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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPYL5 Gene

protein-coding   GIFtS: 51
GCID: GC08M098354

TSPY-Like 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TSPY-Like 51 2
TSPY-Like Protein 52 3
Testis-Specific Y-Encoded-Like Protein 52
KIAA17503

External Ids:    HGNC: 293671   Entrez Gene: 854532   Ensembl: ENSG000001805437   OMIM: 6147215   UniProtKB: Q86VY43   

Export aliases for TSPYL5 gene to outside databases

Previous GC identifers: GC08M098243 GC08M093492


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TSPYL5 Gene: 
TSPYL5 (TSPY-like 5) is a protein-coding gene. Diseases associated with TSPYL5 include lung squamous cell carcinoma, and acute myeloid leukemia. GO annotations related to this gene include protein binding. An important paralog of this gene is SET.

UniProtKB/Swiss-Prot: TSYL5_HUMAN, Q86VY4
Function: Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation
of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes
its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from
interaction with USP7




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPYL5 gene promoter:
         Sox5   MyoD   NF-AT   C/EBPalpha   AREB6   CHOP-10   NF-AT2   POU2F1   POU2F1a   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TSPYL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPYL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

TSPYL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPYL5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M098354:  view genomic region     (about GC identifiers)

Start:
98,285,714 bp from pter      End:
98,290,176 bp from pter
Size:
4,463 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSYL5_HUMAN, Q86VY4 (See protein sequence)
Recommended Name: Testis-specific Y-encoded-like protein 5  
Size: 417 amino acids; 45143 Da
Subunit: Interacts with USP7
Sequence caution: Sequence=BAB21841.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KRF0 Q9C0B3

Explore the universe of human proteins at neXtProt for TSPYL5: NX_Q86VY4

Explore proteomics data for TSPYL5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VY4

  • TSPYL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TSPYL5 Protein Expression
    REFSEQ proteins: NP_277047.2  
    ENSEMBL proteins: 
     ENSP00000322802  

    Human Recombinant Protein Products for TSPYL5: 
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    OriGene Protein Over-expression Lysate for TSPYL5
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TSPYL5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TSPYL5 for ontologies           About GeneDecksing



    TSPYL5 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for TSPYL5 
    Cloud-Clone Corp. CLIAs for TSPYL5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q86VY4

    ProtoNet protein and cluster: Q86VY4

    1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: TSYL5_HUMAN, Q86VY4
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    TSPYL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSYL5_HUMAN, Q86VY4
    Function: Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation
    of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes
    its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from
    interaction with USP7

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    TSPYL5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSPYL5:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPYL5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPYL5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPYL5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPYL5 

    miRNA
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    hsa-miR-193a-3p hsa-let-7d hsa-miR-513a-5p hsa-miR-29b-1* hsa-miR-4267 hsa-let-7g hsa-let-7a hsa-miR-193b
    SwitchGear 3'UTR luciferase reporter plasmidTSPYL5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPYL5

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TSPYL5 (Q86VY41, 3 ENSP000003228024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930091, 3, ENSP000003435354EBI-3436472,EBI-302474 I2D: score=2 STRING: ENSP00000343535
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0008284positive regulation of cell proliferation IMP--
    GO:0031398positive regulation of protein ubiquitination IDA--
    GO:0040008regulation of growth IEA--
    GO:0051897positive regulation of protein kinase B signaling cascade IMP--

    TSPYL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSPYL5 (TSYL5)

    Search CenterWatch for drugs/clinical trials and news about TSPYL5 / TSYL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSPYL5 gene: 
    NM_033512.2  

    Unigene Cluster for TSPYL5:

    TSPY-like 5
    Hs.173094  [show with all ESTs]
    Unigene Representative Sequence: NM_033512
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322128(uc003yhy.3)
    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPYL5 (see all 35):
    hsa-miR-193a-3p hsa-let-7d hsa-miR-513a-5p hsa-miR-29b-1* hsa-miR-4267 hsa-let-7g hsa-let-7a hsa-miR-193b
    SwitchGear 3'UTR luciferase reporter plasmidTSPYL5 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPYL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPYL5

    Additional mRNA sequence: 

    AB051537.1 AK091445.1 AK092272.1 AL080059.2 BC045630.1 

    5 DOTS entries:

    DT.97840214  DT.100026974  DT.86846660  DT.100742854  DT.117251 

    24/105 AceView cDNA sequences (see all 105):

    AA338873 F03819 AW512403 BQ004589 BQ130523 NM_033512 AI076674 AI096375 
    Z45560 CD557452 AA973313 BM684209 BU178255 AL041711 CD724009 F04419 
    F03452 AA747824 AB051537 F07174 BU731581 AA781943 BQ771895 AA403139 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSPYL5 expression in normal human tissues (normalized intensities)      TSPYL5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAAAAAT
    TSPYL5 Expression
    About this image


    TSPYL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)
             Fetal cardiomyocytes (20 weeks)
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Gonad
             XY Germ Cells Testis Cord

    See TSPYL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSPYL5

    SOURCE GeneReport for Unigene cluster: Hs.173094
        SABiosciences Custom PCR Arrays for TSPYL5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TSPYL5 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspyl51 , 5 testis-specific protein, Y-encoded-like 51, 5 78.19(n)1
    73.83(a)1
      15 (13.91 cM)5
    2393641  NM_001085421.11  NP_001078890.11 
     336838765 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    27(a)
    1 → many
    2(89264771-89274104)
    zebrafish
    (Danio rerio)
    Actinopterygii TSPYL16
    TSPY-like 1
    16(a)
    1 → many
    8(26561010-26569017)
    fruit fly
    (Drosophila melanogaster)
    Insecta Set6
    Set
    29(a)
    1 → many
    3R(11089257-11090975)
    worm
    (Caenorhabditis elegans)
    Secernentea spr-26
    Suppressor of presenilin-2
    20(a)
    1 → many
    IV(8891470-8892747)


    ENSEMBL Gene Tree for TSPYL5 (if available)
    TreeFam Gene Tree for TSPYL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSPYL5 gene
    SET2  TSPY6P2  TSPYL12  TSPYL62  TSPY42  TSPY12  TSPY82  TSPYL22  
    TSPYL42  TSPY102  TSPY22  TSPY32  
    6 SIMAP similar genes for TSPYL5 using alignment to 1 protein entry:     TSYL5_HUMAN:
    SET    TSPYL4    TSPY26P    TSPYL1    TSPYL6    TSPYL

    TSPYL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 SNPs in TSPYL5 are shown (see all 172)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1155985621,2
    C--93491704(+) CACCCA/CCCCTT 1 -- int10--------
    rs1894501721,2
    --93491840(+) CACAAC/TTCAGA 1 -- int10--------
    rs1491612991,2
    C--93491861(+) AATTT-/AAGAAGCA 1 -- int10--------
    rs1817699351,2
    --93491917(+) ATTCTA/CATGGG 1 -- int10--------
    rs2005601251,2
    --93492056(+) CTAGT-/CACA  
            
    CAGGG
    1 -- int10--------
    rs1471077051,2
    C--93492057(+) TAGTC-/ACACA 
            
    AGGGT
    1 -- int10--------
    rs570623301,2
    C--93492058(+) AGTCA-/ACAC  
     A
    /CACAA
    GGGTC
    1 -- int10--------
    rs1861282811,2
    --93492350(+) TTCTTC/TCAAAA 1 -- ut310--------
    rs757796321,2
    C,F--93492373(+) GACCAG/ATACAA 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1139697561,2
    C,F--93492445(+) TCTGGC/TGAAGG 1 -- ut311Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for TSPYL5 (98285714 - 98290176 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TSPYL5: --

    Human Gene Mutation Database (HGMD): TSPYL5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TSPYL5
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPYL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614721    OMIM disorders: --

    6 diseases for TSPYL5:    About MalaCards
    lung squamous cell carcinoma    acute myeloid leukemia    myeloid leukemia    squamous cell carcinoma
    gastric cancer    leukemia


    TSPYL5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TSPYL5

    Export disorders for TSPYL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSPYL5 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TSPYL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. TSPYL5 suppresses p53 levels and function by physical interaction with USP7. (PubMed id 21170034)1, 2 Epping M.T....Bernards R. (2011)
    3. TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pa thway. (PubMed id 20079711)1, 2 Kim E.J....Kim I.G. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. TSPYL5 SNPs: association with plasma estradiol concent rations and aromatase expression. (PubMed id 23518928)1 Liu M....Weinshilboum R.M. (2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Genome-wide association study of antipsychotic-induce d QTc interval prolongation. (PubMed id 20921969)4 Aberg K....van den Oord E.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85453 HGNC: 29367 AceView: TSPYL5 Ensembl:ENSG00000180543 euGenes: HUgn85453
    ECgene: TSPYL5 H-InvDB: TSPYL5

    (According to HUGE)
    About This Section
    HUGE: KIAA1750

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSPYL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSPYL5 gene:
    Search GeneIP for patents involving TSPYL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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