TSPY3 Gene
protein-coding GIFtS: 37
GCID: GC0YP009237
|
|
testis specific protein, Y-linked 3
| |
Aliases
for TSPY3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis Specific Protein, Y-Linked 31 2 | | Testis-Specific Y-Encoded Protein 32 |
Export aliases for TSPY3 gene to outside databasesPrevious GC identifer: GC0YP009976 |
Summaries
for TSPY3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSPY3_HUMAN, P0CV98Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)
|
Genomic Views
for TSPY3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_086998.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSPY3 gene promoter:
AREB6 POU3F1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) ZIC2/Zic2 ZID POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPY3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yp11.2 Ensembl cytogenetic band: Yp11.2 HGNC cytogenetic band: Yp11.2TSPY3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP009237: view genomic region
(about GC identifiers)
Start:
|
9,215,731 bp from pter |
End:
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9,307,357 bp from pter |
Size:
|
91,627 bases |
Orientation:
|
plus strand |
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Proteins
for TSPY3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSPY3_HUMAN, P0CV98 (See
protein sequence)Recommended Name: Testis-specific Y-encoded protein 3 Size: 308 amino acids; 35101 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)Explore the universe of human proteins at neXtProt for TSPY3: NX_P0CV98
TSPY3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001071165.2
ENSEMBL proteins: ENSP00000398163 ENSP00000412988 ENSP00000372473 ENSP00000406010 ENSP00000396987
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TSPY3 for ontologies About GeneDecksing
TSPY3 Antibody Products:
Assay Products for TSPY3: |
Protein
Domains /
Families
for TSPY3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPY3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0CV98ProtoNet protein and cluster: P0CV98 UniProtKB/Swiss-Prot: TSPY3_HUMAN, P0CV98Similarity: Belongs to the nucleosome assembly protein (NAP) family |
Function
for TSPY3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSPY3_HUMAN, P0CV98Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY3 |
|
Pathways & Interactions
for TSPY3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPY3
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for TSPY3 (ENSP000003981634) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TSPY3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSPY3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSPY3
Search CenterWatch for drugs/clinical trials and news about TSPY3
|
Transcripts
for TSPY3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSPY3 gene: NM_001077697.2 Unigene Cluster for TSPY3: Testis specific protein, Y-linked 3 Hs.730364 [show with all ESTs]Unigene Representative Sequence: BC1211147 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000457222(uc010nwo.2 uc004fru.3) ENST00000424594 ENST00000491844
ENST00000469322 ENST00000383010 ENST00000440483 ENST00000427871
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSPY3 (NM_001077697) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPY3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPY3 |
Additional cDNA sequence: BC075016.2 BC121114.1 4 DOTS entries: DT.120651221 DT.120654200 DT.120653978 DT.410181
GeneLoc Exon Structure
|
Expression
for TSPY3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSPY3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TSPY3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPY3
SOURCE GeneReport for Unigene cluster: Hs.730364
SABiosciences Custom PCR Arrays for TSPY3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPY3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TSPY3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPY3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPY3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY3 |
Orthologs
for TSPY3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSPY3 gene from 6/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
31(a) |
1 → many |
2(89265460-89270074) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:664306 |
zgc:66430 |
18(a) |
1 → many |
8(26561010-26569017) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Set6 |
Set |
26(a) |
1 → many |
3R(11089257-11090975) |
worm
(Caenorhabditis elegans) |
Secernentea |
spr-26 |
Suppressor of presenilin-2 |
20(a) |
1 → many |
IV(8891457-8892734) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NRP16NRP26 |
template-activating factor I |
23(a)22(a) |
many ↔ manymany ↔ many |
1(28017584-28020049) 1(6481113-6483596) |
rice
(Oryza sativa) |
Liliopsida |
---- |
SET, putative, expressedNAP domain containing protein, putative, expressed... |
26(a)20(a) |
many ↔ manymany ↔ many |
2(22145563-22150173) 4(22758069-22761770) |
ENSEMBL Gene Tree for TSPY3 (if available)
TreeFam Gene Tree for TSPY3 (if available) |
Paralogs
for TSPY3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSPY3 gene
- TSPY101 2 TSPY41 2 TSPY21 2 TSPY11 2 SET2 TSPYL12 TSPYL62 TSPY82
- TSPYL22 TSPYL52 TSPYL42
15 SIMAP similar genes for TSPY3 using alignment to 4 protein entries: TSPY3_HUMAN (see all proteins):TSPY8 TSPY4 TSPY1 TSPY2 TSPY10 LOC728395
FAM197Y1 DKFZp434M235 TSPYL1 TSPYL4 TSPYL TSPY26P
SET TSPYL6 CYorf16
TSPY3 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for TSPY3
PGOHUM00000261045 PGOHUM00000261046 PGOHUM00000261047
|
Genomic Variants
for TSPY3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: TSPY3_HUMAN, P0CV98Polymorphism: Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reportedoriginating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from oneindividual have been reported (PubMed:12815422)
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSPY3 (9215731 - 9307357 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TSPY3
4 CNVs: 83915 0829 2285 97174 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TSPY3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPY3 for disorders About GeneDecksing
7  diseases for TSPY3: About MalaCardsgonadal dysgenesis gonadoblastoma acute myeloid leukemia dysgerminoma
myeloid leukemia leukemia malaria
4 diseases from the University of Copenhagen DISEASES database for TSPY3:Gonadoblastoma Dysgerminoma Turner syndrome Male infertility Export disorders for TSPY3 gene to outside databases
|
Publications
for TSPY3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSPY3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPY3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)2 Skaletsky H.... Page D.C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TSPY3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSPY3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPY3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPY3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSPY3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSPY3 gene:
Search GeneIP for patents involving TSPY3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSPY3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TSPY3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TSPY3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPY3 | | | OriGene Protein Over-expression Lysate for TSPY3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TSPY3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TSPY3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPY3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPY3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPY3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPY3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPY3 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TSPY3 |
| |  |  |  |  | | | | |
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 |
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 | | | TSPY3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY3 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSPY3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPY3 |
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