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Aliases for TSPYL5 Gene

Aliases for TSPYL5 Gene

  • TSPY-Like 5 2 3 5
  • TSPY-Like Protein 5 4
  • KIAA1750 4

External Ids for TSPYL5 Gene

Previous GeneCards Identifiers for TSPYL5 Gene

  • GC08M098243
  • GC08M098354
  • GC08M093492

Summaries for TSPYL5 Gene

GeneCards Summary for TSPYL5 Gene

TSPYL5 (TSPY-Like 5) is a Protein Coding gene. An important paralog of this gene is TSPY4.

UniProtKB/Swiss-Prot for TSPYL5 Gene

  • Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPYL5 Gene

Genomics for TSPYL5 Gene

Regulatory Elements for TSPYL5 Gene

Promoters for TSPYL5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPYL5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPYL5 Gene

Chromosome:
8
Start:
97,273,474 bp from pter
End:
97,277,964 bp from pter
Size:
4,491 bases
Orientation:
Minus strand

Genomic View for TSPYL5 Gene

Genes around TSPYL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPYL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPYL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPYL5 Gene

Proteins for TSPYL5 Gene

  • Protein details for TSPYL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VY4-TSYL5_HUMAN
    Recommended name:
    Testis-specific Y-encoded-like protein 5
    Protein Accession:
    Q86VY4
    Secondary Accessions:
    • B3KRF0
    • Q9C0B3

    Protein attributes for TSPYL5 Gene

    Size:
    417 amino acids
    Molecular mass:
    45143 Da
    Quaternary structure:
    • Interacts with USP7.
    SequenceCaution:
    • Sequence=BAB21841.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TSPYL5 Gene

Proteomics data for TSPYL5 Gene at MOPED

Post-translational modifications for TSPYL5 Gene

  • Ubiquitination at Lys 311
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPYL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPYL5 Gene

Domains & Families for TSPYL5 Gene

Protein Domains for TSPYL5 Gene

Suggested Antigen Peptide Sequences for TSPYL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VY4

UniProtKB/Swiss-Prot:

TSYL5_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPYL5: view

No data available for Gene Families for TSPYL5 Gene

Function for TSPYL5 Gene

Molecular function for TSPYL5 Gene

UniProtKB/Swiss-Prot Function:
Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.
genes like me logo Genes that share phenotypes with TSPYL5: view

Animal Model Products

miRNA for TSPYL5 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPYL5 Gene

Localization for TSPYL5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPYL5 Gene COMPARTMENTS Subcellular localization image for TSPYL5 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSPYL5 Gene

Pathways & Interactions for TSPYL5 Gene

SuperPathways for TSPYL5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPYL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0008284 positive regulation of cell proliferation IMP 20079711
GO:0031398 positive regulation of protein ubiquitination IDA 21170034
GO:0071480 cellular response to gamma radiation IMP 20079711
genes like me logo Genes that share ontologies with TSPYL5: view

No data available for Pathways by source and SIGNOR curated interactions for TSPYL5 Gene

Drugs & Compounds for TSPYL5 Gene

No Compound Related Data Available

Transcripts for TSPYL5 Gene

mRNA/cDNA for TSPYL5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPYL5 Gene

TSPY-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL5 Gene

No ASD Table

Relevant External Links for TSPYL5 Gene

GeneLoc Exon Structure for
TSPYL5
ECgene alternative splicing isoforms for
TSPYL5

Expression for TSPYL5 Gene

mRNA expression in normal human tissues for TSPYL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPYL5 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for TSPYL5 Gene

This gene is overexpressed in Testis (19.7), Fetal ovary (15.1), Ovary (10.3), and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPYL5 Gene



SOURCE GeneReport for Unigene cluster for TSPYL5 Gene Hs.173094

genes like me logo Genes that share expression patterns with TSPYL5: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPYL5 Gene

Orthologs for TSPYL5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPYL5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSPYL5 35
  • 83.62 (n)
  • 81.11 (a)
TSPYL5 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPYL5 35
  • 79.66 (n)
  • 85.92 (a)
TSPYL5 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspyl5 35
  • 78.19 (n)
  • 73.83 (a)
Tspyl5 16
Tspyl5 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSPYL5 35
  • 99.44 (n)
  • 99.04 (a)
TSPYL5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspyl5 35
  • 77.83 (n)
  • 72.37 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TSPY2 36
  • 18 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Set 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spr-2 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 36
  • 25 (a)
OneToMany
Species with no ortholog for TSPYL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPYL5 Gene

ENSEMBL:
Gene Tree for TSPYL5 (if available)
TreeFam:
Gene Tree for TSPYL5 (if available)

Paralogs for TSPYL5 Gene

(6) SIMAP similar genes for TSPYL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPYL5: view

Variants for TSPYL5 Gene

Sequence variations from dbSNP and Humsavar for TSPYL5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_035393 -
VAR_035394 -

Variation tolerance for TSPYL5 Gene

Residual Variation Intolerance Score: 22.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.72; 83.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPYL5 Gene

HapMap Linkage Disequilibrium report
TSPYL5
Human Gene Mutation Database (HGMD)
TSPYL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSPYL5 Gene

Disorders for TSPYL5 Gene

Relevant External Links for TSPYL5

Genetic Association Database (GAD)
TSPYL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPYL5

No disorders were found for TSPYL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPYL5 Gene

Publications for TSPYL5 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression. (PMID: 23518928) Liu M. … Weinshilboum R.M. (Mol. Endocrinol. 2013) 3
  3. TSPYL5 suppresses p53 levels and function by physical interaction with USP7. (PMID: 21170034) Epping M.T. … Bernards R. (Nat. Cell Biol. 2011) 3
  4. TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway. (PMID: 20079711) Kim E.J. … Kim I.G. (Biochem. Biophys. Res. Commun. 2010) 3
  5. Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers. (PMID: 18059362) Jung Y. … Kim T.Y. (Lab. Invest. 2008) 3

Products for TSPYL5 Gene

Sources for TSPYL5 Gene

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