Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSSK1B Gene

Aliases for TSSK1B Gene

  • Testis-Specific Serine Kinase 1B 2 3
  • Serine/Threonine Kinase 22D (Spermiogenesis Associated) 2 3
  • Serine/Threonine-Protein Kinase 22A 3 4
  • Testis-Specific Serine Kinase 1 2 3
  • Testis-Specific Kinase 1 3 4
  • EC 2.7.11.1 4 63
  • STK22D 3 4
  • SPOGA4 3 4
  • TSSK-1 3 4
  • TSSK1 3 4
  • TSK-1 3 4
  • TSK1 3 4
  • Serine/Threonine Kinase FKSG81 3
  • Spermiogenesis Associated 4 3
  • EC 2.7.11 63
  • FKSG81 3
  • SPOGA1 4
  • STK22A 4

External Ids for TSSK1B Gene

Previous HGNC Symbols for TSSK1B Gene

  • STK22D
  • TSSK1

Previous GeneCards Identifiers for TSSK1B Gene

  • GC05M112801
  • GC05M107951
  • GC05M112768

Summaries for TSSK1B Gene

Entrez Gene Summary for TSSK1B Gene

  • TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TSSK1B Gene

TSSK1B (Testis-Specific Serine Kinase 1B) is a Protein Coding gene. Diseases associated with TSSK1B include limited scleroderma and velocardiofacial syndrome. Among its related pathways are Sweet Taste Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TSSK4.

UniProtKB/Swiss-Prot for TSSK1B Gene

  • Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates Ser-288 of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSK1B Gene

Genomics for TSSK1B Gene

Regulatory Elements for TSSK1B Gene

Genomic Location for TSSK1B Gene

Chromosome:
5
Start:
113,432,554 bp from pter
End:
113,435,031 bp from pter
Size:
2,478 bases
Orientation:
Minus strand

Genomic View for TSSK1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSSK1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSK1B Gene

Proteins for TSSK1B Gene

  • Protein details for TSSK1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXA7-TSSK1_HUMAN
    Recommended name:
    Testis-specific serine/threonine-protein kinase 1
    Protein Accession:
    Q9BXA7
    Secondary Accessions:
    • B2R8D9

    Protein attributes for TSSK1B Gene

    Size:
    367 amino acids
    Molecular mass:
    41618 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with TSSK2.
    Miscellaneous:
    • TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides.

neXtProt entry for TSSK1B Gene

Proteomics data for TSSK1B Gene at MOPED

Post-translational modifications for TSSK1B Gene

Other Protein References for TSSK1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TSSK1B Gene

Gene Families for TSSK1B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXA7

UniProtKB/Swiss-Prot:

TSSK1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TSSK1B: view

Function for TSSK1B Gene

Molecular function for TSSK1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Kinase activity is specifically inhibited by 2 classes of compounds: biphenyl compounds (1,1-(biphenyl-4,4-diyl)bis(2,2-dihydroxyethanone)) and 1,2,7-trialky-1H-imidazo[4,5-g]quinoxalin-6-one. Activated by phosphorylation on Thr-174 and potentially by autophosphorylation.
UniProtKB/Swiss-Prot Function:
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates Ser-288 of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.

Enzyme Numbers (IUBMB) for TSSK1B Gene

Gene Ontology (GO) - Molecular Function for TSSK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15733851
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 15733851
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IDA 15733851
genes like me logo Genes that share ontologies with TSSK1B: view
genes like me logo Genes that share phenotypes with TSSK1B: view

Animal Models for TSSK1B Gene

MGI Knock Outs for TSSK1B:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSK1B

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for TSSK1B Gene

Localization for TSSK1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSSK1B Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum. Note=In spermatozoa, present in the sperm head and in the flagellum. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for TSSK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IBA --
GO:0031514 motile cilium ISS --
genes like me logo Genes that share ontologies with TSSK1B: view

No data available for Subcellular locations from COMPARTMENTS for TSSK1B Gene

Pathways & Interactions for TSSK1B Gene

SuperPathways for TSSK1B Gene

Superpath Contained pathways
1 Sweet Taste Signaling
genes like me logo Genes that share pathways with TSSK1B: view

Pathways by source for TSSK1B Gene

1 Qiagen pathway for TSSK1B Gene

Gene Ontology (GO) - Biological Process for TSSK1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 15733851
GO:0007275 multicellular organismal development IEA --
GO:0007286 spermatid development ISS --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with TSSK1B: view

No data available for SIGNOR curated interactions for TSSK1B Gene

Drugs & Compounds for TSSK1B Gene

(2) Drugs for TSSK1B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for TSSK1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with TSSK1B: view

Transcripts for TSSK1B Gene

mRNA/cDNA for TSSK1B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSSK1B Gene

Testis-specific serine kinase 1B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSK1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSK1B Gene

No ASD Table

Relevant External Links for TSSK1B Gene

GeneLoc Exon Structure for
TSSK1B
ECgene alternative splicing isoforms for
TSSK1B

Expression for TSSK1B Gene

mRNA expression in normal human tissues for TSSK1B Gene

mRNA differential expression in normal tissues according to GTEx for TSSK1B Gene

This gene is overexpressed in Testis (x50.8).

Protein differential expression in normal tissues from HIPED for TSSK1B Gene

This gene is overexpressed in Rectum (33.2), Peripheral blood mononuclear cells (17.4), Heart (12.0), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSSK1B Gene



SOURCE GeneReport for Unigene cluster for TSSK1B Gene Hs.519507

mRNA Expression by UniProt/SwissProt for TSSK1B Gene

Q9BXA7-TSSK1_HUMAN
Tissue specificity: Testis-specific. Present in sperm (at protein level).
genes like me logo Genes that share expression patterns with TSSK1B: view

Protein tissue co-expression partners for TSSK1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TSSK1B Gene

Orthologs for TSSK1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSSK1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSSK1B 35
  • 86.26 (n)
  • 85.99 (a)
TSSK1B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSSK1B 35
  • 87.14 (n)
  • 83.75 (a)
-- 36
  • 75 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tssk1 35
  • 86.5 (n)
  • 85.4 (a)
Tssk1 16
Tssk1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSSK1B 35
  • 98.73 (n)
  • 97.55 (a)
rat
(Rattus norvegicus)
Mammalia Tssk1b 35
  • 86.5 (n)
  • 85.95 (a)
oppossum
(Monodelphis domestica)
Mammalia TSSK1B 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010341 35
  • 48.47 (n)
  • 40.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14305 35
  • 54.65 (n)
  • 47.58 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_C27D6.11 35
  • 50 (n)
  • 42 (a)
C27D6.11 36
  • 33 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 11 (a)
ManyToMany
FRK1 36
  • 13 (a)
ManyToMany
KIN4 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13507 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4544 36
  • 51 (a)
OneToMany
Species with no ortholog for TSSK1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TSSK1B Gene

ENSEMBL:
Gene Tree for TSSK1B (if available)
TreeFam:
Gene Tree for TSSK1B (if available)

Paralogs for TSSK1B Gene

Paralogs for TSSK1B Gene

(25) SIMAP similar genes for TSSK1B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TSSK1B Gene

genes like me logo Genes that share paralogs with TSSK1B: view

Variants for TSSK1B Gene

Sequence variations from dbSNP and Humsavar for TSSK1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_041235 -
VAR_041236 -
VAR_041237 -
VAR_041238 -
VAR_041239 -

Variation tolerance for TSSK1B Gene

Residual Variation Intolerance Score: 73.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSK1B Gene

HapMap Linkage Disequilibrium report
TSSK1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSSK1B Gene

Disorders for TSSK1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSSK1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
limited scleroderma
  • systemic sclerosis, limited
velocardiofacial syndrome
  • 22q11 deletion syndrome
- elite association

Relevant External Links for TSSK1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSSK1B
genes like me logo Genes that share disorders with TSSK1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSSK1B Gene

Publications for TSSK1B Gene

  1. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PMID: 15044604) Hao Z. … Visconti P.E. (Mol. Hum. Reprod. 2004) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Evolution of testis-specific kinases TSSK1B and TSSK2 in primates. (PMID: 23258646) Shang P. … Grootegoed J.A. (Andrology 2013) 67
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 67

Products for TSSK1B Gene

Sources for TSSK1B Gene

Back to Top

Content