TSPY2 Gene
protein-coding GIFtS: 40
GCID: GC0YP006114
|
|
testis specific protein, Y-linked 2
| |
Aliases
for TSPY2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Testis Specific Protein, Y-Linked 21 2 | | TSPYQ11 2 3 | | Testis-Specific Y-Encoded Protein Q12 3 | | Testis-Specific Y-Encoded Protein 22 |
Export aliases for TSPY2 gene to outside databasesPrevious GC identifers: GC0YP005819 GC0YP009897 GC0YP006174 |
Summaries
for TSPY2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSPY2_HUMAN, A6NKD2Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)
|
Genomic Views
for TSPY2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011896.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSPY2 gene promoter:
AREB6 ZIC2/Zic2 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPY2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPY2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yp11.2 Ensembl cytogenetic band: Yp11.2 HGNC cytogenetic band: Yp11.2TSPY2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP006114: view genomic region
(about GC identifiers)
Start:
|
6,114,264 bp from pter |
End:
|
6,117,060 bp from pter |
Size:
|
2,797 bases |
Orientation:
|
plus strand |
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Proteins
for TSPY2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSPY2_HUMAN, A6NKD2 (See
protein sequence)Recommended Name: Testis-specific Y-encoded protein 2 Size: 308 amino acids; 35100 Da
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)Explore the universe of human proteins at neXtProt for TSPY2: NX_A6NKD2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NKD2
TSPY2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_072095.2
ENSEMBL proteins: ENSP00000314077 ENSP00000372512
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TSPY2 for ontologies About GeneDecksing
TSPY2 Antibody Products:
Assay Products for TSPY2: |
Protein
Domains /
Families
for TSPY2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPY2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NKD2ProtoNet protein and cluster: A6NKD2 UniProtKB/Swiss-Prot: TSPY2_HUMAN, A6NKD2Similarity: Belongs to the nucleosome assembly protein (NAP) family |
Function
for TSPY2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSPY2_HUMAN, A6NKD2Function: Unknown. May be involved in sperm differentiation and proliferation (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY2 |
|
Pathways & Interactions
for TSPY2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPY2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/12 Interacting proteins for TSPY2 (A6NKD23 ENSP000003140774) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TSPY2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSPY2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSPY2
Search CenterWatch for drugs/clinical trials and news about TSPY2
|
Transcripts
for TSPY2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSPY2 gene: NM_022573.2 Unigene Cluster for TSPY2: Testis specific protein, Y-linked 2 Hs.646249 [show with all ESTs]Unigene Representative Sequence: NM_0225734 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000320701(uc004fqr.1 uc004fqs.1) ENST00000383042 ENST00000470569
ENST00000464674
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TSPY2 (NM_022573) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPY2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPY2 |
Additional cDNA sequence: AK307425.1 2 DOTS entries: DT.120652014 DT.120653211 8 AceView cDNA sequences: AI138810 NM_003308 U58096 BI828033 NM_022573 M94893 AA993340 BG198129
GeneLoc Exon Structure
|
Expression
for TSPY2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSPY2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TSPY2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPY2
SOURCE GeneReport for Unigene cluster: Hs.646249
SABiosciences Custom PCR Arrays for TSPY2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPY2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TSPY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPY2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY2 |
Orthologs
for TSPY2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TSPY2 gene from 6/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
31(a) |
1 → many |
2(89265460-89270074) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:664306 |
zgc:66430 |
18(a) |
1 → many |
8(26561010-26569017) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Set6 |
Set |
26(a) |
1 → many |
3R(11089257-11090975) |
worm
(Caenorhabditis elegans) |
Secernentea |
spr-26 |
Suppressor of presenilin-2 |
20(a) |
1 → many |
IV(8891457-8892734) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NRP16NRP26 |
template-activating factor I |
23(a)22(a) |
many ↔ manymany ↔ many |
1(28017584-28020049) 1(6481113-6483596) |
rice
(Oryza sativa) |
Liliopsida |
---- |
SET, putative, expressedNAP domain containing protein, putative, expressed... |
26(a)20(a) |
many ↔ manymany ↔ many |
2(22145563-22150173) 4(22758069-22761770) |
ENSEMBL Gene Tree for TSPY2 (if available)
TreeFam Gene Tree for TSPY2 (if available) |
Paralogs
for TSPY2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSPY2 gene
- TSPY101 2 TSPY41 2 TSPY31 2 TSPY11 2 SET2 TSPYL12 TSPYL62 TSPY82
- TSPYL22 TSPYL52 TSPYL42
15 SIMAP similar genes for TSPY2 using alignment to 2 protein entries: TSPY2_HUMAN (see all proteins):TSPY8 TSPY1 TSPY4 TSPY3 TSPY10 FAM197Y1
DKFZp434M235 CYorf16 LOC728395 TSPYL4 SET TSPYL1
TSPYL TSPY26P TSPYL6
TSPY2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TSPY2
PGOHUM00000261061
|
Genomic Variants
for TSPY2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: TSPY2_HUMAN, A6NKD2Polymorphism: Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reportedoriginating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11originating from one individual
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSPY2 (6114264 - 6117060 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TSPY2
7 CNVs: 33189 2283 4179 2284 97166 83912 31580 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPY2 |
|
Disorders
/ Diseases
for TSPY2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPY2 for disorders About GeneDecksing
4  diseases for TSPY2: About MalaCardsacute myeloid leukemia myeloid leukemia leukemia malaria
Export disorders for TSPY2 gene to outside databases
|
Publications
for TSPY2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSPY2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPY2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a new TSPY gene family member in Yq (TSPYq1). (PubMed id 10773691)1, 3 Ratti A....Palka G. (2000)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)2 Skaletsky H.... Page D.C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TSPY2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSPY2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPY2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPY2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSPY2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TSPY2 gene:
Search GeneIP for patents involving TSPY2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSPY2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | Search Tocris compounds for TSPY2 |
| |  |  |  |  | | | | |
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 | | | TSPY2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPY2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSPY2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPY2 |
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