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Aliases for TSR1 Gene

Aliases for TSR1 Gene

  • TSR1, 20S RRNA Accumulation, Homolog (S. Cerevisiae) 2 3
  • KIAA1401 4 6
  • TSR1, 20S RRNA Accumulation, Homolog (Yeast) 2

External Ids for TSR1 Gene

Previous GeneCards Identifiers for TSR1 Gene

  • GC17M002173
  • GC17M002225

Summaries for TSR1 Gene

GeneCards Summary for TSR1 Gene

TSR1 (TSR1, 20S RRNA Accumulation, Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with TSR1 include sick building syndrome.

UniProtKB/Swiss-Prot for TSR1 Gene

  • Required during maturation of the 40S ribosomal subunit in the nucleolus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSR1 Gene

Genomics for TSR1 Gene

Regulatory Elements for TSR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TSR1 Gene

2,322,503 bp from pter
2,337,507 bp from pter
15,005 bases
Minus strand

Genomic View for TSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSR1 Gene

Proteins for TSR1 Gene

  • Protein details for TSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-rRNA-processing protein TSR1 homolog
    Protein Accession:
    Secondary Accessions:
    • Q8WUY5
    • Q9NVT0
    • Q9P2E6

    Protein attributes for TSR1 Gene

    804 amino acids
    Molecular mass:
    91810 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91667.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92639.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSR1 Gene

Proteomics data for TSR1 Gene at MOPED

Post-translational modifications for TSR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSR1 Gene

No data available for DME Specific Peptides for TSR1 Gene

Domains for TSR1 Gene

Protein Domains for TSR1 Gene


Suggested Antigen Peptide Sequences for TSR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q2NL82
  • Contains 1 Bms1-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
genes like me logo Genes that share domains with TSR1: view

No data available for Gene Families for TSR1 Gene

Function for TSR1 Gene

Molecular function for TSR1 Gene

UniProtKB/Swiss-Prot Function: Required during maturation of the 40S ribosomal subunit in the nucleolus.

Gene Ontology (GO) - Molecular Function for TSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TSR1: view

Phenotypes for TSR1 Gene

GenomeRNAi human phenotypes for TSR1:
genes like me logo Genes that share phenotypes with TSR1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TSR1 Gene

Localization for TSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSR1 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for TSR1 Gene COMPARTMENTS Subcellular localization image for TSR1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus ISS --
genes like me logo Genes that share ontologies with TSR1: view

Pathways for TSR1 Gene

SuperPathways for TSR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis --
GO:0042255 ribosome assembly ISS --
genes like me logo Genes that share ontologies with TSR1: view

No data available for Pathways by source for TSR1 Gene

Transcripts for TSR1 Gene

Unigene Clusters for TSR1 Gene

TSR1, 20S rRNA accumulation, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP5: -
SP8: -

Relevant External Links for TSR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSR1 Gene

mRNA expression in normal human tissues for TSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSR1 Gene

SOURCE GeneReport for Unigene cluster for TSR1 Gene Hs.388170

genes like me logo Genes that share expressions with TSR1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSR1 Gene

Orthologs for TSR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSR1 35
  • 99.63 (n)
  • 99.88 (a)
TSR1 36
  • 100 (a)
(Bos Taurus)
Mammalia TSR1 35
  • 89.3 (n)
  • 90.37 (a)
TSR1 36
  • 90 (a)
(Canis familiaris)
Mammalia -- 36
  • 89 (a)
-- 36
  • 88 (a)
LOC610048 35
  • 89.14 (n)
  • 88.72 (a)
(Mus musculus)
Mammalia Tsr1 35
  • 84.58 (n)
  • 85.91 (a)
Tsr1 16
Tsr1 36
  • 86 (a)
(Monodelphis domestica)
Mammalia TSR1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia TSR1 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Tsr1 35
  • 84.02 (n)
  • 84.56 (a)
(Gallus gallus)
Aves LOC100857289 35
  • 69.97 (n)
  • 69.13 (a)
TSR1 36
  • 68 (a)
(Anolis carolinensis)
Reptilia TSR1 36
  • 55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8091 35
(Danio rerio)
Actinopterygii -- 35
tsr1 35
  • 59.68 (n)
  • 57.29 (a)
tsr1 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009438 35
  • 51.32 (n)
  • 45.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7338 35
  • 53.11 (n)
  • 46.36 (a)
CG7338 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea tag-151 35
  • 50.9 (n)
  • 41.73 (a)
tag-151 36
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER051C 35
  • 44.02 (n)
  • 33.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSR1 35
  • 44.68 (n)
  • 32.58 (a)
TSR1 36
  • 30 (a)
TSR1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05149g 35
  • 44.52 (n)
  • 34.37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G42440 35
  • 49.93 (n)
  • 42.04 (a)
(Oryza sativa)
Liliopsida Os.18832 35
Os11g0298400 35
  • 48.58 (n)
  • 41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01503 35
  • 46.32 (n)
  • 36.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC23H4.15 35
  • 46.38 (n)
  • 35.63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4090 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8014 36
  • 46 (a)
Species with no ortholog for TSR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSR1 Gene

Gene Tree for TSR1 (if available)
Gene Tree for TSR1 (if available)

Paralogs for TSR1 Gene Pseudogenes for TSR1 Gene

genes like me logo Genes that share paralogs with TSR1: view

No data available for Paralogs for TSR1 Gene

Variants for TSR1 Gene

Sequence variations from dbSNP and Humsavar for TSR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs216210 -- 2,325,773(+) ACGCC(C/T)GGCTA intron-variant
rs413016 -- 2,334,167(-) GTTAG(A/G)GTGCG intron-variant
rs420545 -- 2,334,171(-) TATGG(C/T)TAGGG intron-variant
rs2281726 - 2,333,110(-) AGGAA(A/G)GTTCT reference, missense
rs3785558 -- 2,334,320(-) AATCA(C/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSR1 Gene

Variant ID Type Subtype PubMed ID
nsv833336 CNV Loss 17160897
nsv469765 CNV Complex 16826518
nsv907529 CNV Gain 21882294

Relevant External Links for TSR1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSR1 Gene

Disorders for TSR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TSR1 Gene including...

Search for TSR1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TSR1 Gene

Relevant External Links for TSR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TSR1: view

No data available for UniProtKB/Swiss-Prot for TSR1 Gene

Publications for TSR1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PMID: 19584346) Vasan R.S. … Blankenberg S. (JAMA 2009) 3 48
  4. Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. (PMID: 20020773) Freibaum B.D. … Taylor J.P. (J. Proteome Res. 2010) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for TSR1 Gene

Sources for TSR1 Gene

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