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TSPYL2 Gene

protein-coding   GIFtS: 59
GCID: GC0XP053111

TSPY-Like 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TSPY-Like 21 2     CINAP2 5
CDA12 3 5     CTCL2
DENTT2 3 5     HRIHFB22162
Cell Division Autoantigen 12 3     SE2042
Cutaneous T-Cell Lymphoma-Associated Antigen Se20-42 3     CASK-Interacting Nucleosome Assembly Protein2
Differentially-Expressed Nucleolar TGF-Beta1 Target Protein2 3     CTCL Tumor Antigen Se20-42
Nuclear Protein Of 79 KDa2 3     Cutaneous T-Cell Lymphoma-Associated Tumor Antigen Se20-42
NP792 3     Differentially Expressed Nucleolar TGF-Beta1 Target2
TSPX2 3     Testis-Specific Protein Y Encoded-Like 22
CTCL-Associated Antigen Se20-42 3     Testis-Specific Y-Encoded-Like Protein 22
TSPY-Like Protein 22 3     

External Ids:    HGNC: 243581   Entrez Gene: 640612   Ensembl: ENSG000001842057   OMIM: 3005645   UniProtKB: Q9H2G43   

Export aliases for TSPYL2 gene to outside databases

Previous GC identifers: GC0XP052994 GC0XP053128 GC0XP050176


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPYL2 Gene:
This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1
superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as
an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth.
(provided by RefSeq, Sep 2009)

GeneCards Summary for TSPYL2 Gene:
TSPYL2 (TSPY-like 2) is a protein-coding gene. GO annotations related to this gene include rDNA binding. An important paralog of this gene is SET.

UniProtKB/Swiss-Prot: TSYL2_HUMAN, Q9H2G4
Function: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to
neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by
inducing p53-dependent CDKN1A expression

Gene Wiki entry for TSPYL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011630.15  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPYL2 gene promoter:
         ER-alpha   POU3F1   HSF1 (long)   C/EBPalpha   CREB   AREB6   CHOP-10   Ik-2   deltaCREB   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPYL2 promoter sequence
   Search Chromatin IP Primers for TSPYL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPYL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11

TSPYL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPYL2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP053111:  view genomic region     (about GC identifiers)

Start:
53,111,542 bp from pter      End:
53,117,728 bp from pter
Size:
6,187 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSYL2_HUMAN, Q9H2G4 (See protein sequence)
Recommended Name: Testis-specific Y-encoded-like protein 2  
Size: 693 amino acids; 79435 Da
Subunit: Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By
similarity)
Miscellaneous: Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation
(By similarity)
Miscellaneous: Subject to X inactivation
Sequence caution: Sequence=AAG53596.1; Type=Erroneous initiation;
Secondary accessions: O94799 Q96DG7 Q9BZW6

Explore the universe of human proteins at neXtProt for TSPYL2: NX_Q9H2G4

Explore proteomics data for TSPYL2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation (Probable)1
  • Ubiquitination2 at Lys384
  • Modification sites at PhosphoSitePlus

  • See TSPYL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071400.1  
    ENSEMBL proteins: 
     ENSP00000364591   ENSP00000462287   ENSP00000462635  
    Reactome Protein details: Q9H2G4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q9H2G4

    ProtoNet protein and cluster: Q9H2G4

    1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: TSYL2_HUMAN, Q9H2G4
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    Find genes that share domains with TSPYL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSYL2_HUMAN, Q9H2G4
    Function: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to
    neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by
    inducing p53-dependent CDKN1A expression
    Induction: Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid (ATRA) in lung
    cancer cells (at protein level)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000182rDNA binding NAS11395479
         
    Find genes that share ontologies with TSPYL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TSPYL2:
     Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tspyl2):
     cellular  mortality/aging  nervous system  no phenotypic analysis  reproductive system 
     tumorigenesis 

    Find genes that share phenotypes with TSPYL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tspyl2tm1.1Sich for TSPYL2

       genOway: Develop your customized and physiologically relevant rodent model for TSPYL2

    miRNA
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    miRTarBase miRNAs that target TSPYL2:
    hsa-mir-15a-5p (MIRT004680), hsa-mir-320a (MIRT044649), hsa-mir-335-5p (MIRT016836)

    Block miRNA regulation of human, mouse, rat TSPYL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPYL2 (see all 32):
    hsa-miR-596 hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-519a hsa-miR-4314 hsa-miR-424 hsa-miR-637
    SwitchGear 3'UTR luciferase reporter plasmidTSPYL2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSYL2_HUMAN, Q9H2G4: Nucleus. Cytoplasm (By similarity). Note=Enriched in transcriptionally active regions of
    chromatin in neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    plasma membrane4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA11395479
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with TSPYL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TSPYL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with TSPYL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TSPYL2
        XBP1(S) activates chaperone genes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPYL2
    Interactions:

        GeneGlobe Interaction Network for TSPYL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TSPYL2 (Q9H2G42, 3 ENSP000003645914) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2875685 MINT-2875704 I2D: score=3 STRING: ENSP00000400806
    COILP384322, 3, ENSP000002403164MINT-2875723 I2D: score=3 STRING: ENSP00000240316
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2875742 I2D: score=3 STRING: ENSP00000344782
    CASKO149363, ENSP000003674084I2D: score=3 STRING: ENSP00000367408
    CDK2P249413, ENSP000002669704I2D: score=3 STRING: ENSP00000266970
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007049cell cycle IEA--

    Find genes that share ontologies with TSPYL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPYL2 (TSYL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSPYL2 gene: 
    NM_022117.3  

    Unigene Cluster for TSPYL2:

    TSPY-like 2
    Hs.136164  [show with all ESTs]
    Unigene Representative Sequence: AY040871
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553557(uc004drx.1) ENST00000375442(uc004drw.3) ENST00000579390
    ENST00000578306 ENST00000556808(uc004drv.3) ENST00000463525
    miRNA
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    hsa-miR-596 hsa-miR-15a hsa-miR-503 hsa-miR-301a hsa-miR-519a hsa-miR-4314 hsa-miR-424 hsa-miR-637
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      QuantiTect SYBR Green Assays in human, mouse, rat TSPYL2
      QuantiFast Probe-based Assays in human, mouse, rat TSPYL2

    Additional mRNA sequence: 

    AB015345.1 AF254794.1 AF273046.1 AK292462.1 AL713652.1 AY040871.1 BC001566.1 BC024270.1 

    6 DOTS entries:

    DT.411866  DT.91772923  DT.91772918  DT.86835833  DT.95193180  DT.99961722 

    Selected AceView cDNA sequences (see all 280):

    BQ721304 AI270682 BC024270 BF873700 AI298628 AA516360 CD366683 CK822692 
    AI921773 BF873687 CA392040 AL713652 AY040871 N33443 BM888372 BQ549481 
    BX096759 BQ447742 BM988283 AI215638 CD105238 CA395442 CA392039 BC001566 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
    SP1:              -           -                                         -     -                     
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:              -                                                                                 
    SP5:                                                              -     -     -     -               


    ECgene alternative splicing isoforms for TSPYL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPYL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCGCTGC
    TSPYL2 Expression
    About this image

    TSPYL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPYL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.136164

    UniProtKB/Swiss-Prot: TSYL2_HUMAN, Q9H2G4
    Tissue specificity: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in
    liver and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPYL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPYL2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspyl21 , 5 TSPY-like 21, 5 77.04(n)1
    70.54(a)1
      X (68.46 cM)5
    528081  NM_029836.31  NP_084112.11 
     1523368525 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    2(89264771-89274104)
    zebrafish
    (Danio rerio)
    Actinopterygii TSPY26
    testis specific protein, Y-linked 2
    21(a)
    1 → many
    8(26561010-26569017) ENSDARG00000005015
    fruit fly
    (Drosophila melanogaster)
    Insecta Set6
    Set
    31(a)
    1 → many
    3R(11089257-11090975)
    worm
    (Caenorhabditis elegans)
    Secernentea spr-26
    Protein SPR-2, isoform b (spr-2) mRNA, complete cd...
    26(a)
    1 → many
    IV(8891470-8892747) WBGene00005007


    ENSEMBL Gene Tree for TSPYL2 (if available)
    TreeFam Gene Tree for TSPYL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPYL2 gene
    SET2  TSPY6P2  TSPYL12  TSPYL62  TSPY42  TSPY12  TSPY82  TSPYL52  
    TSPYL42  TSPY102  TSPY22  TSPY32  
    3 SIMAP similar genes for TSPYL2 using alignment to 3 protein entries:     TSYL2_HUMAN (see all proteins):
    TSPYL1    TSPYL6    TSPY26P

    Find genes that share paralogs with TSPYL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPYL2 (see all 183)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123995091,2
    C--53110568(+) agttgA/Ggggat 1 -- us2k10--------
    rs1831160831,2
    --53110747(+) AGAAGA/GGGGGG 1 -- us2k10--------
    rs1859533091,2
    --53111152(+) TCATGC/TGAGCA 1 -- us2k10--------
    rs1923224611,2
    --53111218(+) ACTGGC/TACTTT 1 -- us2k10--------
    rs676362881,2
    C--53111429(+) GCGCG-/ATCGCC 1 -- us2k10--------
    rs1836422061,2
    --53111732(+) GCAGCC/TCCGAG 2 P S mis10--------
    rs3749492511,2
    C--53111950(+) ACGCTC/TGGTGC 4 L syn10--------
    rs2002359101,2
    C--53111952(+) GCTCGC/GTGCTG 4 A G mis10--------
    rs2008237251,2
    --53112053(+) CCTCGA/GGGGGG 4 R G mis10--------
    rs2015274961,2
    C--53112054(+) CTCGGG/TGGGGA 4 G V mis10--------

    HapMap Linkage Disequilibrium report for TSPYL2 (53111542 - 53117728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TSPYL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740175CNV Deletion23290073
    nsv435891CNV Deletion17901297
    nsv508773CNV Insertion20534489

    Locus Specific Mutation Databases (LSDB): TSPYL2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSPYL2
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPYL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300564    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TSPYL2:
    Gonadoblastoma

    Find genes that share disorders with TSPYL2           About GenesLikeMe


    Export disorders for TSPYL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPYL2 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with TSPYL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SET-related cell division autoantigen-1 (CDA1) arrests cell growth. (PubMed id 11395479)1, 2, 3 Chai Z.... Toh B.-H. (J. Biol. Chem. 2001)
    2. Identification of Differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. (PubMed id 11318608)1, 2, 3 Ozbun L.L.... Jakowlew S.B. (Genomics 2001)
    3. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. (PubMed id 17317670)1, 2 Tu Y....Chai Z. (J. Biol. Chem. 2007)
    4. Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates. (PubMed id 15823505)1, 2 Ozbun L.L.... Jakowlew S.B. (Biochim. Biophys. Acta 2005)
    5. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    6. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. (PubMed id 18381359)1, 9 Kandalaft L.E....Jakowlew S.B. (Carcinogenesis 2008)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury. (PubMed id 23929772)1 Chai Z....Cooper M.E. (J. Am. Soc. Nephrol. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. (PubMed id 22038794)1 Drakou C.E.... Zographos S.E. (Proteins 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64061 HGNC: 24358 AceView: TSPYL2 Ensembl:ENSG00000184205 euGenes: HUgn64061
    ECgene: TSPYL2 H-InvDB: TSPYL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TSPYL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPYL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TSPYL2 gene:
    Search GeneIP for patents involving TSPYL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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