TSPYL5 Gene
protein-coding GIFtS : 47
GCID: GC08 M098354
TSPY-like 5
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Aliasesfor TSPYL5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases TSPY-Like 5 1 2 KIAA17501 3 TSPY-Like Protein 52 3 Testis-Specific Y-Encoded-Like Protein 52
Export aliases for TSPYL5 gene to outside databases Previous GC identifers: GC08M098243 GC08M093492
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Summariesfor TSPYL5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TSYL5_HUMAN, Q86VY4 Function : Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of theAkt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7
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Genomic Viewsfor TSPYL5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000008.10 NC_018919.1 NT_008046.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TSPYL5 gene promoter: Sox5 MyoD NF-AT C/EBPalpha AREB6 CHOP-10 NF-AT2 POU2F1 POU2F1a NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for TSPYL5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPYL5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1 TSPYL5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M098354: view genomic region
(about GC identifiers )
Start:
98,285,714 bp from pter
End:
98,290,176 bp from pter
Size:
4,463 bases
Orientation:
minus strand
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Proteinsfor TSPYL5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TSYL5_HUMAN, Q86VY4 (See
protein sequence )Recommended Name: Testis-specific Y-encoded-like protein 5 Size : 417 amino acids; 45143 Da
Subunit : Interacts with USP7
Sequence caution : Sequence=BAB21841.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions : B3KRF0 Q9C0B3Explore the universe of human proteins at neXtProt for TSPYL5: NX_Q86VY4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q86VY4 TSPYL5 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_277047.2 ENSEMBL proteins: ENSP00000322802 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
TSPYL5 for ontologies About GeneDecksing TSPYL5 Antibody Products: Assay Products for TSPYL5:
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Protein
Domains / Familiesfor TSPYL5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TSPYL5 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q86VY4 ProtoNet protein and cluster: Q86VY4
1 Blocks protein family : IPB002164 Nucleosome assembly protein (NAP) UniProtKB/Swiss-Prot: TSYL5_HUMAN, Q86VY4 Similarity : Belongs to the nucleosome assembly protein (NAP) family
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Functionfor TSPYL5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TSYL5_HUMAN, Q86VY4 Function : Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of theAkt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL5 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL5OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPYL5 (NM_033512 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPYL5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPYL5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL5
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IPI --
TSPYL5 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for TSPYL5 :
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Pathways & Interactionsfor TSPYL5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPYL5 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for TSPYL5 (Q86VY4 1 , 3 ENSP00000322802 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006334 nucleosome assembly
IEA -- GO:0008284 positive regulation of cell proliferation
IMP -- GO:0031398 positive regulation of protein ubiquitination
IDA -- GO:0040008 regulation of growth
IEA -- GO:0051897 positive regulation of protein kinase B signaling cascade
IMP --
TSPYL5 for ontologies About GeneDecksing
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Drugs & Compoundsfor TSPYL5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TSPYL5 Search CenterWatch for drugs/clinical trials and news about TSPYL5 / TSYL5
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Transcriptsfor TSPYL5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TSPYL5 gene: NM_033512.2 Unigene Cluster for TSPYL5:
TSPY-like 5 Hs.173094 [show with all ESTs ] Unigene Representative Sequence: NM_033512 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000322128 (uc003yhy.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL5 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL5OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPYL5 (NM_033512 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPYL5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPYL5
Additional cDNA sequence: AB051537.1 AK091445.1 AK092272.1 AL080059.2 BC045630.1
5 DOTS entries : DT.97840214 DT.100026974
DT.86846660 DT.100742854 DT.117251 24/105 AceView cDNA sequences (see all 105 ):
AI076674 AA403139 BU178255 BM684209 BU860463 BQ771895 AA810584 AA338873 AA781943 Z39657 F03819 AI096375 BQ004589 BQ006066 F04419 AB051537 AA747824 BU731581 AW512403 Z45560 F07174 AA973313 BQ130523 NM_033512 GeneLoc Exon Structure
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Expression for TSPYL5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TSPYL5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGGAAAAAT
About this image TSPYL5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See TSPYL5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TSPYL5 SOURCE GeneReport for Unigene cluster: Hs.173094 SABiosciences Custom PCR Arrays for TSPYL5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSPYL5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TSPYL5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSPYL5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSPYL5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL5
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Orthologsfor TSPYL5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSPYL5 gene from 7/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for TSPYL5 (if available)TreeFam Gene Tree for TSPYL5 (if available)
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Paralogsfor TSPYL5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TSPYL5 gene SET 2 TSPYL1 2 TSPYL6 2 TSPY4 2 TSPY1 2 TSPY8 2 TSPYL2 2 TSPYL4 2 TSPY10 2 TSPY2 2 TSPY3 2 6 SIMAP similar genes for TSPYL5 using alignment to 1 protein entry: TSYL5_HUMAN :SET TSPYL4 TSPY26P TSPYL1 TSPYL6 TSPYL
TSPYL5 for paralogs About GeneDecksing
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Genomic Variantsfor TSPYL5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSPYL5
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Disorders
/ Diseasesfor TSPYL5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TSPYL5 for disorders About GeneDecksing
OMIM gene information: 614721
OMIM disorders : --8 diseases for TSPYL5 : About MalaCards lung squamous cell carcinoma acute myeloid leukemia myeloid leukemia squamous cell carcinoma gastric cancer leukemia malaria carcinoma Export disorders for TSPYL5 gene to outside databases
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Publicationsfor TSPYL5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TSPYL5 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with TSPYL5) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970) 1 , 2 , 3 Nagase T.... Ohara O. (2000) TSPYL5 suppresses p53 levels and function by physical interaction with USP7. (PubMed id 21170034) 1 , 2 Epping M.T....Bernards R. (2011) TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pa thway. (PubMed id 20079711) 1 , 2 Kim E.J....Kim I.G. (2010) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers. (PubMed id 18059362) 1 Jung Y....Kim T.Y. (2008) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007)
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External Searches for TSPYL5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TSPYL5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TSPYL5 gene
(According to HUGE )
About This Section
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Specialized Databases showing TSPYL5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TSPYL5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TSPYL5 gene: Search GeneIP for patents involving TSPYL5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TSPYL5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TSPYL5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TSPYL5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSPYL5 OriGene Protein Over-expression Lysate for TSPYL5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TSPYL5 OriGene 3'-UTR Clone for TSPYL5 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TSPYL5 OriGene Custom Protein Services for TSPYL5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPYL5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSPYL5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPYL5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TSPYL5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSPYL5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSPYL5
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TSPYL5 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL5
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TSPYL5
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