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Aliases for TSPY2 Gene

Aliases for TSPY2 Gene

  • Testis Specific Protein, Y-Linked 2 2 3 5
  • Testis-Specific Y-Encoded Protein Q1 3 4
  • TSPYQ1 3 4

External Ids for TSPY2 Gene

Previous GeneCards Identifiers for TSPY2 Gene

  • GC0YP005819
  • GC0YP009897
  • GC0YP006114

Summaries for TSPY2 Gene

GeneCards Summary for TSPY2 Gene

TSPY2 (Testis Specific Protein, Y-Linked 2) is a Protein Coding gene. An important paralog of this gene is TSPY4.

UniProtKB/Swiss-Prot for TSPY2 Gene

  • Unknown. May be involved in sperm differentiation and proliferation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPY2 Gene

Genomics for TSPY2 Gene

Regulatory Elements for TSPY2 Gene


Genomic Location for TSPY2 Gene

Chromosome:
Y
Start:
6,246,223 bp from pter
End:
6,249,019 bp from pter
Size:
2,797 bases
Orientation:
Plus strand

Genomic View for TSPY2 Gene

Genes around TSPY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPY2 Gene

Proteins for TSPY2 Gene

  • Protein details for TSPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKD2-TSPY2_HUMAN
    Recommended name:
    Testis-specific Y-encoded protein 2
    Protein Accession:
    A6NKD2

    Protein attributes for TSPY2 Gene

    Size:
    308 amino acids
    Molecular mass:
    35100 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPY2 Gene

Proteomics data for TSPY2 Gene at MOPED

Post-translational modifications for TSPY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSPY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSPY2 Gene

Domains & Families for TSPY2 Gene

Protein Domains for TSPY2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSPY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKD2

UniProtKB/Swiss-Prot:

TSPY2_HUMAN :
  • Belongs to the nucleosome assembly protein (NAP) family.
Family:
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPY2: view

No data available for Gene Families for TSPY2 Gene

Function for TSPY2 Gene

Molecular function for TSPY2 Gene

UniProtKB/Swiss-Prot Function:
Unknown. May be involved in sperm differentiation and proliferation (By similarity).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPY2 Gene

Localization for TSPY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPY2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPY2 Gene COMPARTMENTS Subcellular localization image for TSPY2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TSPY2 Gene

Pathways & Interactions for TSPY2 Gene

SuperPathways for TSPY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with TSPY2: view

No data available for Pathways by source and SIGNOR curated interactions for TSPY2 Gene

Drugs & Compounds for TSPY2 Gene

No Compound Related Data Available

Transcripts for TSPY2 Gene

mRNA/cDNA for TSPY2 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPY2 Gene

Testis specific protein, Y-linked 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPY2 Gene

No ASD Table

Relevant External Links for TSPY2 Gene

GeneLoc Exon Structure for
TSPY2
ECgene alternative splicing isoforms for
TSPY2

Expression for TSPY2 Gene

mRNA expression in normal human tissues for TSPY2 Gene

mRNA differential expression in normal tissues according to GTEx for TSPY2 Gene

This gene is overexpressed in Testis (x49.8).

SOURCE GeneReport for Unigene cluster for TSPY2 Gene Hs.646249

genes like me logo Genes that share expression patterns with TSPY2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TSPY2 Gene

Orthologs for TSPY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101059018 35
  • 88.85 (n)
  • 77.59 (a)
-- 36
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
TSPY-M2 36
  • 35 (a)
ManyToMany
TSPY-M2 36
  • 41 (a)
ManyToMany
TSPY-M2 36
  • 40 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TSPY2 36
  • 16 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Set 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spr-2 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 36
  • 19 (a)
OneToMany
Species with no ortholog for TSPY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPY2 Gene

ENSEMBL:
Gene Tree for TSPY2 (if available)
TreeFam:
Gene Tree for TSPY2 (if available)

Paralogs for TSPY2 Gene

(16) SIMAP similar genes for TSPY2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TSPY2 Gene

genes like me logo Genes that share paralogs with TSPY2: view

Variants for TSPY2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TSPY2 Gene

A6NKD2-TSPY2_HUMAN
Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11 originating from one individual.

Sequence variations from dbSNP and Humsavar for TSPY2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs28399807 -- 6,247,032(+) TGAAG(C/T)TATTT intron-variant
rs28437872 -- 6,246,897(+) GAAAG(C/G)CGGAG intron-variant
rs28713512 -- 6,246,903(+) CGGAG(A/C)AGGCG intron-variant
rs112253183 -- 6,245,919(+) CCTAA(G/T)GAAGA upstream-variant-2KB
rs201475959 -- 6,246,522(+) CGTGG(A/G)GCGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TSPY2 Gene

Variant ID Type Subtype PubMed ID
dgv2495e1 CNV Complex 17122850
dgv2496e1 CNV Complex 17122850
dgv15n29 CNV Loss 16826518
nsv7473 OTHER Inversion 18451855
nsv510873 CNV Loss 20534489
nsv10012 CNV Gain+Loss 18304495

Relevant External Links for TSPY2 Gene

HapMap Linkage Disequilibrium report
TSPY2

No data available for Variation tolerance for TSPY2 Gene

Disorders for TSPY2 Gene

Relevant External Links for TSPY2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPY2

No disorders were found for TSPY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPY2 Gene

Publications for TSPY2 Gene

  1. Characterization of a new TSPY gene family member in Yq (TSPYq1). (PMID: 10773691) Ratti A. … Palka G. (Cytogenet. Cell Genet. 2000) 2 3 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TSPY2 Gene

Sources for TSPY2 Gene

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