TSSC4 Gene
protein-coding GIFtS: 49
GCID: GC11P002421
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|
tumor suppressing subtransferable candidate 4
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Aliases
for TSSC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Suppressing Subtransferable Candidate 41 2 | | Tumor-Suppressing STF CDNA 4 Protein2 3 | | Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 4 Protein2 3 | | Protein TSSC42 |
Export aliases for TSSC4 gene to outside databasesPrevious GC identifers: GC11P002483 GC11P002624 GC11P002381 GC11P002387 GC11P002378 GC11P002380 GC11P002213 |
Summaries
for TSSC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSSC4:
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with theBeckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breastcancer. This gene is located among several imprinted genes; however, this gene, as well as the pan-hematopoieticexpression gene (PHEMX), escapes imprinting. This gene may play a role in malignancies and disease that involve thisregion. (provided by RefSeq, Jul 2008)
|
Genomic Views
for TSSC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSSC4 gene promoter:
SREBP-1c MyoD STAT5A GATA-1 YY1 SREBP-1b E47 Ik-2 SREBP-1a Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSSC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5TSSC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P002421: view genomic region
(about GC identifiers)
Start:
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2,421,718 bp from pter |
End:
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2,425,106 bp from pter |
Size:
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3,389 bases |
Orientation:
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plus strand |
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Proteins
for TSSC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSSC4_HUMAN, Q9Y5U2 (See
protein sequence)Recommended Name: Protein TSSC4 Size: 329 amino acids; 34326 Da
Secondary accessions: C9JS66 Q86VL2 Q9BRS6Alternative splicing: 2 isoforms: Q9Y5U2-1 Q9Y5U2-2 Explore the universe of human proteins at neXtProt for TSSC4: NX_Q9Y5U2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y5U2
TSSC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005697.2
ENSEMBL proteins: ENSP00000370384 ENSP00000331087 ENSP00000370380 ENSP00000396925 ENSP00000403475 ENSP00000431430 ENSP00000416937 ENSP00000435013 ENSP00000411224
Human Recombinant Protein Products:
TSSC4 Antibody Products:
Assay Products for TSSC4: |
Protein
Domains /
Families
for TSSC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y5U2 UniProtKB/Swiss-Prot: TSSC4_HUMAN, Q9Y5U2Similarity: Belongs to the TSSC4 family |
Function
for TSSC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for TSSC4:tumor suppressing subchromosomal transferable fragment (STF4),in a center of the 11p15 imprinted domain but escapinggenomic imprinting
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSSC4 (NM_005706) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSSC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSC4 |
|
Pathways & Interactions
for TSSC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSSC4
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/7 Interacting proteins for TSSC4 (Q9Y5U22, 3 ENSP000003310874) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
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Drugs & Compounds
for TSSC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSSC4
Search CenterWatch for drugs/clinical trials and news about TSSC4
|
Transcripts
for TSSC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSSC4 gene: NM_005706.2 Unigene Cluster for TSSC4: Tumor suppressing subtransferable candidate 4 Hs.523424 [show with all ESTs]Unigene Representative Sequence: AK09556810 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380996(uc001lwi.3) ENST00000333256(uc001lwk.3 uc001lwl.3)
ENST00000380992 ENST00000437110 ENST00000435795 ENST00000485682 ENST00000440813
ENST00000496468 ENST00000467308 ENST00000451491
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSSC4 (NM_005706) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSSC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSC4 |
Additional cDNA sequence: AF125568.1 AK095568.1 BC006091.1 BC050616.1 4 DOTS entries: DT.114625 DT.99939205 DT.65285794 DT.97848265 24/247 AceView cDNA sequences (see all 247): CA389669 AI627557 AA551362 CF127464 AI914605 BC050616 BQ637823 BE794027 BM555343 AW167950 AI867354 CR626346 AA459413 AA806520 BU145815 BQ214345 CR612628 BQ051497 BM927386 BM558486 AA745925 NM_005706 BF345486 BU172566
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TSSC4 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSSC4
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Expression
for TSSC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSSC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGCAGGAA
About this image
See TSSC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSSC4
SOURCE GeneReport for Unigene cluster: Hs.523424
UniProtKB/Swiss-Prot: TSSC4_HUMAN, Q9Y5U2Tissue specificity: Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues
SABiosciences Custom PCR Arrays for TSSC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSSC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSSC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSSC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSSC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSC4 |
Orthologs
for TSSC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TSSC4 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for TSSC4 (if available)
TreeFam Gene Tree for TSSC4 (if available) |
Paralogs
for TSSC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TSSC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSSC4 (2421718 - 2425106 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TSSC4
2 CNVs: 29895 29896
Human Gene Mutation Database (HGMD): TSSC4
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSSC4 |
|
Disorders
/ Diseases
for TSSC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSSC4 for disorders About GeneDecksing
OMIM gene information: 603852
OMIM disorders: --
6  diseases for TSSC4: About MalaCardsbeckwith-wiedemann syndrome adrenocortical carcinoma wilms tumor breast cancer
rhabdomyosarcoma carcinoma
1 disease from the University of Copenhagen DISEASES database for TSSC4:Beckwith-Wiedemann syndrome Export disorders for TSSC4 gene to outside databases
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Publications
for TSSC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSSC4 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with TSSC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. (PubMed id 10072438)1, 2, 3, 9 Lee M.P....Feinberg A.P. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
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External Searches for TSSC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSSC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSSC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSSC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TSSC4 gene:
Search GeneIP for patents involving TSSC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSSC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSSC4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSSC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSSC4 | | | OriGene Protein Over-expression Lysate for TSSC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSSC4 | | OriGene 3'-UTR Clone for TSSC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSSC4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSSC4 | | OriGene Custom Protein Services for TSSC4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSSC4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSSC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSSC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSSC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSSC4 |
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| | | | Search Tocris compounds for TSSC4 |
| |  |  |  |  | | | | | | Recombinant Protein for TSSC4 |
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 | | | TSSC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSC4 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSSC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSC4 |
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