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TSR2 Gene

protein-coding   GIFtS: 49
GCID: GC0XP054483

TSR2, 20S RRNA Accumulation, Homolog (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TSR2, 20S RRNA Accumulation, Homolog (S. Cerevisiae)1 2
WGG Motif Containing 11 2
DT1P1A102
WGG12
Pre-RRNA-Processing Protein TSR2 Homolog2
N5

External Ids:    HGNC: 254551   Entrez Gene: 901212   Ensembl: ENSG000001585267   OMIM: 6055385   UniProtKB: Q969E83   

Export aliases for TSR2 gene to outside databases

Previous GC identifer: GC0XP051518


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSR2 Gene:
TSR2 (TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with TSR2 include blepharospasm, and thrombotic thrombocytopenic purpura.

UniProtKB/Swiss-Prot: TSR2_HUMAN, Q969E8
Function: May be involved in 20S pre-rRNA processing (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011630.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSR2 gene promoter:
         GATA-3   AML1a   RREB-1   STAT5A   Egr-2   N-Myc   PPAR-gamma1   FAC1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSR2 promoter sequence
   Search Chromatin IP Primers for TSR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22

TSR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSR2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP054483:  view genomic region     (about GC identifiers)

Start:
54,466,834 bp from pter      End:
54,471,920 bp from pter
Size:
5,087 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TSR2_HUMAN, Q969E8 (See protein sequence)
Recommended Name: Pre-rRNA-processing protein TSR2 homolog  
Size: 191 amino acids; 20894 Da

Explore the universe of human proteins at neXtProt for TSR2: NX_Q969E8

Explore proteomics data for TSR2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys44
  • Modification sites at PhosphoSitePlus

  • See TSR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_477511.1  
    ENSEMBL proteins: 
     ENSP00000364293  

    TSR2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019398 Pre-rRNA_process_TSR2

    Graphical View of Domain Structure for InterPro Entry Q969E8

    ProtoNet protein and cluster: Q969E8

    UniProtKB/Swiss-Prot: TSR2_HUMAN, Q969E8
    Similarity: Belongs to the TSR2 family


    TSR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSR2_HUMAN, Q969E8
    Function: May be involved in 20S pre-rRNA processing (Potential)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    TSR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSR2:
     Increased S DNA content 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSR2

    miRNA
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    miRTarBase miRNAs that target TSR2:
    hsa-mir-124-3p (MIRT022680), hsa-mir-1301-3p (MIRT036048)

    Block miRNA regulation of human, mouse, rat TSR2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TSR2:
    hsa-miR-4314 hsa-miR-612 hsa-miR-1236 hsa-miR-378* hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidTSR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TSR2

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSR2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSR2
    Interactions:

        Search GeneGlobe Interaction Network for TSR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TSR2 (Q969E81, 3 ENSP000003642934) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS26P628541, 3, ENSP000003488494EBI-746981,EBI-353438 I2D: score=4 STRING: ENSP00000348849
    USP39Q53GS93, ENSP000003129814I2D: score=2 STRING: ENSP00000312981
    GABARAPO951663I2D: score=2 
    GABARAPL2P605203I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    TSR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSR2 gene: 
    NM_058163.1  

    Unigene Cluster for TSR2:

    TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
    Hs.522662  [show with all ESTs]
    Unigene Representative Sequence: U92980
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375151(uc004dte.3 uc004dtf.3)
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate TSR2:
    hsa-miR-4314 hsa-miR-612 hsa-miR-1236 hsa-miR-378* hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidTSR2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TSR2 (NM_012344)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSR2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TSR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSR2
      QuantiTect SYBR Green Assays in human, mouse, rat TSR2
      QuantiFast Probe-based Assays in human, mouse, rat TSR2

    Additional mRNA sequence: 

    BC007699.1 BC011825.1 U92980.1 

    9 DOTS entries:

    DT.92433742  DT.97792950  DT.100648634  DT.100791786  DT.100791779  DT.100791787  DT.91659152  DT.95094275 
    DT.95242737 

    Selected AceView cDNA sequences (see all 155):

    AA357998 AL036563 AA205265 CR599852 BC007699 AA994152 AA442304 AI754988 
    CA310125 CA866823 AW956616 AI151042 AA043294 BM687921 AI375607 BE670975 
    BI762445 BU161449 BM662040 CR622248 CA396185 BC011825 BX358555 BF026419 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TSR2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                          -                                 
    SP2:                    -     -                                 
    SP3:                                                            
    SP4:                          -           -                     


    ECgene alternative splicing isoforms for TSR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGTGGAAG
    TSR2 Expression
    About this image

    TSR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522662
        Custom PCR Arrays for TSR2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TSR2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tsr21 , 5 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)5
    TSR2 20S rRNA accumulation1
    85.69(n)1
    85.86(a)1
      X (68.46 cM)5
    694991  NM_175146.41  NP_780355.21 
     1510870945 
    lizard
    (Anolis carolinensis)
    Reptilia TSR26
    TSR2, 20S rRNA accumulation, homolog (S. cerevisia...
    51(a)
    1 ↔ 1
    1(205322424-205337045)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480197112   -- 76(n)    48019711 
    zebrafish
    (Danio rerio)
    Actinopterygii dt1p1a10l2 hypothetical protein DT1P1A10 (human) - like 73.33(n)   317639  AY099514.1 


    ENSEMBL Gene Tree for TSR2 (if available)
    TreeFam Gene Tree for TSR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSR2 (see all 72)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490001731,2
    --54465016(+) GGTGTA/GAGCCA 1 -- us2k10--------
    rs70639821,2
    C,A--54465078(+) gtctcG/Actctg 1 -- us2k11Minor allele frequency- A:0.00WA 2
    rs1822900961,2
    --54465399(+) GGCTGA/GTCTTG 1 -- us2k10--------
    rs70510471,2
    C,F,A,H--54465531(+) taagtT/Gttgct 1 -- us2k117Minor allele frequency- G:0.20NS EA NA WA CSA 1964
    rs1862482041,2
    --54465590(+) AAAGTA/GTTTTC 1 -- us2k10--------
    rs1439362651,2
    --54465754(+) AATCTA/GTGGAG 1 -- us2k10--------
    rs1472725401,2
    --54465792(+) TGTTCC/TGGAGA 1 -- us2k10--------
    rs1919158731,2
    --54465895(+) TAGATG/TCTCAA 1 -- us2k10--------
    rs66121581,2
    C,F,A,H--54465948(+) aatatC/Tctact 1 -- us2k1 tfbs319Minor allele frequency- T:0.44NS EA NA WA CSA 1942
    rs120096031,2
    C,H--54466206(+) cgccaT/Ctgcac 1 -- us2k13Minor allele frequency- C:0.00NA WA CSA 5

    HapMap Linkage Disequilibrium report for TSR2 (54466834 - 54471920 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TSR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740175CNV Deletion23290073
    nsv435891CNV Deletion17901297

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSR2
    DNA2.0 Custom Variant and Variant Library Synthesis for TSR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605538    OMIM disorders: --

    3 diseases for TSR2:    
    About MalaCards
    blepharospasm    thrombotic thrombocytopenic purpura    purpura

    1 disease from the University of Copenhagen DISEASES database for TSR2:
    Blepharospasm

    TSR2 for disorders           About GeneDecksing


    Export disorders for TSR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSR2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TSR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PubMed id 9417904)1, 3 Reddy P.H.... Tagle D.A. (Genomics 1997)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. The novel protein TSR2 inhibits the transcriptional activity of nuclear factor-kappaB and induces apoptosis. (PubMed id 21790011)1 He H....Jia S. (Mol. Biol. (Mosk.) 2011)
    7. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    8. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    9. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90121 HGNC: 25455 AceView: DT1P1A10 Ensembl:ENSG00000158526 euGenes: HUgn90121
    ECgene: TSR2 H-InvDB: TSR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSR2 gene:
    Search GeneIP for patents involving TSR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSR2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TSR2  
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     Block miRNA regulation of human, mouse, rat TSR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TSR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSR2 Predesigned siRNA for gene silencing in human, mouse, rat TSR2
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     Custom PCR Arrays for TSR2 Search Chromatin IP Primers for TSR2
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     Search Tocris compounds for TSR2
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TSR2
     Gene Synthesis
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     ThermoFisher Antibodies for TSR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSR2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSR2
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     Search LSBio for Antibodies for TSR2
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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