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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSSK2 Gene

protein-coding   GIFtS: 60
GCID: GC22P019118

testis-specific serine kinase 2

(Previous name: serine/threonine kinase 22B (spermiogenesis associated)...)
(Previous symbol: STK22B)
 Explore 4 diseases affiliated with
TSSK2 via our new
 Human Malady Compendium 
Biological research products
for TSSK2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Testis-Specific Serine Kinase 21 2     TSK22 3
STK22B1 2 3 5     TSSK-22 3
SPOGA21 2 3     EC 2.7.11.13 8
Serine/Threonine Kinase 22B (Spermiogenesis Associated)1 2     FLJ386131
DiGeorge Syndrome Protein G2 3     Spermiogenesis Associated 22
Serine/Threonine-Protein Kinase 22B2 3     Testis Specific Serine Threonine Kinase 22
Testis-Specific Kinase 22 3     Testis-Specific Serine/Threonine-Protein Kinase 22
DGS-G2 3     DGSG3
TSK-22 3     EC 2.7.118

External Ids:    HGNC: 114011   Entrez Gene: 236172   Ensembl: ENSG000002062037   OMIM: 6107105   UniProtKB: Q96PF23   

Export aliases for TSSK2 gene to outside databases

Previous GC identifers: GC22P017495 GC22P017497 GC22P017500 GC22P017502 GC22P017504 GC22P017507 GC22P017509 GC22P002739


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSSK2:
TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 (PubMed
15044604)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2
Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at
'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm.
During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum
originating from the chromatoid body

Gene Wiki entry for TSSK2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011519.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSSK2 gene promoter:
         CREB   NF-1/L   NF-1   AML1a   HTF   NCX/Ncx   deltaCREB   FOXO3   IRF-1   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSSK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSSK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

TSSK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSSK2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P019118:  view genomic region     (about GC identifiers)

Start:
19,118,321 bp from pter      End:
19,120,136 bp from pter
Size:
1,816 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2 (See protein sequence)
Recommended Name: Testis-specific serine/threonine-protein kinase 2  
Size: 358 amino acids; 40939 Da
Cofactor: Magnesium
Subunit: Interacts with TSSK1B
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton, centrosome, centriole. Note=Present in the
cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a
specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis
Miscellaneous: TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides
(PubMed:17566264)
Secondary accessions: Q8IY55

Explore the universe of human proteins at neXtProt for TSSK2: NX_Q96PF2

Post-translational modifications:

  • Autophosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96PF2

  • 4/10 DME Specific Peptides for TSSK2 (Q96PF2) (see all 10)
     LSHSWLQ  DTKTGLR  IVHRDLK  KYCHDLD 

    TSSK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_443732.3  
    ENSEMBL proteins: 
     ENSP00000382544  

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    Uscn Proteins for TSSK2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm ISS--
    GO:0005814centriole IEA--


    TSSK2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TSSK2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q96PF2

    ProtoNet protein and cluster: Q96PF2

    UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2
    Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at
    'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm.
    During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum
    originating from the chromatoid body
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-174, potentially by autophosphorylation (By similarity)
    Biophysicochemical properties: Kinetic parameters: KM=10 uM for ATP;

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0005515protein binding IPI15044604
    GO:0005524ATP binding ISS--
    GO:0042802identical protein binding IPI15044604


    TSSK2 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for TSSK2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel 
     Synthetic lethal with cisplati 

    Animal Models:
         Mouse knock-outs for TSSK2: Tssk1/Tssk2Tssk1/tm1Joch Tssk1/Tssk2Tssk1/tm1.1Agr
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tssk2):
     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    TSSK2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription_CREM signaling in testis
    Transcription_CREM signaling in testis1.00
    Transcription CREM signaling in testis0.96

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TSSK2
        Transcription CREM signaling in testis


    1 GeneGo (Thomson Reuters) Pathway for TSSK2
        Transcription CREM signaling in testis



    TSSK2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSSK2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for TSSK2 (Q96PF21, 3 ENSP000003825444) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSKSQ9UJT21, 3, ENSP000002468014EBI-852089,EBI-852101 I2D: score=3 STRING: ENSP00000246801
    TFGQ927343, ENSP000002408514I2D: score=1 STRING: ENSP00000240851
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1EP496743I2D: score=1 
    TGFBR1P368973I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0007286spermatid development ISS--
    GO:0046777protein autophosphorylation IDA--


    TSSK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TSSK2

    3 HMDB Compounds for TSSK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about TSSK2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSSK2 gene: 
    NM_053006.4  

    Unigene Cluster for TSSK2:

    Testis-specific serine kinase 2
    Hs.694070  [show with all ESTs]
    Unigene Representative Sequence: NM_053006
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000399635(uc002zow.2)

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    Additional cDNA sequence: BC037781.2 

    2 DOTS entries:

    DT.408872  DT.421881 

    1 AceView cDNA sequence:

    NM_053006 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSSK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCAGTCGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TSSK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSSK2

    SOURCE GeneReport for Unigene cluster: Hs.694070

    UniProtKB/Swiss-Prot: TSSK2_HUMAN, Q96PF2
    Tissue specificity: Testis-specific. Present in mature spermatozoa (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TSSK2 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    73(a)
    1 → many
    GL343282.1(739910-740872)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.47972 Oncorhynchus mykiss transcribed sequence with weak more 75.19(n)    BX299786.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG143056
    --
    42(a)
    1 → many
    3R(14424478-14425819)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-3441 Protein TAG-344 47.88(n)
    45.17(a)
      182017  NM_060385.1  NP_492786.1 


    ENSEMBL Gene Tree for TSSK2 (if available)
    TreeFam Gene Tree for TSSK2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSSK2 gene
    TSSK1B2  PRKAA22  HUNK2  TSSK62  TSSK32  PRKAA12  MELK2  TSSK42  
    STK112  
    18/24 SIMAP similar genes for TSSK2 using alignment to 2 protein entries:     TSSK2_HUMAN (see all proteins) (see all similar genes):
    TSSK1    TSSK1B    TSSK3    TSSK6    TSSK4    MARK2
    Par1b    SIK3    KIAA0999    MARK1    SNRK    SIK1
    MARK3    STK33    PRKAA1    CAMK1    NIM1    BRSK2

    TSSK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/15 NCBI SNPs in TSSK2 are shown (see all 15    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178110401,2
    C,F,H,--19116351(+) CAGCCG/ATAGAG 1 -- us2k114Minor allele frequency- A:0.30NA NS EA WA CSA 775
    rs731588761,2
    C,F,--19116501(+) CTCTCA/TGCTTA 1 -- us2k13Minor allele frequency- T:0.14WA NA EA 358
    rs1173055791,2
    C,F,--19116610(+) CCATGC/TCAGGG 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1163794171,2
    F,--19116719(+) GAAACC/TTTCCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs412775991,2
    C,F,--19116824(+) ATGCCT/CGTGAT 1 -- us2k16Minor allele frequency- C:0.08NA EA 248
    rs1443690011,2
    --19116856(+) CCAACA/GCACCT 1 -- us2k10--------
    rs622238731,2
    C,F,--19116887(+) CCACAT/ATTCCC 1 -- us2k16Minor allele frequency- A:0.09NA CSA EA 248
    rs57479951,2
    C--19116954(+) AGGCAG/TCCCGA 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1462132091,2
    --19116981(+) AATGTC/GAGGGT 1 -- us2k10--------
    rs1391551571,2
    --19117067(+) GCCTGA/GTCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TSSK2 (19118321 - 19120136 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TSSK2
         1 CNV: 31071
    Human Gene Mutation Database (HGMD): TSSK2

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TSSK2 for disorders           About GeneDecksing

    OMIM gene information: 610710    OMIM disorders: --

    4 diseases for TSSK2:    About MalaCards
    digeorge syndrome    male infertility    infertility    vaginitis

    2 diseases from the University of Copenhagen DISEASES database for TSSK2:
    Infertility     Male infertility
    Human Genome Epidemiology (HuGE) Navigator: TSSK2 (1 document)

    Export disorders for TSSK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSSK2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with TSSK2)
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    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. Some Single Nucleotide Polymorphisms of the TSSK2 Gen e May Be Associated with Human Spermatogenesis Impairment. (PubMed id 19926886)1, 2 Zhang H....Zhang S. (2009)
    3. Targeted deletion of Tssk1 and 2 causes male infertil ity due to haploinsufficiency. (PubMed id 18533145)1, 2 Xu B....Herr J.C. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    6. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 2 Hao Z....Visconti P.E. (2004)
    7. A transcription map of the DiGeorge and velo-cardio-facial syndrome minimal critical region on 22q11. (PubMed id 8776594)1, 2 Gong W.... Budarf M.L. (1996)
    8. A novel family of serine/threonine kinases participating in spermiogenesis. (PubMed id 9412477)1, 9 Kueng P....Ziemiecki A. (1997)
    9. Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets. (PubMed id 17566264)2, 9 Xu B....Herr J.C. (2007)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23617 HGNC: 11401 AceView: STK22B Ensembl:ENSG00000206203 euGenes: HUgn23617
    ECgene: TSSK2 H-InvDB: TSSK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSSK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSSK2 gene:
    Search GeneIP for patents involving TSSK2

    GeneCards and IP:
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