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Aliases for TSPY4 Gene

Aliases for TSPY4 Gene

  • Testis Specific Protein, Y-Linked 4 2 3 5
  • TSPY10 3
  • TSPY8 3

External Ids for TSPY4 Gene

Previous GeneCards Identifiers for TSPY4 Gene

  • GC0YP009236
  • GC0YP009176

Summaries for TSPY4 Gene

GeneCards Summary for TSPY4 Gene

TSPY4 (Testis Specific Protein, Y-Linked 4) is a Protein Coding gene. An important paralog of this gene is TSPY9P.

UniProtKB/Swiss-Prot for TSPY4 Gene

  • Unknown. May be involved in sperm differentiation and proliferation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPY4 Gene

Genomics for TSPY4 Gene

Genomic Location for TSPY4 Gene

Chromosome:
Y
Start:
9,337,464 bp from pter
End:
9,340,284 bp from pter
Size:
2,821 bases
Orientation:
Plus strand

Genomic View for TSPY4 Gene

Genes around TSPY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPY4 Gene

No data available for Regulatory Elements for TSPY4 Gene

Proteins for TSPY4 Gene

  • Protein details for TSPY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CV99-TSPY4_HUMAN
    Recommended name:
    Testis-specific Y-encoded protein 4
    Protein Accession:
    P0CV99

    Protein attributes for TSPY4 Gene

    Size:
    314 amino acids
    Molecular mass:
    35727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPY4 Gene

Proteomics data for TSPY4 Gene at MOPED

Post-translational modifications for TSPY4 Gene

No Post-translational modifications

Other Protein References for TSPY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPY4 Gene

Domains & Families for TSPY4 Gene

Protein Domains for TSPY4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSPY4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CV99

UniProtKB/Swiss-Prot:

TSPY4_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPY4: view

No data available for Gene Families for TSPY4 Gene

Function for TSPY4 Gene

Molecular function for TSPY4 Gene

UniProtKB/Swiss-Prot Function:
Unknown. May be involved in sperm differentiation and proliferation (By similarity).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPY4 Gene

Localization for TSPY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPY4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPY4 Gene COMPARTMENTS Subcellular localization image for TSPY4 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TSPY4 Gene

Pathways & Interactions for TSPY4 Gene

SuperPathways for TSPY4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with TSPY4: view

No data available for Pathways by source and SIGNOR curated interactions for TSPY4 Gene

Drugs & Compounds for TSPY4 Gene

No Compound Related Data Available

Transcripts for TSPY4 Gene

mRNA/cDNA for TSPY4 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TSPY4 Gene

No ASD Table

Relevant External Links for TSPY4 Gene

GeneLoc Exon Structure for
TSPY4
ECgene alternative splicing isoforms for
TSPY4

Expression for TSPY4 Gene

mRNA expression in normal human tissues for TSPY4 Gene

mRNA differential expression in normal tissues according to GTEx for TSPY4 Gene

This gene is overexpressed in Testis (x53.0).
genes like me logo Genes that share expression patterns with TSPY4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPY4 Gene

Orthologs for TSPY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101059018 35
  • 88.51 (n)
  • 76.9 (a)
-- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
TSPY-M2 36
  • 35 (a)
ManyToMany
TSPY-M2 36
  • 42 (a)
ManyToMany
TSPY-M2 36
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 33 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TSPY2 36
  • 16 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Set 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spr-2 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 36
  • 19 (a)
OneToMany
Species with no ortholog for TSPY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPY4 Gene

ENSEMBL:
Gene Tree for TSPY4 (if available)
TreeFam:
Gene Tree for TSPY4 (if available)

Paralogs for TSPY4 Gene

(16) SIMAP similar genes for TSPY4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TSPY4: view

Variants for TSPY4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TSPY4 Gene

P0CV99-TSPY4_HUMAN
Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from one individual have been reported (PubMed:12815422).

Sequence variations from dbSNP and Humsavar for TSPY4 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs3876329 -- 9,340,133(+) ACTCC(C/T)AAAAA utr-variant-3-prime
rs368120091 -- 9,339,857(+) TAGGG(C/T)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPY4 Gene

Variant ID Type Subtype PubMed ID
nsv7473 OTHER Inversion 18451855
essv6780 CNV CNV 17122850
nsv469840 CNV Loss 16826518
nsv471608 CNV Gain+Loss 15918152

Relevant External Links for TSPY4 Gene

HapMap Linkage Disequilibrium report
TSPY4

No data available for Variation tolerance for TSPY4 Gene

Disorders for TSPY4 Gene

Relevant External Links for TSPY4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPY4

No disorders were found for TSPY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPY4 Gene

Publications for TSPY4 Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TSPY4 Gene

Sources for TSPY4 Gene

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