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Aliases for TSSC1 Gene

Aliases for TSSC1 Gene

  • Tumor Suppressing Subtransferable Candidate 1 2 3 5
  • Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 1 Protein 3 4
  • Endosome-Associated Recycling Protein-Interacting Protein 3 4
  • Tumor-Suppressing STF CDNA 1 Protein 3 4
  • EARP-Interacting Protein 3 4
  • EIPR1 3 4
  • Tumor-Suppressing Subtransferable Fragment Candidate Gene 1 3
  • Protein TSSC1 3

External Ids for TSSC1 Gene

Previous GeneCards Identifiers for TSSC1 Gene

  • GC02M004586
  • GC02M004873
  • GC02M004802
  • GC02M004731

Summaries for TSSC1 Gene

Entrez Gene Summary for TSSC1 Gene

  • This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]

GeneCards Summary for TSSC1 Gene

TSSC1 (Tumor Suppressing Subtransferable Candidate 1) is a Protein Coding gene.

Gene Wiki entry for TSSC1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSC1 Gene

Genomics for TSSC1 Gene

Regulatory Elements for TSSC1 Gene

Enhancers for TSSC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F003221 1.5 FANTOM5 Ensembl ENCODE 6.1 +154.5 154489 3.1 PKNOX1 TBL1XR1 SIN3A EGR1 CBX5 ZNF143 ZNF207 RCOR1 ETV6 CREM TSSC1 ENSG00000235078 GC02M003244 GC02M003097
GH02F003264 1.2 VISTA ENCODE 7 +112.1 112131 2.7 ZNF263 LEF1 PKNOX1 INSM2 MAX ZNF488 ZNF169 TARDBP PBX2 FOS TSSC1 GC02M003270 PIR42894
GH02F003241 1 Ensembl ENCODE 6.7 +135.3 135282 2.0 ELF3 CTCF USF1 MAX ARID4B RAD21 TEAD3 MIXL1 ZNF263 SOX5 TSSC1 GC02M003244 GC02M003097
GH02F003253 0.8 ENCODE 7.2 +123.4 123351 1.5 CTCF MXI1 ZFP64 BMI1 EBF1 RELA EED CREM CHD2 MTA2 TSSC1 PIR42894 GC02M003270
GH02F003276 0.5 FANTOM5 6.4 +100.9 100883 0.2 FOS EGR2 TSSC1 GC02M003270 TSSC1-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSSC1 on UCSC Golden Path with GeneCards custom track

Promoters for TSSC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010997 -1818 2201 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS

Genomic Location for TSSC1 Gene

3,188,925 bp from pter
3,377,882 bp from pter
188,958 bases
Minus strand

Genomic View for TSSC1 Gene

Genes around TSSC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSC1 Gene

Proteins for TSSC1 Gene

  • Protein details for TSSC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TSSC1
    Protein Accession:
    Secondary Accessions:
    • D6W4Y1
    • O43179
    • Q53S19
    • Q53SG2

    Protein attributes for TSSC1 Gene

    387 amino acids
    Molecular mass:
    43603 Da
    Quaternary structure:
    • Interacts with EARP complex components VPS50 and VPS51, and SNAP29.

neXtProt entry for TSSC1 Gene

Post-translational modifications for TSSC1 Gene

  • Ubiquitination at Lys 91, Lys 240, and Lys 382
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TSSC1
  • Santa Cruz Biotechnology (SCBT) Antibodies for TSSC1

No data available for DME Specific Peptides for TSSC1 Gene

Domains & Families for TSSC1 Gene

Gene Families for TSSC1 Gene

Protein Domains for TSSC1 Gene

Suggested Antigen Peptide Sequences for TSSC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 WD repeats.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with TSSC1: view

Function for TSSC1 Gene

Molecular function for TSSC1 Gene

GENATLAS Biochemistry:
tumor suppressing subchromosomal transferable DNA fragment (STF1),homolog of Rb associated protein p48 and Drosophila ,chromatin assembly factor 1 (CAF1),close to HBB@,not localized in the interval STIM1-NUP98

Phenotypes for TSSC1 Gene

genes like me logo Genes that share phenotypes with TSSC1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSSC1 Gene

Localization for TSSC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSSC1 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSSC1 Gene

Pathways & Interactions for TSSC1 Gene

SuperPathways for TSSC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSSC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSSC1 Gene

Transcripts for TSSC1 Gene

Unigene Clusters for TSSC1 Gene

Tumor suppressing subtransferable candidate 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - - - -
SP2: - - - - - - - - - -
SP4: - -

Relevant External Links for TSSC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSSC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSSC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSSC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSSC1 Gene

Protein tissue co-expression partners for TSSC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSSC1 Gene:


SOURCE GeneReport for Unigene cluster for TSSC1 Gene:

genes like me logo Genes that share expression patterns with TSSC1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSSC1 Gene

Orthologs for TSSC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSSC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSSC1 34 35
  • 96.04 (n)
(Monodelphis domestica)
Mammalia TSSC1 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TSSC1 35
  • 91 (a)
(Canis familiaris)
Mammalia TSSC1 34 35
  • 88.89 (n)
(Mus musculus)
Mammalia Tssc1 34 16 35
  • 87.05 (n)
(Rattus norvegicus)
Mammalia Tssc1 34
  • 86.27 (n)
(Bos Taurus)
Mammalia TSSC1 34 35
  • 84.93 (n)
(Gallus gallus)
Aves TSSC1 34 35
  • 83.27 (n)
(Anolis carolinensis)
Reptilia TSSC1 35
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tssc1 34
  • 76.92 (n)
Str.16468 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6182 34
(Danio rerio)
Actinopterygii tssc1 34 35
  • 78.04 (n)
wufj20b01 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006239 34
  • 52.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10646 36 34 35
  • 50.62 (n)
(Caenorhabditis elegans)
Secernentea Y87G2A.11 36 34 35
  • 45.54 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DWA2 34
  • 47.09 (n)
(Oryza sativa)
Liliopsida Os08g0554000 34
  • 47.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8095 34
Species where no ortholog for TSSC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSSC1 Gene

Gene Tree for TSSC1 (if available)
Gene Tree for TSSC1 (if available)

Paralogs for TSSC1 Gene

(1) SIMAP similar genes for TSSC1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TSSC1: view

No data available for Paralogs for TSSC1 Gene

Variants for TSSC1 Gene

Sequence variations from dbSNP and Humsavar for TSSC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10153672 -- 3,309,163(+) tggtc(A/G)atgta intron-variant
rs10165156 -- 3,223,768(+) CCAAA(A/C)CTGCT intron-variant
rs10165474 -- 3,365,997(+) caccc(A/C)gtccg intron-variant
rs10168009 -- 3,264,461(+) AGAAC(G/T)GGATA intron-variant
rs10170208 -- 3,365,993(+) cagcc(A/G)ccccg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSSC1 Gene

Variant ID Type Subtype PubMed ID
dgv1846n106 CNV insertion 24896259
dgv1847n106 CNV deletion 24896259
dgv3702n100 CNV gain 25217958
dgv581e201 CNV deletion 23290073
dgv582e201 CNV deletion 23290073
esv1000150 CNV insertion 20482838
esv1132688 CNV insertion 17803354
esv1275017 CNV insertion 17803354
esv1332508 CNV insertion 17803354
esv1349936 CNV insertion 17803354
esv1457193 CNV insertion 17803354
esv1510808 CNV insertion 17803354
esv1558154 CNV deletion 17803354
esv1597731 CNV deletion 17803354
esv1790966 CNV insertion 17803354
esv2206412 CNV deletion 18987734
esv2535058 CNV deletion 19546169
esv2719482 CNV deletion 23290073
esv2719483 CNV deletion 23290073
esv2719484 CNV deletion 23290073
esv2719486 CNV deletion 23290073
esv2719487 CNV deletion 23290073
esv2719488 CNV deletion 23290073
esv2719489 CNV deletion 23290073
esv2719490 CNV deletion 23290073
nsv954777 CNV deletion 24416366
nsv954741 CNV deletion 24416366
nsv953382 CNV deletion 24416366
nsv953381 CNV deletion 24416366
nsv580773 CNV loss 21841781
nsv580772 CNV loss 21841781
nsv2583 CNV insertion 18451855
nsv2582 CNV insertion 18451855
nsv2581 CNV insertion 18451855
nsv213961 CNV deletion 16902084
nsv213539 CNV deletion 16902084
nsv146 CNV insertion 15895083
nsv1153444 CNV insertion 26484159
nsv1152432 CNV insertion 26484159
nsv1147357 CNV deletion 26484159
nsv1144887 CNV deletion 24896259
nsv1138741 CNV deletion 24896259
nsv1135866 CNV deletion 24896259
nsv1135865 CNV deletion 24896259
nsv1128788 CNV duplication 24896259
nsv1072911 CNV deletion 25765185
nsv1072381 CNV deletion 25765185
nsv1071964 CNV deletion 25765185
nsv1011656 CNV gain 25217958
nsv1003355 CNV gain 25217958
esv992834 CNV deletion 20482838
esv992005 CNV deletion 20482838
esv990138 CNV insertion 20482838
esv6954 CNV gain 19470904
esv6094 CNV loss 19470904
esv3589655 CNV gain 21293372
esv3551644 CNV deletion 23714750
esv3551611 CNV deletion 23714750
esv3551600 CNV deletion 23714750
esv3551578 CNV deletion 23714750
esv3427041 CNV duplication 20981092
esv3425021 CNV duplication 20981092
esv3034 CNV loss 18987735
esv2762238 CNV loss 21179565
esv275148 CNV gain+loss 21479260
esv2719514 CNV deletion 23290073
esv2719513 CNV deletion 23290073
esv2719512 CNV deletion 23290073
esv2719511 CNV deletion 23290073
esv2719509 CNV deletion 23290073
esv2719506 CNV deletion 23290073
esv2719505 CNV deletion 23290073
esv2719504 CNV deletion 23290073
esv2719503 CNV deletion 23290073
esv2719501 CNV deletion 23290073
esv2719499 CNV deletion 23290073
esv2719498 CNV deletion 23290073
esv2719497 CNV deletion 23290073
esv2719495 CNV deletion 23290073
esv2719494 CNV deletion 23290073
esv2719493 CNV deletion 23290073
esv2719492 CNV deletion 23290073
esv2719491 CNV deletion 23290073

Variation tolerance for TSSC1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSSC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSSC1 Gene

Disorders for TSSC1 Gene

Relevant External Links for TSSC1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSSC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSSC1 Gene

Publications for TSSC1 Gene

  1. A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. (PMID: 9403053) Hu R.-J. … Feinberg A.P. (Genomics 1997) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster. (PMID: 9925925) Scelfo R. … Negrini M. (Cytogenet. Cell Genet. 1998) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TSSC1 Gene

Sources for TSSC1 Gene

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