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Aliases for TSSC4 Gene

Aliases for TSSC4 Gene

  • Tumor Suppressing Subtransferable Candidate 4 2 3 5
  • Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 4 Protein 4
  • Tumor-Suppressing STF CDNA 4 Protein 4

External Ids for TSSC4 Gene

Previous GeneCards Identifiers for TSSC4 Gene

  • GC11P002483
  • GC11P002624
  • GC11P002381
  • GC11P002387
  • GC11P002378
  • GC11P002380
  • GC11P002421
  • GC11P002213

Summaries for TSSC4 Gene

Entrez Gene Summary for TSSC4 Gene

  • This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TSSC4 Gene

TSSC4 (Tumor Suppressing Subtransferable Candidate 4) is a Protein Coding gene. Diseases associated with TSSC4 include Beckwith-Wiedemann Syndrome and Wilson-Turner Syndrome.

Additional gene information for TSSC4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSC4 Gene

Genomics for TSSC4 Gene

Regulatory Elements for TSSC4 Gene

Enhancers for TSSC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H001825 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -569.4 -569443 10.4 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 GLIS2 ZNF143 TSSC4 SYT8 KRTAP5-3 KRTAP5-5 GC11P001831 TNNI2
GH11H002139 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -254.3 -254306 13 ELF3 RB1 BATF RAD21 ZEB1 GLIS2 SCRT2 ZNF143 FOS RUNX3 TSSC4 ENSG00000199550 CD81 LSP1 LOC100505570 KRTAP5-6 FAM99B KRTAP5-5 IGF2 TH
GH11H002201 1.4 FANTOM5 ENCODE dbSUPER 13.8 -196.8 -196766 3.5 THRB RARA HSF1 THAP11 SP5 MXD4 ELF1 ZNF592 MYC DRAP1 ASCL2 TSSC4 PHLDA2 TH GC11M002206 MIR4686
GH11H001770 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -628.5 -628497 3.8 HDGF PKNOX1 ATF1 ARNT SIN3A ZBTB7B GATA2 FOS ATF7 MCM3 TSPAN4 SNORA52 PIDD1 IFITM10 TNNI2 ENSG00000255142 SYT8 KRTAP5-6 LOC100505570 FAM99B
GH11H001977 1.3 ENCODE dbSUPER 13.7 -419.4 -419414 7.5 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 SP5 ZHX2 MXD4 MRPL23-AS1 TSSC4 LSP1 KRTAP5-6 FAM99B LOC100505570 GC11P001973 GC11P001986
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSSC4 on UCSC Golden Path with GeneCards custom track

Promoters for TSSC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035938 255 1801 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Locations for TSSC4 Gene

Genomic Locations for TSSC4 Gene
3,434 bases
Plus strand

Genomic View for TSSC4 Gene

Genes around TSSC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSC4 Gene

Proteins for TSSC4 Gene

  • Protein details for TSSC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TSSC4
    Protein Accession:
    Secondary Accessions:
    • C9JS66
    • Q86VL2
    • Q9BRS6

    Protein attributes for TSSC4 Gene

    329 amino acids
    Molecular mass:
    34326 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSSC4 Gene


neXtProt entry for TSSC4 Gene

Post-translational modifications for TSSC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSSC4 Gene

Domains & Families for TSSC4 Gene

Gene Families for TSSC4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSSC4 Gene


Suggested Antigen Peptide Sequences for TSSC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TSSC4 family.
  • Belongs to the TSSC4 family.
genes like me logo Genes that share domains with TSSC4: view

Function for TSSC4 Gene

Molecular function for TSSC4 Gene

GENATLAS Biochemistry:
tumor suppressing subchromosomal transferable fragment (STF4),in a center of the 11p15 imprinted domain but escaping genomic imprinting

Phenotypes From GWAS Catalog for TSSC4 Gene

Gene Ontology (GO) - Molecular Function for TSSC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with TSSC4: view
genes like me logo Genes that share phenotypes with TSSC4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSSC4 Gene

Localization for TSSC4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSSC4 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSSC4 Gene

Pathways & Interactions for TSSC4 Gene

SuperPathways for TSSC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSSC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSSC4 Gene

Drugs & Compounds for TSSC4 Gene

No Compound Related Data Available

Transcripts for TSSC4 Gene

Unigene Clusters for TSSC4 Gene

Tumor suppressing subtransferable candidate 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: - - - -

Relevant External Links for TSSC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSSC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSSC4 Gene

Protein differential expression in normal tissues from HIPED for TSSC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1), CD4 Tcells (7.4), Pancreas (7.3), Lung (7.1), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSSC4 Gene

Protein tissue co-expression partners for TSSC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSSC4 Gene:


SOURCE GeneReport for Unigene cluster for TSSC4 Gene:


mRNA Expression by UniProt/SwissProt for TSSC4 Gene:

Tissue specificity: Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues.
genes like me logo Genes that share expression patterns with TSSC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSSC4 Gene

Orthologs for TSSC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSSC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSSC4 33 34
  • 99.29 (n)
(Canis familiaris)
Mammalia TSSC4 33 34
  • 78.3 (n)
(Bos Taurus)
Mammalia TSSC4 33 34
  • 76.44 (n)
(Rattus norvegicus)
Mammalia Tssc4 33
  • 73.33 (n)
(Mus musculus)
Mammalia Tssc4 33 16 34
  • 72.47 (n)
(Monodelphis domestica)
Mammalia TSSC4 34
  • 45 (a)
(Gallus gallus)
Aves TSSC4 33 34
  • 55.92 (n)
(Anolis carolinensis)
Reptilia TSSC4 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC147133 33
  • 51.7 (n)
(Danio rerio)
Actinopterygii TSSC4 34
  • 29 (a)
Species where no ortholog for TSSC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSSC4 Gene

Gene Tree for TSSC4 (if available)
Gene Tree for TSSC4 (if available)

Paralogs for TSSC4 Gene

No data available for Paralogs for TSSC4 Gene

Variants for TSSC4 Gene

Sequence variations from dbSNP and Humsavar for TSSC4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000269318 -- 2,403,152(+) GAGGT(C/T)AGCGA reference, synonymous-codon
rs1000817165 -- 2,399,161(+) TCTGG(G/T)TTAGG upstream-variant-2KB
rs1000878039 -- 2,398,996(+) GGGAG(C/G)CCCCC upstream-variant-2KB
rs1001058295 -- 2,404,310(+) CCAGG(C/T)TCCAC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001291336 -- 2,400,797(+) TGAGC(C/T)GGTAG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TSSC4 Gene

Variant ID Type Subtype PubMed ID
nsv951287 CNV deletion 24416366
nsv553089 CNV gain 21841781
nsv553047 CNV gain 21841781
nsv509382 CNV insertion 20534489
nsv469928 CNV loss 18288195
nsv467645 CNV gain 19166990
dgv1569n54 CNV loss 21841781

Variation tolerance for TSSC4 Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSC4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSSC4 Gene

Disorders for TSSC4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSSC4 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
wilson-turner syndrome
  • mental retardation, x-linked, syndromic 6
- elite association - COSMIC cancer census association via MalaCards
Search TSSC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSSC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSSC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSSC4 Gene

Publications for TSSC4 Gene

  1. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PMID: 10072438) Lee MP … Feinberg AP (Human molecular genetics 1999) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60

Products for TSSC4 Gene

Sources for TSSC4 Gene

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