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Aliases for TSSK3 Gene

Aliases for TSSK3 Gene

  • Testis-Specific Serine Kinase 3 2 3
  • STK22C 3 4 6
  • Serine/Threonine-Protein Kinase 22C 3 4
  • Testis-Specific Kinase 3 3 4
  • STK22D 3 6
  • SPOGA3 3 4
  • TSSK-3 3 4
  • TSK-3 3 4
  • Serine/Threonine Kinase 22C (Spermiogenesis Associated) 2
  • Testis-Specific Serine/Threonine-Protein Kinase 3 3
  • Testis-Specific Serine/Threonine Kinase 22C 3
  • Spermiogenesis Associated 3 3
  • EC 4
  • EC 2.7.11 63
  • TSK3 3

External Ids for TSSK3 Gene

Previous HGNC Symbols for TSSK3 Gene

  • STK22C

Previous GeneCards Identifiers for TSSK3 Gene

  • GC01P032497
  • GC01P032600
  • GC01P032827
  • GC01P030943

Summaries for TSSK3 Gene

Entrez Gene Summary for TSSK3 Gene

  • This gene encodes a kinase expressed exclusively in the testis that is thought to play a role in either germ cell differentiation or mature sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSSK3 Gene

TSSK3 (Testis-Specific Serine Kinase 3) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is TSSK4.

UniProtKB/Swiss-Prot for TSSK3 Gene

  • May be involved in a signaling pathway during male germ cell development or mature sperm function

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK3 Gene

Genomics for TSSK3 Gene

Regulatory Elements for TSSK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSSK3 Gene

32,351,521 bp from pter
32,364,325 bp from pter
12,805 bases
Plus strand

Genomic View for TSSK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSSK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK3 Gene

Proteins for TSSK3 Gene

  • Protein details for TSSK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific serine/threonine-protein kinase 3
    Protein Accession:
    Secondary Accessions:
    • Q5TEE5

    Protein attributes for TSSK3 Gene

    268 amino acids
    Molecular mass:
    30102 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • The mouse homolog is Stk22d

neXtProt entry for TSSK3 Gene

Proteomics data for TSSK3 Gene at MOPED

Selected DME Specific Peptides for TSSK3 Gene

Post-translational modifications for TSSK3 Gene

Other Protein References for TSSK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for TSSK3 Gene

Suggested Antigen Peptide Sequences for TSSK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96PN8
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK3: view

Function for TSSK3 Gene

Molecular function for TSSK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-168, potentially by autophosphorylation.
UniProtKB/Swiss-Prot Function:
May be involved in a signaling pathway during male germ cell development or mature sperm function

Enzyme Numbers (IUBMB) for TSSK3 Gene

Gene Ontology (GO) - Molecular Function for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TSSK3: view
genes like me logo Genes that share phenotypes with TSSK3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSK3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSSK3 Gene

Localization for TSSK3 Gene

Subcellular locations from

Jensen Localization Image for TSSK3 Gene COMPARTMENTS Subcellular localization image for TSSK3 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSSK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSSK3 Gene

Pathways for TSSK3 Gene

SuperPathways for TSSK3 Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK3: view

Pathways by source for TSSK3 Gene

1 Qiagen pathway for TSSK3 Gene

Gene Ontology (GO) - Biological Process for TSSK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis ISS --
GO:0008152 metabolic process --
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with TSSK3: view

Compounds for TSSK3 Gene

(3) HMDB Compounds for TSSK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
genes like me logo Genes that share compounds with TSSK3: view

Transcripts for TSSK3 Gene

mRNA/cDNA for TSSK3 Gene

Unigene Clusters for TSSK3 Gene

Testis-specific serine kinase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSK3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK3 Gene

No ASD Table

Relevant External Links for TSSK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSSK3 Gene

mRNA expression in normal human tissues for TSSK3 Gene

mRNA differential expression in normal tissues according to GTEx for TSSK3 Gene

This gene is overexpressed in Testis (4.0).

SOURCE GeneReport for Unigene cluster for TSSK3 Gene Hs.512763

genes like me logo Genes that share expressions with TSSK3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TSSK3 Gene

Orthologs for TSSK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSSK3 35
  • 94.65 (n)
  • 96.64 (a)
TSSK3 36
  • 96 (a)
(Canis familiaris)
Mammalia TSSK3 35
  • 94.78 (n)
  • 97.01 (a)
TSSK3 36
  • 97 (a)
(Mus musculus)
Mammalia Tssk3 35
  • 92.79 (n)
  • 97.76 (a)
Tssk3 16
Tssk3 36
  • 98 (a)
(Pan troglodytes)
Mammalia TSSK3 35
  • 99.63 (n)
  • 99.63 (a)
TSSK3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tssk3 35
  • 92.66 (n)
  • 97.39 (a)
(Monodelphis domestica)
Mammalia TSSK3 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
(Gallus gallus)
Aves TSSK3 35
  • 75.06 (n)
  • 78.2 (a)
TSSK3 36
  • 77 (a)
(Anolis carolinensis)
Reptilia TSSK3 36
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14305 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea Y38H8A.4 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 10 (a)
FRK1 36
  • 11 (a)
KIN4 36
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
-- 36
  • 30 (a)
Species with no ortholog for TSSK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TSSK3 Gene

Gene Tree for TSSK3 (if available)
Gene Tree for TSSK3 (if available)

Paralogs for TSSK3 Gene

Paralogs for TSSK3 Gene

genes like me logo Genes that share paralogs with TSSK3: view

Variants for TSSK3 Gene

Sequence variations from dbSNP and Humsavar for TSSK3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12756979 -- 32,360,660(+) GCAAG(G/T)CGCAG upstream-variant-2KB
rs190975489 -- 32,360,467(+) GCCTC(A/G/T)GTCTC upstream-variant-2KB
rs372787853 -- 32,360,618(+) CCTTC(C/T)AATAA upstream-variant-2KB
rs376938272 -- 32,360,587(+) AGGCT(C/T)AGGAT upstream-variant-2KB
rs377211086 -- 32,360,581(+) AAACC(A/G)AGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSSK3 Gene

Variant ID Type Subtype PubMed ID
dgv211n71 CNV Loss 21882294

Relevant External Links for TSSK3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSSK3 Gene

Disorders for TSSK3 Gene

No disorders were found for TSSK3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TSSK3 Gene

Publications for TSSK3 Gene

  1. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. (PMID: 11597141) Visconti P.E. … Kopf G.S. (Genomics 2001) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  4. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. (PMID: 16336268) Bucko-Justyna M. … Trzeciak L. (FEBS J. 2005) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for TSSK3 Gene

  • Addgene plasmids for TSSK3

Sources for TSSK3 Gene

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