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Aliases for TSPY2 Gene

Aliases for TSPY2 Gene

  • Testis Specific Protein, Y-Linked 2 2 3 5
  • Testis-Specific Y-Encoded Protein Q1 3 4
  • TSPYQ1 3 4
  • Testis-Specific Y-Encoded Protein 2 3

External Ids for TSPY2 Gene

Previous GeneCards Identifiers for TSPY2 Gene

  • GC0YP005819
  • GC0YP009897
  • GC0YP006114

Summaries for TSPY2 Gene

GeneCards Summary for TSPY2 Gene

TSPY2 (Testis Specific Protein, Y-Linked 2) is a Protein Coding gene. An important paralog of this gene is TSPY4.

UniProtKB/Swiss-Prot for TSPY2 Gene

  • Unknown. May be involved in sperm differentiation and proliferation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPY2 Gene

Genomics for TSPY2 Gene

Regulatory Elements for TSPY2 Gene

Genomic Location for TSPY2 Gene

6,246,223 bp from pter
6,249,019 bp from pter
2,797 bases
Plus strand

Genomic View for TSPY2 Gene

Genes around TSPY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPY2 Gene

Proteins for TSPY2 Gene

  • Protein details for TSPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific Y-encoded protein 2
    Protein Accession:

    Protein attributes for TSPY2 Gene

    308 amino acids
    Molecular mass:
    35100 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPY2 Gene

Post-translational modifications for TSPY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSPY2 Gene

No data available for DME Specific Peptides for TSPY2 Gene

Domains & Families for TSPY2 Gene

Protein Domains for TSPY2 Gene


Suggested Antigen Peptide Sequences for TSPY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleosome assembly protein (NAP) family.
  • Belongs to the nucleosome assembly protein (NAP) family.
genes like me logo Genes that share domains with TSPY2: view

No data available for Gene Families for TSPY2 Gene

Function for TSPY2 Gene

Molecular function for TSPY2 Gene

UniProtKB/Swiss-Prot Function:
Unknown. May be involved in sperm differentiation and proliferation (By similarity).

Phenotypes for TSPY2 Gene

GenomeRNAi human phenotypes for TSPY2:
genes like me logo Genes that share phenotypes with TSPY2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPY2 Gene

Localization for TSPY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPY2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for TSPY2 Gene COMPARTMENTS Subcellular localization image for TSPY2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TSPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TSPY2: view

Pathways & Interactions for TSPY2 Gene

SuperPathways for TSPY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007506 gonadal mesoderm development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TSPY2: view

No data available for Pathways by source and SIGNOR curated interactions for TSPY2 Gene

Transcripts for TSPY2 Gene

mRNA/cDNA for TSPY2 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPY2 Gene

Testis specific protein, Y-linked 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPY2 Gene

No ASD Table

Relevant External Links for TSPY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPY2 Gene

mRNA differential expression in normal tissues according to GTEx for TSPY2 Gene

This gene is overexpressed in Testis (x49.8).

NURSA nuclear receptor signaling pathways regulating expression of TSPY2 Gene:


SOURCE GeneReport for Unigene cluster for TSPY2 Gene:

genes like me logo Genes that share expression patterns with TSPY2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TSPY2 Gene

Orthologs for TSPY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
LOC101059018 34
  • 88.85 (n)
(Bos Taurus)
Mammalia -- 35
  • 43 (a)
-- 35
  • 40 (a)
-- 35
  • 37 (a)
-- 35
  • 35 (a)
-- 35
  • 35 (a)
TSPY-M2 35 35 35
  • 35 (a)
-- 35
  • 34 (a)
-- 35
  • 33 (a)
-- 35
  • 31 (a)
-- 35
  • 28 (a)
-- 35
  • 27 (a)
(Canis familiaris)
Mammalia -- 35
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 26 (a)
(Danio rerio)
Actinopterygii TSPY2 35
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Set 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea spr-2 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9132 35
  • 19 (a)
Species where no ortholog for TSPY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPY2 Gene

Gene Tree for TSPY2 (if available)
Gene Tree for TSPY2 (if available)

Paralogs for TSPY2 Gene

Paralogs for TSPY2 Gene

(16) SIMAP similar genes for TSPY2 Gene using alignment to 2 proteins: Pseudogenes for TSPY2 Gene

genes like me logo Genes that share paralogs with TSPY2: view

Variants for TSPY2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TSPY2 Gene

Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11 originating from one individual.

Sequence variations from dbSNP and Humsavar for TSPY2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs112253183 -- 6,245,919(+) CCTAA(G/T)GAAGA upstream-variant-2KB
rs201475959 -- 6,246,522(+) CGTGG(A/G)GCGGC nc-transcript-variant, reference, missense
rs28399807 -- 6,247,032(+) TGAAG(C/T)TATTT intron-variant
rs28437872 -- 6,246,897(+) GAAAG(C/G)CGGAG intron-variant
rs28713512 -- 6,246,903(+) CGGAG(A/C)AGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPY2 Gene

Variant ID Type Subtype PubMed ID
dgv18n29 CNV loss 16826518
dgv4339n106 CNV duplication 24896259
esv2758903 CNV gain+loss 17122850
nsv10012 CNV gain+loss 18304495
nsv1078703 CNV duplication 25765185
nsv1150425 CNV duplication 26484159
nsv7473 OTHER inversion 18451855
nsv953729 CNV duplication 24416366

Relevant External Links for TSPY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Variation tolerance for TSPY2 Gene

Disorders for TSPY2 Gene

Relevant External Links for TSPY2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPY2 Gene

Publications for TSPY2 Gene

  1. Characterization of a new TSPY gene family member in Yq (TSPYq1). (PMID: 10773691) Ratti A. … Palka G. (Cytogenet. Cell Genet. 2000) 2 3 64
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  3. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TSPY2 Gene

Sources for TSPY2 Gene

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