK42  HUNK2  
    18/89 SIMAP similar genes for TSSK3 using alignment to 2 protein entries:     TSSK3_HUMAN (see all proteins) (see all similar genes):
    TSSK2    TSSK1    TSSK1B    TSSK6    TSSK4    MARK2
    KIAA0999    SIK3    MARK1    MARK4    NUAK1    Par1b
    SIK1    C14orf20    PRKAA1    BRSK2    NUAK2    BRSK1

    TSSK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/20 SNPs in TSSK3 are shown (see all 20)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0516784
    ----see VAR_0516782 I V mis40--------
    VAR_0412464
    ----see VAR_0412462 S L mis40--------
    VAR_0412454
    ----see VAR_0412452 A T mis40--------
    rs1430575731,2
    --32825929(+) TCTCCC/TGCCTC 1 -- us2k10--------
    rs1909754891,2
    C--32826068(+) GCCTCA/GGTCTC 1 -- us2k10--------
    rs127569791,2
    C,H--32826261(+) GCAAGT/GCGCAG 1 -- us2k15Minor allele frequency- G:0.00NS EA NA 420
    rs783453701,2
    C--32829888(+) ATAAAG/ATAGGG 1 -- ut312Minor allele frequency- A:0.07CSA WA 119
    rs1140914591,2
    C,F--32829933(+) GGTGAT/CATATA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1441849731,2
    --32829984(+) TCTACC/TCCAGC 1 -- ds50010--------
    rs351689751,2
    C--32830063(+) TTTTTT/-AAGAG 1 -- ds50011Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for TSSK3 (32817122 - 32829926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TSSK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv211n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): TSSK3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TSSK3
    DNA2.0 Custom Variant and Variant Library Synthesis for TSSK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TSSK3 for disorders           About MalaCards
    OMIM gene information: 607660    OMIM disorders: --


    TSSK3 for disorders           About GeneDecksing


    Export disorders for TSSK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSSK3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TSSK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. (PubMed id 11597141)1, 2, 3, 9 Visconti P.E.... Kopf G.S. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    7. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. (PubMed id 16336268)1 Bucko-Justyna M....Trzeciak L. (2005)
    8. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81629 HGNC: 15473 AceView: STK22C Ensembl:ENSG00000162526 euGenes: HUgn81629
    ECgene: TSSK3 H-InvDB: TSSK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSSK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSSK3 gene:
    Search GeneIP for patents involving TSSK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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