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Aliases for TSSK2 Gene

Aliases for TSSK2 Gene

  • Testis Specific Serine Kinase 2 2 3
  • Serine/Threonine Kinase 22B (Spermiogenesis Associated) 2 3
  • Serine/Threonine-Protein Kinase 22B 3 4
  • Testis-Specific Serine Kinase 2 3 5
  • DiGeorge Syndrome Protein G 3 4
  • Testis-Specific Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • STK22B 3 4
  • SPOGA2 3 4
  • TSSK-2 3 4
  • DGS-G 3 4
  • TSK-2 3 4
  • TSK2 3 4
  • Testis Specific Serine Threonine Kinase 2 3
  • Testicular Secretory Protein Li 61 3
  • Spermiogenesis Associated 2 3
  • EC 2.7.11 63
  • DGSG 4

External Ids for TSSK2 Gene

Previous HGNC Symbols for TSSK2 Gene

  • STK22B

Previous GeneCards Identifiers for TSSK2 Gene

  • GC22P017495
  • GC22P017497
  • GC22P017500
  • GC22P017502
  • GC22P017504
  • GC22P017507
  • GC22P017509
  • GC22P019118
  • GC22P002739

Summaries for TSSK2 Gene

Entrez Gene Summary for TSSK2 Gene

  • TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TSSK2 Gene

TSSK2 (Testis Specific Serine Kinase 2) is a Protein Coding gene. Diseases associated with TSSK2 include Velocardiofacial Syndrome. Among its related pathways are Sweet Taste Signaling and Transcription_CREM signaling in testis. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot for TSSK2 Gene

  • Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at Ser-288 and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.

Gene Wiki entry for TSSK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK2 Gene

Genomics for TSSK2 Gene

Regulatory Elements for TSSK2 Gene

Enhancers for TSSK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSSK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSSK2 Gene

Chromosome:
22
Start:
19,130,808 bp from pter
End:
19,132,623 bp from pter
Size:
1,816 bases
Orientation:
Plus strand

Genomic View for TSSK2 Gene

Genes around TSSK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK2 Gene

Proteins for TSSK2 Gene

  • Protein details for TSSK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PF2-TSSK2_HUMAN
    Recommended name:
    Testis-specific serine/threonine-protein kinase 2
    Protein Accession:
    Q96PF2
    Secondary Accessions:
    • Q8IY55

    Protein attributes for TSSK2 Gene

    Size:
    358 amino acids
    Molecular mass:
    40939 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with TSSK1B.
    Miscellaneous:
    • TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides.

neXtProt entry for TSSK2 Gene

Proteomics data for TSSK2 Gene at MOPED

Post-translational modifications for TSSK2 Gene

Other Protein References for TSSK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TSSK2 Gene

Gene Families for TSSK2 Gene

Suggested Antigen Peptide Sequences for TSSK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PF2

UniProtKB/Swiss-Prot:

TSSK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK2: view

Function for TSSK2 Gene

Molecular function for TSSK2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10 uM for ATP {ECO:0000269 PubMed:20729278};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-174, potentially by autophosphorylation.
UniProtKB/Swiss-Prot Function:
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at Ser-288 and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.

Enzyme Numbers (IUBMB) for TSSK2 Gene

Gene Ontology (GO) - Molecular Function for TSSK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0005524 ATP binding IEA,ISS --
genes like me logo Genes that share ontologies with TSSK2: view
genes like me logo Genes that share phenotypes with TSSK2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSSK2 Gene

Localization for TSSK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSSK2 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSSK2 Gene COMPARTMENTS Subcellular localization image for TSSK2 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSSK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with TSSK2: view

Pathways & Interactions for TSSK2 Gene

genes like me logo Genes that share pathways with TSSK2: view

Pathways by source for TSSK2 Gene

1 GeneGo (Thomson Reuters) pathway for TSSK2 Gene
1 Qiagen pathway for TSSK2 Gene

Gene Ontology (GO) - Biological Process for TSSK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with TSSK2: view

No data available for SIGNOR curated interactions for TSSK2 Gene

Drugs & Compounds for TSSK2 Gene

(2) Drugs for TSSK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for TSSK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TSSK2: view

Transcripts for TSSK2 Gene

mRNA/cDNA for TSSK2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSSK2 Gene

Testis-specific serine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK2 Gene

No ASD Table

Relevant External Links for TSSK2 Gene

GeneLoc Exon Structure for
TSSK2
ECgene alternative splicing isoforms for
TSSK2

Expression for TSSK2 Gene

mRNA expression in normal human tissues for TSSK2 Gene

Protein differential expression in normal tissues from HIPED for TSSK2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSSK2 Gene



SOURCE GeneReport for Unigene cluster for TSSK2 Gene Hs.694070

mRNA Expression by UniProt/SwissProt for TSSK2 Gene

Q96PF2-TSSK2_HUMAN
Tissue specificity: Testis-specific. Present in mature spermatozoa (at protein level).
genes like me logo Genes that share expression patterns with TSSK2: view

Protein tissue co-expression partners for TSSK2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TSSK2 Gene

Orthologs for TSSK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSSK2 35
  • 89.2 (n)
  • 91.34 (a)
TSSK2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSSK2 35
  • 86.69 (n)
  • 87.43 (a)
TSSK2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tssk2 35
  • 89.48 (n)
  • 92.18 (a)
Tssk2 16
Tssk2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSSK2 35
  • 99.53 (n)
  • 98.6 (a)
TSSK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tssk2 35
  • 89.48 (n)
  • 93.02 (a)
oppossum
(Monodelphis domestica)
Mammalia TSSK2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSSK2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4797 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008765 35
  • 53.21 (n)
  • 41.85 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-344 36
  • 30 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 11 (a)
ManyToMany
FRK1 36
  • 13 (a)
ManyToMany
KIN4 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4544 36
  • 50 (a)
OneToMany
Species with no ortholog for TSSK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TSSK2 Gene

ENSEMBL:
Gene Tree for TSSK2 (if available)
TreeFam:
Gene Tree for TSSK2 (if available)

Paralogs for TSSK2 Gene

Paralogs for TSSK2 Gene

(24) SIMAP similar genes for TSSK2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TSSK2: view

Variants for TSSK2 Gene

Sequence variations from dbSNP and Humsavar for TSSK2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_041241 -
VAR_041242 -
VAR_041243 -
VAR_041244 -
VAR_051677 -

Structural Variations from Database of Genomic Variants (DGV) for TSSK2 Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv914263 CNV Gain 21882294
nsv914268 CNV Gain 21882294
nsv834122 CNV Loss 17160897

Variation tolerance for TSSK2 Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.32; 85.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSK2 Gene

Human Gene Mutation Database (HGMD)
TSSK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSSK2 Gene

Disorders for TSSK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSSK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
velocardiofacial syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TSSK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSSK2

Genetic Association Database (GAD)
TSSK2
Human Genome Epidemiology (HuGE) Navigator
TSSK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSSK2
genes like me logo Genes that share disorders with TSSK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSSK2 Gene

Publications for TSSK2 Gene

  1. Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment. (PMID: 19926886) Zhang H. … Zhang S. (J. Androl. 2010) 3 4 48 67
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  3. A novel family of serine/threonine kinases participating in spermiogenesis. (PMID: 9412477) Kueng P. … Ziemiecki A. (J. Cell Biol. 1997) 3 23
  4. Evolution of testis-specific kinases TSSK1B and TSSK2 in primates. (PMID: 23258646) Shang P. … Grootegoed J.A. (Andrology 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for TSSK2 Gene

Sources for TSSK2 Gene

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