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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPY8 Gene

protein-coding   GIFtS: 28
GCID: GC0YP009197          (predicted)

Testis Specific Protein, Y-Linked 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Specific Protein, Y-Linked 81 2
Testis-Specific Y-Encoded Protein 82

External Ids:    HGNC: 374711   Entrez Gene: 7284032   Ensembl: ENSG000002295497   UniProtKB: P0CW003   

Export aliases for TSPY8 gene to outside databases

Previous GC identifers: GC0YP009256 GC0YP009196


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TSPY8 Gene: 
TSPY8 (testis specific protein, Y-linked 8) is a protein-coding gene. Diseases associated with TSPY8 include acute myeloid leukemia, and myeloid leukemia. An important paralog of this gene is SET.

UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00
Function: May be involved in sperm differentiation and proliferation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000024.9  NT_086998.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TSPY8
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yp11.2   Ensembl cytogenetic band:  Yp11.2   HGNC cytogenetic band: Yp11.2

TSPY8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPY8 gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP009197:  view genomic region     (about GC identifiers)

Start:
9,195,406 bp from pter      End:
9,218,479 bp from pter
Size:
23,074 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00 (See protein sequence)
Recommended Name: Testis-specific Y-encoded protein 8  
Size: 308 amino acids; 35147 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: H7BXJ3

Explore the universe of human proteins at neXtProt for TSPY8: NX_P0CW00

Explore proteomics data for TSPY8 at MOPED 

TSPY8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TSPY8 Protein Expression

REFSEQ proteins: NP_001230650.1  
ENSEMBL proteins: 
 ENSP00000287721   ENSP00000372462   ENSP00000372467   ENSP00000327984   ENSP00000439701  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm IEA--

TSPY8 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR002164 NAP_family

Graphical View of Domain Structure for InterPro Entry P0CW00

ProtoNet protein and cluster: P0CW00

UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00
Similarity: Belongs to the nucleosome assembly protein (NAP) family


TSPY8 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TSPY8_HUMAN, P0CW00
Function: May be involved in sperm differentiation and proliferation (By similarity)

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPY8

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006334nucleosome assembly IEA--
GO:0007283spermatogenesis IEA--
GO:0007506gonadal mesoderm development IEA--
GO:0030154cell differentiation IEA--

TSPY8 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TSPY8

Search CenterWatch for drugs/clinical trials and news about TSPY8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSPY8 gene: 
NM_001243721.1  

Unigene Cluster for TSPY8:

Testis specific protein, Y-linked 8
Hs.740264
Unigene Representative Sequence: NM_001243721
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000287721(uc004frr.2) ENST00000383000 ENST00000477879(uc004frq.2)
ENST00000436159 ENST00000383005 ENST00000330628(uc022cjc.1) ENST00000537415

miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPY8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TSPY8 Expression
About this image


See TSPY8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPY8

SOURCE GeneReport for Unigene cluster: Hs.740264
    SABiosciences Custom PCR Arrays for TSPY8
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TSPY8 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
--
25(a)
1 → many
2(89264771-89274104)
zebrafish
(Danio rerio)
Actinopterygii TSPYL16
TSPY-like 1
15(a)
1 → many
8(26561010-26569017)
fruit fly
(Drosophila melanogaster)
Insecta Set6
Set
26(a)
1 → many
3R(11089257-11090975)
worm
(Caenorhabditis elegans)
Secernentea spr-26
Suppressor of presenilin-2
18(a)
1 → many
IV(8891470-8892747)
        Species with no ortholog for TSPY8

ENSEMBL Gene Tree for TSPY8 (if available)
TreeFam Gene Tree for TSPY8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TSPY8 gene
SET2  TSPY6P2  TSPYL12  TSPYL62  TSPY42  TSPY12  TSPYL22  TSPYL52  
TSPYL42  TSPY102  TSPY22  TSPY32  
16 SIMAP similar genes for TSPY8 using alignment to 5 protein entries:     TSPY8_HUMAN (see all proteins):
TSPY2    TSPY4    TSPY1    TSPY10    TSPY3    TSPY6P
LOC728395    FAM197Y1    TSPYL1    TSPYL    DKFZp434M235    TSPYL4
CYorf16    TSPY26P    SET    TSPYL6

TSPY8 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00
Polymorphism: Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported
originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and
between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from
one individual have been reported (PubMed:12815422)


8 SNPs in TSPY8 are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr Y posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3677541611,2
----9198272(+) TGTGTG/TTGTGT 1 -- ds50010--------
rs3727730561,2
----9198243(+) CTTTGA/TGTTTG 1 -- ds50010--------
rs3686326901,2
----9197998(+) GGACTC/TCCAGT 2 S F mis10--------
rs3746692581,2
----9198268(+) TGTGTA/GTGTGT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for TSPY8 (9195406 - 9218479 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for TSPY8:    About this table     
Variant IDTypeSubtypePubMed ID
nsv469840CNV Loss16826518
nsv471608CNV Gain+Loss15918152
essv6780CNV CNV17122850
nsv7473OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for TSPY8:    About MalaCards
acute myeloid leukemia    myeloid leukemia    leukemia


TSPY8 for disorders           About GeneDecksing


Export disorders for TSPY8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TSPY8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPY8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
  2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 728403 HGNC: 37471 Ensembl:ENSG00000229549 euGenes: HUgn728403 ECgene: TSPY8
H-InvDB: TSPY8

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TSPY8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TSPY8 gene:
Search GeneIP for patents involving TSPY8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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