TSPYL4 Gene
protein-coding GIFtS : 47
GCID: GC06 M116571
TSPY-like 4
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Aliasesfor TSPYL4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases TSPY-Like 4 1 2 DJ486I3.21 KIAA07211 3 TSPY-Like Protein 42 3 Testis-Specific Y-Encoded-Like Protein 42
Export aliases for TSPYL4 gene to outside databases Previous GC identifers: GC06M116616 GC06M116677 GC06M114151
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Summariesfor TSPYL4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TSPYL4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TSPYL4 gene promoter: FOXF2 AML1a POU3F2 E47 Arnt AREB6 SRY LyF-1 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for TSPYL4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TSPYL4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q22.1 Ensembl cytogenetic band: 6q22.1 HGNC cytogenetic band: 6q22.1 TSPYL4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M116571: view genomic region
(about GC identifiers )
Start:
116,571,127 bp from pter
End:
116,575,261 bp from pter
Size:
4,135 bases
Orientation:
minus strand
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Proteinsfor TSPYL4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TSYL4_HUMAN, Q9UJ04 (See
protein sequence )Recommended Name: Testis-specific Y-encoded-like protein 4 Size : 414 amino acids; 45126 Da
Sequence caution : Sequence=BAA34441.1; Type=Erroneous initiation;
Secondary accessions : B4DYQ2 O94828 Q96GW8Explore the universe of human proteins at neXtProt for TSPYL4: NX_Q9UJ04 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UJ04 TSPYL4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_067680.3 ENSEMBL proteins: ENSP00000410943 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
TSPYL4 for ontologies About GeneDecksing TSPYL4 Antibody Products: Assay Products for TSPYL4:
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Protein
Domains / Familiesfor TSPYL4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TSPYL4 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9UJ04 ProtoNet protein and cluster: Q9UJ04
1 Blocks protein family : IPB002164 Nucleosome assembly protein (NAP) UniProtKB/Swiss-Prot: TSYL4_HUMAN, Q9UJ04 Similarity : Belongs to the nucleosome assembly protein (NAP) family
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Functionfor TSPYL4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPYL4 (NM_021648 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPYL4 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TSPYL4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL4
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Pathways & Interactionsfor TSPYL4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPYL4 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)5/54 Interacting proteins for TSPYL4 (Q9UJ04 2 , 3 ENSP00000410943 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 54 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006334 nucleosome assembly
IEA --
TSPYL4 for ontologies About GeneDecksing
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Drugs & Compoundsfor TSPYL4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TSPYL4 Search CenterWatch for drugs/clinical trials and news about TSPYL4 / TSYL4
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Transcriptsfor TSPYL4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TSPYL4 gene: NM_021648.4 Unigene Cluster for TSPYL4:
TSPY-like 4 Hs.284141 [show with all ESTs ] Unigene Representative Sequence: NM_021648 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000420283 (uc003pwn.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TSPYL4 (NM_021648 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPYL4 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TSPYL4
Additional cDNA sequence: AB018264.1 AJ420569.1 AK091559.1 AK302542.1 AL049347.1 AL137639.1 BC009116.1 BC040453.1
4 DOTS entries : DT.455106 DT.121344653
DT.447340 DT.95213659 24/134 AceView cDNA sequences (see all 134 ):
CR603581 AA452859 AA699303 F01388 AW964188 BQ771567 NM_021648 BM720525 BF475790 BQ778159 AL137639 AI698113 C01943 AA468256 AL049347 BF437966 BM991040 AI457849 AI697750 CD644286 AW662150 BU787664 AI184732 BF435830 GeneLoc Exon Structure
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Expression for TSPYL4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TSPYL4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGCTTGAAGG
About this image TSPYL4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Retina Eye Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TSPYL4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TSPYL4 SOURCE GeneReport for Unigene cluster: Hs.284141 SABiosciences Custom PCR Arrays for TSPYL4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSPYL4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TSPYL4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSPYL4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSPYL4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL4
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Orthologsfor TSPYL4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSPYL4 gene from 6/18 species (see all 18 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
--
--
39(a)
1 → many
2(89265460-89270074)
zebrafish (Danio rerio)
Actinopterygii
zgc:664306
zgc:66430
20(a)
1 → many
8(26561010-26569017)
fruit fly (Drosophila melanogaster)
Insecta
Set6
Set
27(a)
1 → many
3R(11089257-11090975)
worm (Caenorhabditis elegans)
Secernentea
spr-26
Suppressor of presenilin-2
22(a)
1 → many
IV(8891457-8892734)
thale cress (Arabidopsis thaliana)
eudicotyledons
NRP26 NRP16
template-activating factor I
25(a) 23(a)
many ↔ manymany ↔ many
1(6481113-6483596) 1(28017584-28020049)
rice (Oryza sativa)
Liliopsida
----
SET, putative, expressedNAP domain containing protein, putative, expressed...
28(a) 25(a)
many ↔ manymany ↔ many
2(22145563-22150173) 4(22758069-22761770)
ENSEMBL Gene Tree for TSPYL4 (if available)TreeFam Gene Tree for TSPYL4 (if available)
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Paralogsfor TSPYL4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TSPYL4 gene SET 2 TSPYL1 2 TSPYL6 2 TSPY4 2 TSPY1 2 TSPY8 2 TSPYL2 2 TSPYL5 2 TSPY10 2 TSPY2 2 TSPY3 2 14 SIMAP similar genes for TSPYL4 using alignment to 2 protein entries: TSYL4_HUMAN (see all proteins ):DKFZp434M235 LOC728395 TSPYL6 SET TSPY26P TSPYL TSPYL1 TSPY8 TSPY10 TSPY2 TSPY3 TSPY4 TSPY1 TSPYL5
TSPYL4 for paralogs About GeneDecksing
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Genomic Variantsfor TSPYL4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TSPYL4 (116571127 - 116575261 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TSPYL4: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSPYL4
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Disorders
/ Diseasesfor TSPYL4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TSPYL4 for disorders About GeneDecksing 4 diseases for TSPYL4 : About MalaCards acute myeloid leukemia myeloid leukemia leukemia malaria Export disorders for TSPYL4 gene to outside databases
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Publicationsfor TSPYL4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TSPYL4 gene integrated from 9 sources : (articles sorted by number of sources associating them with TSPYL4) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452) 1 , 2 Nagase T.... Ohara O. (1998) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PubMed id 12421765) 1 Nakayama M....Ohara O. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TSPYL4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TSPYL4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TSPYL4 gene
(According to HUGE )
About This Section
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Specialized Databases showing TSPYL4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TSPYL4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TSPYL4 gene: Search GeneIP for patents involving TSPYL4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TSPYL4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TSPYL4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TSPYL4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TSPYL4 OriGene Protein Over-expression Lysate for TSPYL4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TSPYL4 OriGene 3'-UTR Clone for TSPYL4 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TSPYL4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TSPYL4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TSPYL4 OriGene Custom Protein Services for TSPYL4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPYL4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TSPYL4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TSPYL4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TSPYL4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TSPYL4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TSPYL4
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TSPYL4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL4
ThermoFisher Antibodies for TSPYL4
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Aliases for TSPYL4
Databases for TSPYL4
Disorders / Diseases for TSPYL4
Domains / Families for TSPYL4
Drugs / Compounds for TSPYL4
Expression for TSPYL4
Function for TSPYL4
Genomic Views for TSPYL4
Intellectual Property for TSPYL4
Orthologs for TSPYL4
Paralogs for TSPYL4
Pathways / Interactions for TSPYL4
Products for TSPYL4
Proteins for TSPYL4
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Search Box for TSPYL4
Summaries for TSPYL4
Transcripts for TSPYL4
Variants for TSPYL4
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