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Aliases for TSPOAP1 Gene

Aliases for TSPOAP1 Gene

  • TSPO Associated Protein 1 2 3
  • Benzodiazepine Receptor (Peripheral) Associated Protein 1 2 3 5
  • BZRAP1 3 4 5
  • Peripheral Benzodiazepine Receptor-Interacting Protein 3 4
  • RIMS-Binding Protein 1 3 4
  • RIM-BP1 3 4
  • PBR-IP 3 4
  • PRAX-1 3 4
  • RIMBP1 3 4
  • Benzodiazapine Receptor (Peripheral) Associated Protein 1 3
  • Benzodiazapine Receptor Peripheral-Associated Protein 1 3
  • KIAA0612 4
  • PRAX1 3
  • RBP1 4

External Ids for TSPOAP1 Gene

Previous HGNC Symbols for TSPOAP1 Gene

  • BZRAP1

Summaries for TSPOAP1 Gene

GeneCards Summary for TSPOAP1 Gene

TSPOAP1 (TSPO Associated Protein 1) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Neurotransmitter Release Cycle. An important paralog of this gene is RIMBP3C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPOAP1 Gene

Genomics for TSPOAP1 Gene

Regulatory Elements for TSPOAP1 Gene

Enhancers for TSPOAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPOAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPOAP1 Gene

58,301,227 bp from pter
58,328,795 bp from pter
27,569 bases
Minus strand

Genomic View for TSPOAP1 Gene

Genes around TSPOAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPOAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPOAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPOAP1 Gene

Proteins for TSPOAP1 Gene

  • Protein details for TSPOAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peripheral-type benzodiazepine receptor-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • O75111
    • Q8N5W3

    Protein attributes for TSPOAP1 Gene

    1857 amino acids
    Molecular mass:
    200051 Da
    Quaternary structure:
    • Interacts with RIMS1 and RIMS2 (By similarity). Interacts with BZRP.
    • Sequence=BAA31587.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TSPOAP1 Gene


neXtProt entry for TSPOAP1 Gene

Proteomics data for TSPOAP1 Gene at MOPED

Post-translational modifications for TSPOAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSPOAP1 Gene

No data available for DME Specific Peptides for TSPOAP1 Gene

Domains & Families for TSPOAP1 Gene

Protein Domains for TSPOAP1 Gene


Graphical View of Domain Structure for InterPro Entry



  • The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2.
  • Belongs to the RIMBP family.
  • The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2.
  • Contains 3 fibronectin type-III domains.
  • Contains 3 SH3 domains.
  • Belongs to the RIMBP family.
genes like me logo Genes that share domains with TSPOAP1: view

No data available for Gene Families for TSPOAP1 Gene

Function for TSPOAP1 Gene

genes like me logo Genes that share phenotypes with TSPOAP1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPOAP1 Gene

Localization for TSPOAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPOAP1 Gene

Cytoplasm. Mitochondrion. Note=Preferentially expressed in the mitochondria in the presence of BZRP.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TSPOAP1 Gene

Pathways & Interactions for TSPOAP1 Gene

genes like me logo Genes that share pathways with TSPOAP1: view

Gene Ontology (GO) - Biological Process for TSPOAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007269 neurotransmitter secretion TAS --
genes like me logo Genes that share ontologies with TSPOAP1: view

No data available for SIGNOR curated interactions for TSPOAP1 Gene

Drugs & Compounds for TSPOAP1 Gene

No Compound Related Data Available

Transcripts for TSPOAP1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TSPOAP1 Gene

No ASD Table

Relevant External Links for TSPOAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPOAP1 Gene

mRNA Expression by UniProt/SwissProt for TSPOAP1 Gene

Tissue specificity: Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TSPOAP1 Gene

Orthologs for TSPOAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPOAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BZRAP1 35
  • 83.16 (n)
  • 80.58 (a)
  • 71 (a)
(Canis familiaris)
Mammalia BZRAP1 35
  • 86.5 (n)
  • 84.26 (a)
  • 84 (a)
(Mus musculus)
Mammalia Bzrap1 35
  • 83.04 (n)
  • 81.85 (a)
Bzrap1 16
Bzrap1 36
  • 83 (a)
(Pan troglodytes)
Mammalia BZRAP1 35
  • 96.88 (n)
  • 95.89 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Bzrap1 35
  • 83.13 (n)
  • 81.36 (a)
(Monodelphis domestica)
Mammalia BZRAP1 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia BZRAP1 36
  • 47 (a)
(Gallus gallus)
Aves BZRAP1 35
  • 62.46 (n)
  • 59.4 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bzrap1 35
  • 62.26 (n)
  • 61.92 (a)
(Danio rerio)
Actinopterygii rimbp2 36
  • 6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rbp 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea tag-168 36
  • 21 (a)
Species with no ortholog for TSPOAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPOAP1 Gene

Gene Tree for TSPOAP1 (if available)
Gene Tree for TSPOAP1 (if available)

Paralogs for TSPOAP1 Gene

Paralogs for TSPOAP1 Gene

genes like me logo Genes that share paralogs with TSPOAP1: view

Variants for TSPOAP1 Gene

Sequence variations from dbSNP and Humsavar for TSPOAP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1053809 -- 58,301,420(-) GGGTT(C/T)TCCGC nc-transcript-variant, utr-variant-3-prime
rs1053810 -- 58,301,400(-) ATCCA(A/C)TCCAT nc-transcript-variant, utr-variant-3-prime
rs1053811 -- 58,301,384(-) ACCCT(C/T)TGAGG nc-transcript-variant, utr-variant-3-prime
rs2240261 -- 58,304,028(-) ACGTG(A/G)CATCC intron-variant
rs2526360 -- 58,308,997(-) CCCCG(A/T)GAACA nc-transcript-variant, reference, synonymous-codon

Variation tolerance for TSPOAP1 Gene

Residual Variation Intolerance Score: 98.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.67; 91.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TSPOAP1 Gene

Disorders for TSPOAP1 Gene

Relevant External Links for TSPOAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPOAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPOAP1 Gene

Publications for TSPOAP1 Gene

  1. Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor. (PMID: 9915832) Galiegue S. … Casellas P. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PMID: 22745667) Asbach B. … Wagner R. (PLoS ONE 2012) 3

Products for TSPOAP1 Gene

Sources for TSPOAP1 Gene