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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TSPY26P Gene

pseudogene GIFtS: 33
GCID: GC20M030777

Testis Specific Protein, Y-Linked 26, Pseudogene

(Previous names: TSPY-like 3, TSPY-like 3 (pseudogene))
(Previous symbol: TSPYL3)

Search for TSPY26P
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Testis Specific Protein, Y-Linked 26, Pseudogene¹ ²		bA392M18.1²
TSPYL3¹ ² ³		Testis-Specific Y-Encoded Protein 26 Pseudogene³
TSPY-Like 3¹		TSPY-Like Protein 3³
TSPY-Like 3 (Pseudogene)¹

External Ids:	HGNC: 16256¹	Entrez Gene: 128854²	Ensembl: ENSG00000235217⁷	UniProtKB: Q9H489³

Export aliases for TSPY26P gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TSPY26P Gene:

TSPY26P (testis specific protein, Y-linked 26, pseudogene) is a pseudogene.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.2 NT_011362.10

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TSPY26P
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY26P

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21

TSPY26P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPY26P gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M030777: view genomic region (about GC identifiers)

Start:	30,774,280 bp from pter	End:	30,778,330 bp from pter
Size:	4,051 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: TSY26_HUMAN, Q9H489 (See protein sequence)

Recommended Name: Putative testis-specific Y-encoded-like protein 3

Size: 355 amino acids; 39573 Da

Caution: Could be the product of a pseudogene

Secondary accessions: Q3MJ63 Q3MJ65

Explore the universe of human proteins at neXtProt for TSPY26P: NX_Q9H489

TSPY26P Protein expression data from MOPED¹, PaxDb² and MAXQB³ : --

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

TSPY26P for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR002164 NAP_family

Graphical View of Domain Structure for InterPro Entry Q9H489

ProtoNet protein and cluster: Q9H489

1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

UniProtKB/Swiss-Prot: TSY26_HUMAN, Q9H489

Similarity: Belongs to the nucleosome assembly protein (NAP) family

TSPY26P for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for TSPY26P:

Synthetic lethal with Ras

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TSPY26P

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	IEA	--

TSPY26P for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about TSPY26P

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

Unigene Cluster for TSPY26P:

Testis specific protein, Y-linked 26, pseudogene

Hs.647447 [show with all ESTs]

Unigene Representative Sequence: BC101558

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000565928(uc002wxm.1) ENST00000476365 ENST00000400643

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Additional mRNA sequence:

BC101556.1 BC101558.1 NR_002781.1

1 DOTS entry:

DT.70104967

21 AceView cDNA sequences:

AW261825 AI963739 CA390378 AI826378 BQ772232 BQ432315 NM_178465 AI383654

BX113258 BE504055 AL935106 AI971189 AI375984 BX647159 AI824863 BE466406

AW196551 BE253715 BE252372 AW294670 BE254800

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPY26P expression in normal human tissues (normalized intensities) TSPY26P embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

TSPY26P expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/1 selected tissues (see all 1) fully expand


Eye (Sensory Organs)
GABAergic Amacrine Cells Inner Nuclear Layer

Genevestigator expression for TSPY26P

SOURCE GeneReport for Unigene cluster: Hs.647447

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TSPY26P gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tspyl3⁵	TSPY-like 3	--		2 (75.41 cM) 153222370

ENSEMBL Gene Tree for TSPY26P (if available)
TreeFam Gene Tree for TSPY26P (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TSPY26P gene

15 SIMAP similar genes for TSPY26P using alignment to 1 protein entry: TSY26_HUMAN:

LOC728395 SET TSPYL4 TSPYL TSPYL1 TSPYL6

TSPY8 TSPY3 TSPY1 TSPY6P TSPY2 TSPY10

TSPY4 TSPYL2 TSPYL5

TSPY26P for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141916429^1,2		--	27565072(+)	`GAGCAC/TGACCA`	1	--	ds500¹		0	--	--	--	--
rs116558796^1,2	C	--	27565154(+)	`TGACTG/TGTGGG`	1	--	ds500¹		0	--	--	--	--
rs6061209^1,2	C,F	--	27565216(+)	`AAGATT/CATGGC`	1	--	ds500¹		6		NA WA CSA	128
rs191807199^1,2		--	27565385(+)	`GAGTGA/CACAGA`	1	--	ds500¹		0	--	--	--	--
rs114767045^1,2	F	--	27565441(+)	`CACCAT/CGGGCC`	1	--	ds500¹		1		WA	118
rs140053456^1,2	C	--	27565464(+)	`CGCCAA/CCCGTA`	1	--	nc-transcript-variant		0	--	--	--	--
rs183059230^1,2		--	27565491(+)	`TTATGA/TAGGCC`	1	--	nc-transcript-variant		0	--	--	--	--
rs6061210^1,2	C	--	27565659(+)	`GGCAAC/TCCTGT`	1	--	nc-transcript-variant		0	--	--	--	--
rs3813922^1,2,4	C,F,H	--	27565847(-)	`CAACCC/ACTACT`	1	--	nc-transcript-variant		23		EA NS NA CSA WA	4036
rs116073983^1,2	C,F	--	27566022(+)	`GATGAT/CGAAGC`	1	--	nc-transcript-variant		1		WA	118

HapMap Linkage Disequilibrium report for TSPY26P (30774280 - 30778330 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for TSPY26P: About this table

Variant ID	Type	Subtype	PubMed ID
nsv833954	CNV	Loss	17160897
nsv833953	CNV	Loss	17160897

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TSPY26P gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPY26P)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 128854	HGNC: 16256	AceView: TSPYL3	Ensembl:ENSG00000235217	euGenes: HUgn128854
ECgene: TSPY26P	H-InvDB: TSPY26P

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TSPY26P	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TSPY26P gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TSPY26P gene:
Search GeneIP for patents involving TSPY26P

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY26P

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TSPY26P
	Browse SwitchGear Promoter luciferase reporter plasmids for TSPY26P

Search ThermoFisher Antibodies for TSPY26P

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TSPY26P

	inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPY26P
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPY26P

Customized:

	lentivirus for stable overexpression of TSPY26P
	lentivirus expression plasmids for stable overexpression of TSPY26P
	adenovirus for overexpression of TSPY26P

Search LSBio for Antibodies for TSPY26P

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TSPY26P Gene

Testis Specific Protein, Y-Linked 26, Pseudogene

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TSPY26P Gene

Testis Specific Protein, Y-Linked 26, Pseudogene

Aliasesfor TSPY26P gene

Summariesfor TSPY26P gene

Genomic Viewsfor TSPY26P gene

Proteinsfor TSPY26P gene

Protein Domains /Familiesfor TSPY26P gene

Functionfor TSPY26P gene

Pathways & Interactionsfor TSPY26P gene

Drugs & Compoundsfor TSPY26P gene

Transcriptsfor TSPY26P gene

Expression for TSPY26P gene

Orthologsfor TSPY26P gene

Paralogsfor TSPY26P gene

Genomic Variantsfor TSPY26P gene

Disorders / Diseasesfor TSPY26P gene

Publicationsfor TSPY26P gene

External Searches for TSPY26P gene

Genome Databases showing TSPY26P gene

Other Databases showing TSPY26P gene

Specialized Databases showing TSPY26P gene

Intellectual Propertyfor TSPY26P gene

Productsfor TSPY26P gene

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Aliases
for TSPY26P gene

Summaries
for TSPY26P gene

Genomic Views
for TSPY26P gene

Proteins
for TSPY26P gene

Protein Domains /
Families
for TSPY26P gene

Function
for TSPY26P gene

Pathways & Interactions
for TSPY26P gene

Drugs & Compounds
for TSPY26P gene

Transcripts
for TSPY26P gene

Expression
for TSPY26P gene

Orthologs
for TSPY26P gene

Paralogs
for TSPY26P gene

Genomic Variants
for TSPY26P gene

Disorders / Diseases
for TSPY26P gene

Publications
for TSPY26P gene

Intellectual Property
for TSPY26P gene

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for TSPY26P gene