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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPYL6 Gene

protein-coding   GIFtS: 42
GCID: GC02M054480

TSPY-Like 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TSPY-Like 61 2
TSPY-Like Protein 62 3
Testis-Specific Y-Encoded-Like Protein 62

External Ids:    HGNC: 145211   Entrez Gene: 3889512   Ensembl: ENSG000001780217   UniProtKB: Q8N8313   

Export aliases for TSPYL6 gene to outside databases

Previous GC identifers: GC02M054391 GC02M054215


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TSPYL6 Gene: 
TSPYL6 (TSPY-like 6) is a protein-coding gene. Diseases associated with TSPYL6 include acute myeloid leukemia, and myeloid leukemia. An important paralog of this gene is SET.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPYL6 gene promoter:
         TBP   C/EBPbeta   p53   AML1a   LUN-1   RORalpha1   MEF-2A   TFIID   aMEF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPYL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPYL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPYL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.2   Ensembl cytogenetic band:  2p16.2   HGNC cytogenetic band: 2p16.3

TSPYL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPYL6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M054480:  view genomic region     (about GC identifiers)

Start:
54,480,315 bp from pter      End:
54,483,409 bp from pter
Size:
3,095 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSYL6_HUMAN, Q8N831 (See protein sequence)
Recommended Name: Testis-specific Y-encoded-like protein 6  
Size: 410 amino acids; 45874 Da
Secondary accessions: Q6NUJ3

Explore the universe of human proteins at neXtProt for TSPYL6: NX_Q8N831

Explore proteomics data for TSPYL6 at MOPED 

TSPYL6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TSPYL6 Protein Expression

REFSEQ proteins: NP_001003937.2  
ENSEMBL proteins: 
 ENSP00000417919  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

TSPYL6 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR002164 NAP_family

Graphical View of Domain Structure for InterPro Entry Q8N831

ProtoNet protein and cluster: Q8N831

1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

UniProtKB/Swiss-Prot: TSYL6_HUMAN, Q8N831
Similarity: Belongs to the nucleosome assembly protein (NAP) family


TSPYL6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TSPYL6:
 Decreased TP53 protein express 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPYL6 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPYL6

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006334nucleosome assembly IEA--

TSPYL6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TSPYL6 (TSYL6)

Search CenterWatch for drugs/clinical trials and news about TSPYL6 / TSYL6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSPYL6 gene: 
NM_001003937.2  

Unigene Cluster for TSPYL6:

TSPY-like 6
Hs.620508  [show with all ESTs]
Unigene Representative Sequence: NM_001003937
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000317802(uc002rxr.2)
miRNA
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Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPYL6

Additional mRNA sequence: 

AK097417.1 AL117628.1 BC068576.1 

1 DOTS entry:

DT.108646 

19 AceView cDNA sequences:

AL042471 AK097417 AA970125 AI138392 AA973319 AA776761 AA400475 AA928151 
AL042470 NM_001003937 AW086060 AA725832 AL117628 BC068576 AA400448 BG037165 
AL042623 AW469541 AW085070 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPYL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTAAATAAA
TSPYL6 Expression
About this image


See TSPYL6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPYL6

SOURCE GeneReport for Unigene cluster: Hs.620508
    SABiosciences Custom PCR Arrays for TSPYL6
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TSPYL6 gene from 5/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
cow
(Bos taurus)
Mammalia TSPYL66
--
(see all 14)
Uncharacterized protein
(see all 14)
51(a)
29(a)
(see all 14)
1 ↔ 1
possible ortholog
(see all 14)
11(36808160-36809404)
X(72300238-72316894)
lizard
(Anolis carolinensis)
Reptilia --
--
26(a)
1 → many
2(89264771-89274104)
zebrafish
(Danio rerio)
Actinopterygii TSPYL16
TSPY-like 1
19(a)
1 → many
8(26561010-26569017)
fruit fly
(Drosophila melanogaster)
Insecta Set6
Set
26(a)
1 → many
3R(11089257-11090975)
worm
(Caenorhabditis elegans)
Secernentea spr-26
Suppressor of presenilin-2
24(a)
1 → many
IV(8891470-8892747)


ENSEMBL Gene Tree for TSPYL6 (if available)
TreeFam Gene Tree for TSPYL6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TSPYL6 gene
SET2  TSPY6P2  TSPYL12  TSPY42  TSPY12  TSPY82  TSPYL22  TSPYL52  
TSPYL42  TSPY102  TSPY22  TSPY32  
13 SIMAP similar genes for TSPYL6 using alignment to 1 protein entry:     TSYL6_HUMAN:
TSPYL    TSPYL1    TSPYL4    TSPY26P    TSPY1    TSPY3
TSPY8    TSPY10    TSPY2    TSPY4    TSPY6P    TSPYL2
TSPYL5

TSPYL6 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TSPYL6
PGOHUM00000247511


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

4 SNPs in TSPYL6 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0353974
----see VAR_0353972 P L mis40--------
VAR_0353954
----see VAR_0353952 A V mis40--------
VAR_0353984
----see VAR_0353982 R C mis40--------
VAR_0353964
----see VAR_0353962 G S mis40--------

HapMap Linkage Disequilibrium report for TSPYL6 (54480315 - 54483409 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TSPYL6:    About this table     
Variant IDTypeSubtypePubMed ID
esv2720078CNV Deletion23290073
nsv457897CNV Gain19166990

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for TSPYL6:    About MalaCards
acute myeloid leukemia    myeloid leukemia    leukemia


TSPYL6 for disorders           About GeneDecksing

Genetic Association Database (GAD): TSPYL6

Export disorders for TSPYL6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TSPYL6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPYL6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 388951 HGNC: 14521 AceView: TSPYL6 Ensembl:ENSG00000178021 euGenes: HUgn388951
ECgene: TSPYL6 H-InvDB: TSPYL6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TSPYL6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TSPYL6 gene:
Search GeneIP for patents involving TSPYL6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Search ThermoFisher Antibodies for TSPYL6
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPYL6
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPYL6
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPYL6
Customized:
 lentivirus for stable overexpression of TSPYL6
 lentivirus expression plasmids for stable overexpression of TSPYL6
 adenovirus for overexpression of TSPYL6
 LSBio Antibodies in human, mouse, rat for TSPYL6
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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