TSPO2 Gene
protein-coding GIFtS: 43
GCID: GC06P041012
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translocator protein 2(Previous name: benzodiazapine receptor (peripheral)-like 1 )
(Previous symbol: BZRPL1)
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Aliases
for TSPO2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocator Protein 21 2 | | BZRPL11 2 3 | | Benzodiazapine Receptor (Peripheral)-Like 11 2 | | Peripheral-Type Benzodiazepine Receptor-Like Protein 12 3 | | DJ34B21.21 |
Export aliases for TSPO2 gene to outside databasesPrevious GC identifers: GC06P041119 GC06P040728 |
Summaries
for TSPO2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TSPO2_HUMAN, Q5TGU0Function: Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocytematuration
|
Genomic Views
for TSPO2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TSPO2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPO2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPO2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1TSPO2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P041012: view genomic region
(about GC identifiers)
Start:
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41,010,237 bp from pter |
End:
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41,012,076 bp from pter |
Size:
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1,840 bases |
Orientation:
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plus strand |
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Proteins
for TSPO2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TSPO2_HUMAN, Q5TGU0 (See
protein sequence)Recommended Name: Translocator protein 2 Size: 170 amino acids; 19129 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B2RPR2 B7ZMN8 Q3SX82Alternative splicing: 2 isoforms: Q5TGU0-1 Q5TGU0-2 Explore the universe of human proteins at neXtProt for TSPO2: NX_Q5TGU0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TGU0
TSPO2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001010873.1 NP_001153198.1
ENSEMBL proteins: ENSP00000362255 ENSP00000362252 ENSP00000419985
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
ISS | -- | | GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TSPO2 for ontologies About GeneDecksing
TSPO2 Antibody Products:
Assay Products for TSPO2: |
Protein
Domains /
Families
for TSPO2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPO2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5TGU0ProtoNet protein and cluster: Q5TGU0 1 Blocks protein family: IPB004307 TspO and MBR related proteins
UniProtKB/Swiss-Prot: TSPO2_HUMAN, Q5TGU0Domain: The C-terminal region mediates cholesterol-binding (By similarity)Similarity: Belongs to the TspO/BZRP family |
Function
for TSPO2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TSPO2_HUMAN, Q5TGU0Function: Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocytematuration
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPO2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- | | GO:0015485 | cholesterol binding |
ISS | -- |
TSPO2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TSPO2:
|
Pathways & Interactions
for TSPO2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPO2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
TSPO2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TSPO2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TSPO2
Search CenterWatch for drugs/clinical trials and news about TSPO2
|
Transcripts
for TSPO2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TSPO2 gene (2 alternative transcripts): NM_001010873.2 NM_001159726.1 Unigene Cluster for TSPO2: Translocator protein 2 Hs.357392 [show with all ESTs]Unigene Representative Sequence: NM_0010108733 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373161(uc003opj.3 uc003opk.3 uc011dub.2) ENST00000373158
ENST00000470917
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TSPO2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TSPO2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TSPO2 (NM_001010873) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TSPO2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPO2 |
Additional cDNA sequence: BC104440.2 BC104441.2 BC137560.1 BC137565.1 BC144710.1 2 DOTS entries: DT.40189711 DT.100669779 6 AceView cDNA sequences: BU657409 BU655765 AI052224 BX282068 AI038082 R98203
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TSPO2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for TSPO2
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Expression
for TSPO2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TSPO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGAGGAGG
About this image
See TSPO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPO2
SOURCE GeneReport for Unigene cluster: Hs.357392
SABiosciences Custom PCR Arrays for TSPO2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TSPO2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPO2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPO2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPO2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO2 |
Orthologs
for TSPO2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TSPO2 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for TSPO2 (if available)
TreeFam Gene Tree for TSPO2 (if available) |
Paralogs
for TSPO2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TSPO2 gene
- TSPO2
2 SIMAP similar genes for TSPO2 using alignment to 1 protein entry: TSPO2_HUMAN:PBR TSPO
TSPO2 for paralogs About GeneDecksing
|
Genomic Variants
for TSPO2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TSPO2 (41010237 - 41012076 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TSPO2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TSPO2 |
|
Disorders
/ Diseases
for TSPO2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPO2 for disorders About GeneDecksing
2  diseases for TSPO2: About MalaCardspulmonary disease cholesterol
Human Genome Epidemiology (HuGE) Navigator: TSPO2 (0 documents)
Export disorders for TSPO2 gene to outside databases
|
Publications
for TSPO2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TSPO2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TSPO2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. (PubMed id 19729679)1, 2, 3 Fan J.... Papadopoulos V. (2009)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1 Hosgood H.D....Lan Q. (2009)
- Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1 Skibola C.F....Smith M.T. (2008)
- Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1 Hosgood H.D....Lan Q. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TSPO2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TSPO2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPO2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPO2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TSPO2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TSPO2 gene:
Search GeneIP for patents involving TSPO2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSPO2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TSPO2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TSPO2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPO2 |
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