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Aliases for TSPO2 Gene

Aliases for TSPO2 Gene

  • Translocator Protein 2 2 3 5
  • Peripheral-Type Benzodiazepine Receptor-Like Protein 1 3 4
  • Benzodiazapine Receptor (Peripheral)-Like 1 2 3
  • BZRPL1 3 4
  • Similar To RIKEN CDNA 2510027D20 2

External Ids for TSPO2 Gene

Previous HGNC Symbols for TSPO2 Gene

  • BZRPL1

Previous GeneCards Identifiers for TSPO2 Gene

  • GC06P041119
  • GC06P041012
  • GC06P040728

Summaries for TSPO2 Gene

GeneCards Summary for TSPO2 Gene

TSPO2 (Translocator Protein 2) is a Protein Coding gene. GO annotations related to this gene include cholesterol binding. An important paralog of this gene is TSPO.

UniProtKB/Swiss-Prot for TSPO2 Gene

  • Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPO2 Gene

Genomics for TSPO2 Gene

Regulatory Elements for TSPO2 Gene

Enhancers for TSPO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G041062 1.5 FANTOM5 ENCODE dbSUPER 12.2 +23.2 23199 4.4 FOXA2 ATF1 MLX ARID4B DMAP1 TCF12 SLC30A9 GATA2 SP5 MIER2 ADCY10P1 APOBEC2 TSPO2 UNC5CL NFYA
GH06G040995 1.3 Ensembl ENCODE 11.9 -43.4 -43415 5.3 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 SLC30A9 ZNF416 ZNF143 FOS JUNB UNC5CL TSPO2 NFYA LOC101929555 GC06P040912
GH06G041070 1.4 ENCODE dbSUPER 10.7 +32.2 32214 5.9 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1 ADCY10P1 TSPO2 UNC5CL APOBEC2 NFYA OARD1
GH06G040953 1.3 Ensembl ENCODE dbSUPER 10.3 -84.3 -84284 6.3 SOX13 CTCF FOXA2 NFIB ZMYM3 CEBPG ZNF48 NR2F6 FOS MAFK ADCY10P1 UNC5CL TSPO2 GC06P040912 LOC101929555
GH06G040961 1.3 Ensembl ENCODE dbSUPER 10.3 -79.2 -79182 1.8 HDGF ELF3 FOS CEBPB ELF4 JUNB REST ELF1 ZNF592 CREB3 UNC5CL TSPO2 GC06P040912 LOC101929555
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPO2 Gene

Chromosome:
6
Start:
41,041,370 bp from pter
End:
41,044,337 bp from pter
Size:
2,968 bases
Orientation:
Plus strand

Genomic View for TSPO2 Gene

Genes around TSPO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPO2 Gene

Proteins for TSPO2 Gene

  • Protein details for TSPO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TGU0-TSPO2_HUMAN
    Recommended name:
    Translocator protein 2
    Protein Accession:
    Q5TGU0
    Secondary Accessions:
    • B2RPR2
    • B7ZMN8
    • Q3SX82

    Protein attributes for TSPO2 Gene

    Size:
    170 amino acids
    Molecular mass:
    19129 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPO2 Gene

Post-translational modifications for TSPO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSPO2 Gene

No data available for DME Specific Peptides for TSPO2 Gene

Domains & Families for TSPO2 Gene

Protein Domains for TSPO2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TSPO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TGU0

UniProtKB/Swiss-Prot:

TSPO2_HUMAN :
  • The C-terminal region mediates cholesterol-binding.
  • Belongs to the TspO/BZRP family.
Domain:
  • The C-terminal region mediates cholesterol-binding.
Family:
  • Belongs to the TspO/BZRP family.
genes like me logo Genes that share domains with TSPO2: view

No data available for Gene Families for TSPO2 Gene

Function for TSPO2 Gene

Molecular function for TSPO2 Gene

UniProtKB/Swiss-Prot Function:
Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation.

Gene Ontology (GO) - Molecular Function for TSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015485 cholesterol binding ISS --
genes like me logo Genes that share ontologies with TSPO2: view
genes like me logo Genes that share phenotypes with TSPO2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPO2 Gene

Localization for TSPO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPO2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPO2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPO2: view

Pathways & Interactions for TSPO2 Gene

SuperPathways for TSPO2 Gene

No Data Available

Interacting Proteins for TSPO2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362255%0d%0a9606.ENSP00000332887%0d%0a9606.ENSP00000244763%0d%0a9606.ENSP00000312122%0d%0a9606.ENSP00000349696%0d%0a9606.ENSP00000260585%0d%0a
Selected Interacting proteins: Q5TGU0-TSPO2_HUMAN ENSP00000362255 for TSPO2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TSPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TSPO2: view

No data available for Pathways by source and SIGNOR curated interactions for TSPO2 Gene

Transcripts for TSPO2 Gene

mRNA/cDNA for TSPO2 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSPO2 Gene

Translocator protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for TSPO2 Gene

GeneLoc Exon Structure for
TSPO2
ECgene alternative splicing isoforms for
TSPO2

Expression for TSPO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPO2 Gene

This gene is overexpressed in Whole Blood (x29.6).

NURSA nuclear receptor signaling pathways regulating expression of TSPO2 Gene:

TSPO2

SOURCE GeneReport for Unigene cluster for TSPO2 Gene:

Hs.357392
genes like me logo Genes that share expression patterns with TSPO2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPO2 Gene

Orthologs for TSPO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPO2 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia TSPO2 34 35
  • 85.45 (n)
rat
(Rattus norvegicus)
Mammalia Tspo2 34
  • 77.71 (n)
mouse
(Mus musculus)
Mammalia Tspo2 34 16 35
  • 77.16 (n)
oppossum
(Monodelphis domestica)
Mammalia TSPO2 35
  • 54 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPO2 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPO2 35
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPO2 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tspo 35
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG2789 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41G7.9 35
  • 17 (a)
OneToMany
Species where no ortholog for TSPO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TSPO2 Gene

ENSEMBL:
Gene Tree for TSPO2 (if available)
TreeFam:
Gene Tree for TSPO2 (if available)

Paralogs for TSPO2 Gene

Paralogs for TSPO2 Gene

(2) SIMAP similar genes for TSPO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TSPO2: view

Variants for TSPO2 Gene

Sequence variations from dbSNP and Humsavar for TSPO2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000039207 -- 41,039,841(+) TTACA(C/T)AAGGT upstream-variant-2KB
rs1000324590 -- 41,043,577(+) GGTGT(A/G)GAAGG reference, stop-gained
rs1000412179 -- 41,039,586(+) TTCTT(A/G)AACTA upstream-variant-2KB
rs1001019051 -- 41,041,005(+) AGGCT(C/G)TGAAG upstream-variant-2KB
rs1001840857 -- 41,042,851(+) CCTCC(A/G)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPO2 Gene

Variant ID Type Subtype PubMed ID
nsv526577 CNV loss 19592680

Variation tolerance for TSPO2 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 34.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPO2 Gene

Disorders for TSPO2 Gene

Relevant External Links for TSPO2

Genetic Association Database (GAD)
TSPO2
Human Genome Epidemiology (HuGE) Navigator
TSPO2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPO2

No disorders were found for TSPO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPO2 Gene

Publications for TSPO2 Gene

  1. Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. (PMID: 19729679) Fan J. … Papadopoulos V. (J. Biol. Chem. 2009) 2 3 4 64
  2. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 64
  3. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PMID: 18636124) Skibola C.F. … Smith M.T. (PLoS ONE 2008) 3 46 64
  4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64

Products for TSPO2 Gene

Sources for TSPO2 Gene

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