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Aliases for TSPYL5 Gene

Aliases for TSPYL5 Gene

  • TSPY Like 5 2 3 5
  • Testis-Specific Y-Encoded-Like Protein 5 2
  • TSPY-Like Protein 5 4
  • KIAA1750 4

External Ids for TSPYL5 Gene

Previous GeneCards Identifiers for TSPYL5 Gene

  • GC08M098243
  • GC08M098354
  • GC08M093492

Summaries for TSPYL5 Gene

GeneCards Summary for TSPYL5 Gene

TSPYL5 (TSPY Like 5) is a Protein Coding gene. Diseases associated with TSPYL5 include Peritoneum Cancer. An important paralog of this gene is TSPYL4.

UniProtKB/Swiss-Prot for TSPYL5 Gene

  • Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.

Additional gene information for TSPYL5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPYL5 Gene

Genomics for TSPYL5 Gene

Regulatory Elements for TSPYL5 Gene

Enhancers for TSPYL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H097277 0.8 ENCODE 17.1 +0.2 185 1 GTF2F1 PKNOX1 MAX SIN3A NFXL1 BMI1 ZBTB40 RAD21 RFX5 E2F1 TSPYL5 PIR56210
GH08H097259 0.8 Ensembl ENCODE 16 +18.3 18264 0 CTCF CC2D1A CTBP2 SPI1 TSPYL5 ENSG00000260640 PIR56210
GH08H097231 1.1 Ensembl ENCODE 10.7 +45.4 45447 1 ELF3 FOXA2 MLX RARA CREM PPARG KAT8 NFIL3 MIER3 KLF16 TSPYL5 ENSG00000260640 LOC105375655
GH08H097324 1.2 Ensembl ENCODE 9.7 -47.4 -47435 1 ATF1 TCF12 ZNF766 GATA2 ATF7 CAVIN1 ZNF592 MEF2D NFIL3 SMARCA4 TSPYL5 GC08P097360
GH08H097553 1 Ensembl ENCODE 10 -275.8 -275757 0 CTCF TFAP4 ARID4B RAD21 YY1 CC2D1A ZNF316 GATA3 SMC3 SMARCA5 TSPYL5 LOC105375657 RPS2P33
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPYL5 on UCSC Golden Path with GeneCards custom track

Promoters for TSPYL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227528 64 1000 GTF2F1 PKNOX1 ESRRA SIN3A MAX NFXL1 BMI1 RAD21 RFX5 E2F1

Genomic Location for TSPYL5 Gene

Chromosome:
8
Start:
97,273,474 bp from pter
End:
97,277,964 bp from pter
Size:
4,491 bases
Orientation:
Minus strand

Genomic View for TSPYL5 Gene

Genes around TSPYL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPYL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPYL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPYL5 Gene

Proteins for TSPYL5 Gene

  • Protein details for TSPYL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VY4-TSYL5_HUMAN
    Recommended name:
    Testis-specific Y-encoded-like protein 5
    Protein Accession:
    Q86VY4
    Secondary Accessions:
    • B3KRF0
    • Q9C0B3

    Protein attributes for TSPYL5 Gene

    Size:
    417 amino acids
    Molecular mass:
    45143 Da
    Quaternary structure:
    • Interacts with USP7.
    SequenceCaution:
    • Sequence=BAB21841.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TSPYL5 Gene

Post-translational modifications for TSPYL5 Gene

  • Ubiquitination at Lys311
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPYL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPYL5 Gene

Domains & Families for TSPYL5 Gene

Gene Families for TSPYL5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSPYL5 Gene

Suggested Antigen Peptide Sequences for TSPYL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VY4

UniProtKB/Swiss-Prot:

TSYL5_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPYL5: view

Function for TSPYL5 Gene

Molecular function for TSPYL5 Gene

UniProtKB/Swiss-Prot Function:
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.

Phenotypes From GWAS Catalog for TSPYL5 Gene

Gene Ontology (GO) - Molecular Function for TSPYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21170034
genes like me logo Genes that share ontologies with TSPYL5: view
genes like me logo Genes that share phenotypes with TSPYL5: view

Animal Model Products

CRISPR Products

miRNA for TSPYL5 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TSPYL5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPYL5 Gene

Localization for TSPYL5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPYL5 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSPYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TSPYL5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSPYL5 Gene

Pathways & Interactions for TSPYL5 Gene

SuperPathways for TSPYL5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0008284 positive regulation of cell proliferation IMP 20079711
GO:0031398 positive regulation of protein ubiquitination IDA 21170034
GO:0040008 regulation of growth IEA --
GO:0051897 positive regulation of protein kinase B signaling IMP 20079711
genes like me logo Genes that share ontologies with TSPYL5: view

No data available for Pathways by source and SIGNOR curated interactions for TSPYL5 Gene

Drugs & Compounds for TSPYL5 Gene

No Compound Related Data Available

Transcripts for TSPYL5 Gene

mRNA/cDNA for TSPYL5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPYL5 Gene

TSPY-like 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TSPYL5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL5 Gene

No ASD Table

Relevant External Links for TSPYL5 Gene

GeneLoc Exon Structure for
TSPYL5
ECgene alternative splicing isoforms for
TSPYL5

Expression for TSPYL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPYL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPYL5 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for TSPYL5 Gene

This gene is overexpressed in Testis (19.7), Fetal ovary (15.1), Ovary (10.3), and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSPYL5 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSPYL5 Gene:

TSPYL5

SOURCE GeneReport for Unigene cluster for TSPYL5 Gene:

Hs.173094

Evidence on tissue expression from TISSUES for TSPYL5 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TSPYL5: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPYL5 Gene

Orthologs for TSPYL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPYL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPYL5 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia TSPYL5 33 34
  • 83.62 (n)
dog
(Canis familiaris)
Mammalia TSPYL5 33 34
  • 79.66 (n)
mouse
(Mus musculus)
Mammalia Tspyl5 33 16 34
  • 78.19 (n)
rat
(Rattus norvegicus)
Mammalia Tspyl5 33
  • 77.83 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TSPY2 34
  • 18 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Set 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spr-2 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 34
  • 25 (a)
OneToMany
Species where no ortholog for TSPYL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPYL5 Gene

ENSEMBL:
Gene Tree for TSPYL5 (if available)
TreeFam:
Gene Tree for TSPYL5 (if available)

Paralogs for TSPYL5 Gene

(6) SIMAP similar genes for TSPYL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPYL5: view

Variants for TSPYL5 Gene

Sequence variations from dbSNP and Humsavar for TSPYL5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000173029 -- 97,278,008(+) CCGCC(G/T)CTGCG intron-variant, upstream-variant-2KB
rs1000266731 -- 97,274,041(+) AGTCA(C/T)GGTTG intron-variant, utr-variant-3-prime
rs1000630836 -- 97,276,048(+) AGCCA(A/G)AAATA intron-variant, utr-variant-3-prime
rs1001083611 -- 97,274,809(+) GAAAG(-/GCCCAGCTCT)GCTTT intron-variant, utr-variant-3-prime
rs1001544059 -- 97,274,864(+) GATTC(C/T)GCCCA intron-variant, utr-variant-3-prime

Variation tolerance for TSPYL5 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.72; 83.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPYL5 Gene

Human Gene Mutation Database (HGMD)
TSPYL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPYL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSPYL5 Gene

Disorders for TSPYL5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPYL5 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
peritoneum cancer
  • cancer of peritoneum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPYL5

Genetic Association Database (GAD)
TSPYL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPYL5
genes like me logo Genes that share disorders with TSPYL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPYL5 Gene

Publications for TSPYL5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. TSPYL5 suppresses p53 levels and function by physical interaction with USP7. (PMID: 21170034) Epping MT … Bernards R (Nature cell biology 2011) 3 4 60
  3. TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway. (PMID: 20079711) Kim EJ … Kim IG (Biochemical and biophysical research communications 2010) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance. (PMID: 26386860) Qiu X … Zheng F (Digestive diseases and sciences 2016) 3 60

Products for TSPYL5 Gene

Sources for TSPYL5 Gene

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