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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPY26P Gene

pseudogene   GIFtS: 33
GCID: GC20M030777

Testis Specific Protein, Y-Linked 26, Pseudogene

(Previous names: TSPY-like 3, TSPY-like 3 (pseudogene))
(Previous symbol: TSPYL3)
  Search for TSPY26P
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Testis Specific Protein, Y-Linked 26, Pseudogene1 2     bA392M18.12
TSPYL31 2 3     Testis-Specific Y-Encoded Protein 26 Pseudogene3
TSPY-Like 31     TSPY-Like Protein 33
TSPY-Like 3 (Pseudogene)1     

External Ids:    HGNC: 162561   Entrez Gene: 1288542   Ensembl: ENSG000002352177   UniProtKB: Q9H4893   

Export aliases for TSPY26P gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TSPY26P Gene: 
TSPY26P (testis specific protein, Y-linked 26, pseudogene) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TSPY26P
         Other transcription factors

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   Search SABiosciences Chromatin IP Primers for TSPY26P

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY26P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

TSPY26P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPY26P gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M030777:  view genomic region     (about GC identifiers)

Start:
30,774,280 bp from pter      End:
30,778,330 bp from pter
Size:
4,051 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSY26_HUMAN, Q9H489 (See protein sequence)
Recommended Name: Putative testis-specific Y-encoded-like protein 3  
Size: 355 amino acids; 39573 Da
Caution: Could be the product of a pseudogene
Secondary accessions: Q3MJ63 Q3MJ65

Explore the universe of human proteins at neXtProt for TSPY26P: NX_Q9H489

TSPY26P Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

TSPY26P for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR002164 NAP_family

Graphical View of Domain Structure for InterPro Entry Q9H489

ProtoNet protein and cluster: Q9H489

1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

UniProtKB/Swiss-Prot: TSY26_HUMAN, Q9H489
Similarity: Belongs to the nucleosome assembly protein (NAP) family


TSPY26P for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TSPY26P:
 Synthetic lethal with Ras 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPY26P

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006334nucleosome assembly IEA--

TSPY26P for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TSPY26P (TSY26)

Search CenterWatch for drugs/clinical trials and news about TSPY26P

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for TSPY26P:

Testis specific protein, Y-linked 26, pseudogene
Hs.647447  [show with all ESTs]
Unigene Representative Sequence: BC101558
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000565928(uc002wxm.1) ENST00000476365 ENST00000400643
miRNA
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Additional mRNA sequence: 

BC101556.1 BC101558.1 NR_002781.1 

1 DOTS entry:

DT.70104967 

21 AceView cDNA sequences:

AW261825 AI963739 CA390378 AI826378 BQ772232 BQ432315 NM_178465 AI383654 
BX113258 BE504055 AL935106 AI971189 AI375984 BX647159 AI824863 BE466406 
AW196551 BE253715 BE252372 AW294670 BE254800 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPY26P expression in normal human tissues (normalized intensities)      TSPY26P embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TSPY26P Expression
About this image


TSPY26P expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Eye (Sensory Organs)
         GABAergic Amacrine Cells Inner Nuclear Layer

Genevestigator expression for TSPY26P

SOURCE GeneReport for Unigene cluster: Hs.647447
    SABiosciences Custom PCR Arrays for TSPY26P
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TSPY26P gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tspyl35 TSPY-like 3   --   2 (75.41 cM) 153222370 


ENSEMBL Gene Tree for TSPY26P (if available)
TreeFam Gene Tree for TSPY26P (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TSPY26P gene
15 SIMAP similar genes for TSPY26P using alignment to 1 protein entry:     TSY26_HUMAN:
LOC728395    SET    TSPYL4    TSPYL    TSPYL1    TSPYL6
TSPY8    TSPY3    TSPY1    TSPY6P    TSPY2    TSPY10
TSPY4    TSPYL2    TSPYL5

TSPY26P for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/45 SNPs in TSPY26P are shown (see all 45)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1419164291,2
--27565072(+) GAGCAC/TGACCA 1 -- ds50010--------
rs1165587961,2
C--27565154(+) TGACTG/TGTGGG 1 -- ds50010--------
rs60612091,2
C,F--27565216(+) AAGATT/CATGGC 1 -- ds50016Minor allele frequency- C:0.34NA WA CSA 128
rs1918071991,2
--27565385(+) GAGTGA/CACAGA 1 -- ds50010--------
rs1147670451,2
F--27565441(+) CACCAT/CGGGCC 1 -- ds50011Minor allele frequency- C:0.05WA 118
rs1400534561,2
C--27565464(+) CGCCAA/CCCGTA 1 -- nc-transcript-variant0--------
rs1830592301,2
--27565491(+) TTATGA/TAGGCC 1 -- nc-transcript-variant0--------
rs60612101,2
C--27565659(+) GGCAAC/TCCTGT 1 -- nc-transcript-variant0--------
rs38139221,2,4
C,F,H--27565847(-) CAACCC/ACTACT 1 -- nc-transcript-variant23Minor allele frequency- A:0.25EA NS NA CSA WA 4036
rs1160739831,2
C,F--27566022(+) GATGAT/CGAAGC 1 -- nc-transcript-variant1Minor allele frequency- C:0.03WA 118

HapMap Linkage Disequilibrium report for TSPY26P (30774280 - 30778330 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TSPY26P:    About this table     
Variant IDTypeSubtypePubMed ID
nsv833954CNV Loss17160897
nsv833953CNV Loss17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TSPY26P gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPY26P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 128854 HGNC: 16256 AceView: TSPYL3 Ensembl:ENSG00000235217 euGenes: HUgn128854
ECgene: TSPY26P H-InvDB: TSPY26P

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TSPY26P Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TSPY26P gene:
Search GeneIP for patents involving TSPY26P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPY26P
Customized:
 lentivirus for stable overexpression of TSPY26P
 lentivirus expression plasmids for stable overexpression of TSPY26P
 adenovirus for overexpression of TSPY26P
 Search LSBio for Antibodies for TSPY26P
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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