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Aliases for TSPYL2 Gene

Aliases for TSPYL2 Gene

  • TSPY-Like 2 2 3 5
  • Differentially-Expressed Nucleolar TGF-Beta1 Target Protein 3 4
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se20-4 3 4
  • CTCL-Associated Antigen Se20-4 3 4
  • Cell Division Autoantigen 1 3 4
  • Nuclear Protein Of 79 KDa 3 4
  • TSPY-Like Protein 2 3 4
  • DENTT 3 4
  • CDA1 3 4
  • NP79 3 4
  • TSPX 3 4
  • Cutaneous T-Cell Lymphoma-Associated Tumor Antigen Se20-4 3
  • Differentially Expressed Nucleolar TGF-Beta1 Target 3
  • CASK-Interacting Nucleosome Assembly Protein 3
  • Testis-Specific Protein Y Encoded-Like 2 3
  • CTCL Tumor Antigen Se20-4 3
  • HRIHFB2216 3
  • CINAP 3
  • SE204 3
  • CTCL 3

External Ids for TSPYL2 Gene

Previous GeneCards Identifiers for TSPYL2 Gene

  • GC0XP052994
  • GC0XP053128
  • GC0XP050176
  • GC0XP053111

Summaries for TSPYL2 Gene

Entrez Gene Summary for TSPYL2 Gene

  • This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

GeneCards Summary for TSPYL2 Gene

TSPYL2 (TSPY-Like 2) is a Protein Coding gene. Diseases associated with TSPYL2 include dyserythropoietic anemia, congenital, type ia and gonadoblastoma. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification. GO annotations related to this gene include rDNA binding. An important paralog of this gene is TSPY4.

UniProtKB/Swiss-Prot for TSPYL2 Gene

  • Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.

Gene Wiki entry for TSPYL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPYL2 Gene

Genomics for TSPYL2 Gene

Regulatory Elements for TSPYL2 Gene

Enhancers for TSPYL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPYL2 on UCSC Golden Path with GeneCards custom track

Promoters for TSPYL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPYL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPYL2 Gene

Chromosome:
X
Start:
53,082,360 bp from pter
End:
53,088,546 bp from pter
Size:
6,187 bases
Orientation:
Plus strand

Genomic View for TSPYL2 Gene

Genes around TSPYL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPYL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPYL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPYL2 Gene

Proteins for TSPYL2 Gene

  • Protein details for TSPYL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2G4-TSYL2_HUMAN
    Recommended name:
    Testis-specific Y-encoded-like protein 2
    Protein Accession:
    Q9H2G4
    Secondary Accessions:
    • O94799
    • Q96DG7
    • Q9BZW6

    Protein attributes for TSPYL2 Gene

    Size:
    693 amino acids
    Molecular mass:
    79435 Da
    Quaternary structure:
    • Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).
    Miscellaneous:
    • Subject to X inactivation.
    • Synaptic activity down-regulates TSPYL2 protein levels by inducing rapid proteasomal degradation.
    SequenceCaution:
    • Sequence=AAG53596.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TSPYL2 Gene

Proteomics data for TSPYL2 Gene at MOPED

Post-translational modifications for TSPYL2 Gene

  • Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
  • Ubiquitination at Lys 384
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPYL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPYL2 Gene

Domains & Families for TSPYL2 Gene

Protein Domains for TSPYL2 Gene

Suggested Antigen Peptide Sequences for TSPYL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2G4

UniProtKB/Swiss-Prot:

TSYL2_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPYL2: view

No data available for Gene Families for TSPYL2 Gene

Function for TSPYL2 Gene

Molecular function for TSPYL2 Gene

UniProtKB/Swiss-Prot Function:
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
UniProtKB/Swiss-Prot Induction:
Up-regulated in growth-arrested T-cells. Induced by TGFB1 and all-trans retinoic acid (ATRA) in lung cancer cells (at protein level).
genes like me logo Genes that share phenotypes with TSPYL2: view

Animal Models for TSPYL2 Gene

MGI Knock Outs for TSPYL2:

Animal Model Products

CRISPR Products

miRNA for TSPYL2 Gene

miRTarBase miRNAs that target TSPYL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPYL2 Gene

Localization for TSPYL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPYL2 Gene

Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPYL2 Gene COMPARTMENTS Subcellular localization image for TSPYL2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TSPYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11395479
GO:0005730 nucleolus IDA 11395479
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TSPYL2: view

Pathways & Interactions for TSPYL2 Gene

genes like me logo Genes that share pathways with TSPYL2: view

Gene Ontology (GO) - Biological Process for TSPYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008156 negative regulation of DNA replication IDA 11395479
GO:0009966 regulation of signal transduction NAS 11395479
GO:0016568 chromatin modification IEA --
GO:0030308 negative regulation of cell growth IDA 11395479
genes like me logo Genes that share ontologies with TSPYL2: view

No data available for SIGNOR curated interactions for TSPYL2 Gene

Drugs & Compounds for TSPYL2 Gene

No Compound Related Data Available

Transcripts for TSPYL2 Gene

Unigene Clusters for TSPYL2 Gene

TSPY-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPYL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - -
SP2:
SP3:
SP4: -
SP5: - - - -

Relevant External Links for TSPYL2 Gene

GeneLoc Exon Structure for
TSPYL2
ECgene alternative splicing isoforms for
TSPYL2

Expression for TSPYL2 Gene

mRNA expression in normal human tissues for TSPYL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TSPYL2 Gene

This gene is overexpressed in Lung (41.1), Testis (9.7), and Fetal Brain (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPYL2 Gene



SOURCE GeneReport for Unigene cluster for TSPYL2 Gene Hs.136164

mRNA Expression by UniProt/SwissProt for TSPYL2 Gene

Q9H2G4-TSYL2_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
genes like me logo Genes that share expression patterns with TSPYL2: view

Protein tissue co-expression partners for TSPYL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TSPYL2 Gene

Orthologs for TSPYL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPYL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TSPYL2 35
  • 81.15 (n)
  • 75.11 (a)
TSPYL2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TSPYL2 35
  • 84.41 (n)
  • 78.89 (a)
TSPYL2 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tspyl2 35
  • 77.04 (n)
  • 70.54 (a)
Tspyl2 16
Tspyl2 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TSPYL2 35
  • 85.58 (n)
  • 83.33 (a)
-- 36
  • 31 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tspyl2 35
  • 75.97 (n)
  • 69.97 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TSPY2 36
  • 21 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Set 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spr-2 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 36
  • 26 (a)
OneToMany
Species with no ortholog for TSPYL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPYL2 Gene

ENSEMBL:
Gene Tree for TSPYL2 (if available)
TreeFam:
Gene Tree for TSPYL2 (if available)

Paralogs for TSPYL2 Gene

(3) SIMAP similar genes for TSPYL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPYL2: view

Variants for TSPYL2 Gene

Sequence variations from dbSNP and Humsavar for TSPYL2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_075536 -
rs6650050 -- 53,084,207(+) ACATA(A/C)AATAA intron-variant
rs7885663 -- 53,085,145(+) GCTTG(C/T)TCCTG intron-variant
rs7891342 -- 53,086,676(+) GCATT(C/T)CCAGG intron-variant, utr-variant-3-prime
rs7891374 -- 53,086,727(+) CTGAG(C/T)CCAGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TSPYL2 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv508773 CNV Insertion 20534489

Variation tolerance for TSPYL2 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPYL2 Gene

HapMap Linkage Disequilibrium report
TSPYL2
Human Gene Mutation Database (HGMD)
TSPYL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPYL2 Gene

Disorders for TSPYL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSPYL2 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
dyserythropoietic anemia, congenital, type ia
  • anemia, congenital dyserythropoietic, type i
gonadoblastoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPYL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPYL2
genes like me logo Genes that share disorders with TSPYL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPYL2 Gene

Publications for TSPYL2 Gene

  1. SET-related cell division autoantigen-1 (CDA1) arrests cell growth. (PMID: 11395479) Chai Z. … Toh B.-H. (J. Biol. Chem. 2001) 2 3 4 67
  2. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. (PMID: 18381359) Kandalaft L.E. … Jakowlew S.B. (Carcinogenesis 2008) 3 23
  3. Identification of Differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. (PMID: 11318608) Ozbun L.L. … Jakowlew S.B. (Genomics 2001) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TSPYL2 Gene

Sources for TSPYL2 Gene

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