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Aliases for TSPYL2 Gene

Aliases for TSPYL2 Gene

  • TSPY-Like 2 2 3
  • DENTT 3 4 6
  • CDA1 3 4 6
  • Differentially-Expressed Nucleolar TGF-Beta1 Target Protein 3 4
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se20-4 3 4
  • CTCL-Associated Antigen Se20-4 3 4
  • Cell Division Autoantigen 1 3 4
  • Nuclear Protein Of 79 KDa 3 4
  • TSPY-Like Protein 2 3 4
  • CINAP 3 6
  • NP79 3 4
  • TSPX 3 4
  • Cutaneous T-Cell Lymphoma-Associated Tumor Antigen Se20-4 3
  • Differentially Expressed Nucleolar TGF-Beta1 Target 3
  • CASK-Interacting Nucleosome Assembly Protein 3
  • Testis-Specific Y-Encoded-Like Protein 2 3
  • Testis-Specific Protein Y Encoded-Like 2 3
  • CTCL Tumor Antigen Se20-4 3
  • HRIHFB2216 3
  • SE204 3
  • CTCL 3

External Ids for TSPYL2 Gene

Summaries for TSPYL2 Gene

Entrez Gene Summary for TSPYL2 Gene

  • This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

GeneCards Summary for TSPYL2 Gene

TSPYL2 (TSPY-Like 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include rDNA binding. An important paralog of this gene is TSPY2.

UniProtKB/Swiss-Prot for TSPYL2 Gene

  • Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

Gene Wiki entry for TSPYL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPYL2 Gene

Genomics for TSPYL2 Gene

Genomic Location for TSPYL2 Gene

53,082,360 bp from pter
53,088,546 bp from pter
6,187 bases
Plus strand

Genomic View for TSPYL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPYL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPYL2 Gene

Regulatory Elements for TSPYL2 Gene

Proteins for TSPYL2 Gene

  • Protein details for TSPYL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded-like protein 2
    Protein Accession:
    Secondary Accessions:
    • O94799
    • Q96DG7
    • Q9BZW6

    Protein attributes for TSPYL2 Gene

    693 amino acids
    Molecular mass:
    79435 Da
    Quaternary structure:
    • Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).
    • Subject to X inactivation
    • Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.
    • Sequence=AAG53596.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSPYL2 Gene

Proteomics data for TSPYL2 Gene at MOPED

Post-translational modifications for TSPYL2 Gene

  • Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys384

Other Protein References for TSPYL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPYL2 Gene

Domains for TSPYL2 Gene

Protein Domains for TSPYL2 Gene


  • Belongs to the nucleosome assembly protein (NAP) family.:
    • Q9H2G4
genes like me logo Genes that share domains with TSPYL2: view

No data available for Gene Families for TSPYL2 Gene

Function for TSPYL2 Gene

Molecular function for TSPYL2 Gene

UniProtKB/Swiss-Prot Function: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
UniProtKB/Swiss-Prot Induction: Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid (ATRA) in lung cancer cells (at protein level).

Gene Ontology (GO) - Molecular Function for TSPYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000182 rDNA binding NAS 11395479
genes like me logo Genes that share ontologies with TSPYL2: view
genes like me logo Genes that share phenotypes with TSPYL2: view

Animal Models for TSPYL2 Gene

MGI Knock Outs for TSPYL2:

miRNA for TSPYL2 Gene

miRTarBase miRNAs that target TSPYL2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TSPYL2 Gene

Localization for TSPYL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPYL2 Gene

Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TSPYL2 Gene COMPARTMENTS Subcellular localization image for TSPYL2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TSPYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 11395479
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with TSPYL2: view

Pathways for TSPYL2 Gene

genes like me logo Genes that share pathways with TSPYL2: view

Gene Ontology (GO) - Biological Process for TSPYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with TSPYL2: view

Transcripts for TSPYL2 Gene

Unigene Clusters for TSPYL2 Gene

TSPY-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - -
SP4: -
SP5: - - - -

Relevant External Links for TSPYL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPYL2 Gene

mRNA expression in normal human tissues for TSPYL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPYL2 Gene

SOURCE GeneReport for Unigene cluster for TSPYL2 Gene Hs.136164

mRNA Expression by UniProt/SwissProt for TSPYL2 Gene

Tissue specificity: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
genes like me logo Genes that share expressions with TSPYL2: view

Orthologs for TSPYL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPYL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 31 (a)
  • 85.58 (n)
  • 83.33 (a)
(Bos Taurus)
Mammalia TSPYL2 36
  • 81.15 (n)
  • 75.11 (a)
  • 75 (a)
(Canis familiaris)
Mammalia TSPYL2 36
  • 84.41 (n)
  • 78.89 (a)
  • 76 (a)
(Mus musculus)
Mammalia Tspyl2 36
  • 77.04 (n)
  • 70.54 (a)
Tspyl2 16
Tspyl2 37
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 27 (a)
(Rattus norvegicus)
Mammalia Tspyl2 36
  • 75.97 (n)
  • 69.97 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 39 (a)
(Danio rerio)
Actinopterygii TSPY2 37
  • 21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 37
  • 31 (a)
(Caenorhabditis elegans)
Secernentea spr-2 37
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 37
  • 26 (a)
Species with no ortholog for TSPYL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPYL2 Gene

Gene Tree for TSPYL2 (if available)
Gene Tree for TSPYL2 (if available)

Paralogs for TSPYL2 Gene

Paralogs for TSPYL2 Gene

Selected SIMAP similar genes for TSPYL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPYL2: view

Variants for TSPYL2 Gene

Sequence variations from dbSNP and Humsavar for TSPYL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6650050 -- 53,084,207(+) ACATA(A/C)AATAA intron-variant
rs7885663 -- 53,085,145(+) GCTTG(C/T)TCCTG intron-variant
rs7891342 -- 53,086,676(+) GCATT(C/T)CCAGG intron-variant, utr-variant-3-prime
rs7891374 -- 53,086,727(+) CTGAG(C/T)CCAGA intron-variant, utr-variant-3-prime
rs12399509 -- 53,081,386(+) agttg(A/G)gggat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSPYL2 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv508773 CNV Insertion 20534489

Relevant External Links for TSPYL2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for TSPYL2 Gene

(1) University of Copenhagen DISEASES for TSPYL2 Gene

genes like me logo Genes that share disorders with TSPYL2: view

No data available for UniProtKB/Swiss-Prot for TSPYL2 Gene

Publications for TSPYL2 Gene

  1. Identification of Differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. (PMID: 11318608) Ozbun L.L. … Jakowlew S.B. (Genomics 2001) 2 3 4
  2. SET-related cell division autoantigen-1 (CDA1) arrests cell growth. (PMID: 11395479) Chai Z. … Toh B.-H. (J. Biol. Chem. 2001) 2 3 4
  3. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. (PMID: 18381359) Kandalaft L.E. … Jakowlew S.B. (Carcinogenesis 2008) 3 23
  4. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  5. Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates. (PMID: 15823505) Ozbun L.L. … Jakowlew S.B. (Biochim. Biophys. Acta 2005) 3 4

Products for TSPYL2 Gene

  • antibodies-online proteins for TSPYL2
  • antibodies-online antibodies for TSPYL2
  • antibodies-online kits for TSPYL2

Sources for TSPYL2 Gene

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