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TSPYL6 Gene

protein-coding   GIFtS: 45
GCID: GC02M054480

TSPY-Like 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TSPY-Like 61 2
TSPY-Like Protein 62 3
Testis-Specific Y-Encoded-Like Protein 62

External Ids:    HGNC: 145211   Entrez Gene: 3889512   Ensembl: ENSG000001780217   UniProtKB: Q8N8313   

Export aliases for TSPYL6 gene to outside databases

Previous GC identifers: GC02M054391 GC02M054215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSPYL6 Gene:
TSPYL6 (TSPY-like 6) is a protein-coding gene. Diseases associated with TSPYL6 include acute myeloid leukemia, and myeloid leukemia. An important paralog of this gene is SET.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPYL6 gene promoter:
         TBP   C/EBPbeta   p53   AML1a   LUN-1   RORalpha1   MEF-2A   TFIID   aMEF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPYL6 promoter sequence
   Search Chromatin IP Primers for TSPYL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPYL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.2   Ensembl cytogenetic band:  2p16.2   HGNC cytogenetic band: 2p16.3

TSPYL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPYL6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M054480:  view genomic region     (about GC identifiers)

Start:
54,480,315 bp from pter      End:
54,483,409 bp from pter
Size:
3,095 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TSYL6_HUMAN, Q8N831 (See protein sequence)
Recommended Name: Testis-specific Y-encoded-like protein 6  
Size: 410 amino acids; 45874 Da
Secondary accessions: Q6NUJ3

Explore the universe of human proteins at neXtProt for TSPYL6: NX_Q8N831

Explore proteomics data for TSPYL6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSPYL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001003937.2  
    ENSEMBL proteins: 
     ENSP00000417919  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q8N831

    ProtoNet protein and cluster: Q8N831

    1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: TSYL6_HUMAN, Q8N831
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    TSPYL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TSPYL6:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPYL6
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    hsa-mir-423-5p (MIRT038015)

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    1 qRT-PCR Assays for microRNA that regulate TSPYL6:
    hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmidTSPYL6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TSPYL6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPYL6
    Interactions:

        Search GeneGlobe Interaction Network for TSPYL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TSPYL6 (ENSP000004179194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASF1AENSP000002295954STRING: ENSP00000229595
    ASF1BENSP000002633824STRING: ENSP00000263382
    H2AFVENSP000003084054STRING: ENSP00000308405
    H2AFZENSP000002964174STRING: ENSP00000296417
    NAP1L1ENSP000002611824STRING: ENSP00000261182
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    TSPYL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPYL6 (TSYL6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TSPYL6 gene: 
    NM_001003937.2  

    Unigene Cluster for TSPYL6:

    TSPY-like 6
    Hs.620508  [show with all ESTs]
    Unigene Representative Sequence: NM_001003937
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000317802(uc002rxr.2)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate TSPYL6:
    hsa-miR-516b
    SwitchGear 3'UTR luciferase reporter plasmidTSPYL6 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TSPYL6

    Additional mRNA sequence: 

    AK097417.1 AL117628.1 BC068576.1 

    1 DOTS entry:

    DT.108646 

    19 AceView cDNA sequences:

    AK097417 AA400475 AA776761 AA970125 AL042471 AI138392 AA928151 AA973319 
    NM_001003937 AA400448 AL117628 AA725832 AL042470 BC068576 AW086060 AL042623 
    AW085070 BG037165 AW469541 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPYL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAAATAAA
    TSPYL6 Expression
    About this image

    TSPYL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPYL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.620508
        Custom PCR Arrays for TSPYL6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPYL6 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    1 → many
    2(89264771-89274104)
    zebrafish
    (Danio rerio)
    Actinopterygii TSPY26
    testis specific protein, Y-linked 2
    20(a)
    1 → many
    8(26561010-26569017) ENSDARG00000005015
    fruit fly
    (Drosophila melanogaster)
    Insecta Set6
    Set
    29(a)
    1 → many
    3R(11089257-11090975)
    worm
    (Caenorhabditis elegans)
    Secernentea spr-26
    Protein SPR-2, isoform b (spr-2) mRNA, complete cd...
    24(a)
    1 → many
    IV(8891470-8892747) WBGene00005007
            Species with no ortholog for TSPYL6

    ENSEMBL Gene Tree for TSPYL6 (if available)
    TreeFam Gene Tree for TSPYL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPYL6 gene
    SET2  TSPY6P2  TSPYL12  TSPY42  TSPY12  TSPY82  TSPYL22  TSPYL52  
    TSPYL42  TSPY102  TSPY22  TSPY32  
    13 SIMAP similar genes for TSPYL6 using alignment to 1 protein entry:     TSYL6_HUMAN:
    TSPYL    TSPYL1    TSPYL4    TSPY26P    TSPY1    TSPY3
    TSPY8    TSPY10    TSPY2    TSPY4    TSPY6P    TSPYL2
    TSPYL5

    TSPYL6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TSPYL6
    PGOHUM00000247511


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for TSPYL6    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs134248081,2,4
    ----see VAR_0353972 mis40--------
    rs67437191,2,4
    ----see VAR_0353952 mis40--------
    rs171897431,2,4
    ----see VAR_0353982 mis40--------
    rs8437041,2,4
    ----see VAR_0353962 mis40--------

    HapMap Linkage Disequilibrium report for TSPYL6 (54480315 - 54483409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TSPYL6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720078CNV Deletion23290073
    nsv457897CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for TSPYL6:    About MalaCards
    acute myeloid leukemia    myeloid leukemia    leukemia


    TSPYL6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TSPYL6

    Export disorders for TSPYL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPYL6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TSPYL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388951 HGNC: 14521 AceView: TSPYL6 Ensembl:ENSG00000178021 euGenes: HUgn388951
    ECgene: TSPYL6 H-InvDB: TSPYL6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPYL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPYL6 gene:
    Search GeneIP for patents involving TSPYL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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