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Aliases for TSR1 Gene

Aliases for TSR1 Gene

  • TSR1, Ribosome Maturation Factor 2 3
  • TSR1, 20S RRNA Accumulation, Homolog (S. Cerevisiae) 5
  • TSR1, 20S RRNA Accumulation, Homolog (Yeast) 2
  • KIAA1401 4

External Ids for TSR1 Gene

Previous GeneCards Identifiers for TSR1 Gene

  • GC17M002173
  • GC17M002225

Summaries for TSR1 Gene

GeneCards Summary for TSR1 Gene

TSR1 (TSR1, Ribosome Maturation Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for TSR1 Gene

  • Required during maturation of the 40S ribosomal subunit in the nucleolus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSR1 Gene

Genomics for TSR1 Gene

Regulatory Elements for TSR1 Gene

Enhancers for TSR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSR1 on UCSC Golden Path with GeneCards custom track

Promoters for TSR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSR1 Gene

Chromosome:
17
Start:
2,322,503 bp from pter
End:
2,337,507 bp from pter
Size:
15,005 bases
Orientation:
Minus strand

Genomic View for TSR1 Gene

Genes around TSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSR1 Gene

Proteins for TSR1 Gene

  • Protein details for TSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2NL82-TSR1_HUMAN
    Recommended name:
    Pre-rRNA-processing protein TSR1 homolog
    Protein Accession:
    Q2NL82
    Secondary Accessions:
    • Q8WUY5
    • Q9NVT0
    • Q9P2E6

    Protein attributes for TSR1 Gene

    Size:
    804 amino acids
    Molecular mass:
    91810 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91667.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92639.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSR1 Gene

Proteomics data for TSR1 Gene at MOPED

Post-translational modifications for TSR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSR1 Gene

No data available for DME Specific Peptides for TSR1 Gene

Domains & Families for TSR1 Gene

Protein Domains for TSR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TSR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2NL82

UniProtKB/Swiss-Prot:

TSR1_HUMAN :
  • Contains 1 Bms1-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
Domain:
  • Contains 1 Bms1-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
genes like me logo Genes that share domains with TSR1: view

No data available for Gene Families for TSR1 Gene

Function for TSR1 Gene

Molecular function for TSR1 Gene

UniProtKB/Swiss-Prot Function:
Required during maturation of the 40S ribosomal subunit in the nucleolus.
genes like me logo Genes that share phenotypes with TSR1: view

Animal Model Products

miRNA for TSR1 Gene

miRTarBase miRNAs that target TSR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSR1 Gene

Localization for TSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSR1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSR1 Gene COMPARTMENTS Subcellular localization image for TSR1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TSR1 Gene

Pathways & Interactions for TSR1 Gene

genes like me logo Genes that share pathways with TSR1: view

Pathways by source for TSR1 Gene

Gene Ontology (GO) - Biological Process for TSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with TSR1: view

No data available for SIGNOR curated interactions for TSR1 Gene

Drugs & Compounds for TSR1 Gene

No Compound Related Data Available

Transcripts for TSR1 Gene

Unigene Clusters for TSR1 Gene

TSR1, 20S rRNA accumulation, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:

Relevant External Links for TSR1 Gene

GeneLoc Exon Structure for
TSR1
ECgene alternative splicing isoforms for
TSR1

Expression for TSR1 Gene

mRNA expression in normal human tissues for TSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSR1 Gene

This gene is overexpressed in Amniocyte (38.1), Bone marrow mesenchymal stem cell (11.9), and Breast (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSR1 Gene



SOURCE GeneReport for Unigene cluster for TSR1 Gene Hs.388170

genes like me logo Genes that share expression patterns with TSR1: view

Protein tissue co-expression partners for TSR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSR1 Gene

Orthologs for TSR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSR1 35
  • 89.3 (n)
  • 90.37 (a)
TSR1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC610048 35
  • 89.14 (n)
  • 88.72 (a)
-- 36
  • 89 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tsr1 35
  • 84.58 (n)
  • 85.91 (a)
Tsr1 16
Tsr1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSR1 35
  • 99.63 (n)
  • 99.88 (a)
TSR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsr1 35
  • 84.02 (n)
  • 84.56 (a)
oppossum
(Monodelphis domestica)
Mammalia TSR1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSR1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857289 35
  • 69.97 (n)
  • 69.13 (a)
TSR1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSR1 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8091 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
tsr1 35
  • 59.68 (n)
  • 57.29 (a)
tsr1 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009438 35
  • 51.32 (n)
  • 45.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7338 35
  • 53.11 (n)
  • 46.36 (a)
CG7338 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-151 35
  • 50.9 (n)
  • 41.73 (a)
tag-151 36
  • 39 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER051C 35
  • 44.02 (n)
  • 33.56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05149g 35
  • 44.52 (n)
  • 34.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSR1 35
  • 44.68 (n)
  • 32.58 (a)
TSR1 36
  • 30 (a)
OneToOne
TSR1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G42440 35
  • 49.93 (n)
  • 42.04 (a)
rice
(Oryza sativa)
Liliopsida Os.18832 35
Os11g0298400 35
  • 48.58 (n)
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4090 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01503 35
  • 46.32 (n)
  • 36.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC23H4.15 35
  • 46.38 (n)
  • 35.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8014 36
  • 46 (a)
OneToOne
Species with no ortholog for TSR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSR1 Gene

ENSEMBL:
Gene Tree for TSR1 (if available)
TreeFam:
Gene Tree for TSR1 (if available)

Paralogs for TSR1 Gene

Pseudogenes.org Pseudogenes for TSR1 Gene

genes like me logo Genes that share paralogs with TSR1: view

No data available for Paralogs for TSR1 Gene

Variants for TSR1 Gene

Sequence variations from dbSNP and Humsavar for TSR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2281726 - 2,333,110(-) AGGAA(A/G)GTTCT reference, missense
VAR_037212 -
VAR_037213 -
VAR_037214 -
rs216210 -- 2,325,773(+) ACGCC(C/T)GGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSR1 Gene

Variant ID Type Subtype PubMed ID
nsv833336 CNV Loss 17160897
nsv469765 CNV Complex 16826518
nsv907529 CNV Gain 21882294

Variation tolerance for TSR1 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.31; 85.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSR1 Gene

HapMap Linkage Disequilibrium report
TSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSR1 Gene

Disorders for TSR1 Gene

Relevant External Links for TSR1

Genetic Association Database (GAD)
TSR1
Human Genome Epidemiology (HuGE) Navigator
TSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSR1

No disorders were found for TSR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSR1 Gene

Publications for TSR1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals. (PMID: 20805244) Carron C. … Gleizes P.E. (Nucleic Acids Res. 2011) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for TSR1 Gene

Sources for TSR1 Gene

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