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Aliases for TSSC4 Gene

Aliases for TSSC4 Gene

  • Tumor Suppressing Subtransferable Candidate 4 2 3
  • Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 4 Protein 4
  • Tumor-Suppressing STF CDNA 4 Protein 4

External Ids for TSSC4 Gene

Previous GeneCards Identifiers for TSSC4 Gene

  • GC11P002483
  • GC11P002624
  • GC11P002381
  • GC11P002387
  • GC11P002378
  • GC11P002380
  • GC11P002421
  • GC11P002213

Summaries for TSSC4 Gene

Entrez Gene Summary for TSSC4 Gene

  • This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve this region. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for TSSC4 Gene

TSSC4 (Tumor Suppressing Subtransferable Candidate 4) is a Protein Coding gene. Diseases associated with TSSC4 include adrenocortical carcinoma and rhabdomyosarcoma.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSC4 Gene

Genomics for TSSC4 Gene

Regulatory Elements for TSSC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSSC4 Gene

Start:
2,400,488 bp from pter
End:
2,403,878 bp from pter
Size:
3,391 bases
Orientation:
Plus strand

Genomic View for TSSC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSSC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSC4 Gene

Proteins for TSSC4 Gene

  • Protein details for TSSC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5U2-TSSC4_HUMAN
    Recommended name:
    Protein TSSC4
    Protein Accession:
    Q9Y5U2
    Secondary Accessions:
    • C9JS66
    • Q86VL2
    • Q9BRS6

    Protein attributes for TSSC4 Gene

    Size:
    329 amino acids
    Molecular mass:
    34326 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSSC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSSC4 Gene

Proteomics data for TSSC4 Gene at MOPED

Post-translational modifications for TSSC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSSC4 Gene

Domains for TSSC4 Gene

Protein Domains for TSSC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSSC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5U2

UniProtKB/Swiss-Prot:

TSSC4_HUMAN :
  • Q9Y5U2
Family:
  • Belongs to the TSSC4 family.
genes like me logo Genes that share domains with TSSC4: view

No data available for Gene Families for TSSC4 Gene

Function for TSSC4 Gene

Molecular function for TSSC4 Gene

GENATLAS Biochemistry:
tumor suppressing subchromosomal transferable fragment (STF4),in a center of the 11p15 imprinted domain but escaping genomic imprinting

Gene Ontology (GO) - Molecular Function for TSSC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TSSC4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSSC4 Gene

Localization for TSSC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSSC4 Gene COMPARTMENTS Subcellular localization image for TSSC4 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSSC4 Gene

Pathways for TSSC4 Gene

SuperPathways for TSSC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSSC4 Gene

None

No data available for Pathways by source for TSSC4 Gene

Transcripts for TSSC4 Gene

Unigene Clusters for TSSC4 Gene

Tumor suppressing subtransferable candidate 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSC4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSC4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: - - - -
SP7:

Relevant External Links for TSSC4 Gene

GeneLoc Exon Structure for
TSSC4
ECgene alternative splicing isoforms for
TSSC4

Expression for TSSC4 Gene

mRNA expression in normal human tissues for TSSC4 Gene

Protein differential expression in normal tissues for TSSC4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1), CD4 Tcells (7.4), Pancreas (7.3), Lung (7.1), and Fetal Brain (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSSC4 Gene

SOURCE GeneReport for Unigene cluster for TSSC4 Gene Hs.523424

mRNA Expression by UniProt/SwissProt for TSSC4 Gene

Q9Y5U2-TSSC4_HUMAN
Tissue specificity: Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues.
genes like me logo Genes that share expressions with TSSC4: view

Expression partners for TSSC4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TSSC4 Gene

Orthologs for TSSC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSSC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSSC4 35
  • 76.44 (n)
  • 70.36 (a)
TSSC4 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSSC4 35
  • 78.3 (n)
  • 70.44 (a)
TSSC4 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tssc4 35
  • 72.47 (n)
  • 66.45 (a)
Tssc4 16
Tssc4 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSSC4 35
  • 99.29 (n)
  • 99.09 (a)
TSSC4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tssc4 35
  • 73.33 (n)
  • 67.1 (a)
oppossum
(Monodelphis domestica)
Mammalia TSSC4 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSSC4 35
  • 55.92 (n)
  • 49.67 (a)
TSSC4 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSSC4 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC147133 35
  • 51.7 (n)
  • 40.82 (a)
zebrafish
(Danio rerio)
Actinopterygii TSSC4 36
  • 29 (a)
OneToOne
Species with no ortholog for TSSC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSSC4 Gene

ENSEMBL:
Gene Tree for TSSC4 (if available)
TreeFam:
Gene Tree for TSSC4 (if available)

Paralogs for TSSC4 Gene

No data available for Paralogs for TSSC4 Gene

Variants for TSSC4 Gene

Sequence variations from dbSNP and Humsavar for TSSC4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs739673 -- 2,399,270(-) CTGCA(A/G)AGAGG upstream-variant-2KB
rs739674 -- 2,399,597(-) AGAGA(A/G)CTCCC upstream-variant-2KB
rs800351 -- 2,400,164(+) AGGGC(C/T)GCCCC upstream-variant-2KB
rs1008265 - 2,403,004(+) CAAGC(A/G)GCCCC missense, reference
rs2234273 -- 2,401,578(+) GTCAC(C/T)CTGGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TSSC4 Gene

Variant ID Type Subtype PubMed ID
nsv467645 CNV Gain 19166990
nsv896806 CNV Loss 21882294
nsv469928 CNV Loss 18288195
dgv1000n71 CNV Loss 21882294
nsv896811 CNV Loss 21882294
nsv896812 CNV Loss 21882294
nsv509382 CNV Insertion 20534489
nsv896820 CNV Loss 21882294
nsv896821 CNV Loss 21882294

Relevant External Links for TSSC4 Gene

HapMap Linkage Disequilibrium report
TSSC4
Human Gene Mutation Database (HGMD)
TSSC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSSC4 Gene

Disorders for TSSC4 Gene

(1) University of Copenhagen DISEASES for TSSC4 Gene

genes like me logo Genes that share disorders with TSSC4: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for TSSC4 Gene

Publications for TSSC4 Gene

  1. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PMID: 10072438) Lee M.P. … Feinberg A.P. (Hum. Mol. Genet. 1999) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TSSC4 Gene

Sources for TSSC4 Gene

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