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Aliases for TSPYL4 Gene

Aliases for TSPYL4 Gene

  • TSPY-Like 4 2 3 5
  • TSPY-Like Protein 4 3 4
  • DJ486I3.2 3
  • KIAA0721 4

External Ids for TSPYL4 Gene

Previous GeneCards Identifiers for TSPYL4 Gene

  • GC06M116571
  • GC06M116616
  • GC06M116677
  • GC06M114151

Summaries for TSPYL4 Gene

GeneCards Summary for TSPYL4 Gene

TSPYL4 (TSPY-Like 4) is a Protein Coding gene. An important paralog of this gene is TSPY4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPYL4 Gene

Genomics for TSPYL4 Gene

Regulatory Elements for TSPYL4 Gene

Enhancers for TSPYL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPYL4 on UCSC Golden Path with GeneCards custom track

Promoters for TSPYL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPYL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPYL4 Gene

116,249,961 bp from pter
116,254,140 bp from pter
4,180 bases
Minus strand

Genomic View for TSPYL4 Gene

Genes around TSPYL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPYL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPYL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPYL4 Gene

Proteins for TSPYL4 Gene

  • Protein details for TSPYL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded-like protein 4
    Protein Accession:
    Secondary Accessions:
    • B4DYQ2
    • O94828
    • Q96GW8

    Protein attributes for TSPYL4 Gene

    414 amino acids
    Molecular mass:
    45126 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34441.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSPYL4 Gene

Proteomics data for TSPYL4 Gene at MOPED

Post-translational modifications for TSPYL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSPYL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPYL4 Gene

Domains & Families for TSPYL4 Gene

Protein Domains for TSPYL4 Gene

Suggested Antigen Peptide Sequences for TSPYL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPYL4: view

No data available for Gene Families for TSPYL4 Gene

Function for TSPYL4 Gene

Phenotypes for TSPYL4 Gene

GenomeRNAi human phenotypes for TSPYL4:
genes like me logo Genes that share phenotypes with TSPYL4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPYL4 Gene

Localization for TSPYL4 Gene

Subcellular locations from

Jensen Localization Image for TSPYL4 Gene COMPARTMENTS Subcellular localization image for TSPYL4 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSPYL4 Gene

Pathways & Interactions for TSPYL4 Gene

SuperPathways for TSPYL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPYL4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TSPYL4 Gene

Drugs & Compounds for TSPYL4 Gene

No Compound Related Data Available

Transcripts for TSPYL4 Gene

mRNA/cDNA for TSPYL4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(134) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPYL4 Gene

TSPY-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL4 Gene

No ASD Table

Relevant External Links for TSPYL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPYL4 Gene

mRNA expression in normal human tissues for TSPYL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPYL4 Gene

This gene is overexpressed in Prostate (44.6) and Fetal Brain (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPYL4 Gene

SOURCE GeneReport for Unigene cluster for TSPYL4 Gene Hs.284141

genes like me logo Genes that share expression patterns with TSPYL4: view

Protein tissue co-expression partners for TSPYL4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TSPYL4 Gene

Orthologs for TSPYL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPYL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TSPYL4 35
  • 85.92 (n)
  • 82.28 (a)
  • 82 (a)
(Canis familiaris)
Mammalia TSPYL4 35
  • 77.06 (n)
  • 76.97 (a)
  • 72 (a)
(Mus musculus)
Mammalia Tspyl4 35
  • 81.48 (n)
  • 79.51 (a)
Tspyl4 16
Tspyl4 36
  • 79 (a)
(Pan troglodytes)
Mammalia TSPYL4 35
  • 99.44 (n)
  • 99.03 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tspyl4 35
  • 79.56 (n)
  • 77.34 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
(Danio rerio)
Actinopterygii TSPY2 36
  • 19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea spr-2 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 36
  • 23 (a)
Species with no ortholog for TSPYL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPYL4 Gene

Gene Tree for TSPYL4 (if available)
Gene Tree for TSPYL4 (if available)

Paralogs for TSPYL4 Gene

(15) SIMAP similar genes for TSPYL4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TSPYL4: view

Variants for TSPYL4 Gene

Sequence variations from dbSNP and Humsavar for TSPYL4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2232470 - 116,253,920(-) GGACC(A/G/T)AGACC reference, missense
rs1204831 -- 116,249,661(-) TATTA(A/T)TAACT downstream-variant-500B
rs1204832 -- 116,250,874(+) ATCAC(C/T)ACACA utr-variant-3-prime
rs1204833 -- 116,251,665(+) GGAGG(A/G)GGAGG utr-variant-3-prime
rs1204852 -- 116,255,630(-) ACGAT(A/G)CCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSPYL4 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680

Variation tolerance for TSPYL4 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPYL4 Gene

Disorders for TSPYL4 Gene

Relevant External Links for TSPYL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPYL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPYL4 Gene

Publications for TSPYL4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TSPYL4 Gene

Sources for TSPYL4 Gene