TSR3 Gene
protein-coding GIFtS : 40
GCID: GC16 M001401
TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) (Previous name: chromosome 16 open reading frame 42 ) (Previous symbol: C16orf42 )
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Aliasesfor TSR3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases TSR3, 20S RRNA Accumulation, Homolog (S. Cerevisiae) 1 2 Probable Ribosome Biogenesis Protein C16orf422 C16orf421 2 3 Ribosome Biogenesis Protein TSR3 Homolog2 MGC243811 UND313L3 Chromosome 16 Open Reading Frame 421
Export aliases for TSR3 gene to outside databases Previous GC identifer: GC16M001400
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Summariesfor TSR3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TSR3_HUMAN, Q9UJK0 Function : Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity)Gene Wiki entry for TSR3 (C16orf42)
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Genomic Viewsfor TSR3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010393.16 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for TSR3 Other transcription factors Search SABiosciences Chromatin IP Primers for TSR3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TSR3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3 TSR3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M001401: view genomic region
(about GC identifiers )
Start:
1,399,241 bp from pter
End:
1,401,912 bp from pter
Size:
2,672 bases
Orientation:
minus strand
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Proteinsfor TSR3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TSR3_HUMAN, Q9UJK0 (See
protein sequence )Recommended Name: Ribosome biogenesis protein TSR3 homolog Size : 312 amino acids; 33596 Da
Secondary accessions : Q6PJT8Explore the universe of human proteins at neXtProt for TSR3: NX_Q9UJK0 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UJK0 TSR3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001001410.1 ENSEMBL proteins: ENSP00000007390 ENSP00000455722 Human Recombinant Protein Products: TSR3 Antibody Products: Assay Products for TSR3:
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Protein
Domains / Familiesfor TSR3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TSR3 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9UJK0 ProtoNet protein and cluster: Q9UJK0
2 Blocks protein families : IPB007177 Protein of unknown function DUF367 IPB007209 Possible metal-binding region in RNase L inhibitor UniProtKB/Swiss-Prot: TSR3_HUMAN, Q9UJK0 Similarity : Belongs to the TSR3 family
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Functionfor TSR3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TSR3_HUMAN, Q9UJK0 Function : Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSR3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSR3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for TSR3 Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSR3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSR3
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Pathways & Interactionsfor TSR3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSR3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)5/33 Interacting proteins for TSR3 (Q9UJK0 3 ENSP00000007390 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 33 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006364 rRNA processing
IEA --
TSR3 for ontologies About GeneDecksing
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Drugs & Compoundsfor TSR3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TSR3 Search CenterWatch for drugs/clinical trials and news about TSR3
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Transcriptsfor TSR3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TSR3 gene: NM_001001410.2 Unigene Cluster for TSR3:
TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) Hs.134846 [show with all ESTs ] Unigene Representative Sequence: BC013943 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000007390 (uc002cll.3 ) ENST00000566296 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSR3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSR3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript Custom all cDNA clones Services for TSR3 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSR3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSR3
Additional cDNA sequence: BC011785.2 BC013943.1 BC016699.1 BC017325.2
6 DOTS entries : DT.75118306 DT.449556
DT.92435001 DT.97840633 DT.100815748 DT.92434995 24/68 AceView cDNA sequences (see all 68 ):
AI923651 AW406663 AI659324 AW007556 AI423636 AI264852 BI064315 BC017325 AI094880 AI341540 NM_001001410 AI091298 AI560264 AI972013 AI971937 AI813672 AI660316 BC013943 AI672681 AI971966 AW007602 BE674893 AW341301 AI925218 GeneLoc Exon Structure
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Expression for TSR3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section See probesets specificity/sensitivity at GeneAnnot CGAP TAG: -- TSR3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Brain Hypothalamus Brain Neural Tube Diencephalon Neural Tube Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TSR3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TSR3 SOURCE GeneReport for Unigene cluster: Hs.134846 SABiosciences Custom PCR Arrays for TSR3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSR3Browse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TSR3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSR3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSR3
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Orthologsfor TSR3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSR3 gene from 9/32 species (see all 32 ) About this table
ENSEMBL Gene Tree for TSR3 (if available)TreeFam Gene Tree for TSR3 (if available)
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Paralogsfor TSR3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor TSR3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSR3
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Disorders
/ Diseasesfor TSR3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TSR3 for disorders About GeneDecksing 1 disease for TSR3 : About MalaCards malaria Export disorders for TSR3 gene to outside databases
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Publicationsfor TSR3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TSR3 gene integrated from 9 sources : (articles sorted by number of sources associating them with TSR3) Utopia : connect your pdf to the dynamic world of online information
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553) 1 , 2 Martin J.... Pennacchio L.A. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797) 1 , 2 Daniels R.J....Higgs D.R. (2001) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008)
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External Searches for TSR3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TSR3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TSR3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TSR3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TSR3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TSR3 gene: Search GeneIP for patents involving TSR3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TSR3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TSR3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TSR3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSR3 OriGene Protein Over-expression Lysate for TSR3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TSR3 OriGene 3'-UTR Clone for TSR3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSR3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSR3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TSR3 OriGene Custom Protein Services for TSR3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSR3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSR3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TSR3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TSR3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSR3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSR3
Search Tocris compounds for TSR3
TSR3 Proteins, Antibodies, CLIAs, and ELISAs
ThermoFisher Antibodies for TSR3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSR3
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Genomic Views for TSR3
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