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TSPY3 Gene

protein-coding   GIFtS: 33
GCID: GC0YP009237

Testis Specific Protein, Y-Linked 3

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Specific Protein, Y-Linked 31 2
CT782
Testis-Specific Y-Encoded Protein 32

External Ids:    HGNC: 338761   Entrez Gene: 7281372   Ensembl: ENSG000002289277   UniProtKB: P0CV983   

Export aliases for TSPY3 gene to outside databases

Previous GC identifer: GC0YP009976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSPY3 Gene:
TSPY3 (testis specific protein, Y-linked 3) is a protein-coding gene. An important paralog of this gene is SET.

UniProtKB/Swiss-Prot: TSPY3_HUMAN, P0CV98
Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TSPY3 gene promoter:
         AREB6   POU3F1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   ZIC2/Zic2   ZID   POU3F2   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yp11.2   Ensembl cytogenetic band:  Yp11.2   HGNC cytogenetic band: Yp11.2

TSPY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPY3 gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP009237:  view genomic region     (about GC identifiers)

Start:
9,236,030 bp from pter      End:
9,307,357 bp from pter
Size:
71,328 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSPY3_HUMAN, P0CV98 (See protein sequence)
Recommended Name: Testis-specific Y-encoded protein 3  
Size: 308 amino acids; 35101 Da

Explore the universe of human proteins at neXtProt for TSPY3: NX_P0CV98

REFSEQ proteins: NP_001071165.2  
ENSEMBL proteins: 
 ENSP00000398163   ENSP00000412988   ENSP00000406010   ENSP00000396987  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR002164 NAP_family

Graphical View of Domain Structure for InterPro Entry P0CV98

ProtoNet protein and cluster: P0CV98

UniProtKB/Swiss-Prot: TSPY3_HUMAN, P0CV98
Similarity: Belongs to the nucleosome assembly protein (NAP) family


Find genes that share domains with TSPY3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TSPY3_HUMAN, P0CV98
Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TSPY3_HUMAN, P0CV98: Cytoplasm (By similarity). Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
mitochondrion1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005737cytoplasm IEA--

Find genes that share ontologies with TSPY3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPY3
Interactions:

    Search GeneGlobe Interaction Network for TSPY3

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for TSPY3 (ENSP000003981634) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
CSNK2A1ENSP000002172444STRING: ENSP00000217244
TSPY2ENSP000003140774STRING: ENSP00000314077
EEF1A1ENSP000003300544STRING: ENSP00000330054
EEF1A2ENSP000002171824STRING: ENSP00000217182
UBCENSP000003448184STRING: ENSP00000344818
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006334nucleosome assembly IEA--
GO:0007283spermatogenesis IEA--
GO:0007506gonadal mesoderm development IEA--
GO:0030154cell differentiation IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TSPY3 gene: 
NM_001077697.2  

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000457222(uc010nwo.2 uc004fru.3) ENST00000424594 ENST00000491844
ENST00000469322 ENST00000440483 ENST00000427871
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TSPY3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TSPY3 Expression
About this image

TSPY3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TSPY3 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
Uncharacterized protein
25(a)
many ↔ many
9(54897330-54907664)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
26(a)
1 → many
2(89264771-89274104)
zebrafish
(Danio rerio)
Actinopterygii TSPY26
testis specific protein, Y-linked 2
16(a)
1 → many
8(26561010-26569017) ENSDARG00000005015
fruit fly
(Drosophila melanogaster)
Insecta Set6
Set
26(a)
1 → many
3R(11089257-11090975)
worm
(Caenorhabditis elegans)
Secernentea spr-26
Protein SPR-2, isoform b (spr-2) mRNA, complete cd...
20(a)
1 → many
IV(8891470-8892747) WBGene00005007


ENSEMBL Gene Tree for TSPY3 (if available)
TreeFam Gene Tree for TSPY3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TSPY3 gene
TSPY101 2  TSPY41 2  TSPY81 2  TSPY21 2  TSPY11 2  SET2  TSPY6P2  TSPYL12  
TSPYL62  TSPYL22  TSPYL52  TSPYL42  
16 SIMAP similar genes for TSPY3 using alignment to 3 protein entries:     TSPY3_HUMAN (see all proteins):
TSPY8    TSPY2    TSPY1    TSPY4    TSPY10    TSPY6P
LOC728395    FAM197Y1    DKFZp434M235    TSPYL1    TSPYL4    TSPYL
TSPY26P    SET    TSPYL6    CYorf16

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3 Pseudogenes.org Pseudogenes for TSPY3
PGOHUM00000261045 PGOHUM00000261046 PGOHUM00000261047


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
TSPY3_HUMAN, P0CV98: Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported
originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and
between 20 and 60 copies per Y chromosome are expected. 35 tandemly repeated gene copies on Yp11 originating from
one individual have been reported (PubMed:12815422)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for TSPY3:    About this table    

Variant IDTypeSubtypePubMed ID
nsv469840CNV Loss16826518
nsv471608CNV Gain+Loss15918152
essv6780CNV CNV17122850
nsv7473OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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4 diseases from the University of Copenhagen DISEASES database for TSPY3:
Gonadoblastoma     Dysgerminoma     Turner syndrome     Male infertility

Find genes that share disorders with TSPY3           About GenesLikeMe


Export disorders for TSPY3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TSPY3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TSPY3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  2. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)2 Skaletsky H.... Page D.C. (Nature 2003)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 728137 HGNC: 33876 Ensembl:ENSG00000228927 euGenes: HUgn728137 ECgene: TSPY3
H-InvDB: TSPY3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TSPY3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TSPY3 gene:
Search GeneIP for patents involving TSPY3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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