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Aliases for TSPY8 Gene

Aliases for TSPY8 Gene

  • Testis Specific Protein, Y-Linked 8 2 3

External Ids for TSPY8 Gene

Previous GeneCards Identifiers for TSPY8 Gene

  • GC0YP009256
  • GC0YP009196
  • GC0YP009197

Summaries for TSPY8 Gene

GeneCards Summary for TSPY8 Gene

TSPY8 (Testis Specific Protein, Y-Linked 8) is a Protein Coding gene. An important paralog of this gene is TSPY2.

UniProtKB/Swiss-Prot for TSPY8 Gene

  • May be involved in sperm differentiation and proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPY8 Gene

Genomics for TSPY8 Gene

Genomic Location for TSPY8 Gene

9,357,797 bp from pter
9,380,870 bp from pter
23,074 bases
Plus strand

Genomic View for TSPY8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPY8 Gene

No data available for Regulatory Elements for TSPY8 Gene

Proteins for TSPY8 Gene

  • Protein details for TSPY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded protein 8
    Protein Accession:
    Secondary Accessions:
    • H7BXJ3

    Protein attributes for TSPY8 Gene

    308 amino acids
    Molecular mass:
    35147 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPY8 Gene

Proteomics data for TSPY8 Gene at MOPED

Post-translational modifications for TSPY8 Gene

No Post-translational modifications

Other Protein References for TSPY8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPY8 Gene

Domains & Families for TSPY8 Gene

Protein Domains for TSPY8 Gene


Suggested Antigen Peptide Sequences for TSPY8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPY8: view

No data available for Gene Families for TSPY8 Gene

Function for TSPY8 Gene

Molecular function for TSPY8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sperm differentiation and proliferation.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPY8 Gene

Localization for TSPY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPY8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for TSPY8 Gene COMPARTMENTS Subcellular localization image for TSPY8 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TSPY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TSPY8: view

Pathways & Interactions for TSPY8 Gene

SuperPathways for TSPY8 Gene

No Data Available

Interacting Proteins for TSPY8 Gene

Gene Ontology (GO) - Biological Process for TSPY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0007283 spermatogenesis IEA --
GO:0007506 gonadal mesoderm development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSPY8: view

No data available for Pathways by source and SIGNOR curated interactions for TSPY8 Gene

Drugs & Compounds for TSPY8 Gene

No Compound Related Data Available

Transcripts for TSPY8 Gene

mRNA/cDNA for TSPY8 Gene

(3) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TSPY8 Gene

No ASD Table

Relevant External Links for TSPY8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPY8 Gene

mRNA expression in normal human tissues for TSPY8 Gene

mRNA differential expression in normal tissues according to GTEx for TSPY8 Gene

This gene is overexpressed in Testis (x52.6).

SOURCE GeneReport for Unigene cluster for TSPY8 Gene Hs.740264

genes like me logo Genes that share expression patterns with TSPY8: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPY8 Gene

Orthologs for TSPY8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPY8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC101059018 35
  • 88.62 (n)
  • 76.9 (a)
  • 96 (a)
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
-- 36
  • 35 (a)
-- 36
  • 34 (a)
-- 36
  • 37 (a)
-- 36
  • 33 (a)
-- 36
  • 31 (a)
-- 36
  • 28 (a)
-- 36
  • 35 (a)
-- 36
  • 27 (a)
-- 36
  • 40 (a)
TSPY-M2 36
  • 34 (a)
TSPY-M2 36
  • 41 (a)
TSPY-M2 36
  • 40 (a)
(Canis familiaris)
Mammalia -- 36
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
(Danio rerio)
Actinopterygii TSPY2 36
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea spr-2 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 36
  • 19 (a)
Species with no ortholog for TSPY8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPY8 Gene

Gene Tree for TSPY8 (if available)
Gene Tree for TSPY8 (if available)

Paralogs for TSPY8 Gene

Paralogs for TSPY8 Gene

genes like me logo Genes that share paralogs with TSPY8: view

Variants for TSPY8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TSPY8 Gene

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from one individual have been reported (PubMed:12815422).

Sequence variations from dbSNP and Humsavar for TSPY8 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs1085096 -- 9,360,634(+) caaac(A/T)caaag downstream-variant-500B
rs3930331 -- 9,360,731(-) TCCAT(G/T)AAGAG downstream-variant-500B
rs77336777 -- 9,360,448(-) TTTTT(A/G)GGAGT utr-variant-3-prime, downstream-variant-500B
rs367754161 -- 9,360,663(+) TGTGT(G/T)TGTGT downstream-variant-500B
rs368632690 -- 9,360,389(+) GGACT(C/T)CCAGT reference, missense, utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPY8 Gene

Variant ID Type Subtype PubMed ID
nsv7473 OTHER Inversion 18451855
essv6780 CNV CNV 17122850
nsv469840 CNV Loss 16826518
nsv471608 CNV Gain+Loss 15918152

Relevant External Links for TSPY8 Gene

HapMap Linkage Disequilibrium report

No data available for Variation tolerance for TSPY8 Gene

Disorders for TSPY8 Gene

Relevant External Links for TSPY8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSPY8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPY8 Gene

Publications for TSPY8 Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 67

Products for TSPY8 Gene

Sources for TSPY8 Gene

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