TSPY4 Gene
protein-coding GIFtS: 32
GCID: GC0YP009176
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|
testis specific protein, Y-linked 4
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Aliases
for TSPY4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis Specific Protein, Y-Linked 41 2 | | TSPY102 | | TSPY82 | | Testis-Specific Y-Encoded Protein 42 |
Export aliases for TSPY4 gene to outside databasesPrevious GC identifer: GC0YP009236 |
Summaries
for TSPY4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSPY4_HUMAN, P0CV99Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)
|
Genomic Views
for TSPY4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TSPY4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPY4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yp11.2 Ensembl cytogenetic band: Yp11.2 HGNC cytogenetic band: Yp11.2TSPY4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP009176: view genomic region
(about GC identifiers)
Start:
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9,175,073 bp from pter |
End:
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9,177,893 bp from pter |
Size:
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2,821 bases |
Orientation:
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plus strand |
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Proteins
for TSPY4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSPY4_HUMAN, P0CV99 (See
protein sequence)Recommended Name: Testis-specific Y-encoded protein 4 Size: 314 amino acids; 35727 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)Explore the universe of human proteins at neXtProt for TSPY4: NX_P0CV99
TSPY4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001157943.1
ENSEMBL proteins: ENSP00000399668 ENSP00000372471
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TSPY4 for ontologies About GeneDecksing
TSPY4 Antibody Products:
Assay Products for TSPY4: |
Protein
Domains /
Families
for TSPY4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPY4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0CV99ProtoNet protein and cluster: P0CV99 UniProtKB/Swiss-Prot: TSPY4_HUMAN, P0CV99Similarity: Belongs to the nucleosome assembly protein (NAP) family |
Function
for TSPY4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSPY4_HUMAN, P0CV99Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY4 |
|
Pathways & Interactions
for TSPY4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPY4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TSPY4 (ENSP000003996684) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TSPY4 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSPY4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSPY4
Search CenterWatch for drugs/clinical trials and news about TSPY4
|
Transcripts
for TSPY4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSPY4 gene: NM_001164471.1 4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426950(uc004frn.2 uc004fro.2 uc022cja.1) ENST00000383008
ENST00000466036 ENST00000482082
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSPY4 (NM_001164471) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPY4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPY4 |
GeneLoc Exon Structure
|
Expression
for TSPY4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSPY4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TSPY4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPY4
SABiosciences Custom PCR Arrays for TSPY4
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TSPY4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPY4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPY4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY4 |
Orthologs
for TSPY4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSPY4 gene from 6/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
31(a) |
1 → many |
2(89265460-89270074) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:664306 |
zgc:66430 |
18(a) |
1 → many |
8(26561010-26569017) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Set6 |
Set |
26(a) |
1 → many |
3R(11089257-11090975) |
worm
(Caenorhabditis elegans) |
Secernentea |
spr-26 |
Suppressor of presenilin-2 |
20(a) |
1 → many |
IV(8891457-8892734) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NRP16NRP26 |
template-activating factor I |
23(a)22(a) |
many ↔ manymany ↔ many |
1(28017584-28020049) 1(6481113-6483596) |
rice
(Oryza sativa) |
Liliopsida |
---- |
SET, putative, expressedNAP domain containing protein, putative, expressed... |
26(a)20(a) |
many ↔ manymany ↔ many |
2(22145563-22150173) 4(22758069-22761770) |
ENSEMBL Gene Tree for TSPY4 (if available)
TreeFam Gene Tree for TSPY4 (if available) |
Paralogs
for TSPY4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSPY4 gene
- TSPY101 2 TSPY31 2 TSPY21 2 TSPY11 2 SET2 TSPYL12 TSPYL62 TSPY82
- TSPYL22 TSPYL52 TSPYL42
15 SIMAP similar genes for TSPY4 using alignment to 2 protein entries: TSPY4_HUMAN (see all proteins):TSPY8 TSPY1 TSPY2 TSPY10 TSPY3 FAM197Y1
DKFZp434M235 CYorf16 TSPYL1 LOC728395 TSPYL4 SET
TSPYL TSPYL6 TSPY26P
TSPY4 for paralogs About GeneDecksing
|
Genomic Variants
for TSPY4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: TSPY4_HUMAN, P0CV99Polymorphism: Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reportedoriginating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from oneindividual have been reported (PubMed:12815422)
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSPY4 (9175073 - 9177893 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TSPY4
4 CNVs: 83915 0829 2285 97174 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPY4 |
|
Disorders
/ Diseases
for TSPY4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPY4 for disorders About GeneDecksing
4  diseases for TSPY4: About MalaCardsacute myeloid leukemia myeloid leukemia leukemia malaria
Export disorders for TSPY4 gene to outside databases
|
Publications
for TSPY4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSPY4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPY4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)2 Skaletsky H.... Page D.C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TSPY4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TSPY4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPY4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPY4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSPY4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSPY4 gene:
Search GeneIP for patents involving TSPY4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSPY4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
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 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPY4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPY4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPY4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPY4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPY4 |
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 | | | TSPY4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY4 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSPY4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPY4 |
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