Aliases for TSPYL2 Gene
External Ids for TSPYL2 Gene
Previous GeneCards Identifiers for TSPYL2 Gene
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
GeneCards Summary for TSPYL2 Gene
TSPYL2 (TSPY-Like 2) is a Protein Coding gene. Diseases associated with TSPYL2 include Dyserythropoietic Anemia, Congenital, Type Ia and Gonadoblastoma. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification. GO annotations related to this gene include rDNA binding. An important paralog of this gene is TSPY4.
UniProtKB/Swiss-Prot for TSPYL2 Gene
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.