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Aliases for TSPY3 Gene

Aliases for TSPY3 Gene

  • Testis Specific Protein, Y-Linked 3 2 3
  • Testis-Specific Y-Encoded Protein 3 3
  • CT78 3

External Ids for TSPY3 Gene

Previous GeneCards Identifiers for TSPY3 Gene

  • GC0YP009976
  • GC0YP009237

Summaries for TSPY3 Gene

GeneCards Summary for TSPY3 Gene

TSPY3 (Testis Specific Protein, Y-Linked 3) is a Protein Coding gene. An important paralog of this gene is TSPY2.

UniProtKB/Swiss-Prot for TSPY3 Gene

  • Unknown. May be involved in sperm differentiation and proliferation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPY3 Gene

Genomics for TSPY3 Gene

Regulatory Elements for TSPY3 Gene

Genomic Location for TSPY3 Gene

9,398,421 bp from pter
9,401,223 bp from pter
2,803 bases
Plus strand

Genomic View for TSPY3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSPY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPY3 Gene

Proteins for TSPY3 Gene

  • Protein details for TSPY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded protein 3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TSPY3 Gene

    308 amino acids
    Molecular mass:
    35101 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPY3 Gene

Proteomics data for TSPY3 Gene at MOPED

Post-translational modifications for TSPY3 Gene

No Post-translational modifications

Other Protein References for TSPY3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPY3 Gene

Domains for TSPY3 Gene

Protein Domains for TSPY3 Gene


Suggested Antigen Peptide Sequences for TSPY3 Gene

Graphical View of Domain Structure for InterPro Entry



  • P0CV98
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPY3: view

No data available for Gene Families for TSPY3 Gene

Function for TSPY3 Gene

Molecular function for TSPY3 Gene

UniProtKB/Swiss-Prot Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSPY3 Gene

Localization for TSPY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPY3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for TSPY3 Gene COMPARTMENTS Subcellular localization image for TSPY3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TSPY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TSPY3: view

Pathways for TSPY3 Gene

SuperPathways for TSPY3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0007283 spermatogenesis IEA --
GO:0007506 gonadal mesoderm development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSPY3: view

No data available for Pathways by source for TSPY3 Gene

Transcripts for TSPY3 Gene

mRNA/cDNA for TSPY3 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPY3 Gene

Testis specific protein, Y-linked 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TSPY3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TSPY3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPY3 Gene

No ASD Table

Relevant External Links for TSPY3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPY3 Gene

mRNA expression in normal human tissues for TSPY3 Gene

mRNA differential expression in normal tissues according to GTEx for TSPY3 Gene

This gene is overexpressed in Testis (51.2).

SOURCE GeneReport for Unigene cluster for TSPY3 Gene Hs.730364

genes like me logo Genes that share expressions with TSPY3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for TSPY3 Gene

Orthologs for TSPY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPY3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC101059018 35
  • 88.62 (n)
  • 77.24 (a)
  • 97 (a)
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
-- 36
  • 35 (a)
-- 36
  • 35 (a)
-- 36
  • 37 (a)
-- 36
  • 33 (a)
-- 36
  • 31 (a)
-- 36
  • 28 (a)
-- 36
  • 36 (a)
-- 36
  • 28 (a)
-- 36
  • 41 (a)
TSPY-M2 36
  • 35 (a)
TSPY-M2 36
  • 41 (a)
TSPY-M2 36
  • 41 (a)
(Canis familiaris)
Mammalia -- 36
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
(Danio rerio)
Actinopterygii TSPY2 36
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea spr-2 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 36
  • 19 (a)
Species with no ortholog for TSPY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPY3 Gene

Gene Tree for TSPY3 (if available)
Gene Tree for TSPY3 (if available)

Paralogs for TSPY3 Gene

Paralogs for TSPY3 Gene

Selected SIMAP similar genes for TSPY3 Gene using alignment to 3 proteins: Pseudogenes for TSPY3 Gene

genes like me logo Genes that share paralogs with TSPY3: view

Variants for TSPY3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TSPY3 Gene

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from one individual have been reported (PubMed:12815422).

Sequence variations from dbSNP and Humsavar for TSPY3 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs3926917 -- 9,400,954(-) CTTTG(A/C)AATGT intron-variant
rs141241792 -- 9,397,161(+) GGCCT(A/G)GGGCA upstream-variant-2KB
rs372659318 -- 9,396,708(+) AACCC(A/G)TCTTA upstream-variant-2KB
rs376945201 -- 9,397,045(+) TCCCC(C/G)CAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TSPY3 Gene

Variant ID Type Subtype PubMed ID
nsv7473 OTHER Inversion 18451855
essv6780 CNV CNV 17122850
nsv469840 CNV Loss 16826518
nsv471608 CNV Gain+Loss 15918152

Relevant External Links for TSPY3 Gene

HapMap Linkage Disequilibrium report

Disorders for TSPY3 Gene

(4) University of Copenhagen DISEASES for TSPY3 Gene

genes like me logo Genes that share disorders with TSPY3: view

No data available for UniProtKB/Swiss-Prot for TSPY3 Gene

Publications for TSPY3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  3. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 4

Products for TSPY3 Gene

Sources for TSPY3 Gene

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