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TSPY1 Gene

protein-coding   GIFtS: 51
GCID: GC0YP009304

Testis Specific Protein, Y-Linked 1

(Previous names: testis specific protein, Y-linked)
(Previous symbol: TSPY)
  See TSPY1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Testis Specific Protein, Y-Linked 11 2     Testis Specific Protein, Y-Linked1
TSPY1 2 3 5     DYS142
Cancer/Testis Antigen 781 2 3     pJA9232
CT782 3     Testis-Specific Y-Encoded Protein 12

External Ids:    HGNC: 123811   Entrez Gene: 72582   Ensembl: ENSG000002589927   OMIM: 4801005   UniProtKB: Q015343   

Export aliases for TSPY1 gene to outside databases

Previous GC identifers: GC0YP008919 GC0YP009898


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPY1 Gene:
The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis.
Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional orthologous gene is
found in mouse. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Oct 2010)

GeneCards Summary for TSPY1 Gene:
TSPY1 (testis specific protein, Y-linked 1) is a protein-coding gene. Diseases associated with TSPY1 include gonadoblastoma, and sudden infant death with dysgenesis of the testes syndrome. An important paralog of this gene is SET.

UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534
Function: May be involved in sperm differentiation and proliferation

Gene Wiki entry for TSPY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000024.9  NT_011878.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPY1 gene promoter:
         AREB6   p53   POU3F1   Cart-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   ZIC2/Zic2   ZID   POU3F2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPY1 promoter sequence
   Search Chromatin IP Primers for TSPY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yp11.2   Ensembl cytogenetic band:  Yp11.2   HGNC cytogenetic band: Yp11.2

TSPY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPY1 gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP009304:  view genomic region     (about GC identifiers)

Start:
9,236,076 bp from pter      End:
9,307,358 bp from pter
Size:
71,283 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534 (See protein sequence)
Recommended Name: Testis-specific Y-encoded protein 1  
Size: 308 amino acids; 35012 Da
Developmental stage: Detected in 22-week old testis
Sequence caution: Sequence=AAA36570.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA61238.1; Type=Miscellaneous discrepancy; Note=Probable unspliced transcript; Sequence=CAA29640.1;
Type=Miscellaneous discrepancy; Note=Sequence of unknown origin inserted in the coding sequence; Sequence=X74029;
Type=Frameshift; Positions=Several;
Secondary accessions: A6NJD2 O00216 P09002 Q0VAD3 Q9UNN7
Alternative splicing: 2 isoforms:  Q01534-1   Q01534-2   

Explore the universe of human proteins at neXtProt for TSPY1: NX_Q01534

Explore proteomics data for TSPY1 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TSPY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001184171.1  NP_003299.2  

    ENSEMBL proteins: 
     ENSP00000403304   ENSP00000389324  

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    antibodies-online peptides for TSPY1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002164 NAP_family

    Graphical View of Domain Structure for InterPro Entry Q01534

    ProtoNet protein and cluster: Q01534

    1 Blocks protein domain: IPB002164 Nucleosome assembly protein (NAP)

    UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534
    Similarity: Belongs to the nucleosome assembly protein (NAP) family


    Find genes that share domains with TSPY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSPY1_HUMAN, Q01534
    Function: May be involved in sperm differentiation and proliferation
    Induction: Up-regulated by androgen in a prostate cancer cell line

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI18649364
         
    Find genes that share ontologies with TSPY1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Tspy-ps):
     muscle 

    Find genes that share phenotypes with TSPY1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPY1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSPY1_HUMAN, Q01534: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with TSPY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPY1
    Interactions:

        Search GeneGlobe Interaction Network for TSPY1

    Selected Interacting proteins for TSPY1 (Q015341, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2A1P684003I2D: score=2 
    EEF1A1P681043I2D: score=2 
    EEF1A2Q056393I2D: score=1 
    HIST2H2ACQ167773I2D: score=1 
    HIST2H2BEQ167783I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0007283spermatogenesis IEA--
    GO:0007506gonadal mesoderm development IEA--
    GO:0007548sex differentiation TAS1284595
    GO:0008283cell proliferation TAS8923009

    Find genes that share ontologies with TSPY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPY1

    1 Novoseek inferred chemical compound relationship for TSPY1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 38.2 4 15958521 (3)



    Find genes that share compounds with TSPY1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSPY1 gene (2 alternative transcripts): 
    NM_001197242.1  NM_003308.3  

    Unigene Clusters for TSPY1:

    Testis specific protein, Y-linked 1
    Hs.556121  [show with all ESTs], Hs.647493  [show with all ESTs]
    Unigene Representative Sequences: AK308271, M94893
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451548(uc004frw.4 uc004frx.4) ENST00000423647
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TSPY1
      QuantiFast Probe-based Assays in human, mouse, rat TSPY1

    Additional mRNA sequence: 

    AY130858.1 BC121113.1 M94893.1 U58096.1 

    10 DOTS entries:

    DT.410181  DT.120653978  DT.120651912  DT.120653195  DT.120654200  DT.40106229  DT.100016306  DT.120651221 
    DT.120652014  DT.120653211 

    8 AceView cDNA sequences:

    U58096 NM_003308 BI828033 AI138810 M94893 NM_022573 AA993340 BG198129 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTATGCA
    TSPY1 Expression
    About this image


    TSPY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             XY Germ Cells Testis Cord
             Testis Interstitium
     
     Gonad
             XY Germ Cells Testis Cord
    TSPY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPY1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.556121 Hs.647493

    UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534
    Tissue specificity: Specifically expressed in testicular tissues. Isoform 1 and isoform 2 are expressed in
    spermatogonia and spermatocytes. Found in early testicular carcinoma in situ, spermatogonial cells in testicular
    tissues of 46,X,Y female and in prostate cancer cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPY1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspy-ps5 testis specific protein-Y encoded, pseudogene   --   Y 1055764 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    1 → many
    2(89264771-89274104)
    zebrafish
    (Danio rerio)
    Actinopterygii TSPY26
    testis specific protein, Y-linked 2
    16(a)
    1 → many
    8(26561010-26569017) ENSDARG00000005015
    fruit fly
    (Drosophila melanogaster)
    Insecta Set6
    Set
    26(a)
    1 → many
    3R(11089257-11090975)
    worm
    (Caenorhabditis elegans)
    Secernentea spr-26
    Protein SPR-2, isoform b (spr-2) mRNA, complete cd...
    19(a)
    1 → many
    IV(8891470-8892747) WBGene00005007


    ENSEMBL Gene Tree for TSPY1 (if available)
    TreeFam Gene Tree for TSPY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPY1 gene
    TSPY101 2  TSPY31 2  TSPY21 2  TSPY81 2  TSPY41 2  SET2  TSPY6P2  TSPYL12  
    TSPYL62  TSPYL22  TSPYL52  TSPYL42  
    16 SIMAP similar genes for TSPY1 using alignment to 2 protein entries:     TSPY1_HUMAN (see all proteins):
    TSPY4    TSPY8    TSPY2    TSPY10    TSPY3    TSPY6P
    FAM197Y1    LOC728395    DKFZp434M235    TSPYL1    TSPYL    TSPYL4
    CYorf16    SET    TSPY26P    TSPYL6

    Find genes that share paralogs with TSPY1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TSPY1 (see all 14)
    PGOHUM00000233678 PGOHUM00000233682 PGOHUM00000233695 PGOHUM00000233698 PGOHUM00000233715


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    TSPY1_HUMAN, Q01534: Variants Val-Glu-Val-Val-Ala-Glu-79 Ins and Arg-195 are shown to be present in a number of TSPY1
    copies of the Yp11 loci. Variant Arg-195 is shown to be present at least in one TSPY1 copy of the Yq locus
    TSPY1_HUMAN, Q01534: Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported
    originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and
    between 20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies
    on Yp11 originating from one individual


    Selected SNPs for TSPY1 (see all 20)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3765075811,2
    C--9306576(+) TCGTAC/TATGTA 2 -- int10--------
    rs801261641,2
    C--9307436(+) TGTTTT/ATCCAC 2 -- ds50011Minor allele frequency- A:0.00NA 2
    VAR_0162274
    ----see VAR_0162272 P R mis40--------
    VAR_0162284
    ----see VAR_0162282 I F mis40--------
    rs2003892511,2
    ----9304945(+) GAGCTA/GCTGGC 4 L syn10--------
    rs3763152691,2
    ----9304534(+) ACGACC/GGAGGA 2 -- us2k10--------
    rs2014247381,2
    ----9304974(+) GCCGGG/TTAATG 4 G V mis10--------
    rs1995326571,2
    ----9306051(+) AGTGGA/GAGGAA 2 -- int10--------
    rs3707812951,2
    ----9307492(+) CTCTTA/CTGGAA 2 -- ds50010--------
    rs3750166831,2
    ----9307583(+) GACAGA/CTGGGA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TSPY1 (9236076 - 9307358 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TSPY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469840CNV Loss16826518
    nsv471608CNV Gain+Loss15918152
    nsv7473OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): TSPY1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TSPY1
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 480100    OMIM disorders: --

    UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534
  • Note=TSPY is located in the gonadoblastoma critical region and is preferentially expressed in tumor germ
    cells of gonadoblastoma specimens. Expression also correlates with testicular seminoma and tumorigenesis of the
    prostate gland

  • 8 diseases for TSPY1:    
    About MalaCards
    gonadoblastoma    sudden infant death with dysgenesis of the testes syndrome    45,x/46,xy mixed gonadal dysgenesis    spermatogenic failure, y-linked, 2
    swyer syndrome    turner syndrome    germ cell tumors    prostate cancer

    4 diseases from the University of Copenhagen DISEASES database for TSPY1:
    Gonadoblastoma     Dysgerminoma     Turner syndrome     Male infertility

    Find genes that share disorders with TSPY1           About GenesLikeMe

    9 Novoseek inferred disease relationships for TSPY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gonadoblastoma 91.8 18 17349529 (6), 10629567 (2), 15241014 (2), 10090875 (1) (see all 8)
    testicular carcinoma 71.4 1 8923009 (1)
    turners syndrome 59.1 1 18545811 (1)
    infertility male 42.4 3 17509197 (2), 19773397 (1)
    prostate cancer 35.7 8 11743352 (2), 16618725 (2), 10090875 (1), 11257712 (1) (see all 6)
    azoospermia 33.5 1 15524154 (1)
    carcinoma 7.17 1 17349529 (1)
    tumors 6.07 4 17349529 (1), 8533770 (1), 17977648 (1), 16618725 (1)
    cancer 0 2 16106251 (1), 16207477 (1)

    Genetic Association Database (GAD): TSPY1
    Human Genome Epidemiology (HuGE) Navigator: TSPY1 (1 document)

    Export disorders for TSPY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPY1 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with TSPY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TSPY1 copy number variation influences spermatogenesis and shows differences among Y lineages. (PubMed id 19773397)1, 4, 9 Giachini C....Krausz C. (J. Clin. Endocrinol. Metab. 2009)
    2. Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues. (PubMed id 8923009)1, 2, 9 Schnieders F....Schmidtke J. (Hum. Mol. Genet. 1996)
    3. Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes. (PubMed id 12527192)1, 2, 9 Krick R.... Arnemann J. (Gene 2003)
    4. TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome. (PubMed id 8244388)1, 2, 9 Manz E.... Schmidtke J. (Genomics 1993)
    5. Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY. (PubMed id 1765369)1, 2, 9 Arnemann J.... Schmidtke J. (Genomics 1991)
    6. Molecular isolation and characterization of an expressed gene from the human Y chromosome. (PubMed id 1284595)1, 2, 9 Zhang J.S....Lau Y.-F.C. (Hum. Mol. Genet. 1992)
    7. Expression analysis of thirty one Y chromosome genes in human prostate cancer. (PubMed id 10747295)1, 2, 9 Lau Y.-F.C. and Zhang J. (Mol. Carcinog. 2000)
    8. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. (PubMed id 10090875)1, 2, 9 Lau Y.-F.C. (Am. J. Hum. Genet. 1999)
    9. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (Nature 2003)
    10. TSPY variants in six loci on the human Y chromosome. (PubMed id 11173833)1, 2 Dechend F.... Schmidtke J. (Cytogenet. Cell Genet. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7258 HGNC: 12381 AceView: TSPY1.2 Ensembl:ENSG00000258992 euGenes: HUgn7258
    ECgene: TSPY1 H-InvDB: TSPY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPY1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPY1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPY1 gene:
    Search GeneIP for patents involving TSPY1

    GeneCards and IP:
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