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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSSK1B Gene

protein-coding   GIFtS: 46
GCID: GC05M112801

Testis-Specific Serine Kinase 1B

(Previous names: serine/threonine kinase 22D (spermiogenesis associated),...)
(Previous symbols: STK22D, TSSK1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis-Specific Serine Kinase 1B1 2     TSK12 3
STK22D1 2 3 5     TSSK-12 3
TSSK11 2 3 5     EC 2.7.11.13 8
Serine/Threonine Kinase 22D (Spermiogenesis Associated)1 2     Serine/Threonine Kinase FKSG812
Testis-Specific Serine Kinase 11 2     Spermiogenesis Associated 42
Serine/Threonine-Protein Kinase 22A2 3     Testis-Specific Serine/Threonine-Protein Kinase 12
Testis-Specific Kinase 12 3     SPOGA13
SPOGA42 3     STK22A3
TSK-12 3     EC 2.7.118

External Ids:    HGNC: 149681   Entrez Gene: 839422   Ensembl: ENSG000002121227   OMIM: 6107095   UniProtKB: Q9BXA73   

Export aliases for TSSK1B gene to outside databases

Previous GC identifer: GC05M107951


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSSK1B Gene:
TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 (PubMed
15044604)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TSSK1B Gene: 
TSSK1B (testis-specific serine kinase 1B) is a protein-coding gene. Diseases associated with TSSK1B include vaginitis. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is TSSK6.

UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7
Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates
'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm.
During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the
flagellum originating from the chromatoid body




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSSK1B gene promoter:
         c-Fos   RP58   AP-1   AML1a   FOXD1   C/EBPalpha   S8   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSSK1B promoter sequence
   Search SABiosciences Chromatin IP Primers for TSSK1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSK1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.2   Ensembl cytogenetic band:  5q22.2   HGNC cytogenetic band: 5q22.2

TSSK1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSSK1B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M112801:  view genomic region     (about GC identifiers)

Start:
112,768,251 bp from pter      End:
112,770,728 bp from pter
Size:
2,478 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7 (See protein sequence)
Recommended Name: Testis-specific serine/threonine-protein kinase 1  
Size: 367 amino acids; 41618 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with TSSK2
Subcellular location: Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity).
Cell projection, cilium, flagellum (By similarity). Note=In spermatozoa, present in the sperm head and in the
flagellum (By similarity)
Miscellaneous: TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides
(PubMed:17566264)
Secondary accessions: B2R8D9

Explore the universe of human proteins at neXtProt for TSSK1B: NX_Q9BXA7

Explore proteomics data for TSSK1B at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXA7

  • 4/8 DME Specific Peptides for TSSK1B (Q9BXA7) (see all 8)
     VVHRDLK  VAIKIID  KYCHDLD  WSLGVILY 

    TSSK1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSSK1B Protein Expression
    REFSEQ proteins: NP_114417.1  
    ENSEMBL proteins: 
     ENSP00000375081  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0031514motile cilium ISS--

    TSSK1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: testis-specific serine kinase 1B 
    Testis specific kinase (TSSK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9BXA7

    ProtoNet protein and cluster: Q9BXA7

    UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    TSSK1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSSK1_HUMAN, Q9BXA7
    Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates
    'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm.
    During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the
    flagellum originating from the chromatoid body
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Kinase activity is specifically inhibited by 2 classes of compounds: biphenyl compounds
    (1,1'-(biphenyl-4,4'-diyl)bis(2,2-dihydroxyethanone)) and 1,2,7-trialky-1H-imidazo[4,5-g]quinoxalin-6-one.
    Activated by phosphorylation on Thr-174 and potentially by autophosphorylation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA15733851
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA15733851
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    TSSK1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TSSK1B:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tssk1):
     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    TSSK1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TSSK1B: Tssk1/Tssk2Tssk1/tm1.1Agr Tssk1/Tssk2Tssk1/tm1Joch

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSSK1B 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSSK1B

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TSSK1B (Q9BXA73 ENSP000003750814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHEK2O960173, ENSP000003720234I2D: score=1 STRING: ENSP00000372023
    TGFBR2P371733, ENSP000003519054I2D: score=1 STRING: ENSP00000351905
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA15733851
    GO:0007275multicellular organismal development IEA--
    GO:0007286spermatid development ISS--

    TSSK1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSSK1B (TSSK1)

    1 HMDB Compound for TSSK1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about TSSK1B / TSSK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSSK1B gene: 
    NM_032028.3  

    Unigene Cluster for TSSK1B:

    Testis-specific serine kinase 1B
    Hs.519507  [show with all ESTs]
    Unigene Representative Sequence: NM_032028
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000390666(uc003kqm.2)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF348076.1 AK122904.1 AK313332.1 AY028964.1 BC022515.1 

    2 DOTS entries:

    DT.91685702  DT.101981148 

    20 AceView cDNA sequences:

    BX108209 AY028964 BI828631 AF348076 AK122904 BI828374 BI520325 BI827146 
    BG702732 BM564104 BI826097 BC022515 BI829912 NM_032028 BI825498 BI830403 
    CD558041 AI025816 BI561727 AI218011 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSSK1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCAGGTGG
    TSSK1B Expression
    About this image


    See TSSK1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSSK1B

    SOURCE GeneReport for Unigene cluster: Hs.519507

    UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7
    Tissue specificity: Testis-specific. Present in sperm (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TSSK1B gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tssk11 , 5 testis-specific serine kinase 11, 5 86.59(n)1
    85.4(a)1
      16 (11.09 cM)5
    221141  NM_009435.21  NP_033461.21 
     178942035 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    71(a)
    1 → many
    GL343282.1(739910-740872)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92221 CG9222 51.88(n)
    45.86(a)
      33867  NM_135155.2  NP_608999.2 
    worm
    (Caenorhabditis elegans)
    Secernentea C27D6.116
    Y38H8A.46
    (see all 5)
    Protein Y38H8A.4
    (see all 5)
    31(a)
    30(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    II(5159716-5161130)
    IV(13470562-13472263)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRR16
    Serine/threonine protein kinase that inhibits pher...
    15(a)
    1 → many
    XI(221344-222900)


    ENSEMBL Gene Tree for TSSK1B (if available)
    TreeFam Gene Tree for TSSK1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSSK1B gene
    TSSK62  TSSK32  MELK2  TSSK22  TSSK42  HUNK2  
    18/25 SIMAP similar genes for TSSK1B using alignment to 1 protein entry:     TSSK1_HUMAN(see all similar genes):
    TSSK1    TSSK2    TSSK3    TSSK6    MARK2    Par1b
    TSSK4    SIK3    MARK1    MARK4    SIK2    BRSK2
    KIAA0999    SIK1    SNRK    HUNK    CAMK1    PRKAA1

    TSSK1B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TSSK1B
    PGOHUM00000246404


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 SNPs in TSSK1B are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412364
    ----see VAR_0412362 H Y mis40--------
    VAR_0412374
    ----see VAR_0412372 V L mis40--------
    VAR_0412394
    ----see VAR_0412392 G W mis40--------
    VAR_0412384
    ----see VAR_0412382 R C mis40--------
    VAR_0412404
    ----see VAR_0412402 G E mis40--------
    VAR_0412354
    ----see VAR_0412352 A T mis40--------

    HapMap Linkage Disequilibrium report for TSSK1B (112768251 - 112770728 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSSK1B: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TSSK1B
    DNA2.0 Custom Variant and Variant Library Synthesis for TSSK1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610709    OMIM disorders: --

    2 diseases for TSSK1B:    About MalaCards
    vaginitis    


    TSSK1B for disorders           About GeneDecksing


    Export disorders for TSSK1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSSK1B gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TSSK1B)
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    1. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 2, 3 Hao Z....Visconti P.E. (2004)
    2. Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. (PubMed id 19530700)1, 2 Zhang L.... Liu G. (2009)
    3. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PubMed id 15733851)1, 2 Jaleel M....Alessi D.R. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Evolution of testis-specific kinases TSSK1B and TSSK2 in primates. (PubMed id 23258646)1 Shang P....Grootegoed J.A. (2013)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. (PubMed id 20729278)2 Li Y.... Salicioni A.M. (2011)
    8. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    9. Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets. (PubMed id 17566264)2 Xu B....Herr J.C. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83942 HGNC: 14968 AceView: STK22D Ensembl:ENSG00000212122 euGenes: HUgn83942
    ECgene: TSSK1B H-InvDB: TSSK1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSSK1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSSK1B gene:
    Search GeneIP for patents involving TSSK1B

    GeneCards and IP:
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