TSPY8 Gene
protein-coding GIFtS: 28
GCID: GC0YP009197 (predicted)
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testis specific protein, Y-linked 8
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Aliases
for TSPY8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis Specific Protein, Y-Linked 81 2 | | Testis-Specific Y-Encoded Protein 82 |
Export aliases for TSPY8 gene to outside databasesPrevious GC identifers: GC0YP009256 GC0YP009196 |
Summaries
for TSPY8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)
|
Genomic Views
for TSPY8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_086998.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TSPY8
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPY8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yp11.2 Ensembl cytogenetic band: Yp11.2 HGNC cytogenetic band: Yp11.2TSPY8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP009197: view genomic region
(about GC identifiers)
Start:
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9,195,406 bp from pter |
End:
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9,218,479 bp from pter |
Size:
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23,074 bases |
Orientation:
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plus strand |
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Proteins
for TSPY8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00 (See
protein sequence)Recommended Name: Testis-specific Y-encoded protein 8 Size: 314 amino acids; 35727 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)Explore the universe of human proteins at neXtProt for TSPY8: NX_P0CW00
TSPY8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001230650.1
ENSEMBL proteins: ENSP00000287721 ENSP00000372462 ENSP00000372467 ENSP00000327984 ENSP00000439701
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TSPY8 for ontologies About GeneDecksing
TSPY8 Antibody Products:
Assay Products for TSPY8: |
Protein
Domains /
Families
for TSPY8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPY8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0CW00ProtoNet protein and cluster: P0CW00 UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00Similarity: Belongs to the nucleosome assembly protein (NAP) family |
Function
for TSPY8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY8 |
|
Pathways & Interactions
for TSPY8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPY8
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TSPY8 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSPY8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSPY8
Search CenterWatch for drugs/clinical trials and news about TSPY8 
|
Transcripts
for TSPY8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSPY8 gene: NM_001243721.1 Unigene Cluster for TSPY8: Testis specific protein, Y-linked 8 Hs.740264 Unigene Representative Sequence: NM_0012437217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287721(uc004frr.2) ENST00000383000 ENST00000477879(uc004frq.2)
ENST00000436159 ENST00000383005 ENST00000330628(uc022cjc.1) ENST00000537415
GeneLoc Exon Structure
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Expression
for TSPY8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSPY8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TSPY8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPY8
SOURCE GeneReport for Unigene cluster: Hs.740264
SABiosciences Custom PCR Arrays for TSPY8
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TSPY8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPY8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPY8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY8 |
Orthologs
for TSPY8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSPY8 gene from 6/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
31(a) |
1 → many |
2(89265460-89270074) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:664306 |
zgc:66430 |
17(a) |
1 → many |
8(26561010-26569017) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Set6 |
Set |
26(a) |
1 → many |
3R(11089257-11090975) |
worm
(Caenorhabditis elegans) |
Secernentea |
spr-26 |
Suppressor of presenilin-2 |
19(a) |
1 → many |
IV(8891457-8892734) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NRP16NRP26 |
template-activating factor I |
22(a)22(a) |
many ↔ manymany ↔ many |
1(28017584-28020049) 1(6481113-6483596) |
rice
(Oryza sativa) |
Liliopsida |
---- |
SET, putative, expressedNAP domain containing protein, putative, expressed... |
25(a)20(a) |
many ↔ manymany ↔ many |
2(22145563-22150173) 4(22758069-22761770) |
ENSEMBL Gene Tree for TSPY8 (if available)
TreeFam Gene Tree for TSPY8 (if available) |
Paralogs
for TSPY8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSPY8 gene
- SET2 TSPYL12 TSPYL62 TSPY42 TSPY12 TSPYL22 TSPYL52 TSPYL42
- TSPY102 TSPY22 TSPY32
15 SIMAP similar genes for TSPY8 using alignment to 6 protein entries: TSPY8_HUMAN (see all proteins):TSPY4 TSPY2 TSPY1 TSPY10 TSPY3 LOC728395
FAM197Y1 TSPYL1 DKFZp434M235 TSPYL TSPYL4 SET
CYorf16 TSPY26P TSPYL6
TSPY8 for paralogs About GeneDecksing
|
Genomic Variants
for TSPY8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: TSPY8_HUMAN, P0CW00Polymorphism: Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reportedoriginating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from oneindividual have been reported (PubMed:12815422)
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPY8 |
|
Disorders
/ Diseases
for TSPY8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPY8 for disorders About GeneDecksing
4  diseases for TSPY8: About MalaCardsacute myeloid leukemia myeloid leukemia leukemia malaria
Export disorders for TSPY8 gene to outside databases
|
Publications
for TSPY8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSPY8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPY8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for TSPY8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TSPY8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPY8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPY8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSPY8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSPY8 gene:
Search GeneIP for patents involving TSPY8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSPY8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPY8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPY8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPY8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPY8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPY8 |
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 |  |  |  | |
| | | | Search Tocris compounds for TSPY8 |
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 | | | TSPY8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY8 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSPY8 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TSPY8 |
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