TSSC1 Gene
protein-coding GIFtS: 49
GCID: GC02M003171
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|
tumor suppressing subtransferable candidate 1
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Aliases
for TSSC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Suppressing Subtransferable Candidate 11 2 | | Tumor-Suppressing STF CDNA 1 Protein2 3 | | Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 1 Protein2 3 | | Protein TSSC12 |
Export aliases for TSSC1 gene to outside databasesPrevious GC identifers: GC02M004586 GC02M004873 GC02M004802 GC02M004731 |
Summaries
for TSSC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSSC1:
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located inthe imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have beenassociated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung,ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides onchromosome 2 rather than chromosome 11. (provided by RefSeq, Dec 2008)
Gene Wiki entry for TSSC1
|
Genomic Views
for TSSC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022221.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSSC1 gene promoter:
NF-YA HSF1 (long) CBF-C Arnt Max HSF1short CP1A CP1C NF-Y c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSSC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p25.3 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25.3TSSC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M003171: view genomic region
(about GC identifiers)
Start:
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3,192,696 bp from pter |
End:
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3,381,653 bp from pter |
Size:
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188,958 bases |
Orientation:
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minus strand |
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Proteins
for TSSC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSSC1_HUMAN, Q53HC9 (See
protein sequence)Recommended Name: Protein TSSC1 Size: 387 amino acids; 43603 Da
Secondary accessions: D6W4Y1 O43179 Q53S19 Q53SG2Explore the universe of human proteins at neXtProt for TSSC1: NX_Q53HC9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53HC9
TSSC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003301.1
ENSEMBL proteins: ENSP00000371559 ENSP00000381652 ENSP00000389228 ENSP00000393350 ENSP00000403043 ENSP00000389080 ENSP00000385756 ENSP00000400214
Human Recombinant Protein Products:
TSSC1 Antibody Products:
Assay Products for TSSC1: |
Protein
Domains /
Families
for TSSC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSSC1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q53HC9ProtoNet protein and cluster: Q53HC9 UniProtKB/Swiss-Prot: TSSC1_HUMAN, Q53HC9Similarity: Contains 5 WD repeats |
Function
for TSSC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for TSSC1:tumor suppressing subchromosomal transferable DNA fragment (STF1),homolog of Rb associated protein p48 and Drosophila,chromatin assembly factor 1 (CAF1),close to HBB@,not localized in the interval STIM1-NUP98
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSSC1 (NM_003310) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSSC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSC1 |
|
Pathways & Interactions
for TSSC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSSC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for TSSC1 (Q53HC93 ENSP000003715594) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for TSSC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSSC1
Search CenterWatch for drugs/clinical trials and news about TSSC1
|
Transcripts
for TSSC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSSC1 gene: NM_003310.2 Unigene Cluster for TSSC1: Tumor suppressing subtransferable candidate 1 Hs.502770 [show with all ESTs]Unigene Representative Sequence: AK12628814 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382125(uc002qxj.2) ENST00000478754(uc002qxi.2) ENST00000398659
ENST00000496433 ENST00000455162 ENST00000441271 ENST00000463662 ENST00000435721
ENST00000482570 ENST00000470625 ENST00000443925 ENST00000406835 ENST00000462515
ENST00000444776
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSSC1 (NM_003310) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSSC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSC1 |
Additional cDNA sequence: AF019952.1 AK026522.1 AK126288.1 AK222652.1 BC002485.2 15 DOTS entries: DT.450242 DT.101983268 DT.100834396 DT.100834401 DT.75176254 DT.92441178 DT.97855520 DT.100834407 DT.120994072 DT.120994132 DT.40106649 DT.92441175 DT.95256812 DT.95358424 DT.95256840 24/328 AceView cDNA sequences (see all 328): CR597871 AA923741 BX113645 AL555406 CR619999 BE465959 BM832595 CR608131 BI753239 BU176271 BQ216227 BI823136 CR626366 CR607271 CR621784 CR603500 BI761181 BI819617 BM456159 BI823773 AA809941 CR594856 CR601008 CR592052
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TSSC1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b |
|---|
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| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | - | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSSC1
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Expression
for TSSC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSSC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTCCATCT
About this image
See TSSC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSSC1
SOURCE GeneReport for Unigene cluster: Hs.502770
SABiosciences Custom PCR Arrays for TSSC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSSC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSSC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSSC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSSC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSC1 |
Orthologs
for TSSC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSSC1 gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for TSSC1 (if available)
TreeFam Gene Tree for TSSC1 (if available) |
Paralogs
for TSSC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TSSC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSSC1 (3192696 - 3381653 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 31 variations for TSSC1
15 CNVs: 43255 61743 89427 89420 35832 89422 35830 97745 78375 78381 0521 89425 89421 78383 78378
15/16 Indels (see all 16): 78379 60282 78380 45993 89424 26666 89426 26665 78377 78376 78382 89423 40300 12052 34343 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSSC1 |
|
Disorders
/ Diseases
for TSSC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSSC1 for disorders About GeneDecksing
OMIM gene information: 608998
OMIM disorders: --
7  diseases for TSSC1: About MalaCardsadrenocortical carcinoma beckwith-wiedemann syndrome carcinoma wilms tumor
breast cancer rhabdomyosarcoma malaria
Export disorders for TSSC1 gene to outside databases
|
Publications
for TSSC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSSC1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TSSC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. (PubMed id 9403053)1, 2, 3 Hu R.-J.... Feinberg A.P. (1997)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster. (PubMed id 9925925)1, 3 Scelfo R....Negrini M. (1998)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
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External Searches for TSSC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSSC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSSC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSSC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TSSC1 gene:
Search GeneIP for patents involving TSSC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSSC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TSSC1 | | OriGene shRNA RFP for TSSC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSSC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSSC1 | | | OriGene Protein Over-expression Lysate for TSSC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSSC1 | | OriGene 3'-UTR Clone for TSSC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSSC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSSC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSSC1 | | OriGene Custom Protein Services for TSSC1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSSC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSSC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSSC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSSC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSSC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSSC1 |
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| | | | Search Tocris compounds for TSSC1 |
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 | | | TSSC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSSC1 |
|  |  |  | | | | ThermoFisher Antibodies for TSSC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSSC1 |
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