Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPYL6 Gene

Aliases for TSPYL6 Gene

  • TSPY Like 6 2 3 5
  • TSPY-Like Protein 6 4

External Ids for TSPYL6 Gene

Previous GeneCards Identifiers for TSPYL6 Gene

  • GC02M054391
  • GC02M054480

Summaries for TSPYL6 Gene

GeneCards Summary for TSPYL6 Gene

TSPYL6 (TSPY Like 6) is a Protein Coding gene. An important paralog of this gene is TSPYL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPYL6 Gene

Genomics for TSPYL6 Gene

Regulatory Elements for TSPYL6 Gene

Enhancers for TSPYL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F054238 0.8 Ensembl ENCODE 44.1 +16.2 16226 2.3 ZNF202 GLIS1 FOS ZIC2 WT1 TSPYL6 ENSG00000203327 RNU7-172P C2orf73 RPS27A ACYP2 GC02P054224
GH02F054207 1.2 Ensembl ENCODE 19.8 +48.0 47996 2.1 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 MIER2 PPARG PPARGC1A TSPYL6 SPTBN1 RNU7-172P C2orf73 ACYP2 GC02M054187 GC02M054119
GH02F054041 1.5 FANTOM5 Ensembl ENCODE 9.6 +212.6 212629 3.6 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 CBX5 FOS SP5 ACYP2 RNU7-172P EML6 TSPYL6 HMGB1P31 GPR75 RPL21P30
GH02F054212 0.7 ENCODE 20 +43.6 43622 1.1 ZNF146 TEAD1 HLF BHLHE40 ZMYM3 CEBPB CEBPG EP300 BRF2 ZKSCAN1 TSPYL6 RNU7-172P ACYP2 C2orf73 GC02M054187 GC02M054119
GH02F054121 1.1 Ensembl ENCODE 10.2 +133.7 133673 3.0 ELF3 TBP ZSCAN9 DNMT3B FOS CREM MIXL1 ZNF680 PPARG KAT8 RNU7-172P TSPYL6 ENSG00000272156 HMGB1P31 ACYP2 LOC105374615
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPYL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPYL6 Gene

54,253,178 bp from pter
54,256,272 bp from pter
3,095 bases
Minus strand

Genomic View for TSPYL6 Gene

Genes around TSPYL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPYL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPYL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPYL6 Gene

Proteins for TSPYL6 Gene

  • Protein details for TSPYL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded-like protein 6
    Protein Accession:
    Secondary Accessions:
    • Q6NUJ3

    Protein attributes for TSPYL6 Gene

    410 amino acids
    Molecular mass:
    45874 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPYL6 Gene

Post-translational modifications for TSPYL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSPYL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPYL6 Gene

Domains & Families for TSPYL6 Gene

Protein Domains for TSPYL6 Gene

Suggested Antigen Peptide Sequences for TSPYL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPYL6: view

No data available for Gene Families for TSPYL6 Gene

Function for TSPYL6 Gene

genes like me logo Genes that share phenotypes with TSPYL6: view

Animal Model Products

miRNA for TSPYL6 Gene

miRTarBase miRNAs that target TSPYL6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPYL6 Gene

Localization for TSPYL6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPYL6 gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSPYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TSPYL6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSPYL6 Gene

Pathways & Interactions for TSPYL6 Gene

SuperPathways for TSPYL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPYL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
genes like me logo Genes that share ontologies with TSPYL6: view

No data available for Pathways by source and SIGNOR curated interactions for TSPYL6 Gene

Transcripts for TSPYL6 Gene

mRNA/cDNA for TSPYL6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPYL6 Gene

TSPY-like 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL6 Gene

No ASD Table

Relevant External Links for TSPYL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPYL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPYL6 Gene

mRNA differential expression in normal tissues according to GTEx for TSPYL6 Gene

This gene is overexpressed in Testis (x45.7).

Protein differential expression in normal tissues from HIPED for TSPYL6 Gene

This gene is overexpressed in Serum (37.5), Plasma (22.4), and Testis (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPYL6 Gene

Protein tissue co-expression partners for TSPYL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSPYL6 Gene:


SOURCE GeneReport for Unigene cluster for TSPYL6 Gene:

genes like me logo Genes that share expression patterns with TSPYL6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TSPYL6 Gene

Orthologs for TSPYL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPYL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPYL6 34 35
  • 99.51 (n)
(Bos Taurus)
Mammalia TSPYL6 35
  • 52 (a)
(Mus musculus)
Mammalia Tspyl3 35
  • 47 (a)
(Canis familiaris)
Mammalia -- 35
  • 28 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
(Danio rerio)
Actinopterygii TSPY2 35
  • 20 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea spr-2 35
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 35
  • 25 (a)
Species where no ortholog for TSPYL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPYL6 Gene

Gene Tree for TSPYL6 (if available)
Gene Tree for TSPYL6 (if available)

Paralogs for TSPYL6 Gene

(13) SIMAP similar genes for TSPYL6 Gene using alignment to 1 proteins: Pseudogenes for TSPYL6 Gene

genes like me logo Genes that share paralogs with TSPYL6: view

Variants for TSPYL6 Gene

Sequence variations from dbSNP and Humsavar for TSPYL6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10165485 -- 54,254,499(+) AGCAA(C/T)TGTCC intron-variant, utr-variant-3-prime
rs111630263 -- 54,253,168(+) AAAAG(A/G)ACAAT intron-variant, downstream-variant-500B
rs111886241 -- 54,256,253(+) TTTGC(A/G)CCGCC intron-variant, utr-variant-5-prime
rs112087013 -- 54,256,819(+) TTTGT(-/T/TTTGT)ATTTT intron-variant, upstream-variant-2KB
rs113162319 -- 54,253,566(+) CTTCT(A/G)TTCTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TSPYL6 Gene

Variant ID Type Subtype PubMed ID
nsv582012 CNV gain 21841781
nsv457897 CNV gain 19166990
nsv1011975 CNV loss 25217958
nsv1009828 CNV loss 25217958
nsv1004632 CNV loss 25217958
esv3892403 CNV loss 25118596
esv2762639 CNV gain 21179565
esv2720078 CNV deletion 23290073
dgv3845n100 CNV gain 25217958

Variation tolerance for TSPYL6 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.55; 82.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPYL6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPYL6 Gene

Disorders for TSPYL6 Gene

Relevant External Links for TSPYL6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPYL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPYL6 Gene

Publications for TSPYL6 Gene

  1. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TSPYL6 Gene

Sources for TSPYL6 Gene

Loading form....