TSR1 Gene
protein-coding GIFtS: 51
GCID: GC17M002225
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TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)(Previous names: TSR1, 20S rRNA accumulation, homolog (yeast) )
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Aliases
for TSR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TSR1, 20S RRNA Accumulation, Homolog (S. Cerevisiae)1 2 | | FLJ105341 | | TSR1, 20S RRNA Accumulation, Homolog (Yeast)1 | | Pre-RRNA-Processing Protein TSR1 Homolog2 | | KIAA14013 |
Export aliases for TSR1 gene to outside databasesPrevious GC identifer: GC17M002173 |
Summaries
for TSR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSR1_HUMAN, Q2NL82Function: Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)
|
Genomic Views
for TSR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSR1 gene promoter:
ISGF-3 AML1a YY1 AREB6 CREB deltaCREB FOXO4 SEF-1 (1) Pax-4a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3TSR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M002225: view genomic region
(about GC identifiers)
Start:
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2,225,951 bp from pter |
End:
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2,240,801 bp from pter |
Size:
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14,851 bases |
Orientation:
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minus strand |
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Proteins
for TSR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSR1_HUMAN, Q2NL82 (See
protein sequence)Recommended Name: Pre-rRNA-processing protein TSR1 homolog Size: 804 amino acids; 91810 Da
Subcellular location: Nucleus, nucleolus (By similarity)
Sequence caution: Sequence=BAA91667.1; Type=Erroneous initiation; Sequence=BAA92639.1; Type=Erroneous initiation;
Secondary accessions: Q8WUY5 Q9NVT0 Q9P2E6Explore the universe of human proteins at neXtProt for TSR1: NX_Q2NL82
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2NL82
TSR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060598.3
ENSEMBL proteins: ENSP00000301364 ENSP00000461192 ENSP00000459012 ENSP00000461498
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
ISS | -- |
TSR1 for ontologies About GeneDecksing
TSR1 Antibody Products:
Assay Products for TSR1: |
Protein
Domains /
Families
for TSR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSR1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2NL82ProtoNet protein and cluster: Q2NL82 1 Blocks protein family: IPB012948 AARP2CN
UniProtKB/Swiss-Prot: TSR1_HUMAN, Q2NL82Similarity: Belongs to the BMS1/TSR1 family. TSR1 subfamily |
Function
for TSR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSR1_HUMAN, Q2NL82Function: Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSR1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSR1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TSR1 (NM_002531) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSR1 |
1 GenomeRNAi human phenotype for TSR1:
|
Pathways & Interactions
for TSR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSR1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/187 Interacting proteins for TSR1 (Q2NL822, 3 ENSP000003013644) via UniProtKB, MINT, STRING, and/or I2D (see all 187)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042255 | ribosome assembly |
ISS | -- |
TSR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSR1
Search CenterWatch for drugs/clinical trials and news about TSR1
|
Transcripts
for TSR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSR1 gene: NM_018128.4 Unigene Cluster for TSR1: TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) Hs.388170 [show with all ESTs]Unigene Representative Sequence: NM_0181286 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000301364(uc002fuj.3) ENST00000575049 ENST00000570951 ENST00000576112
ENST00000571806 ENST00000576202
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSR1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSR1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSR1 (NM_002531) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSR1 |
Additional cDNA sequence: AB037822.1 AK001396.1 AK026565.1 BC019090.2 BC110851.1 BC126110.1 18 DOTS entries: DT.446103 DT.100817839 DT.454995 DT.121010968 DT.121011040 DT.121010955 DT.95071991 DT.100817832 DT.97804098 DT.100817835 DT.121010845 DT.121010958 DT.121011001 DT.95172359 DT.99974731 DT.100044581 DT.121010822 DT.92025418 24/267 AceView cDNA sequences (see all 267): BE790497 BM833849 AA243263 CB113068 AA371082 F01206 BI861233 BI857727 BU157011 AJ276247 NM_018128 AA112267 BQ632030 BM981708 CB157142 BG180297 AI635360 AI989853 AA563823 BU170130 BQ021716 BM684397 CB160404 BE797160
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TSR1 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TSR1
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Expression
for TSR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTAAAAGAA
About this image
See TSR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSR1
SOURCE GeneReport for Unigene cluster: Hs.388170
SABiosciences Custom PCR Arrays for TSR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSR1 |
Orthologs
for TSR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSR1 gene from 9/37 species (see all 37) About this table
ENSEMBL Gene Tree for TSR1 (if available)
TreeFam Gene Tree for TSR1 (if available) |
Paralogs
for TSR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSR1 gene
TSR1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TSR1
PGOHUM00000235231
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Genomic Variants
for TSR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSR1 (2225951 - 2240801 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSR1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSR1 |
|
Disorders
/ Diseases
for TSR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSR1 for disorders About GeneDecksing
OMIM gene information: 611214
OMIM disorders: --
5  diseases for TSR1: About MalaCardsthrombotic thrombocytopenic purpura blepharospasm purpura thymoma
malaria
2 diseases from the University of Copenhagen DISEASES database for TSR1:Thymoma Sick building syndrome Human Genome Epidemiology (HuGE) Navigator: TSR1 (1 document)
Export disorders for TSR1 gene to outside databases
|
Publications
for TSR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSR1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with TSR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for TSR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSR1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TSR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSR1 gene:
Search GeneIP for patents involving TSR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSR1 | | | OriGene Protein Over-expression Lysate for TSR1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSR1 | | OriGene 3'-UTR Clone for TSR1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TSR1 | | OriGene Custom Protein Services for TSR1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSR1 |
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| | | | Search Tocris compounds for TSR1 |
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 | | | TSR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSR1 |
|  |  |  | | | | ThermoFisher Antibody for TSR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSR1 |
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