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Aliases for TSSC4 Gene

Aliases for TSSC4 Gene

  • Tumor Suppressing Subtransferable Candidate 4 2 3
  • Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 4 Protein 4
  • Tumor-Suppressing STF CDNA 4 Protein 4

External Ids for TSSC4 Gene

Previous GeneCards Identifiers for TSSC4 Gene

  • GC11P002483
  • GC11P002624
  • GC11P002381
  • GC11P002387
  • GC11P002378
  • GC11P002380
  • GC11P002421
  • GC11P002213

Summaries for TSSC4 Gene

Entrez Gene Summary for TSSC4 Gene

  • This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TSSC4 Gene

TSSC4 (Tumor Suppressing Subtransferable Candidate 4) is a Protein Coding gene. Diseases associated with TSSC4 include beckwith-wiedemann syndrome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSC4 Gene

Genomics for TSSC4 Gene

Regulatory Elements for TSSC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSSC4 Gene

2,400,445 bp from pter
2,403,878 bp from pter
3,434 bases
Plus strand

Genomic View for TSSC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSSC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSC4 Gene

Proteins for TSSC4 Gene

  • Protein details for TSSC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TSSC4
    Protein Accession:
    Secondary Accessions:
    • C9JS66
    • Q86VL2
    • Q9BRS6

    Protein attributes for TSSC4 Gene

    329 amino acids
    Molecular mass:
    34326 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSSC4 Gene


neXtProt entry for TSSC4 Gene

Proteomics data for TSSC4 Gene at MOPED

Post-translational modifications for TSSC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSSC4 Gene

Domains & Families for TSSC4 Gene

Protein Domains for TSSC4 Gene


Suggested Antigen Peptide Sequences for TSSC4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TSSC4 family.
  • Belongs to the TSSC4 family.
genes like me logo Genes that share domains with TSSC4: view

No data available for Gene Families for TSSC4 Gene

Function for TSSC4 Gene

Molecular function for TSSC4 Gene

GENATLAS Biochemistry:
tumor suppressing subchromosomal transferable fragment (STF4),in a center of the 11p15 imprinted domain but escaping genomic imprinting

Gene Ontology (GO) - Molecular Function for TSSC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TSSC4: view

Phenotypes for TSSC4 Gene

genes like me logo Genes that share phenotypes with TSSC4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSSC4 Gene

Localization for TSSC4 Gene

Subcellular locations from

Jensen Localization Image for TSSC4 Gene COMPARTMENTS Subcellular localization image for TSSC4 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSSC4 Gene

Pathways & Interactions for TSSC4 Gene

SuperPathways for TSSC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSSC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSSC4 Gene

Drugs & Compounds for TSSC4 Gene

No Compound Related Data Available

Transcripts for TSSC4 Gene

Unigene Clusters for TSSC4 Gene

Tumor suppressing subtransferable candidate 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: - - - -

Relevant External Links for TSSC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSSC4 Gene

mRNA expression in normal human tissues for TSSC4 Gene

Protein differential expression in normal tissues from HIPED for TSSC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1), CD4 Tcells (7.4), Pancreas (7.3), Lung (7.1), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSSC4 Gene

SOURCE GeneReport for Unigene cluster for TSSC4 Gene Hs.523424

mRNA Expression by UniProt/SwissProt for TSSC4 Gene

Tissue specificity: Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues.
genes like me logo Genes that share expression patterns with TSSC4: view

Protein tissue co-expression partners for TSSC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TSSC4 Gene

Orthologs for TSSC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSSC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSSC4 35
  • 76.44 (n)
  • 70.36 (a)
TSSC4 36
  • 66 (a)
(Canis familiaris)
Mammalia TSSC4 35
  • 78.3 (n)
  • 70.44 (a)
TSSC4 36
  • 68 (a)
(Mus musculus)
Mammalia Tssc4 35
  • 72.47 (n)
  • 66.45 (a)
Tssc4 16
Tssc4 36
  • 64 (a)
(Pan troglodytes)
Mammalia TSSC4 35
  • 99.29 (n)
  • 99.09 (a)
TSSC4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tssc4 35
  • 73.33 (n)
  • 67.1 (a)
(Monodelphis domestica)
Mammalia TSSC4 36
  • 45 (a)
(Gallus gallus)
Aves TSSC4 35
  • 55.92 (n)
  • 49.67 (a)
TSSC4 36
  • 41 (a)
(Anolis carolinensis)
Reptilia TSSC4 36
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC147133 35
  • 51.7 (n)
  • 40.82 (a)
(Danio rerio)
Actinopterygii TSSC4 36
  • 29 (a)
Species with no ortholog for TSSC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSSC4 Gene

Gene Tree for TSSC4 (if available)
Gene Tree for TSSC4 (if available)

Paralogs for TSSC4 Gene

No data available for Paralogs for TSSC4 Gene

Variants for TSSC4 Gene

Sequence variations from dbSNP and Humsavar for TSSC4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs739673 -- 2,399,270(-) CTGCA(A/G)AGAGG upstream-variant-2KB
rs739674 -- 2,399,597(-) AGAGA(A/G)CTCCC upstream-variant-2KB
rs800351 -- 2,400,164(+) AGGGC(C/T)GCCCC upstream-variant-2KB
rs1008265 - 2,403,004(+) CAAGC(A/G)GCCCC missense, reference
rs2074251 -- 2,399,013(+) ACCAG(C/T)GAGCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSSC4 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV Gain 19166990
nsv896806 CNV Loss 21882294
nsv469928 CNV Loss 18288195
dgv1000n71 CNV Loss 21882294
nsv896811 CNV Loss 21882294
nsv896812 CNV Loss 21882294
nsv509382 CNV Insertion 20534489
nsv896820 CNV Loss 21882294
nsv896821 CNV Loss 21882294

Variation tolerance for TSSC4 Gene

Residual Variation Intolerance Score: 92.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSC4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSSC4 Gene

Disorders for TSSC4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSSC4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association
Search TSSC4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TSSC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSSC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSSC4 Gene

Publications for TSSC4 Gene

  1. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PMID: 10072438) Lee M.P. … Feinberg A.P. (Hum. Mol. Genet. 1999) 2 23 67
  2. Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. (PMID: 10907850) Yatsuki H. … Mukai T. (DNA Res. 2000) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for TSSC4 Gene

Sources for TSSC4 Gene

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