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Aliases for TSPYL4 Gene

Aliases for TSPYL4 Gene

  • TSPY Like 4 2 3 5
  • TSPY-Like Protein 4 3 4
  • Testis-Specific Y-Encoded-Like Protein 4 3
  • DJ486I3.2 3
  • KIAA0721 4

External Ids for TSPYL4 Gene

Previous GeneCards Identifiers for TSPYL4 Gene

  • GC06M116571
  • GC06M116616
  • GC06M116677
  • GC06M114151

Summaries for TSPYL4 Gene

GeneCards Summary for TSPYL4 Gene

TSPYL4 (TSPY Like 4) is a Protein Coding gene. Diseases associated with TSPYL4 include Epileptic Encephalopathy, Early Infantile, 6. An important paralog of this gene is TSPYL1.

Additional gene information for TSPYL4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPYL4 Gene

Genomics for TSPYL4 Gene

Regulatory Elements for TSPYL4 Gene

Enhancers for TSPYL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H116228 1.3 FANTOM5 Ensembl ENCODE 18 +24.7 24656 1.1 MXI1 PKNOX1 RFX1 ATF1 MAX BMI1 RFX5 ZNF217 MTA1 POLR2A DSE TSPYL4 KPNA5 TSPYL1 GC06P116233 GC06P116234 PIR35709 COL10A1
GH06H116250 1.1 ENCODE 20.8 +0.6 601 5.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 TSPYL4 DSE ENSG00000240050 ENSG00000234117 TSPYL1 RSPH4A GC06M116250
GH06H116276 1.4 ENCODE dbSUPER 13.4 -25.3 -25287 5.1 HDGF FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 CALHM6 TSPYL4 CALHM4 TSPYL1 TRAPPC3L KRT18P22 CBX3P9 ENSG00000244158 ENSG00000234117 ZUFSP
GH06H116098 1.4 Ensembl ENCODE 9.6 +153.5 153490 4.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 KPNA5 NT5DC1 COL10A1 TSPYL4 FRK GC06M116078
GH06H116105 1 Ensembl ENCODE 9.4 +147.8 147828 1.9 SOX13 TBP FOXA2 SAP130 MAX ARID4B CEBPG ZNF644 ZSCAN9 LCORL TSPYL4 TSPYL1 NT5DC1 NIP7P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPYL4 on UCSC Golden Path with GeneCards custom track

Promoters for TSPYL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for TSPYL4 Gene

Genomic Locations for TSPYL4 Gene
4,180 bases
Minus strand

Genomic View for TSPYL4 Gene

Genes around TSPYL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPYL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPYL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPYL4 Gene

Proteins for TSPYL4 Gene

  • Protein details for TSPYL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded-like protein 4
    Protein Accession:
    Secondary Accessions:
    • B4DYQ2
    • O94828
    • Q96GW8

    Protein attributes for TSPYL4 Gene

    414 amino acids
    Molecular mass:
    45126 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34441.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSPYL4 Gene

Post-translational modifications for TSPYL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSPYL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPYL4 Gene

Domains & Families for TSPYL4 Gene

Gene Families for TSPYL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSPYL4 Gene

Suggested Antigen Peptide Sequences for TSPYL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPYL4: view

Function for TSPYL4 Gene

Gene Ontology (GO) - Molecular Function for TSPYL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TSPYL4: view

Phenotypes for TSPYL4 Gene

GenomeRNAi human phenotypes for TSPYL4:
genes like me logo Genes that share phenotypes with TSPYL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPYL4 Gene

Localization for TSPYL4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPYL4 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TSPYL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TSPYL4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TSPYL4 Gene

Pathways & Interactions for TSPYL4 Gene

SuperPathways for TSPYL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPYL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
genes like me logo Genes that share ontologies with TSPYL4: view

No data available for Pathways by source and SIGNOR curated interactions for TSPYL4 Gene

Drugs & Compounds for TSPYL4 Gene

No Compound Related Data Available

Transcripts for TSPYL4 Gene

mRNA/cDNA for TSPYL4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(134) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPYL4 Gene

TSPY-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL4 Gene

No ASD Table

Relevant External Links for TSPYL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPYL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPYL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPYL4 Gene

This gene is overexpressed in Prostate (44.6) and Fetal Brain (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPYL4 Gene

Protein tissue co-expression partners for TSPYL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TSPYL4 Gene:


SOURCE GeneReport for Unigene cluster for TSPYL4 Gene:


Evidence on tissue expression from TISSUES for TSPYL4 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with TSPYL4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPYL4 Gene

Orthologs for TSPYL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPYL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPYL4 33 34
  • 99.44 (n)
(Bos Taurus)
Mammalia TSPYL4 33 34
  • 85.92 (n)
(Mus musculus)
Mammalia Tspyl4 33 16 34
  • 81.48 (n)
(Rattus norvegicus)
Mammalia Tspyl4 33
  • 79.56 (n)
(Canis familiaris)
Mammalia TSPYL4 33 34
  • 77.06 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
(Danio rerio)
Actinopterygii TSPY2 34
  • 19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea spr-2 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 34
  • 23 (a)
Species where no ortholog for TSPYL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPYL4 Gene

Gene Tree for TSPYL4 (if available)
Gene Tree for TSPYL4 (if available)

Paralogs for TSPYL4 Gene

(15) SIMAP similar genes for TSPYL4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TSPYL4: view

Variants for TSPYL4 Gene

Sequence variations from dbSNP and Humsavar for TSPYL4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000044427 -- 116,254,783(+) ACTGA(A/G)AGAAA intron-variant, upstream-variant-2KB
rs1000543320 -- 116,251,719(+) TATCT(C/T)TTCCT utr-variant-3-prime
rs1001315624 -- 116,254,457(+) ACAGG(C/G)CTTCC intron-variant, upstream-variant-2KB
rs1002052883 -- 116,252,014(+) GAGAG(G/T)GAGTA utr-variant-3-prime
rs1002423617 -- 116,252,439(+) CATGG(C/T)CACAG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TSPYL4 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV gain 19592680
esv3576211 CNV gain 25503493

Variation tolerance for TSPYL4 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPYL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPYL4 Gene

Disorders for TSPYL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPYL4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 6
  • dravet syndrome, modifier of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPYL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSPYL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPYL4 Gene

Publications for TSPYL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TSPYL4 Gene

Sources for TSPYL4 Gene

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