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Aliases for TSR2 Gene

Aliases for TSR2 Gene

  • TSR2, 20S RRNA Accumulation, Homolog (S. Cerevisiae) 2 3
  • WGG Motif Containing 1 2 3
  • Pre-RRNA-Processing Protein TSR2 Homolog 3
  • DT1P1A10 3
  • DBA14 3
  • WGG1 3

External Ids for TSR2 Gene

Previous GeneCards Identifiers for TSR2 Gene

  • GC0XP051518

Summaries for TSR2 Gene

GeneCards Summary for TSR2 Gene

TSR2 (TSR2, 20S RRNA Accumulation, Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TSR2 include blepharospasm and diamond-blackfan anemia.

UniProtKB/Swiss-Prot for TSR2 Gene

  • May be involved in 20S pre-rRNA processing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSR2 Gene

Genomics for TSR2 Gene

Regulatory Elements for TSR2 Gene

Genomic Location for TSR2 Gene

54,440,401 bp from pter
54,445,487 bp from pter
5,087 bases
Plus strand

Genomic View for TSR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSR2 Gene

Proteins for TSR2 Gene

  • Protein details for TSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-rRNA-processing protein TSR2 homolog
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TSR2 Gene

    191 amino acids
    Molecular mass:
    20894 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSR2 Gene

Proteomics data for TSR2 Gene at MOPED

Post-translational modifications for TSR2 Gene

  • Ubiquitination at Lys44
  • Modification sites at PhosphoSitePlus

Other Protein References for TSR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSR2 Gene

Domains for TSR2 Gene

Protein Domains for TSR2 Gene


Suggested Antigen Peptide Sequences for TSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q969E8
  • Belongs to the TSR2 family.
genes like me logo Genes that share domains with TSR2: view

No data available for Gene Families for TSR2 Gene

Function for TSR2 Gene

Molecular function for TSR2 Gene

UniProtKB/Swiss-Prot Function: May be involved in 20S pre-rRNA processing.

Gene Ontology (GO) - Molecular Function for TSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TSR2: view

Phenotypes for TSR2 Gene

GenomeRNAi human phenotypes for TSR2:
genes like me logo Genes that share phenotypes with TSR2: view

Animal Model Products

CRISPR Products

miRNA for TSR2 Gene

miRTarBase miRNAs that target TSR2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSR2 Gene

Localization for TSR2 Gene

Subcellular locations from

Jensen Localization Image for TSR2 Gene COMPARTMENTS Subcellular localization image for TSR2 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TSR2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSR2 Gene

Pathways for TSR2 Gene

SuperPathways for TSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing --
genes like me logo Genes that share ontologies with TSR2: view

No data available for Pathways by source for TSR2 Gene

Transcripts for TSR2 Gene

mRNA/cDNA for TSR2 Gene

(155) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSR2 Gene

TSR2, 20S rRNA accumulation, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSR2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TSR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSR2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP4: - -

Relevant External Links for TSR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSR2 Gene

mRNA expression in normal human tissues for TSR2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSR2 Gene

SOURCE GeneReport for Unigene cluster for TSR2 Gene Hs.522662

genes like me logo Genes that share expressions with TSR2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSR2 Gene

Orthologs for TSR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSR2 35
  • 98.87 (n)
  • 96.61 (a)
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
TSR2 35
  • 88.77 (n)
  • 87.89 (a)
TSR2 36
  • 87 (a)
(Canis familiaris)
Mammalia TSR2 35
  • 89.07 (n)
  • 88.36 (a)
TSR2 36
  • 88 (a)
(Mus musculus)
Mammalia Tsr2 35
  • 85.69 (n)
  • 85.86 (a)
Tsr2 16
Tsr2 36
  • 84 (a)
(Monodelphis domestica)
Mammalia TSR2 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia TSR2 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Tsr2 35
  • 86.74 (n)
  • 86.91 (a)
(Anolis carolinensis)
Reptilia TSR2 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tsr2 35
  • 57.97 (n)
  • 44.57 (a)
(Danio rerio)
Actinopterygii dt1p1a10l 35
tsr2 35
  • 55.86 (n)
  • 46.15 (a)
tsr2 36
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSR2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for TSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSR2 Gene

Gene Tree for TSR2 (if available)
Gene Tree for TSR2 (if available)

Paralogs for TSR2 Gene

No data available for Paralogs for TSR2 Gene

Variants for TSR2 Gene

Sequence variations from dbSNP and Humsavar for TSR2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5914139 -- 54,444,731(+) GGGGT(A/G)GGGGG utr-variant-3-prime
rs5915119 -- 54,439,715(+) gctga(C/G)gcacg upstream-variant-2KB
rs5915120 -- 54,442,635(+) TACTG(G/T)CTAAT intron-variant
rs5960306 -- 54,441,786(+) CCCCC(C/T)TGAAA intron-variant
rs5961065 -- 54,441,871(+) CTAGT(C/T)CTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSR2 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073

Relevant External Links for TSR2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSR2 Gene

Disorders for TSR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TSR2 Gene including...

Search for TSR2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TSR2 Gene

genes like me logo Genes that share disorders with TSR2: view

No data available for UniProtKB/Swiss-Prot for TSR2 Gene

Publications for TSR2 Gene

  1. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy P.H. … Tagle D.A. (Genomics 1997) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3

Products for TSR2 Gene

Sources for TSR2 Gene

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