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Aliases & Descriptions for TSPY1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CT78 3 | | DYS14 2 | | TSPY 2, 3 | | pJA923 2 |
| | | Descriptions |
|---|
| Cancer/testis antigen 78 3 | | testis specific protein, Y-linked 1 | | testis specific protein, Y-linked 1 2 |
|
| | Search outside databases for aliases for TSPY1 genePrevious GC identifer: GC0YP008919 |
Summaries for TSPY1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534Function: May be involved in sperm differentiation and proliferationGene Wiki entry for TSPY1 |
Genomic Location for TSPY1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TSPY1 gene 
Entrez Gene cytogenetic band: Yp11.2 Ensembl cytogenetic band: Yp11.2 HGNC cytogenetic band: Yp11.2TSPY1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP009898:
(about GC identifiers)
Start:
|
9,914,564 bp from pter |
End:
|
9,917,358 bp from pter |
Size:
|
2,795 bases |
Orientation:
|
plus strand |
1 alternative location:
| ChrY+ 6,174,264-6,177,053 |
RefSeq DNA sequence:- NC_000024.8 NT_011878.9
| Proteins for TSPY1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534 (See
protein sequence)Recommended Name: Testis-specific Y-encoded protein 1 Size: 308 amino acids; 35101 Da
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus
Developmental stage: Detected in 22-week old testis
Sequence caution: Sequence=AAA61238.1; Type=Miscellaneous discrepancy; Note=Probable unspliced transcript; Sequence=X74029; Type=Frameshift; Positions=Several;
Secondary accessions: O00216 P09002 Q0VAD3 Q9UNN7Alternative splicing: 2 isoforms: Q01534-1 Q01534-2 (Additional isoforms seem to exist)Post-translational modifications:
Phosphorylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003299.2
ENSEMBL proteins: ENSP00000372512 ENSP00000314077
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TSPY1: Assays for TSPY1: | Protein
Domains/ Families for TSPY1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q01534
ProtoNet protein and cluster: Q01534 1 Blocks protein family: IPB002164 Nucleosome assembly protein (NAP)
UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534Similarity: Belongs to the nucleosome assembly protein (NAP) family | Gene Function for TSPY1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003308
Applied Biosystems Silencer® siRNAs for TSPY1
Sigma-Aldrich siRNA for TSPY1  Sigma-Aldrich shRNA for TSPY1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003308                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003308                                  untagged cDNA clone in CMV expression vector: NM_003308 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003308
UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534Function: May be involved in sperm differentiation and proliferationInduction: Up-regulated by androgen in a prostate cancer cell line1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Tspy-ps):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TSPY1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for TSPY1 (ENSP000003140773 Q015341) via UniProtKB, MINT, and/or STRINGAbout this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
): About this table
|
Drugs & Compounds for TSPY1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TSPY1
|
Transcripts for TSPY1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003308
Sigma-Aldrich siRNA for TSPY1  Sigma-Aldrich shRNA for TSPY1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003308 REFSEQ mRNAs for TSPY1 gene: NM_003308.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003308               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003308                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003308                                  untagged cDNA clone in CMV expression vector: NM_003308  Additional cDNA sequence: U58096.1 6 DOTS entries: DT.410181 DT.120653978 DT.120653195 DT.40106229 DT.120651221 DT.120651912 8 AceView cDNA sequences:NM_003308 BI828033 AI138810 U58096 AA993340 M94893 NM_022573 BG198129
highest scoring ESTs for TSPY1:M94893 U58096 NM_003308 AK093413 AA608988 AA725833 AI138810 AY130858 BG198129 M98525 Unigene Clusters for TSPY1: Testis specific protein, Y-linked 1 Hs.592352 , Hs.647494 [show with all ESTs], Hs.710329 Unigene Representative Sequences: AK308271, M94893, U58096
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000383042
ENST00000320701
|
Expression for TSPY1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TSPY1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TSPY1
1 / 2 / 3 6 probe-sets matching TSPY1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.592352 Hs.647494 Hs.710329
Expression variation in blood from EXPOLDB for TSPY1 UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534Tissue specificity: Specifically expressed in testicular tissues. Isoform 1 and isoform 2 are expressed in spermatogonia and spermatocytes. Found in early testicular carcinoma in situ, spermatogonial cells in testicular tissues of 46,X,Y female and in prostate cancer cell lines |
Orthologs for TSPY1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TSPY1 gene from 3 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
LOC4733011 |
-- |
similar to Testis-Specific Protein Y (TSPY) |
81.51(n) 70.55(a) |
473301 XM_528672.2 XP_528672.2 |
cow (Bos taurus) |
LOC7868111 |
-- |
similar to Testis-specific Y-encoded protein 1 (Cancer/testis more |
69.81(n) 53.21(a) |
786811 XM_001254382.1 XP_001254383.1 |
mouse (Mus musculus) |
Tspy-ps5 |
Y |
testis specific protein-Y encoded, pseudogene |
-- |
AJ001379 |
About this table Species with no ortholog for TSPY1
ENSEMBL Gene Tree for TSPY1 | Paralogs for TSPY1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TSPY1 gene
- LOC7283951 2 LOC7284121 LOC7281321 LOC7281371 TSPY21 LOC7284031 SET2 TSPYL12
- TSPYL62 ENSG000001876572 ENSG000002156012 TSPYL22 TSPYL52 TSPYL42 ENSG000001886562 TSPY32
|
SNPs/Variants for TSPY1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534Polymorphism: Variants Val-Glu-Val-Val-Ala-Glu-79 Ins and Arg-195 are shown to be present in a number of TSPY1 copies of the Yp11 loci. Variant Arg-195 is shown to be present at least in one TSPY1 copy of the Yq locusPolymorphism: Maps to a tandemly repeated region on chromosome Yp11; additionally at least one copy is reported originating from Yq. The gene is thought to be present with an inter-individual variation in copy number and between 20 and 60 copies per Y chromosome are expected. PubMed:12815422 reports 35 tandemly repeated gene copies on Yp11 originating from one individual |
Disorders & Mutations for TSPY1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 480100
UniProtKB/Swiss-Prot: TSPY1_HUMAN, Q01534
May be associated with gonadoblastoma (GBY) [MIM:424500]. GBY is a rare tumor that rises mostly in the dysgenetic gonads of phenotypic females who harbor some Y-chromosomal material. Copies of TSPY fall within the GBY critical region and TSPY1 is preferentially expressed in the germ cells of tumor aggregates in GBY Expression correlates with testicular seminoma, and tumorigenesis of the prostate gland Lies in a chromosomal region that is frequently deleted in infertile males9 Novoseek disease relationships for TSPY1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gonadoblastoma |
90.85 |
18 |
17349529 (6), 10629567 (2), 15241014 (2), 10090875 (1) (see all 8) |
| testicular carcinoma |
72.42 |
1 |
8923009 (1) |
| turners syndrome |
55.32 |
1 |
18545811 (1) |
| prostate cancer |
38.00 |
8 |
11743352 (2), 16618725 (2), 10090875 (1), 11257712 (1) (see all 6) |
| azoospermia |
35.09 |
1 |
15524154 (1) |
| infertility male |
32.96 |
2 |
17509197 (2) |
| tumors |
5.62 |
4 |
17349529 (1), 8533770 (1), 17977648 (1), 16618725 (1) |
| carcinoma |
1.37 |
1 |
17349529 (1) |
| cancer |
0.00 |
2 |
16106251 (1), 16207477 (1) |
About this table
|
Medical News for TSPY1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TSPY1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/78 PubMed articles for TSPY1 gene (see all 78
):- Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues. (PubMed id 8923009)1, 3, 4 Schnieders F....Schmidtke J. (1996)
- Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes. (PubMed id 12527192)1, 3, 4 Krick R.... Arnemann J. (2003)
- TSPY-related sequences represent a microheterogeneous gene family. (PubMed id 8244388)1, 3, 4 Manz E.... Schmidtke J. (1993)
- Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY. (PubMed id 1765369)1, 3, 4 Arnemann J.... Schmidtke J. (1991)
- Molecular isolation and characterization of an expressed gene from the human Y chromosome. (PubMed id 1284595)1, 3, 4 Zhang J.S....Lau Y.-F.C. (1992)
- Expression analysis of thirty one Y chromosome genes in human prostate cancer. (PubMed id 10747295)1, 3, 4 Lau Y.-F.C. and Zhang J. (2000)
- Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. (PubMed id 10090875)1, 3, 4 Lau Y.-F.C. (1999)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)3, 4 Skaletsky H....Page D.C. (2003)
- TSPY variants in six loci on the human Y chromosome. (PubMed id 11173833)3, 4 Dechend F.... Schmidtke J. (2000)
- Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma. (PubMed id 11173850)3, 4 Lau Y.-F.C.... Koemueves L.G. (2000)
|
Search for TSPY1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TSPY1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TSPY1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPY1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TSPY1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TSPY1:

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