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TSSK2 Gene

protein-coding   GIFtS: 58
GCID: GC22P019118

Testis-Specific Serine Kinase 2

(Previous name: serine/threonine kinase 22B (spermiogenesis associated))
(Previous symbol: STK22B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis-Specific Serine Kinase 21 2     TSK22 3
STK22B1 2 3 5     TSSK-22 3
Serine/Threonine Kinase 22B (Spermiogenesis Associated)1 2     EC 2.7.11.13 8
DiGeorge Syndrome Protein G2 3     Spermiogenesis Associated 22
Serine/Threonine-Protein Kinase 22B2 3     Testis Specific Serine Threonine Kinase 22
Testis-Specific Kinase 22 3     Testis-Specific Serine/Threonine-Protein Kinase 22
DGS-G2 3     DGSG3
SPOGA22 3     EC 2.7.118
TSK-22 3     

External Ids:    HGNC: 114011   Entrez Gene: 236172   Ensembl: ENSG000002062037   OMIM: 6107105   UniProtKB: Q96PF23   

Export aliases for TSSK2 gene to outside databases

Previous GC identifers: GC22P017495 GC22P017497 GC22P017500 GC22P017502 GC22P017504 GC22P017507 GC22P017509 GC22P002739


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSSK2 Gene:
TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 (PubMed
15044604)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TSSK2 Gene:
TSSK2 (testis-specific serine kinase 2) is a protein-coding gene. Diseases associated with TSSK2 include digeorge syndrome, and vaginitis. GO annotations related to this gene include magnesium ion binding and identical protein binding. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2
Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates
TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the
cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of
the flagellum originating from the chromatoid body

Gene Wiki entry for TSSK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TSSK2 gene promoter:
         CREB   NF-1/L   NF-1   AML1a   HTF   NCX/Ncx   deltaCREB   FOXO3   IRF-1   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSSK2 promoter sequence
   Search Chromatin IP Primers for TSSK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSSK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

TSSK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSSK2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P019118:  view genomic region     (about GC identifiers)

Start:
19,118,321 bp from pter      End:
19,120,136 bp from pter
Size:
1,816 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2 (See protein sequence)
Recommended Name: Testis-specific serine/threonine-protein kinase 2  
Size: 358 amino acids; 40939 Da
Cofactor: Magnesium
Subunit: Interacts with TSSK1B
Miscellaneous: TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides
(PubMed:17566264)
Secondary accessions: Q8IY55

Explore the universe of human proteins at neXtProt for TSSK2: NX_Q96PF2

Explore proteomics data for TSSK2 at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TSSK2 (Q96PF2) (see all 10)
     LSHSWLQ  DTKTGLR  IVHRDLK  KYCHDLD 


    See TSSK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443732.3  
    ENSEMBL proteins: 
     ENSP00000382544  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific serine kinase 2
    Testis specific kinase (TSSK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96PF2

    ProtoNet protein and cluster: Q96PF2

    UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    TSSK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSSK2_HUMAN, Q96PF2
    Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates
    TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the
    cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of
    the flagellum originating from the chromatoid body
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-174, potentially by autophosphorylation (By similarity)
    Biophysicochemical properties: Kinetic parameters: KM=10 uM for ATP;

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15044604
         
    TSSK2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for TSSK2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel 
     Synthetic lethal with cisplati 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tssk2):
     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    TSSK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TSSK2: Tssk1/Tssk2Tssk1/tm1Joch Tssk1/Tssk2Tssk1/tm1.1Agr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSSK2
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    5 qRT-PCR Assays for microRNAs that regulate TSSK2:
    hsa-miR-24-2* hsa-miR-140-5p hsa-miR-24-1* hsa-miR-1914 hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidTSSK2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSSK2_HUMAN, Q96PF2: Cytoplasm (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome, centriole. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the
    equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids,
    concentrates in centrioles during flagellogenesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm ISS--
    GO:0005814centriole IEA--

    TSSK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TSSK2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcription CREM signaling in testis
    Transcription CREM signaling in testis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TSSK2
        Sperm Motility

    1 GeneGo (Thomson Reuters) Pathway for TSSK2
        Transcription CREM signaling in testis



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSSK2
    Interactions:

        Search GeneGlobe Interaction Network for TSSK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TSSK2 (Q96PF21, 3 ENSP000003825444) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSKSQ9UJT21, 3, ENSP000002468014EBI-852089,EBI-852101 I2D: score=3 STRING: ENSP00000246801
    TFGQ927343, ENSP000002408514I2D: score=1 STRING: ENSP00000240851
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1EP496743I2D: score=1 
    TGFBR1P368973I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0007286spermatid development ISS--
    GO:0046777protein autophosphorylation IDA--

    TSSK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSSK2

    3 HMDB Compounds for TSSK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSSK2 gene: 
    NM_053006.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000399635(uc002zow.2)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTSSK2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat TSSK2
      QuantiFast Probe-based Assays in human, mouse, rat TSSK2

    1 AceView cDNA sequence:

    NM_053006 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSSK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCAGTCGG
    TSSK2 Expression
    About this image

    TSSK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSSK2 Protein Expression

    UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2
    Tissue specificity: Testis-specific. Present in mature spermatozoa (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSSK2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tssk21 , 5 testis-specific serine kinase 21, 5 89.48(n)1
    92.18(a)1
      16 (11.09 cM)5
    221151  NM_009436.21  NP_033462.21 
     178986375 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    72(a)
    1 → many
    GL343282.1(739910-740872)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.47972 Oncorhynchus mykiss transcribed sequence with weak more 75.19(n)    BX299786.2 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0087651 AgaP_AGAP008765 53.21(n)
    41.85(a)
      1275620  XM_314887.4  XP_314887.4 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3446
    Protein TAG-344 (tag-344) mRNA, complete cds
    30(a)
    many ↔ many
    I(10644284-10645617) WBGene00015230
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN46
    FRK16
    (see all 3)
    Serine/threonine protein kinase that inhibits the ...
    Putative protein kinase; similar to Kin4p; green f...
    (see all 3)
    14(a)
    13(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XV(775846-778248) YOR233W
    XVI(283464-286061) YPL141C


    ENSEMBL Gene Tree for TSSK2 (if available)
    TreeFam Gene Tree for TSSK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSSK2 gene
    TSSK62  TSSK32  TSSK1B2  TSSK42  
    Selected SIMAP similar genes for TSSK2 using alignment to 2 protein entries:     TSSK2_HUMAN (see all proteins) (see all similar genes):
    TSSK1    TSSK1B    TSSK3    TSSK6    TSSK4    MARK2
    Par1b    SIK3    KIAA0999    MARK1    SNRK    SIK1
    MARK3    STK33    PRKAA1    CAMK1    NIM1K    BRSK2

    TSSK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSSK2 (see all 23)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178110401,2
    C,F,H--19116351(+) CAGCCG/ATAGAG 1 -- us2k114Minor allele frequency- A:0.30NA NS EA WA CSA 775
    rs731588761,2
    C,F--19116501(+) CTCTCA/TGCTTA 1 -- us2k13Minor allele frequency- T:0.14WA NA EA 358
    rs1173055791,2
    C,F--19116610(+) CCATGC/TCAGGG 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1163794171,2
    F--19116719(+) GAAACC/TTTCCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs412775991,2
    C,F--19116824(+) ATGCCT/CGTGAT 1 -- us2k16Minor allele frequency- C:0.08NA EA 248
    rs1443690011,2
    --19116856(+) CCAACA/GCACCT 1 -- us2k10--------
    rs622238731,2
    C,F--19116887(+) CCACAT/ATTCCC 1 -- us2k16Minor allele frequency- A:0.09NA CSA EA 248
    rs57479951,2
    C--19116954(+) AGGCAG/TCCCGA 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1462132091,2
    --19116981(+) AATGTC/GAGGGT 1 -- us2k10--------
    rs1391551571,2
    --19117067(+) GCCTGA/GTCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSSK2 (19118321 - 19120136 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TSSK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv435744CNV Deletion17901297
    nsv834122CNV Loss17160897
    nsv914263CNV Gain21882294
    nsv914268CNV Gain21882294

    Human Gene Mutation Database (HGMD): TSSK2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610710    OMIM disorders: --

    5 diseases for TSSK2:    
    About MalaCards
    digeorge syndrome    vaginitis    male infertility    infertility
    malaria

    1 disease from the University of Copenhagen DISEASES database for TSSK2:
    Infertility

    TSSK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TSSK2
    Human Genome Epidemiology (HuGE) Navigator: TSSK2 (1 document)

    Export disorders for TSSK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSSK2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TSSK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment. (PubMed id 19926886)1, 2, 4 Zhang H....Zhang S. (J. Androl. 2010)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    3. Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency. (PubMed id 18533145)1, 2 Xu B.... Herr J.C. (Dev. Biol. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    6. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 2 Hao Z....Visconti P.E. (Mol. Hum. Reprod. 2004)
    7. A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11. (PubMed id 8776594)1, 2 Gong W.... Budarf M.L. (Hum. Mol. Genet. 1996)
    8. A novel family of serine/threonine kinases participating in spermiogenesis. (PubMed id 9412477)1, 9 Kueng P....Ziemiecki A. (J. Cell Biol. 1997)
    9. Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets. (PubMed id 17566264)2, 9 Xu B.... Herr J.C. (Soc. Reprod. Fertil. Suppl. 2007)
    10. Evolution of testis-specific kinases TSSK1B and TSSK2 in primates. (PubMed id 23258646)1 Shang P....Grootegoed J.A. (Andrology 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23617 HGNC: 11401 AceView: STK22B Ensembl:ENSG00000206203 euGenes: HUgn23617
    ECgene: TSSK2 H-InvDB: TSSK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSSK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSSK2 gene:
    Search GeneIP for patents involving TSSK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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