Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TSSK1B Gene

protein-coding   GIFtS: 44
GCID: GC05M112768

Testis-Specific Serine Kinase 1B

(Previous names: serine/threonine kinase 22D (spermiogenesis associated),...)
(Previous symbols: STK22D, TSSK1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Testis-Specific Serine Kinase 1B1 2     TSK12 3
STK22D1 2 3 5     TSSK-12 3
TSSK11 2 3 5     EC 2.7.11.13 8
Serine/Threonine Kinase 22D (Spermiogenesis Associated)1 2     Serine/Threonine Kinase FKSG812
Testis-Specific Serine Kinase 11 2     Spermiogenesis Associated 42
Serine/Threonine-Protein Kinase 22A2 3     Testis-Specific Serine/Threonine-Protein Kinase 12
Testis-Specific Kinase 12 3     SPOGA13
SPOGA42 3     STK22A3
TSK-12 3     EC 2.7.118

External Ids:    HGNC: 149681   Entrez Gene: 839422   Ensembl: ENSG000002121227   OMIM: 6107095   UniProtKB: Q9BXA73   

Export aliases for TSSK1B gene to outside databases

Previous GC identifers: GC05M112801 GC05M107951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TSSK1B Gene:
TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 (PubMed
15044604)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TSSK1B Gene:
TSSK1B (testis-specific serine kinase 1B) is a protein-coding gene. Diseases associated with TSSK1B include vaginitis, and malaria. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7
Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates
'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm.
During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the
flagellum originating from the chromatoid body




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSSK1B gene promoter:
         c-Fos   RP58   AP-1   AML1a   FOXD1   C/EBPalpha   S8   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSSK1B promoter sequence
   Search Chromatin IP Primers for TSSK1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSSK1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.2   Ensembl cytogenetic band:  5q22.2   HGNC cytogenetic band: 5q22.2

TSSK1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSSK1B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M112768:  view genomic region     (about GC identifiers)

Start:
112,768,251 bp from pter      End:
112,770,728 bp from pter
Size:
2,478 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7 (See protein sequence)
Recommended Name: Testis-specific serine/threonine-protein kinase 1  
Size: 367 amino acids; 41618 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with TSSK2
Miscellaneous: TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides
(PubMed:17566264)
Secondary accessions: B2R8D9

Explore the universe of human proteins at neXtProt for TSSK1B: NX_Q9BXA7

Explore proteomics data for TSSK1B at MOPED

Post-translational modifications: 

  • Autophosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TSSK1B (Q9BXA7) (see all 8)
     VVHRDLK  VAIKIID  KYCHDLD  WSLGVILY 


    See TSSK1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114417.1  
    ENSEMBL proteins: 
     ENSP00000375081  

    TSSK1B Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TSSK1B Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TSSK1B
    OriGene Protein Over-expression Lysate for TSSK1B
    OriGene MassSpec for TSSK1B
    OriGene Custom Protein Services for TSSK1B
    GenScript Custom Purified and Recombinant Proteins Services for TSSK1B
    Novus Biologicals TSSK1B Proteins
    Novus Biologicals TSSK1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TSSK1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSSK1B
    Novus Biologicals TSSK1B Antibodies
    Search for Antibodies for TSSK1B at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TSSK1B
    Search LSBio for Antibodies for TSSK1B

    TSSK1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSSK1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSSK1B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific serine kinase 1B
    Testis specific kinase (TSSK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9BXA7

    ProtoNet protein and cluster: Q9BXA7

    UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    TSSK1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSSK1_HUMAN, Q9BXA7
    Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates
    'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm.
    During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the
    flagellum originating from the chromatoid body
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Kinase activity is specifically inhibited by 2 classes of compounds: biphenyl compounds
    (1,1'-(biphenyl-4,4'-diyl)bis(2,2-dihydroxyethanone)) and 1,2,7-trialky-1H-imidazo[4,5-g]quinoxalin-6-one.
    Activated by phosphorylation on Thr-174 and potentially by autophosphorylation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA15733851
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15733851
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    TSSK1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TSSK1B:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tssk1):
     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    TSSK1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TSSK1B: Tssk1/Tssk2Tssk1/tm1.1Agr Tssk1/Tssk2Tssk1/tm1Joch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSSK1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSSK1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSSK1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSSK1B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TSSK1B using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TSSK1B:
    hsa-miR-522 hsa-miR-138-2* hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidTSSK1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSSK1B
    Predesigned siRNA for gene silencing in human, mouse, rat TSSK1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSSK1B

    Clone
    Products:
         
    OriGene clones in human, mouse for TSSK1B (see all 8)
    OriGene ORF clones in mouse, rat for TSSK1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSSK1B (NM_032028)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSSK1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK1B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSSK1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for TSSK1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TSSK1_HUMAN, Q9BXA7: Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity).
    Cell projection, cilium, flagellum (By similarity). Note=In spermatozoa, present in the sperm head and in the
    flagellum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0031514motile cilium ISS--

    TSSK1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TSSK1B
        Sperm Motility


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSSK1B
    Interactions:

        Search GeneGlobe Interaction Network for TSSK1B

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for TSSK1B (Q9BXA73 ENSP000003750814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2O960173, ENSP000003720234I2D: score=1 STRING: ENSP00000372023
    TGFBR2P371733, ENSP000003519054I2D: score=1 STRING: ENSP00000351905
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    RPTORENSP000003072724STRING: ENSP00000307272
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA15733851
    GO:0007275multicellular organismal development IEA--
    GO:0007286spermatid development ISS--

    TSSK1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSSK1B (TSSK1)

    1 HMDB Compound for TSSK1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TSSK1B gene: 
    NM_032028.3  

    Unigene Cluster for TSSK1B:

    Testis-specific serine kinase 1B
    Hs.519507  [show with all ESTs]
    Unigene Representative Sequence: NM_032028
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390666(uc003kqm.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSSK1B using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TSSK1B:
    hsa-miR-522 hsa-miR-138-2* hsa-miR-224*
    SwitchGear 3'UTR luciferase reporter plasmidTSSK1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSSK1B
    Predesigned siRNA for gene silencing in human, mouse, rat TSSK1B
    Clone
    Products:
         
    OriGene clones in human, mouse for TSSK1B (see all 8)
    OriGene ORF clones in mouse, rat for TSSK1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSSK1B (NM_032028)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSSK1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK1B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TSSK1B
    OriGene qSTAR qPCR primer pairs in human, mouse for TSSK1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSSK1B
      QuantiTect SYBR Green Assays in human, mouse, rat TSSK1B
      QuantiFast Probe-based Assays in human, mouse, rat TSSK1B

    Additional mRNA sequence: 

    AF348076.1 AK122904.1 AK313332.1 AY028964.1 BC022515.1 

    2 DOTS entries:

    DT.91685702  DT.101981148 

    20 AceView cDNA sequences:

    AF348076 BI828631 BX108209 AK122904 BI828374 AY028964 BG702732 AI025816 
    BI829912 BI830403 BI826097 BI561727 BC022515 BI827146 BI825498 BI520325 
    NM_032028 CD558041 BM564104 AI218011 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TSSK1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAGGTGG
    TSSK1B Expression
    About this image

    TSSK1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSSK1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519507

    UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7
    Tissue specificity: Testis-specific. Present in sperm (at protein level)

        Custom PCR Arrays for TSSK1B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TSSK1B
    OriGene qSTAR qPCR primer pairs in human, mouse for TSSK1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSSK1B
    QuantiTect SYBR Green Assays in human, mouse, rat TSSK1B
    QuantiFast Probe-based Assays in human, mouse, rat TSSK1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSSK1B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tssk11 , 5 testis-specific serine kinase 11, 5 86.5(n)1
    85.4(a)1
      16 (11.09 cM)5
    221141  NM_009435.21  NP_033461.21 
     178942035 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    73(a)
    1 → many
    GL343282.1(739910-740872)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG143051 CG14305 54.65(n)
    47.58(a)
      42233  NM_142475.2  NP_650732.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C27D6.111 CELE_C27D6.11 50(n)
    42(a)
      3564833  NM_001026824.1  NP_001021995.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN46
    FRK16
    (see all 3)
    Serine/threonine protein kinase that inhibits the ...
    Putative protein kinase; similar to Kin4p; green f...
    (see all 3)
    14(a)
    13(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XV(775846-778248) YOR233W
    XVI(283464-286061) YPL141C


    ENSEMBL Gene Tree for TSSK1B (if available)
    TreeFam Gene Tree for TSSK1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TSSK1B gene
    TSSK62  TSSK32  TSSK22  TSSK42  
    Selected SIMAP similar genes for TSSK1B using alignment to 1 protein entry:     TSSK1_HUMAN(see all similar genes):
    TSSK1    TSSK2    TSSK3    TSSK6    MARK2    Par1b
    TSSK4    SIK3    MARK1    MARK4    SIK2    BRSK2
    KIAA0999    SIK1    SNRK    HUNK    CAMK1    PRKAA1

    TSSK1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TSSK1B
    PGOHUM00000246404


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    6 SNPs for TSSK1B    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559300041,2,4
    ----see VAR_0412362 mis40--------
    rs559405131,2,4
    ----see VAR_0412372 mis40--------
    rs346968151,2,4
    ----see VAR_0412392 mis40--------
    rs557385301,2,4
    ----see VAR_0412382 mis40--------
    rs119534781,2,4
    ----see VAR_0412402 mis40--------
    VAR_0412354
    ----see VAR_0412352 A T mis40--------

    HapMap Linkage Disequilibrium report for TSSK1B (112768251 - 112770728 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSSK1B: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TSSK1B
    DNA2.0 Custom Variant and Variant Library Synthesis for TSSK1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610709    OMIM disorders: --

    2 diseases for TSSK1B:    About MalaCards
    vaginitis    malaria


    TSSK1B for disorders           About GeneDecksing


    Export disorders for TSSK1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TSSK1B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TSSK1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 2, 3 Hao Z....Visconti P.E. (Mol. Hum. Reprod. 2004)
    2. Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. (PubMed id 19530700)1, 2 Zhang L.... Liu G. (J. Med. Chem. 2009)
    3. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PubMed id 15733851)1, 2 Jaleel M....Alessi D.R. (FEBS Lett. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Evolution of testis-specific kinases TSSK1B and TSSK2 in primates. (PubMed id 23258646)1 Shang P....Grootegoed J.A. (Andrology 2013)
    6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    7. Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. (PubMed id 20729278)2 Li Y.... Salicioni A.M. (Mol. Hum. Reprod. 2011)
    8. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    9. Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets. (PubMed id 17566264)2 Xu B.... Herr J.C. (Soc. Reprod. Fertil. Suppl. 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 83942 HGNC: 14968 AceView: STK22D Ensembl:ENSG00000212122 euGenes: HUgn83942
    ECgene: TSSK1B H-InvDB: TSSK1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TSSK1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TSSK1B gene:
    Search GeneIP for patents involving TSSK1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant TSSK1B Protein
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSSK1B  
     OriGene qPCR primer pairs and template standards for TSSK1B   OriGene Protein Over-expression Lysate for TSSK1B  
     OriGene MassSpec something-or-other for TSSK1B   OriGene clones in human, mouse for TSSK1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSSK1B   OriGene Purified Protein for TSSK1B  
     OriGene ORF clones in mouse, rat for TSSK1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSSK1B   OriGene Custom Protein Services for TSSK1B  

     
     
     Block miRNA regulation of human, mouse, rat TSSK1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TSSK1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSSK1B Predesigned siRNA for gene silencing in human, mouse, rat TSSK1B
     QuantiFast Probe-based Assays in human, mouse, rat TSSK1B QuantiTect SYBR Green Assays in human, mouse, rat TSSK1B
     Custom PCR Arrays for TSSK1B Search Chromatin IP Primers for TSSK1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSSK1B  Search GeneGlobe Interaction Network for TSSK1B
     Regulatory tfbs in TSSK1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for TSSK1B GenScript cDNA clones with any tag delivered in your preferred vector for TSSK1B
     GenScript Custom Assay Services for TSSK1B GenScript Custom overexpressing Cell Line Services for TSSK1B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TSSK1B (TSSK1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TSSK1B antibodies
     TSSK1B proteins
     TSSK1B lysates
     Search for Antibodies for TSSK1B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TSSK1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TSSK1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK1B
     SwitchGear 3'UTR luciferase reporter plasmids for TSSK1B
     SwitchGear Promoter luciferase reporter plasmids for TSSK1B
     ThermoFisher Antibodies for TSSK1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSK1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSSK1B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSSK1B
     Search LSBio for Antibodies for TSSK1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSSK1B gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4