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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPYL2 Gene

protein-coding   GIFtS: 59
GCID: GC0XP053111

TSPY-like 2

 Explore 12 diseases affiliated with
TSPYL2 via our new
 Human Malady Compendium 
Biological research products
for TSPYL2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
TSPY-Like 21 2     TSPX2 3
CDA11 2 3 5     CTCL-Associated Antigen Se20-42 3
DENTT1 2 3 5     TSPY-Like Protein 22 3
CINAP1 2 5     SE20-41
CTCL1 2     SE2042
HRIHFB22161 2     CASK-Interacting Nucleosome Assembly Protein2
Cell Division Autoantigen 12 3     CTCL Tumor Antigen Se20-42
Cutaneous T-Cell Lymphoma-Associated Antigen Se20-42 3     Cutaneous T-Cell Lymphoma-Associated Tumor Antigen Se20-42
Differentially-Expressed Nucleolar TGF-Beta1 Target Protein2 3     Differentially Expressed Nucleolar TGF-Beta1 Target2
Nuclear Protein Of 79 KDa2 3     Testis-Specific Protein Y Encoded-Like 22
NP792 3     Testis-Specific Y-Encoded-Like Protein 22

External Ids:    HGNC: 243581   Entrez Gene: 640612   Ensembl: ENSG000001842057   OMIM: 3005645   UniProtKB: Q9H2G43   

Export aliases for TSPYL2 gene to outside databases

Previous GC identifers: GC0XP052994 GC0XP053128 GC0XP050176


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSPYL2:
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1
superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an
inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. (provided by
RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: TSYL2_HUMAN, Q9H2G4
Function: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal
synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing
p53-dependent CDKN1A expression

Gene Wiki entry for TSPYL2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011630.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPYL2 gene promoter:
         ER-alpha   POU3F1   HSF1 (long)   C/EBPalpha   CREB   AREB6   CHOP-10   Ik-2   deltaCREB   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPYL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPYL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPYL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11

TSPYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPYL2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP053111:  view genomic region     (about GC identifiers)

Start:
53,111,542 bp from pter      End:
53,117,728 bp from pter
Size:
6,187 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSYL2_HUMAN, Q9H2G4 (See protein sequence)
Recommended Name: Testis-specific Y-encoded-like protein 2  
Size: 693 amino acids; 79435 Da
Subunit: Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TRB1 and TSPYL2 (By
similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Enriched in transcriptionally active regions of
chromatin in neurons (By similarity)
Miscellaneous: Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation (By
similarity)
Miscellaneous: Subject to X inactivation
Sequence caution: Sequence=AAG53596.1; Type=Erroneous initiation;
Secondary accessions: O94799 Q96DG7 Q9BZW6

Explore the universe of human proteins at neXtProt for TSPYL2: NX_Q9H2G4

Post-translational modifications:

  • Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2G4

  • TSPYL2 Protein expression data from MOPED and PaxDb:    About this image 
    TSPYL2 Protein Expression
    REFSEQ proteins: NP_071400.1  
    ENSEMBL proteins: 
     ENSP00000364591   ENSP00000462287   ENSP00000462635  
    Reactome Protein details: Q9H2G4
    Human Recombinant Protein Products for TSPYL2: 
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    Uscn Proteins for TSPYL2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    TSPYL2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TSPYL2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q9H2G4

    ProtoNet protein and cluster: Q9H2G4

    1 Blocks protein family: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: TSYL2_HUMAN, Q9H2G4
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSYL2_HUMAN, Q9H2G4
    Function: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal
    synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing
    p53-dependent CDKN1A expression
    Induction: Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid (ATRA) in lung cancer
    cells (at protein level)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000182rDNA binding NAS11395479
         
    TSPYL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TSPYL2:
     Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tspyl2):
     cellular  mortality/aging  nervous system  no phenotypic analysis  reproductive system 
     tumorigenesis 

    TSPYL2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Tspyl2tm1.1Sich for TSPYL2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TSPYL2 

    miRNA
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    miRTarBase miRNAs that target TSPYL2:
    hsa-mir-15a (MIRT004680)

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    hsa-miR-596 hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-519a hsa-miR-4314 hsa-miR-424 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidTSPYL2 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperone Genes by XBP1(S)1.00
    Unfolded Protein Response0.71
    Activation of Chaperones by IRE1alpha0.94
    2Expression of TSPYL2
    Expression of TSPYL21.00
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for TSPYL2
        Activation of Chaperone Genes by XBP1(S)
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha
    Expression of TSPYL2
    Unfolded Protein Response



    TSPYL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSPYL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/16 Interacting proteins for TSPYL2 (Q9H2G42, 3 ENSP000003645914) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2875685 MINT-2875704 I2D: score=3 STRING: ENSP00000400806
    COILP384322, 3, ENSP000002403164MINT-2875723 I2D: score=3 STRING: ENSP00000240316
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2875742 I2D: score=3 STRING: ENSP00000344782
    CASKO149363, ENSP000003674084I2D: score=3 STRING: ENSP00000367408
    CDK2P249413, ENSP000002669704I2D: score=3 STRING: ENSP00000266970
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007049cell cycle IEA--

    TSPYL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TSPYL2
    Search CenterWatch for drugs/clinical trials and news about TSPYL2 / TSYL2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TSPYL2 gene: 
    NM_022117.3  

    Unigene Cluster for TSPYL2:

    TSPY-like 2
    Hs.136164  [show with all ESTs]
    Unigene Representative Sequence: AY040871
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553557(uc004drx.1) ENST00000375442(uc004drw.3) ENST00000579390
    ENST00000578306 ENST00000556808(uc004drv.3) ENST00000463525

    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate TSPYL2 (see all 32):
    hsa-miR-596 hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-519a hsa-miR-4314 hsa-miR-424 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidTSPYL2 3' UTR sequence
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    Additional cDNA sequence: 

    AB015345.1 AF254794.1 AF273046.1 AK292462.1 AL713652.1 AY040871.1 BC001566.1 BC024270.1 

    6 DOTS entries:

    DT.411866  DT.91772923  DT.91772918  DT.86835833  DT.95193180  DT.99961722 

    24/280 AceView cDNA sequences (see all 280):

    AI270682 CA392039 BU542511 BQ549481 AI885120 BU076287 AI215638 BC024270 
    BQ935272 BU616170 BM888372 AA516360 CA392040 AI298628 BC001566 CD105238 
    AI299712 CK822691 AY040871 AI921773 BQ721304 BM509936 CB217101 N33443 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
    SP1:              -           -                                         -     -                     
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:              -                                                                                 
    SP5:                                                              -     -     -     -               


    ECgene alternative splicing isoforms for TSPYL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TSPYL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGGCGCTGC
    TSPYL2 Expression
    About this image
    See TSPYL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TSPYL2

    SOURCE GeneReport for Unigene cluster: Hs.136164

    UniProtKB/Swiss-Prot: TSYL2_HUMAN, Q9H2G4
    Tissue specificity: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver
    and pancreas

        SABiosciences Custom PCR Arrays for TSPYL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TSPYL2 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    38(a)
    1 → many
    2(89265460-89270074)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:664306
    zgc:66430
    20(a)
    1 → many
    8(26561010-26569017)
    fruit fly
    (Drosophila melanogaster)
    Insecta Set6
    Set
    29(a)
    1 → many
    3R(11089257-11090975)
    worm
    (Caenorhabditis elegans)
    Secernentea spr-26
    Suppressor of presenilin-2
    25(a)
    1 → many
    IV(8891457-8892734)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NRP26
    NRP16
    template-activating factor I
    30(a)
    25(a)
    many ↔ many
    many ↔ many
    1(6481113-6483596)
    1(28017584-28020049)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    SET, putative, expressed
    30(a)
    30(a)
    many ↔ many
    many ↔ many
    4(22758069-22761770)
    2(22145563-22150173)


    ENSEMBL Gene Tree for TSPYL2 (if available)
    TreeFam Gene Tree for TSPYL2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TSPYL2 gene
    SET2  TSPYL12  TSPYL62  TSPY42  TSPY12  TSPY82  TSPYL52  TSPYL42  
    TSPY102  TSPY22  TSPY32  
    3 SIMAP similar genes for TSPYL2 using alignment to 3 protein entries:     TSYL2_HUMAN (see all proteins):
    TSPYL1    TSPYL6    TSPY26P

    TSPYL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/120 NCBI SNPs in TSPYL2 are shown (see all 120    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123995091,2
    C--53110568(+) agttgA/Ggggat 1 -- us2k10--------
    rs1831160831,2
    --53110747(+) AGAAGA/GGGGGG 1 -- us2k10--------
    rs1859533091,2
    --53111152(+) TCATGC/TGAGCA 1 -- us2k10--------
    rs1923224611,2
    --53111218(+) ACTGGC/TACTTT 1 -- us2k10--------
    rs676362881,2
    C--53111429(+) GCGCG-/ATCGCC 1 -- us2k10--------
    rs1836422061,2
    --53111732(+) GCAGCC/TCCGAG 2 P S mis10--------
    rs2008237251,2
    --53112053(+) CCTCGA/GGGGGG 2 R G mis10--------
    rs1880417951,2
    --53112090(+) ACAGTC/TGAGCA 2 S L mis10--------
    rs1442649211,2
    C,F--53112146(+) GGGCGC/TCCCAG 2 P S mis11Minor allele frequency- T:0.00NA 3838
    rs1922791491,2
    --53112257(+) GGCGGA/CGGAGG 2 R syn10--------

    HapMap Linkage Disequilibrium report for TSPYL2 (53111542 - 53117728 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TSPYL2
         1 CNV: 23256
    Locus Specific Mutation Databases (LSDB): TSPYL2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TSPYL2 for disorders           About GeneDecksing

    OMIM gene information: 300564    OMIM disorders: --

    12 diseases for TSPYL2:    About MalaCards
    cutaneous t cell lymphoma    dyserythropoietic anemia    congenital dyserythropoietic anemia    gonadoblastoma
    acute myeloid leukemia    myeloid leukemia    anemia    leukemia
    lung cancer    ataxia    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TSPYL2:
    Gonadoblastoma

    Export disorders for TSPYL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TSPYL2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TSPYL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SET-related cell division autoantigen-1 (CDA1) arrests cell growth. (PubMed id 11395479)1, 2, 3 Chai Z.... Toh B.-H. (2001)
    2. Identification of Differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. (PubMed id 11318608)1, 2, 3 Ozbun L.L.... Jakowlew S.B. (2001)
    3. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. (PubMed id 17317670)1, 2 Tu Y....Chai Z. (2007)
    4. Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates. (PubMed id 15823505)1, 2 Ozbun L.L.... Jakowlew S.B. (2005)
    5. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (2001)
    6. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. (PubMed id 18381359)1, 9 Kandalaft L.E....Jakowlew S.B. (2008)
    7. hCINAP is an atypical mammalian nuclear adenylate kina se with an ATPase motif: structural and functional studies. (PubMed id 22038794)1 Drakou C.E....Zographos S.E. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. The X-linked tumor suppressor TSPX interacts and promo tes degradation of the hepatitis B viral protein HBx via the proteasome pathway. (PubMed id 21829568)1 Kido T....Lau Y.F. (2011)
    10. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. (PubMed id 21204751)1 Lau Y.F....Kido T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64061 HGNC: 24358 AceView: TSPYL2 Ensembl:ENSG00000184205 euGenes: HUgn64061
    ECgene: TSPYL2 H-InvDB: TSPYL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TSPYL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPYL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TSPYL2 gene:
    Search GeneIP for patents involving TSPYL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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