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TSPO2 Gene

protein-coding   GIFtS: 43
GCID: GC06P041012

Translocator Protein 2

(Previous name: benzodiazapine receptor (peripheral)-like 1)
(Previous symbol: BZRPL1)
  See TSPO2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocator Protein 21 2
BZRPL11 2 3
Benzodiazapine Receptor (Peripheral)-Like 11 2
Peripheral-Type Benzodiazepine Receptor-Like Protein 12 3
Similar To RIKEN CDNA 2510027D201

External Ids:    HGNC: 212561   Entrez Gene: 2226422   Ensembl: ENSG000001122127   UniProtKB: Q5TGU03   

Export aliases for TSPO2 gene to outside databases

Previous GC identifers: GC06P041119 GC06P040728


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TSPO2 Gene:
TSPO2 (translocator protein 2) is a protein-coding gene. Diseases associated with TSPO2 include lung cancer susceptibility, and lung cancer. GO annotations related to this gene include cholesterol binding. An important paralog of this gene is TSPO.

UniProtKB/Swiss-Prot: TSPO2_HUMAN, Q5TGU0
Function: Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in
erythrocyte maturation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TSPO2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPO2 promoter sequence
   Search Chromatin IP Primers for TSPO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TSPO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPO2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041012:  view genomic region     (about GC identifiers)

Start:
41,010,237 bp from pter      End:
41,012,076 bp from pter
Size:
1,840 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TSPO2_HUMAN, Q5TGU0 (See protein sequence)
Recommended Name: Translocator protein 2  
Size: 170 amino acids; 19129 Da
Secondary accessions: B2RPR2 B7ZMN8 Q3SX82
Alternative splicing: 2 isoforms:  Q5TGU0-1   Q5TGU0-2   

Explore the universe of human proteins at neXtProt for TSPO2: NX_Q5TGU0

Explore proteomics data for TSPO2 at MOPED


See TSPO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001010873.1  NP_001153198.1  

ENSEMBL proteins: 
 ENSP00000362255   ENSP00000362252   ENSP00000419985  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR004307 TspO_MBR

Graphical View of Domain Structure for InterPro Entry Q5TGU0

ProtoNet protein and cluster: Q5TGU0

1 Blocks protein domain: IPB004307 TspO and MBR related proteins

UniProtKB/Swiss-Prot: TSPO2_HUMAN, Q5TGU0
Domain: The C-terminal region mediates cholesterol-binding (By similarity)
Similarity: Belongs to the TspO/BZRP family


Find genes that share domains with TSPO2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TSPO2_HUMAN, Q5TGU0
Function: Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in
erythrocyte maturation

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015485cholesterol binding ISS--
     
Find genes that share ontologies with TSPO2           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for TSPO2:
 Increased gamma-H2AX phosphory 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TSPO2_HUMAN, Q5TGU0: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3
golgi apparatus1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum ISS--
GO:0005789endoplasmic reticulum membrane IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TSPO2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPO2
Interactions:

    Search GeneGlobe Interaction Network for TSPO2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for TSPO2 (ENSP000003622554) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SEC13ENSP000003121224STRING: ENSP00000312122
SSR1ENSP000002447634STRING: ENSP00000244763
UQCR10ENSP000003328874STRING: ENSP00000332887
APRTENSP000003676154STRING: ENSP00000367615
PDHBENSP000003072414STRING: ENSP00000307241
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport IEA--

Find genes that share ontologies with TSPO2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for TSPO2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TSPO2 gene (2 alternative transcripts): 
NM_001010873.2  NM_001159726.1  

Unigene Cluster for TSPO2:

Translocator protein 2
Hs.357392  [show with all ESTs]
Unigene Representative Sequence: NM_001010873
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373161(uc003opj.3 uc003opk.3 uc011dub.2) ENST00000373158
ENST00000470917
miRNA
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat TSPO2

Additional mRNA sequence: 

BC104440.2 BC104441.2 BC137560.1 BC137565.1 BC144710.1 

2 DOTS entries:

DT.40189711  DT.100669779 

6 AceView cDNA sequences:

AI052224 BX282068 BU657409 BU655765 AI038082 R98203 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TSPO2    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:                                    
SP2:                    -               


ECgene alternative splicing isoforms for TSPO2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TSPO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAGAGGAGG
TSPO2 Expression
About this image


TSPO2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Blood (Hematopoietic System)
         Proerythroblasts Hematopoietic Bone Marrow
TSPO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TSPO2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.357392
    Custom PCR Arrays for TSPO2
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TSPO2 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tspo21 , 5 translocator protein 21, 5 77.16(n)1
68.52(a)1
  17 (24.12 cM)5
700261  NM_027292.21  NP_081568.11 
 484479565 
chicken
(Gallus gallus)
Aves TSPO26
translocator protein 2
40(a)
1 ↔ 1
26(4636547-4641634)
lizard
(Anolis carolinensis)
Reptilia TSPO26
translocator protein 2
42(a)
1 ↔ 1
4(123329489-123337813)
zebrafish
(Danio rerio)
Actinopterygii tspo6
translocator protein
40(a)
1 → many
6(40509083-40514117) ENSDARG00000026655
fruit fly
(Drosophila melanogaster)
Insecta CG27896
--
30(a)
1 → many
2L(559612-560523)
worm
(Caenorhabditis elegans)
Secernentea C41G7.96
Protein C41G7.9, isoform b
17(a)
1 → many
I(9515001-9516776) WBGene00077771


ENSEMBL Gene Tree for TSPO2 (if available)
TreeFam Gene Tree for TSPO2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TSPO2 gene
TSPO2  
2 SIMAP similar genes for TSPO2 using alignment to 1 protein entry:     TSPO2_HUMAN:
PBR    TSPO

Find genes that share paralogs with TSPO2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TSPO2 (see all 69)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs675256131,2
C--41008956(+) GAGGGG/TCTCCT 2 -- us2k13Minor allele frequency- T:0.20NA EA 242
rs1167459421,2
C,F--41009292(+) AAACAG/AGAAGG 2 -- us2k11Minor allele frequency- A:0.02NA 120
rs22812551,2
C,F,A,H--41009441(+) CAGGCA/GCAGTG 2 -- us2k119Minor allele frequency- G:0.21NS EA NA WA CSA 2099
rs22812561,2
C,F,H--41009596(+) GTAATC/TCCAGC 2 -- us2k14Minor allele frequency- T:0.50NA WA 8
rs1466833541,2
--41009633(+) CACTTC/GAACTA 2 -- us2k10--------
rs1406662551,2
--41009925(+) AAGCAA/GCATGC 2 -- us2k10--------
rs1145990221,2
C,F--41010005(+) GATGCT/CTGTGC 2 -- us2k11Minor allele frequency- C:0.03WA 118
rs117568931,2
C,F,A,H--41010058(+) CTCATA/CCCCCA 2 -- us2k118Minor allele frequency- C:0.22NS EA NA WA 2342
rs1832344141,2
--41010112(+) TCCACC/GGTGTC 2 -- us2k10--------
rs1877694171,2
--41010130(+) CAAGTC/TTGAAT 2 -- us2k10--------

HapMap Linkage Disequilibrium report for TSPO2 (41010237 - 41012076 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for TSPO2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv526577CNV Loss19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TSPO2
DNA2.0 Custom Variant and Variant Library Synthesis for TSPO2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for TSPO2:    
About MalaCards
lung cancer susceptibility    lung cancer


Find genes that share disorders with TSPO2           About GenesLikeMe

Genetic Association Database (GAD): TSPO2
Human Genome Epidemiology (HuGE) Navigator: TSPO2 (0 documents)

Export disorders for TSPO2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TSPO2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TSPO2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. (PubMed id 19729679)1, 2, 3 Fan J.... Papadopoulos V. (J. Biol. Chem. 2009)
  2. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
  3. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)
  4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 222642 HGNC: 21256 AceView: BZRPL1 Ensembl:ENSG00000112212 euGenes: HUgn222642
ECgene: TSPO2 H-InvDB: TSPO2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TSPO2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TSPO2 gene:
Search GeneIP for patents involving TSPO2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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