Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TSPO Gene

protein-coding   GIFtS: 64
GCID: GC22P043547

Translocator Protein (18kDa)

(Previous name: benzodiazapine receptor (peripheral))
(Previous symbol: BZRP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocator Protein (18kDa)1 2     Peripheral-Type Benzodiazepine Receptor/Recognition Site1
BZRP1 2 3 5     DBI2
PBR2 3 5     IBP2
Mitochondrial Benzodiazepine Receptor2 3     PTBR2
Peripheral-Type Benzodiazepine Receptor2 3     Benzodiazepine Peripheral Binding Site2
MBR2 3     mDRC2
PKBS2 3     pk182
BPBS2 5     Translocator Protein2
PBS2 5     PBRS3
Benzodiazapine Receptor (Peripheral)1     

External Ids:    HGNC: 11581   Entrez Gene: 7062   Ensembl: ENSG000001003007   OMIM: 1096105   UniProtKB: P305363   
UniProtKB: B1AH883   

Export aliases for TSPO gene to outside databases

Previous GC identifers: GC22P041877 GC22P026505


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSPO Gene:
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts
with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key
factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis.
Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is
considered non-coding, and the other variants encode the same protein. (provided by RefSeq, Feb 2012)

GeneCards Summary for TSPO Gene: 
TSPO (translocator protein (18kDa)) is a protein-coding gene. Diseases associated with TSPO include hepatic encephalopathy, and generalized anxiety disorder, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors). GO annotations related to this gene include cholesterol binding and androgen binding. An important paralog of this gene is TSPO2.

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536
Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely
to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport
of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in
steroidogenic cells (By similarity)

Gene Wiki entry for TSPO (Translocator protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TSPO gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPO promoter sequence
   Search SABiosciences Chromatin IP Primers for TSPO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.3

TSPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPO gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P043547:  view genomic region     (about GC identifiers)

Start:
43,547,520 bp from pter      End:
43,559,248 bp from pter
Size:
11,729 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536 (See protein sequence)
Recommended Name: Translocator protein  
Size: 169 amino acids; 18828 Da
Subunit: Interacts with BZRAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein
Secondary accessions: Q53Y59 Q6ICF9 Q96TF6
Alternative splicing: 2 isoforms:  P30536-1   B1AH88-1   (No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support)

UniProtKB/Swiss-Prot: TSPOB_HUMAN, B1AH88 (See protein sequence)

Recommended Name: Putative peripheral benzodiazepine receptor-related protein  
Size: 102 amino acids; 10537 Da
Caution: Product of a dubious CDS prediction
Secondary accessions: Q13849 Q6IAZ7
Alternative splicing: 2 isoforms:  B1AH88-1   P30536-1   (No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support)

Explore the universe of human proteins at neXtProt for TSPO: NX_B1AH88

Explore proteomics data for TSPO at MOPED 

TSPO Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TSPO Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_000705.2  NP_001243459.1  NP_001243460.1  

ENSEMBL proteins: 
 ENSP00000338004   ENSP00000463495   ENSP00000405685   ENSP00000328973   ENSP00000379563  

Human Recombinant Protein Products for TSPO: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for TSPO
OriGene Protein Over-expression Lysate for TSPO
OriGene MassSpec for TSPO 
OriGene Custom Protein Services for TSPO
GenScript Custom Purified and Recombinant Proteins Services for TSPO
Novus Biologicals TSPO Protein
Novus Biologicals TSPO Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for TSPO 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005741mitochondrial outer membrane IEA--
GO:0016021integral to membrane IEA--

TSPO for ontologies           About GeneDecksing



TSPO Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Cell Signaling Technology (CST) Antibodies for TSPO 
OriGene Antibodies for TSPO
OriGene Custom Antibody Services for TSPO
GenScript Custom Superior Antibodies Services for TSPO
Novus Biologicals TSPO Antibodies
Abcam antibodies for TSPO (P30536, B1AH88)
Cloud-Clone Corp. Antibodies for TSPO 
ThermoFisher Antibody for TSPO
LSBio Antibodies in human, mouse, rat for TSPO 

Assay Products for TSPO: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for TSPO
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for TSPO
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for TSPO 
Cloud-Clone Corp. CLIAs for TSPO


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR004307 TspO_MBR

Graphical View of Domain Structure for InterPro Entry P30536
Graphical View of Domain Structure for InterPro Entry B1AH88

ProtoNet protein and cluster: P30536

1 Blocks protein domain: IPB004307 TspO and MBR related proteins

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536
Similarity: Belongs to the TspO/BZRP family


TSPO for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TSPOA_HUMAN, P30536
Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely
to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport
of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in
steroidogenic cells (By similarity)

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005497androgen binding IEA--
GO:0005515protein binding ----
GO:0008503benzodiazepine receptor activity IEA--
GO:0015485cholesterol binding TAS16822554
     
TSPO for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TSPO:
 Decreased Salmonella enterica  

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPO 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPO

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPO 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPO 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPO
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TSPO
SwitchGear 3'UTR luciferase reporter plasmidTSPO 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TSPO
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPO

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TSPO
Sirion Biotech Customized adenovirus for overexpression of TSPO

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for TSPO (see all 11)
OriGene ORF clones in mouse, rat for TSPO
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): TSPO (NM_007311)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPO
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPO
Sirion Biotech Customized lentivirus for stable overexpression of TSPO 
                     Customized lentivirus expression plasmids for stable overexpression of TSPO 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for TSPO
Search LifeMap BioReagents cell lines for TSPO
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TSPO About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Neuroactive ligand-receptor interaction0.37
2Glucose / Energy Metabolism
Glucose / Energy Metabolism
3Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)
Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)
4Benzodiazepine Pathway, Pharmacodynamics
Benzodiazepine Pathway, Pharmacodynamics
5"Ca, cAMP and Lipid Signaling"
"Ca, cAMP and Lipid Signaling"

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 Cell Signaling Technology (CST) Pathways for TSPO
    Ca, cAMP and Lipid Signaling
Glucose / Energy Metabolism

1 GeneGo (Thomson Reuters) Pathway for TSPO
    Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)

1 PharmGKB Pathway for TSPO
    Benzodiazepine Pathway, Pharmacodynamics

2         Kegg Pathways  (Kegg details for TSPO):
    Neuroactive ligand-receptor interaction
HTLV-I infection


TSPO for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPO

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/29 Interacting proteins for TSPO (P305363 ENSP000003289734) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
InteractantInteraction Details
GeneCardExternal ID(s)
BZRAP1O951533, ENSP000003458244I2D: score=3 STRING: ENSP00000345824
SLX1AQ9BQ833I2D: score=1 
SLX1BQ9BQ833I2D: score=1 
DBIP071083, ENSP000003111174I2D: score=2 STRING: ENSP00000311117
INTS1Q8N2013I2D: score=1 
About this table

Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006626protein targeting to mitochondrion TAS1326278
GO:0006694steroid biosynthetic process IEA--
GO:0006783heme biosynthetic process TAS16822554
GO:0006820anion transport TAS16822554
GO:0006915apoptotic process TAS16822554

TSPO for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TSPO for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Enzo Life Sciences drugs & compounds for TSPO

Browse Tocris compounds for TSPO (TSPOB)

2 HMDB Compounds for TSPO    About this table
CompoundSynonyms CAS #PubMed Ids
Heme(protoporphyrinato)iron (see all 19)14875-96-8--
ZolpidemAmbien (see all 7)82626-48-0--

10/13 DrugBank Compounds for TSPO (see all 13)    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
ClonazepamChlonazepam (see all 2)1622-61-3targetother/unknown10558889 2723642 1691678 11752352 10423168 2364987
Flunitrazepam-- 1622-62-4targetagonist1847384 2723642 1651852 19443999 9098698 1320691
Eszopiclone-- 138729-47-2targetagonist18265473 17139284 17016423 19744401
Lorazepam(+/-)-Lorazepam (see all 3)846-49-1targetother1647706 8787774 17156911 16959136
ChlormezanoneChlormethazanone (see all 12)80-77-3targetagonist17139284 11752352 17016423
Ketazolam-- 27223-35-4targetagonist11752352 17631921 11443263
TemazepamHydroxydiazepam (see all 4)846-50-4targetother12850901 7911332 16959136
Alprazolam-- 28981-97-7targetother17139284 17016423
Diazepam-- 439-14-5targetpotentiator11752352 17631921
Zaleplon-- 151319-34-5targetother17139284 17016423

10/119 Novoseek inferred chemical compound relationships for TSPO gene (see all 119)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
benzodiazepine 98.6 2697 8306240 (10), 10664825 (9), 17027961 (8), 8868371 (7) (see all 99)
pk 11195 94.4 93 17291492 (3), 16051742 (2), 17555551 (2), 18800007 (2) (see all 52)
iomazenil 93.1 17 7662908 (1), 12440611 (1), 8691270 (1), 9212889 (1) (see all 16)
flumazenil 92.6 89 10023509 (3), 8880096 (3), 8282018 (2), 8545530 (2) (see all 73)
benzodiazepines 86.6 76 1980690 (3), 1637606 (2), 8262176 (2), 14678758 (2) (see all 63)
diazepam 85.1 118 10576594 (5), 1316281 (3), 8080486 (3), 1321091 (3) (see all 78)
bretazenil 80.1 8 8981602 (2), 8748388 (1), 9839004 (1), 8868371 (1) (see all 7)
zolpidem 79.1 34 8925872 (3), 1361878 (3), 11370287 (2), 10755807 (2) (see all 26)
gaba 77 122 1965016 (6), 2160756 (2), 1649416 (2), 8306240 (2) (see all 76)
triakontatetraneuropeptide 77 5 19456330 (1), 8380885 (1), 9460762 (1)

Search CenterWatch for drugs/clinical trials and news about TSPO / TSPOB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSPO gene (4 alternative transcripts): 
NM_000714.5  NM_001256530.1  NM_001256531.1  NM_007311.3  

Unigene Cluster for TSPO:

Translocator protein (18kDa)
Hs.202  [show with all ESTs]
Unigene Representative Sequence: BM924710
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000337554(uc003bdn.3 uc003bdo.3) ENST00000583777 ENST00000472378
ENST00000428336 ENST00000329563 ENST00000396265
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TSPO
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TSPO
SwitchGear 3'UTR luciferase reporter plasmidTSPO 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TSPO
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPO
Clone
Products:
     
OriGene clones in human, mouse for TSPO (see all 11)
OriGene ORF clones in mouse, rat for TSPO
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): TSPO (NM_007311)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPO
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPO
Sirion Biotech Customized lentivirus for stable overexpression of TSPO 
                     Customized lentivirus expression plasmids for stable overexpression of TSPO 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TSPO
OriGene qSTAR qPCR primer pairs in human, mouse for TSPO
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPO
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPO
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPO

Additional mRNA sequence: 

AF075589.1 AF075590.1 AY998017.1 BC001110.2 BT006949.1 CR456409.1 CR457007.1 L21950.1 
M36035.1 NR_046308.1 

7 DOTS entries:

DT.40127929  DT.98131737  DT.100801819  DT.100643566  DT.97855685  DT.97855686  DT.97821978 

24/442 AceView cDNA sequences (see all 442):

BU177060 BU625404 AW469169 BM756266 BQ927812 BQ182755 AF075590 BG575252 
CR619651 CA307061 BE908317 BQ083702 BG171507 BM905068 CR617902 BM694225 
CD370271 BM853651 AW328575 BX391144 CR609727 BQ773690 BM784742 BM842268 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TSPO    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
SP1:        -     -     -                                             
SP2:                    -                                             
SP3:                                      -                           
SP4:        -     -     -     -     -     -                           
SP5:                                                                  


ECgene alternative splicing isoforms for TSPO

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPO expression in normal human tissues (normalized intensities)      TSPO embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAATTTTATA
TSPO Expression
About this image


TSPO expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Eye (Sensory Organs)
         Mature Horizontal Cells Inner Nuclear Layer
 
 Liver (Hepatobiliary System)
 
 Adrenal Gland (Endocrine System)

See TSPO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPO

SOURCE GeneReport for Unigene cluster: Hs.202

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536
Tissue specificity: Found in many tissue types. Expressed at the highest levels under normal conditions in tissues
that synthesize steroids

UniProtKB/Swiss-Prot: TSPOB_HUMAN, B1AH88
Tissue specificity: Ubiquitous

    SABiosciences Expression via Pathway-Focused PCR Arrays including TSPO: 
          Neurotransmitter Receptors in human mouse rat
          Mitochondria in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TSPO
OriGene qSTAR qPCR primer pairs in human, mouse for TSPO
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TSPO
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPO
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPO
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSPO gene from 8/16 species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tspo1 , 5 translocator protein1, 5 81.66(n)1
81.07(a)1
  15 (39.40 cM)5
122571  NM_009775.41  NP_033905.31 
 835635735 
chicken
(Gallus gallus)
Aves TSPO1 translocator protein (18kDa) 63.71(n)
62.66(a)
  418226  XM_416451.3  XP_416451.1 
lizard
(Anolis carolinensis)
Reptilia TSPO6
translocator protein (18kDa)
59(a)
1 ↔ 1
5(86755491-86774618)
African clawed frog
(Xenopus laevis)
Amphibia bzrp-A-prov2 Benzodiazepin receptor (peripheral) 76.54(n)    BC041505.1 
zebrafish
(Danio rerio)
Actinopterygii BI842839.12   -- 81.07(n)    BI842839.1 
fruit fly
(Drosophila melanogaster)
Insecta CG27891 CG2789 56.82(n)
46.98(a)
  33231  NM_134687.3  NP_608531.1 
worm
(Caenorhabditis elegans)
Secernentea C41G7.96
Protein C41G7.9, isoform b
23(a)
1 → many
I(9515001-9516776)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A00220g1 hypothetical protein 40.65(n)
30.89(a)
  2896501  XM_451009.1  XP_451009.1 


ENSEMBL Gene Tree for TSPO (if available)
TreeFam Gene Tree for TSPO (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TSPO gene
TSPO22  
2 SIMAP similar genes for TSPO using alignment to 4 protein entries:     TSPOA_HUMAN (see all proteins):
PBR    TSPO2

TSPO for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/351 SNPs in TSPO are shown (see all 351)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs57591921,2
C,A,H--26503749(+) GCTGGG/CATTAA 2 -- us2k11Minor allele frequency- C:0.00NA 2
rs72855901,2
C,F--26503770(+) cacaaC/Tgccca 2 -- us2k11Minor allele frequency- T:0.50WA 2
rs1808319341,2
--26503806(+) ATGGGG/TTTTCA 2 -- us2k10--------
rs1874342981,2
--43545660(+) TCAAGA/CGATTC 2 -- us2k10--------
rs1917921201,2
--43545944(+) CACTGA/CAACCT 4 -- us2k10--------
rs1389071,2
C,F--43546013(+) ggcacG/Acacca 4 -- us2k11Minor allele frequency- A:0.00CSA 1
rs1829516851,2
C--43546085(+) GGTCTC/TGAACT 4 -- us2k10--------
rs1900514671,2
C--43546182(+) AAAAAA/GAAAAA 4 -- us2k10--------
rs1496358291,2
C--43546225(+) GCTCAC/TGCCTG 4 -- us2k10--------
rs1857198971,2
--43546284(+) GAGTTC/TGAGAC 4 -- us2k10--------

HapMap Linkage Disequilibrium report for TSPO (43547520 - 43559248 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/16 variations for TSPO (see all 16):    About this table     
Variant IDTypeSubtypePubMed ID
esv2671621CNV Deletion23128226
esv2724299CNV Deletion23290073
esv1998181CNV Deletion18987734
esv3468CNV Deletion18987735
dgv4988n71CNV Loss21882294
esv8520CNV Loss19470904
nsv915215CNV Loss21882294
nsv520927CNV Loss19592680
nsv915201CNV Loss21882294
dgv4987n71CNV Loss21882294


Human Gene Mutation Database (HGMD): TSPO
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TSPO
DNA2.0 Custom Variant and Variant Library Synthesis for TSPO

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 109610    OMIM disorders: --

20/106 diseases for TSPO (see all 106):    About MalaCards
hepatic encephalopathy    generalized anxiety disorder    wernicke encephalopathy    hepatic coma
anxiety disorder    fibromyalgia    parametritis    focal epilepsy
olivopontocerebellar atrophy    congenital lipoid adrenal hyperplasia    panic disorder    lipoid adrenal hyperplasia
stiff-person syndrome    somatoform disorder    cerebral artery occlusion    temporal lobe epilepsy
acute liver failure    epilepsies, partial    cerebral infarction    cerebrovascular disease

8 diseases from the University of Copenhagen DISEASES database for TSPO:
Cancer     Interstitial cystitis     Vascular disease     Eye disease
Asthma     Brain disease     Neurodegenerative disease     Heart disease

TSPO for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/93 Novoseek inferred disease relationships for TSPO gene (see all 93)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hepatic encephalopathy 78.4 53 8276347 (5), 11687160 (4), 15106178 (4), 2172467 (3) (see all 31)
hepatic coma 60.7 5 2161396 (1), 9347201 (1), 16563564 (1), 7748297 (1) (see all 5)
chronic insomnia 60.3 1 19201632 (1)
epilepsy temporal lobe 57.7 17 11893007 (2), 12199729 (2), 11518000 (2), 10599778 (1) (see all 14)
panic disorder 53.6 29 10664825 (5), 10023509 (3), 7624108 (3), 9928900 (3) (see all 16)
epilepsies partial 52.8 14 10390953 (2), 1317662 (2), 8956845 (1), 9795703 (1) (see all 12)
anxiety disorders 48.6 10 8748388 (1), 1324584 (1), 10103141 (1), 1687977 (1) (see all 10)
glioma 47.8 40 16026165 (4), 7714547 (3), 9540054 (3), 15276076 (3) (see all 21)
stupor 45.6 2 1357403 (1), 19477714 (1)
epilepsy 45.2 11 11882054 (2), 9237052 (1), 8797068 (1), 10390953 (1) (see all 7)

Genetic Association Database (GAD): TSPO
Human Genome Epidemiology (HuGE) Navigator: TSPO (8 documents)

Export disorders for TSPO gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TSPO gene, integrated from 9 sources (see all 892):
(articles sorted by number of sources associating them with TSPO)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. (PubMed id 8307574)1, 2, 9 Lin D.... Miller W.L. (1993)
  2. The human 'peripheral-type' benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. (PubMed id 1326278)1, 3, 9 Chang Y.J....Strauss J.F. (1992)
  3. Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder. (PubMed id 16511838)1, 4, 9 Nakamura K....Mori N. (2006)
  4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
  5. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
  6. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
  7. Genes related to sex steroids, neural growth, and soc ial-emotional behavior are associated with autistic traits, empathy, and Asperg er syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (2009)
  8. Translocator protein (18kDa): new nomenclature for the peripheral- type benzodiazepine receptor based on its structure and molecular function. (PubMed id 16822554)1, 3 Papadopoulos V.... Gavish M. (2006)
  9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
  10. Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. (PubMed id 1847678)1, 3 Riond J....Ferrara P. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 706 HGNC: 1158 AceView: BZRP Ensembl:ENSG00000100300 euGenes: HUgn706
ECgene: TSPO Kegg: 706 H-InvDB: TSPO

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TSPO Pharmacogenomics, SNPs, Pathways
NIEHS-SNPshttp://egp.gs.washington.edu/data/bzrp/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TSPO gene:
Search GeneIP for patents involving TSPO

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for TSPO   OriGene RNAi products in human, mouse, rat for TSPO  
 OriGene qPCR primer pairs and template standards for TSPO   OriGene Protein Over-expression Lysate for TSPO  
 OriGene MassSpec something-or-other for TSPO   OriGene clones in human, mouse for TSPO  
 OriGene qSTAR qPCR primer pairs in human, mouse for TSPO   OriGene Purified Protein for TSPO  
 OriGene ORF clones in mouse, rat for TSPO   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for TSPO   OriGene Custom Protein Services for TSPO  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TSPO
 QIAGEN SeqTarget long-range PCR primers for resequencing TSPO
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPO
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TSPO
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TSPO
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TSPO
 GenScript Custom Purified and Recombinant Proteins Services for TSPO GenScript cDNA clones with any tag delivered in your preferred vector for TSPO
 GenScript Custom Assay Services for TSPO GenScript Custom Superior Antibodies Services for TSPO
 GenScript Custom overexpressing Cell Line Services for TSPO CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Antibodies & Assays for TSPO 

 Regulatory tfbs in TSPO promoter
 Search Chromatin IP Primers for TSPO
 RT2 qPCR Primer Assay in human, mouse, rat TSPO
 Search GNC Networks for TSPO
 SABiosciences PCR Arrays including human, mouse, rat TSPO
 Search Tocris compounds for TSPO (TSPOB)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Drugs for TSPO
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 TSPO antibodies
 TSPO proteins
 TSPO lysates
 Antibodies for TSPO
 See all of Abcam's Antibodies, Kits and Proteins for TSPO
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for TSPO
 Antibodies for TSPO
 ELISAs for TSPO
 CLIAs for TSPO
 Search LifeMap BioReagents cell lines for TSPO
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO
 SwitchGear 3'UTR luciferase reporter plasmids for TSPO
 SwitchGear Promoter luciferase reporter plasmids for TSPO
 ThermoFisher Antibody for TSPO
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPO
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TSPO
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TSPO
Customized:
 lentivirus for stable overexpression of TSPO
 lentivirus expression plasmids for stable overexpression of TSPO
 adenovirus for overexpression of TSPO
 LSBio Antibodies in human, mouse, rat for TSPO
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      TSPO gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4