TSR2 Gene
protein-coding GIFtS: 47
GCID: GC0XP054483
|
|
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
| |
Aliases
for TSR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TSR2, 20S RRNA Accumulation, Homolog (S. Cerevisiae)1 2 | | DT1P1A101 2 | | WGG11 2 | | RP1-112K5.21 | | Pre-RRNA-Processing Protein TSR2 Homolog2 | | WGG Motif Containing 12 |
Export aliases for TSR2 gene to outside databasesPrevious GC identifer: GC0XP051518 |
Summaries
for TSR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSR2_HUMAN, Q969E8Function: May be involved in 20S pre-rRNA processing (Potential)
|
Genomic Views
for TSR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSR2 gene promoter:
GATA-3 AML1a RREB-1 STAT5A Egr-2 N-Myc PPAR-gamma1 FAC1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22TSR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP054483: view genomic region
(about GC identifiers)
Start:
|
54,466,834 bp from pter |
End:
|
54,471,920 bp from pter |
Size:
|
5,087 bases |
Orientation:
|
plus strand |
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Proteins
for TSR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSR2_HUMAN, Q969E8 (See
protein sequence)Recommended Name: Pre-rRNA-processing protein TSR2 homolog Size: 191 amino acids; 20894 DaExplore the universe of human proteins at neXtProt for TSR2: NX_Q969E8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969E8
TSR2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_477511.1
ENSEMBL proteins: ENSP00000364293
Human Recombinant Protein Products for TSR2:
TSR2 Antibody Products:
Assay Products for TSR2: |
Protein
Domains /
Families
for TSR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSR2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969E8ProtoNet protein and cluster: Q969E8 UniProtKB/Swiss-Prot: TSR2_HUMAN, Q969E8Similarity: Belongs to the TSR2 family |
Function
for TSR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TSR2_HUMAN, Q969E8Function: May be involved in 20S pre-rRNA processing (Potential) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TSR2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TSR2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSR2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSR2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSR2 (NM_012344) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSR2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSR2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSR2 |
|
Pathways & Interactions
for TSR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSR2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/18 Interacting proteins for TSR2 (Q969E81, 3 ENSP000003642934) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
IEA | -- |
TSR2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSR2
Search CenterWatch for drugs/clinical trials and news about TSR2
|
Transcripts
for TSR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSR2 gene: NM_058163.1 Unigene Cluster for TSR2: TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) Hs.522662 [show with all ESTs]Unigene Representative Sequence: U929801 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375151(uc004dte.3 uc004dtf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSR2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSR2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSR2 (NM_012344) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSR2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSR2 |
Additional cDNA sequence: BC007699.1 BC011825.1 U92980.1 9 DOTS entries: DT.92433742 DT.97792950 DT.100648634 DT.100791786 DT.100791779 DT.100791787 DT.91659152 DT.95094275 DT.95242737 24/155 AceView cDNA sequences (see all 155): AA442304 BC011825 AI309278 CA866823 AA437239 BQ055651 AA316497 BF026419 AA778652 BX360883 BU849182 CR599852 AA994152 BM687921 CR594539 BX358555 AA858201 AA043294 AW956616 CA396185 AI754988 AI375607 AI151042 BG287661
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TSR2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for TSR2
|
Expression
for TSR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGTGGAAG
About this image
See TSR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSR2
SOURCE GeneReport for Unigene cluster: Hs.522662
SABiosciences Custom PCR Arrays for TSR2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSR2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSR2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSR2 |
Orthologs
for TSR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSR2 gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tsr21 , 5 |
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)5
TSR2 20S rRNA accumulation1 |
85.69(n)1
85.86(a)1 |
|
X (68.46 cM)5
694991 NM_175146.41 NP_780355.21
1510870945 |
lizard
(Anolis carolinensis) |
Reptilia |
TSR26 |
-- |
48(a) |
1 ↔ 1 |
1(205322424-205336840) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480197112 |
-- |
76(n) |
|
48019711 |
zebrafish
(Danio rerio) |
Actinopterygii |
dt1p1a10l2 |
hypothetical protein DT1P1A10 (human) - like |
73.33(n) |
|
317639 AY099514.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG145436 |
-- |
21(a) |
1 ↔ 1 |
3R(21882349-21883072) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y51H4A.156 |
Protein Y51H4A.15 |
18(a) |
1 ↔ 1 |
IV(16656580-16657326) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G279906AT3G225106 |
Pre-rRNA-processing protein TSR2 |
24(a)23(a) |
many → 1many → 1 |
5(10017036-10018441) 3(7973429-7974292) |
rice
(Oryza sativa) |
Liliopsida |
-- |
pre-rRNA-processing protein TSR2, putative, expres... |
21(a) |
1 ↔ 1 |
8(25204044-25207388) |
ENSEMBL Gene Tree for TSR2 (if available)
TreeFam Gene Tree for TSR2 (if available) |
Paralogs
for TSR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TSR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSR2 (54466834 - 54471920 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TSR2
1 CNV: 23256 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSR2 |
|
Disorders
/ Diseases
for TSR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSR2 for disorders About GeneDecksing
3  diseases for TSR2: About MalaCardsthrombotic thrombocytopenic purpura blepharospasm purpura
1 disease from the University of Copenhagen DISEASES database for TSR2:Blepharospasm Export disorders for TSR2 gene to outside databases
|
Publications
for TSR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSR2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TSR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PubMed id 9417904)1, 3 Reddy P.H....Tagle D.A. (1997)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The novel protein TSR2 inhibits the transcriptional a ctivity of nuclear factor-kappaB and induces apoptosis. (PubMed id 21790011)1 He H....Jia S. (2011)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
|
External Searches for TSR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSR2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSR2 gene:
Search GeneIP for patents involving TSR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSR2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSR2 |
| |
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| |  |  |  |  | | | | |
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 |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSR2 |
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