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Aliases for TSSC1 Gene

Aliases for TSSC1 Gene

  • Tumor Suppressing Subtransferable Candidate 1 2 3 5
  • Tumor-Suppressing Subchromosomal Transferable Fragment Candidate Gene 1 Protein 4
  • Tumor-Suppressing STF CDNA 1 Protein 4

External Ids for TSSC1 Gene

Previous GeneCards Identifiers for TSSC1 Gene

  • GC02M004586
  • GC02M004873
  • GC02M004802
  • GC02M004731

Summaries for TSSC1 Gene

Entrez Gene Summary for TSSC1 Gene

  • This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]

GeneCards Summary for TSSC1 Gene

TSSC1 (Tumor Suppressing Subtransferable Candidate 1) is a Protein Coding gene.

Gene Wiki entry for TSSC1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSSC1 Gene

Genomics for TSSC1 Gene

Regulatory Elements for TSSC1 Gene

Enhancers for TSSC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSSC1 on UCSC Golden Path with GeneCards custom track

Promoters for TSSC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSSC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSSC1 Gene

Chromosome:
2
Start:
3,188,925 bp from pter
End:
3,377,882 bp from pter
Size:
188,958 bases
Orientation:
Minus strand

Genomic View for TSSC1 Gene

Genes around TSSC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSSC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSSC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSSC1 Gene

Proteins for TSSC1 Gene

  • Protein details for TSSC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53HC9-TSSC1_HUMAN
    Recommended name:
    Protein TSSC1
    Protein Accession:
    Q53HC9
    Secondary Accessions:
    • D6W4Y1
    • O43179
    • Q53S19
    • Q53SG2

    Protein attributes for TSSC1 Gene

    Size:
    387 amino acids
    Molecular mass:
    43603 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSSC1 Gene

Proteomics data for TSSC1 Gene at MOPED

Post-translational modifications for TSSC1 Gene

  • Ubiquitination at Lys 91, Lys 240, and Lys 382
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TSSC1

No data available for DME Specific Peptides for TSSC1 Gene

Domains & Families for TSSC1 Gene

Gene Families for TSSC1 Gene

Protein Domains for TSSC1 Gene

Suggested Antigen Peptide Sequences for TSSC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q53HC9

UniProtKB/Swiss-Prot:

TSSC1_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with TSSC1: view

Function for TSSC1 Gene

Molecular function for TSSC1 Gene

GENATLAS Biochemistry:
tumor suppressing subchromosomal transferable DNA fragment (STF1),homolog of Rb associated protein p48 and Drosophila ,chromatin assembly factor 1 (CAF1),close to HBB@,not localized in the interval STIM1-NUP98

Phenotypes for TSSC1 Gene

genes like me logo Genes that share phenotypes with TSSC1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSSC1 Gene

Localization for TSSC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSSC1 Gene COMPARTMENTS Subcellular localization image for TSSC1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSSC1 Gene

Pathways & Interactions for TSSC1 Gene

SuperPathways for TSSC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSSC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TSSC1 Gene

Drugs & Compounds for TSSC1 Gene

No Compound Related Data Available

Transcripts for TSSC1 Gene

Unigene Clusters for TSSC1 Gene

Tumor suppressing subtransferable candidate 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSSC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - - - -
SP2: - - - - - - - - - -
SP3:
SP4: - -
SP5:
SP6:

Relevant External Links for TSSC1 Gene

GeneLoc Exon Structure for
TSSC1
ECgene alternative splicing isoforms for
TSSC1

Expression for TSSC1 Gene

mRNA expression in normal human tissues for TSSC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSSC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSSC1 Gene



SOURCE GeneReport for Unigene cluster for TSSC1 Gene Hs.502770

genes like me logo Genes that share expression patterns with TSSC1: view

Protein tissue co-expression partners for TSSC1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSSC1 Gene

Orthologs for TSSC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSSC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSSC1 35
  • 84.93 (n)
  • 88.89 (a)
TSSC1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSSC1 35
  • 88.89 (n)
  • 94.06 (a)
TSSC1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tssc1 35
  • 87.05 (n)
  • 93.26 (a)
Tssc1 16
Tssc1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSSC1 35
  • 96.04 (n)
  • 95.35 (a)
TSSC1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tssc1 35
  • 86.27 (n)
  • 93.52 (a)
oppossum
(Monodelphis domestica)
Mammalia TSSC1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSSC1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSSC1 35
  • 83.27 (n)
  • 92.67 (a)
TSSC1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSSC1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16468 35
tssc1 35
  • 76.92 (n)
  • 87.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6182 35
zebrafish
(Danio rerio)
Actinopterygii tssc1 35
  • 78.04 (n)
  • 85.01 (a)
wufj20b01 35
tssc1 36
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10646 37
  • 39 (a)
CG10646 35
  • 50.62 (n)
  • 40.43 (a)
CG10646 36
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006239 35
  • 52.14 (n)
  • 39.04 (a)
worm
(Caenorhabditis elegans)
Secernentea Y87G2A.11 37
  • 34 (a)
Y87G2A.11 35
  • 45.54 (n)
  • 37.18 (a)
Y87G2A.11 36
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons DWA2 35
  • 47.09 (n)
  • 38.25 (a)
rice
(Oryza sativa)
Liliopsida Os08g0554000 35
  • 47.06 (n)
  • 39.71 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8095 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for TSSC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSSC1 Gene

ENSEMBL:
Gene Tree for TSSC1 (if available)
TreeFam:
Gene Tree for TSSC1 (if available)

Paralogs for TSSC1 Gene

(1) SIMAP similar genes for TSSC1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TSSC1: view

No data available for Paralogs for TSSC1 Gene

Variants for TSSC1 Gene

Sequence variations from dbSNP and Humsavar for TSSC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1551295 -- 3,215,379(-) TGGCC(A/G)GTGGC intron-variant
rs745997 -- 3,193,183(-) TCCCT(C/G)TGCCC intron-variant
rs748720 -- 3,205,155(-) CTTGC(C/T)GTGCA intron-variant
rs748721 -- 3,205,391(-) CCCAC(A/G)GTTCC intron-variant
rs752594 -- 3,204,505(+) GGGTG(C/T)AATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSSC1 Gene

Variant ID Type Subtype PubMed ID
nsv873578 CNV Gain 21882294
nsv873579 CNV Loss 21882294
nsv873580 CNV Loss 21882294
nsv2581 CNV Insertion 18451855
nsv873581 CNV Gain 21882294
nsv146 CNV Insertion 15895083
esv2719482 CNV Deletion 23290073
esv2719483 CNV Deletion 23290073
esv990138 CNV Insertion 20482838
esv6954 CNV Gain 19470904
esv1332508 CNV Insertion 17803354
nsv213961 CNV Loss 16902084
esv2719484 CNV Deletion 23290073
esv1275017 CNV Insertion 17803354
nsv2582 CNV Insertion 18451855
esv2719486 CNV Deletion 23290073
esv1457193 CNV Insertion 17803354
esv3034 CNV Deletion 18987735
esv1790966 CNV Insertion 17803354
esv2719487 CNV Deletion 23290073
esv1132688 CNV Insertion 17803354
esv1510808 CNV Insertion 17803354
esv2719488 CNV Deletion 23290073
esv2719489 CNV Deletion 23290073
esv2719490 CNV Deletion 23290073
esv2206412 CNV Deletion 18987734
esv992005 CNV Deletion 20482838
esv1558154 CNV Deletion 17803354
esv2719491 CNV Deletion 23290073
esv275148 CNV Gain+Loss 21479260
esv2719492 CNV Deletion 23290073
nsv873582 CNV Loss 21882294
esv2719493 CNV Deletion 23290073
esv2719494 CNV Deletion 23290073
nsv213539 CNV Loss 16902084
esv2719495 CNV Deletion 23290073
esv2719497 CNV Deletion 23290073
esv1000150 CNV Insertion 20482838
esv2719498 CNV Deletion 23290073
esv2719499 CNV Deletion 23290073
esv2535058 CNV Deletion 19546169
dgv622e201 CNV Deletion 23290073
esv1597731 CNV Deletion 17803354
esv2719501 CNV Deletion 23290073
nsv873583 CNV Gain 21882294
esv2719503 CNV Deletion 23290073
esv2719504 CNV Deletion 23290073
esv2719505 CNV Deletion 23290073
esv2719506 CNV Deletion 23290073
dgv623e201 CNV Deletion 23290073
esv2719509 CNV Deletion 23290073
esv2719511 CNV Deletion 23290073
nsv2583 CNV Insertion 18451855
esv2719512 CNV Deletion 23290073
esv2719513 CNV Deletion 23290073
esv6094 CNV Loss 19470904
esv992834 CNV Deletion 20482838
esv1349936 CNV Insertion 17803354
esv2719514 CNV Deletion 23290073
nsv873584 CNV Loss 21882294

Variation tolerance for TSSC1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSSC1 Gene

Disorders for TSSC1 Gene

Relevant External Links for TSSC1

Genetic Association Database (GAD)
TSSC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSSC1

No disorders were found for TSSC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSSC1 Gene

Publications for TSSC1 Gene

  1. A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. (PMID: 9403053) Hu R.-J. … Feinberg A.P. (Genomics 1997) 2 3 4 67
  2. Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster. (PMID: 9925925) Scelfo R. … Negrini M. (Cytogenet. Cell Genet. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Runx2 induces bone osteolysis by transcriptional suppression of TSSC1. (PMID: 23933319) Wang D.C. … Yuan Z.N. (Biochem. Biophys. Res. Commun. 2013) 3

Products for TSSC1 Gene

Sources for TSSC1 Gene

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