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Aliases for TSR3 Gene

Aliases for TSR3 Gene

  • TSR3, Acp Transferase Ribosome Maturation Factor 2 3 5
  • C16orf42 3 4
  • TSR3, 20S RRNA Accumulation, Homolog (S. Cerevisiae) 2
  • Probable Ribosome Biogenesis Protein C16orf42 3
  • Ribosome Biogenesis Protein TSR3 Homolog 3
  • TSR3, 20S RRNA Accumulation, Homolog 3
  • Chromosome 16 Open Reading Frame 42 2
  • UND313L 4

External Ids for TSR3 Gene

Previous HGNC Symbols for TSR3 Gene

  • C16orf42

Previous GeneCards Identifiers for TSR3 Gene

  • GC16M001400
  • GC16M001401
  • GC16M001402
  • GC16M001403

Summaries for TSR3 Gene

GeneCards Summary for TSR3 Gene

TSR3 (TSR3, Acp Transferase Ribosome Maturation Factor) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression.

UniProtKB/Swiss-Prot for TSR3 Gene

  • Probable pre-rRNA processing protein involved in ribosome biogenesis.

Gene Wiki entry for TSR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSR3 Gene

Genomics for TSR3 Gene

Regulatory Elements for TSR3 Gene

Enhancers for TSR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F001377 0.7 ENCODE 12.9 -26.9 -26930 3.3 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 FOS KLF13 ZNF263 IFT140 CCDC154 HN1L ENSG00000279473 GNPTG TSR3 RNPS1 CHTF18 TMEM204 BAIAP3
GH16F001296 1 Ensembl ENCODE 11.8 +52.7 52728 5.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF143 FOS KLF13 ZNF263 ENSG00000261505 ENSG00000260954 JMJD8 ENSG00000226890 BAIAP3 ENSG00000200059 PRSS29P ENSG00000261240 ZNF598 UBE2I
GH16F001295 0.8 ENCODE 11.8 +56.2 56176 0.5 RPS20P2 TPSD1 BAIAP3 GNPTG TSR3 ENSG00000260710 TPSP2
GH16F001291 0.9 FANTOM5 ENCODE 11.8 +60.7 60720 0.4 SAP130 ARID4B YY1 E2F1 HIC1 SCRT2 NR2F6 ZNF687 NFIA L3MBTL2 BAIAP3 TPSD1 RPS20P2 GNPTG TSR3 UBE2I CACNA1H TPSP2 ENSG00000260710
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TSR3 on UCSC Golden Path with GeneCards custom track

Promoters for TSR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502258 -289 2001 ATF1 CREB3L1 MLX ARID4B SIN3A ETS1 YY1 ELK1 ZNF207 ZNF143

Genomic Location for TSR3 Gene

1,349,240 bp from pter
1,351,911 bp from pter
2,672 bases
Minus strand

Genomic View for TSR3 Gene

Genes around TSR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSR3 Gene

Proteins for TSR3 Gene

  • Protein details for TSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosome biogenesis protein TSR3 homolog
    Protein Accession:
    Secondary Accessions:
    • Q6PJT8

    Protein attributes for TSR3 Gene

    312 amino acids
    Molecular mass:
    33596 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSR3 Gene

Post-translational modifications for TSR3 Gene

  • Ubiquitination at Lys 103, Lys 136, and Lys 192
  • Modification sites at PhosphoSitePlus

Other Protein References for TSR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSR3 Gene

Domains & Families for TSR3 Gene

Suggested Antigen Peptide Sequences for TSR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TSR3 family.
  • Belongs to the TSR3 family.
genes like me logo Genes that share domains with TSR3: view

No data available for Gene Families for TSR3 Gene

Function for TSR3 Gene

Molecular function for TSR3 Gene

UniProtKB/Swiss-Prot Function:
Probable pre-rRNA processing protein involved in ribosome biogenesis.

Phenotypes for TSR3 Gene

genes like me logo Genes that share phenotypes with TSR3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSR3 Gene

Localization for TSR3 Gene

Subcellular locations from

Jensen Localization Image for TSR3 Gene COMPARTMENTS Subcellular localization image for TSR3 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSR3 Gene

Pathways & Interactions for TSR3 Gene

genes like me logo Genes that share pathways with TSR3: view

Interacting Proteins for TSR3 Gene

Gene Ontology (GO) - Biological Process for TSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030490 maturation of SSU-rRNA IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with TSR3: view

No data available for SIGNOR curated interactions for TSR3 Gene

Transcripts for TSR3 Gene

mRNA/cDNA for TSR3 Gene

Unigene Clusters for TSR3 Gene

TSR3, 20S rRNA accumulation, homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSR3 Gene

No ASD Table

Relevant External Links for TSR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSR3 Gene

This gene is overexpressed in Adrenal (50.7) and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSR3 Gene

Protein tissue co-expression partners for TSR3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSR3 Gene:


SOURCE GeneReport for Unigene cluster for TSR3 Gene:

genes like me logo Genes that share expression patterns with TSR3: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSR3 Gene

Orthologs for TSR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSR3 34 35
  • 98.57 (n)
(Bos Taurus)
Mammalia TSR3 34
  • 84.94 (n)
C25H16ORF42 35
  • 82 (a)
(Canis familiaris)
Mammalia TSR3 34 35
  • 83.45 (n)
(Rattus norvegicus)
Mammalia Tsr3 34
  • 81.39 (n)
(Mus musculus)
Mammalia Tsr3 34 16 35
  • 80.04 (n)
(Monodelphis domestica)
Mammalia TSR3 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia TSR3 35
  • 64 (a)
(Gallus gallus)
Aves C14H16ORF42 34 35
  • 60.83 (n)
(Anolis carolinensis)
Reptilia TSR3 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tsr3 34
  • 57.95 (n)
(Danio rerio)
Actinopterygii tsr3 34 35
  • 59.58 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4338 34 35
  • 55.34 (n)
(Caenorhabditis elegans)
Secernentea F52C12.2 34 35
  • 51.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSR3 35 37
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G10070 34
  • 50.97 (n)
(Oryza sativa)
Liliopsida Os03g0195200 34
  • 50.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
Species where no ortholog for TSR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSR3 Gene

Gene Tree for TSR3 (if available)
Gene Tree for TSR3 (if available)

Paralogs for TSR3 Gene

No data available for Paralogs for TSR3 Gene

Variants for TSR3 Gene

Sequence variations from dbSNP and Humsavar for TSR3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs137853826 untested 1,352,123(+) TGCAG(A/C)GAAGA upstream-variant-2KB, reference, missense
rs111267196 -- 1,350,227(+) AGGTC(C/T)GGAAA upstream-variant-2KB, reference, synonymous-codon
rs111354267 -- 1,351,124(+) CAAAC(A/G)GACTT intron-variant, upstream-variant-2KB
rs111476616 -- 1,353,631(+) CAATC(A/C)ACCAA intron-variant, upstream-variant-2KB
rs111790048 -- 1,353,253(+) ATTAT(A/G)GGCGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSR3 Gene

Variant ID Type Subtype PubMed ID
dgv2692n100 CNV gain 25217958
esv2422427 CNV duplication 17116639
esv2762143 CNV gain 21179565
nsv1046314 CNV loss 25217958
nsv428316 CNV gain+loss 18775914
nsv471066 CNV loss 18288195
nsv952899 CNV deletion 24416366
nsv974746 CNV duplication 23825009

Variation tolerance for TSR3 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSR3 Gene

Disorders for TSR3 Gene

Relevant External Links for TSR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSR3 Gene

Publications for TSR3 Gene

  1. Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. (PMID: 27084949) Meyer B. … Entian K.D. (Nucleic Acids Res. 2016) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 64

Products for TSR3 Gene

Sources for TSR3 Gene

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