TSSK1B Gene
protein-coding GIFtS: 46
GCID: GC05M112801
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testis-specific serine kinase 1B(Previous names: serine/threonine kinase 22D (spermiogenesis associated),...)
(Previous symbols: STK22D, TSSK1)
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Aliases
for TSSK1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis-Specific Serine Kinase 1B1 2 | | TSSK-12 3 | | STK22D1 2 3 5 | | EC 2.7.11.13 8 | | TSSK11 2 3 5 | | FKSG811 | | SPOGA41 2 3 | | Serine/Threonine Kinase FKSG812 | | Serine/Threonine Kinase 22D (Spermiogenesis Associated)1 2 | | Spermiogenesis Associated 42 | | Testis-Specific Serine Kinase 11 2 | | Testis-Specific Serine/Threonine-Protein Kinase 12 | | Serine/Threonine-Protein Kinase 22A2 3 | | SPOGA13 | | Testis-Specific Kinase 12 3 | | STK22A3 | | TSK-12 3 | | EC 2.7.118 | | TSK12 3 | | |
Export aliases for TSSK1B gene to outside databasesPrevious GC identifer: GC05M107951 |
Summaries
for TSSK1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSSK1B:
TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 (PubMed15044604)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. Duringspermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellumoriginating from the chromatoid body
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Genomic Views
for TSSK1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSSK1B gene promoter:
c-Fos RP58 AP-1 AML1a FOXD1 C/EBPalpha S8 FOXJ2 (long isoform) c-Jun FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSSK1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSK1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q22.2 Ensembl cytogenetic band: 5q22.2 HGNC cytogenetic band: 5q22.2TSSK1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M112801: view genomic region
(about GC identifiers)
Start:
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112,768,251 bp from pter |
End:
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112,770,728 bp from pter |
Size:
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2,478 bases |
Orientation:
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minus strand |
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Proteins
for TSSK1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7 (See
protein sequence)Recommended Name: Testis-specific serine/threonine-protein kinase 1 Size: 367 amino acids; 41618 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with TSSK2
Subcellular location: Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Cellprojection, cilium, flagellum (By similarity). Note=In spermatozoa, present in the sperm head and in the flagellum (Bysimilarity)
Miscellaneous: TSSK1B might be used as a target for male contraception or and intra-vaginal spermicides(PubMed:17566264)
Secondary accessions: B2R8D9Explore the universe of human proteins at neXtProt for TSSK1B: NX_Q9BXA7
Post-translational modifications:
Autophosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXA7
4/8 DME Specific Peptides for TSSK1B (Q9BXA7) (see all 8)
TSSK1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114417.1
ENSEMBL proteins: ENSP00000375081
Human Recombinant Protein Products for TSSK1B:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TSSK1B for ontologies About GeneDecksing
TSSK1B Antibody Products:
Assay Products for TSSK1B: |
Protein
Domains /
Families
for TSSK1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSSK1B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXA7ProtoNet protein and cluster: Q9BXA7 UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for TSSK1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TSSK1_HUMAN, Q9BXA7Function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. Duringspermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellumoriginating from the chromatoid bodyCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Kinase activity is specifically inhibited by 2 classes of compounds: biphenyl compounds(1,1'-(biphenyl-4,4'-diyl)bis(2,2-dihydroxyethanone)) and 1,2,7-trialky-1H-imidazo[4,5-g]quinoxalin-6-one. Activatedby phosphorylation on Thr-174 and potentially by autophosphorylation Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TSSK1B for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for TSSK1B:
3 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Tssk1):
TSSK1B for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for TSSK1B: Tssk1/Tssk2Tssk1/tm1.1Agr Tssk1/Tssk2Tssk1/tm1Joch
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK1B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK1B |
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Pathways & Interactions
for TSSK1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSSK1B
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TSSK1B (Q9BXA73 ENSP000003750814) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TSSK1B for ontologies About GeneDecksing
|
Drugs & Compounds
for TSSK1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSSK1B
1 HMDB Compound for TSSK1B About this table
Search CenterWatch for drugs/clinical trials and news about TSSK1B / TSSK1
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Transcripts
for TSSK1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSSK1B gene: NM_032028.3 Unigene Cluster for TSSK1B: Testis-specific serine kinase 1B Hs.519507 [show with all ESTs]Unigene Representative Sequence: NM_0320281 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000390666(uc003kqm.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSK1B (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSSK1B (NM_032028) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF348076.1 AK122904.1 AK313332.1 AY028964.1 BC022515.1 2 DOTS entries: DT.91685702 DT.101981148 20 AceView cDNA sequences: AK122904 AY028964 BI828374 BI828631 BX108209 AF348076 BI826097 BI829912 NM_032028 CD558041 BC022515 BM564104 BI561727 BI520325 AI025816 BG702732 BI827146 BI825498 BI830403 AI218011
GeneLoc Exon Structure
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Expression
for TSSK1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSSK1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCAGGTGG
About this image
See TSSK1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSSK1B
SOURCE GeneReport for Unigene cluster: Hs.519507
UniProtKB/Swiss-Prot: TSSK1_HUMAN, Q9BXA7Tissue specificity: Testis-specific. Present in sperm (at protein level)
SABiosciences Custom PCR Arrays for TSSK1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSSK1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSSK1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSSK1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSSK1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK1B |
Orthologs
for TSSK1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSSK1B gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for TSSK1B (if available)
TreeFam Gene Tree for TSSK1B (if available) |
Paralogs
for TSSK1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSSK1B gene
- TSSK62 PRKAA12 TSSK32 MELK2 TSSK22 PRKAA22 TSSK42 STK112
- HUNK2
18/25 SIMAP similar genes for TSSK1B using alignment to 1 protein entry: TSSK1_HUMAN(see all similar genes):TSSK1 TSSK2 TSSK3 TSSK6 MARK2 Par1b
TSSK4 SIK3 MARK1 MARK4 SIK2 BRSK2
KIAA0999 SIK1 SNRK HUNK CAMK1 PRKAA1
TSSK1B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TSSK1B
PGOHUM00000246404
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Genomic Variants
for TSSK1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TSSK1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSSK1B for disorders About GeneDecksing
OMIM gene information: 610709
OMIM disorders: --
1  disease for TSSK1B: About MalaCardsvaginitis
Export disorders for TSSK1B gene to outside databases
|
Publications
for TSSK1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSSK1B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TSSK1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PubMed id 15044604)1, 2, 3 Hao Z....Visconti P.E. (2004)
- Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. (PubMed id 19530700)1, 2 Zhang L.... Liu G. (2009)
- Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PubMed id 15733851)1, 2 Jaleel M....Alessi D.R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. (PubMed id 20729278)2 Li Y.... Salicioni A.M. (2011)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets. (PubMed id 17566264)2 Xu B....Herr J.C. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for TSSK1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSSK1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSSK1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSSK1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSSK1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSSK1B gene:
Search GeneIP for patents involving TSSK1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSSK1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | TSSK1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSK1B |
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