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Aliases for TSSC1 Gene

Aliases for TSSC1 Gene

  • Tumor Suppressing Subtransferable Candidate 1 2 3
  • Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 1 Protein 4
  • Tumor-Suppressing STF CDNA 1 Protein 4

External Ids for TSSC1 Gene

Previous GeneCards Identifiers for TSSC1 Gene

  • GC02M004586
  • GC02M004873
  • GC02M004802
  • GC02M004731

Summaries for TSSC1 Gene

Entrez Gene Summary for TSSC1 Gene

  • This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]

GeneCards Summary for TSSC1 Gene

TSSC1 (Tumor Suppressing Subtransferable Candidate 1) is a Protein Coding gene. Diseases associated with TSSC1 include wilms tumor and breast cancer.

Gene Wiki entry for TSSC1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSC1 Gene

Genomics for TSSC1 Gene

Regulatory Elements for TSSC1 Gene

Genomic Location for TSSC1 Gene

Start:
3,188,925 bp from pter
End:
3,377,882 bp from pter
Size:
188,958 bases
Orientation:
Minus strand

Genomic View for TSSC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSSC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSC1 Gene

Proteins for TSSC1 Gene

  • Protein details for TSSC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53HC9-TSSC1_HUMAN
    Recommended name:
    Protein TSSC1
    Protein Accession:
    Q53HC9
    Secondary Accessions:
    • D6W4Y1
    • O43179
    • Q53S19
    • Q53SG2

    Protein attributes for TSSC1 Gene

    Size:
    387 amino acids
    Molecular mass:
    43603 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSSC1 Gene

Proteomics data for TSSC1 Gene at MOPED

Post-translational modifications for TSSC1 Gene

  • Ubiquitination at Lys91, Lys240, and Lys382
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSSC1 Gene

Domains for TSSC1 Gene

Gene Families for TSSC1 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for TSSC1 Gene

Suggested Antigen Peptide Sequences for TSSC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q53HC9

UniProtKB/Swiss-Prot:

TSSC1_HUMAN :
  • Q53HC9
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with TSSC1: view

Function for TSSC1 Gene

Molecular function for TSSC1 Gene

GENATLAS Biochemistry: tumor suppressing subchromosomal transferable DNA fragment (STF1),homolog of Rb associated protein p48 and Drosophila ,chromatin assembly factor 1 (CAF1),close to HBB@,not localized in the interval STIM1-NUP98

Gene Ontology (GO) - Molecular Function for TSSC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TSSC1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSSC1 Gene

Localization for TSSC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSSC1 Gene COMPARTMENTS Subcellular localization image for TSSC1 gene
Compartment Confidence
cytoskeleton 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSSC1 Gene

Pathways for TSSC1 Gene

SuperPathways for TSSC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSSC1 Gene

None

No data available for Pathways by source for TSSC1 Gene

Transcripts for TSSC1 Gene

Unigene Clusters for TSSC1 Gene

Tumor suppressing subtransferable candidate 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSSC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSSC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - -
SP5:
SP6:

Relevant External Links for TSSC1 Gene

GeneLoc Exon Structure for
TSSC1
ECgene alternative splicing isoforms for
TSSC1

Expression for TSSC1 Gene

mRNA expression in normal human tissues for TSSC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSSC1 Gene

SOURCE GeneReport for Unigene cluster for TSSC1 Gene Hs.502770

genes like me logo Genes that share expressions with TSSC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSSC1 Gene

Orthologs for TSSC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSSC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSSC1 35
  • 96.04 (n)
  • 95.35 (a)
TSSC1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSSC1 35
  • 84.93 (n)
  • 88.89 (a)
TSSC1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSSC1 35
  • 88.89 (n)
  • 94.06 (a)
TSSC1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tssc1 35
  • 87.05 (n)
  • 93.26 (a)
Tssc1 16
Tssc1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSSC1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSSC1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tssc1 35
  • 86.27 (n)
  • 93.52 (a)
chicken
(Gallus gallus)
Aves TSSC1 35
  • 83.27 (n)
  • 92.67 (a)
TSSC1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSSC1 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6182 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16468 35
tssc1 35
  • 76.92 (n)
  • 87.08 (a)
zebrafish
(Danio rerio)
Actinopterygii tssc1 35
  • 78.04 (n)
  • 85.01 (a)
tssc1 36
  • 85 (a)
OneToOne
wufj20b01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006239 35
  • 52.14 (n)
  • 39.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10646 35
  • 50.62 (n)
  • 40.43 (a)
CG10646 36
  • 40 (a)
OneToOne
CG10646 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea Y87G2A.11 35
  • 45.54 (n)
  • 37.18 (a)
Y87G2A.11 36
  • 36 (a)
OneToOne
Y87G2A.11 37
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DWA2 35
  • 47.09 (n)
  • 38.25 (a)
rice
(Oryza sativa)
Liliopsida Os08g0554000 35
  • 47.06 (n)
  • 39.71 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8095 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for TSSC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSSC1 Gene

ENSEMBL:
Gene Tree for TSSC1 (if available)
TreeFam:
Gene Tree for TSSC1 (if available)

Paralogs for TSSC1 Gene

Selected SIMAP similar genes for TSSC1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TSSC1: view

No data available for Paralogs for TSSC1 Gene

Variants for TSSC1 Gene

Sequence variations from dbSNP and Humsavar for TSSC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6836 -- 3,189,027(-) CTGCA(A/G)TAGTA utr-variant-3-prime
rs8136 -- 3,189,141(-) ATGCC(C/T)GAACC utr-variant-3-prime
rs17682 -- 3,189,269(+) GCTGC(A/G)ACTGT utr-variant-3-prime
rs745997 -- 3,193,183(-) TCCCT(C/G)TGCCC intron-variant
rs748720 -- 3,205,155(-) CTTGC(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSSC1 Gene

Variant ID Type Subtype PubMed ID
nsv873578 CNV Gain 21882294
nsv873579 CNV Loss 21882294
nsv873580 CNV Loss 21882294
nsv2581 CNV Insertion 18451855
nsv873581 CNV Gain 21882294
nsv146 CNV Insertion 15895083
esv2719482 CNV Deletion 23290073
esv2719483 CNV Deletion 23290073
esv990138 CNV Insertion 20482838
esv6954 CNV Gain 19470904
esv1332508 CNV Insertion 17803354
nsv213961 CNV Loss 16902084
esv2719484 CNV Deletion 23290073
esv1275017 CNV Insertion 17803354
nsv2582 CNV Insertion 18451855
esv2719486 CNV Deletion 23290073
esv1457193 CNV Insertion 17803354
esv3034 CNV Deletion 18987735
esv1790966 CNV Insertion 17803354
esv2719487 CNV Deletion 23290073
esv1132688 CNV Insertion 17803354
esv1510808 CNV Insertion 17803354
esv2719488 CNV Deletion 23290073
esv2719489 CNV Deletion 23290073
esv2719490 CNV Deletion 23290073
esv2206412 CNV Deletion 18987734
esv992005 CNV Deletion 20482838
esv1558154 CNV Deletion 17803354
esv2719491 CNV Deletion 23290073
esv275148 CNV Gain+Loss 21479260
esv2719492 CNV Deletion 23290073
nsv873582 CNV Loss 21882294
esv2719493 CNV Deletion 23290073
esv2719494 CNV Deletion 23290073
nsv213539 CNV Loss 16902084
esv2719495 CNV Deletion 23290073
esv2719497 CNV Deletion 23290073
esv1000150 CNV Insertion 20482838
esv2719498 CNV Deletion 23290073
esv2719499 CNV Deletion 23290073
esv2535058 CNV Deletion 19546169
dgv622e201 CNV Deletion 23290073
esv1597731 CNV Deletion 17803354
esv2719501 CNV Deletion 23290073
nsv873583 CNV Gain 21882294
esv2719503 CNV Deletion 23290073
esv2719504 CNV Deletion 23290073
esv2719505 CNV Deletion 23290073
esv2719506 CNV Deletion 23290073
dgv623e201 CNV Deletion 23290073
esv2719509 CNV Deletion 23290073
esv2719511 CNV Deletion 23290073
nsv2583 CNV Insertion 18451855
esv2719512 CNV Deletion 23290073
esv2719513 CNV Deletion 23290073
esv6094 CNV Loss 19470904
esv992834 CNV Deletion 20482838
esv1349936 CNV Insertion 17803354
esv2719514 CNV Deletion 23290073
nsv873584 CNV Loss 21882294

Relevant External Links for TSSC1 Gene

HapMap Linkage Disequilibrium report
TSSC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSSC1 Gene

Disorders for TSSC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TSSC1 Gene including...

Search for TSSC1 Gene in MalaCards »

Relevant External Links for TSSC1

Genetic Association Database (GAD)
TSSC1
genes like me logo Genes that share disorders with TSSC1: view

No data available for UniProtKB/Swiss-Prot for TSSC1 Gene

Publications for TSSC1 Gene

  1. A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. (PMID: 9403053) Hu R.-J. … Feinberg A.P. (Genomics 1997) 2 3 4
  2. Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster. (PMID: 9925925) Scelfo R. … Negrini M. (Cytogenet. Cell Genet. 1998) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

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Sources for TSSC1 Gene

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