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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TSPO Gene

protein-coding GIFtS: 64
GCID: GC22P043547

translocator protein (18kDa)

(Previous name: benzodiazapine receptor (peripheral) )
(Previous symbol: BZRP)

Explore 116 diseases affiliated with
TSPO via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Translocator Protein (18kDa)¹ ²		Mitochondrial Benzodiazepine Receptor² ³
BZRP¹ ² ³ ⁵		Peripheral-Type Benzodiazepine Receptor² ³
PBR¹ ² ³ ⁵		BPBS² ⁵
MBR¹ ² ³		PBS² ⁵
PKBS¹ ² ³		Benzodiazapine Receptor (Peripheral)¹
DBI¹ ²		PTBR²
IBP¹ ²		Benzodiazepine Peripheral Binding Site²
MDRC¹		Translocator Protein²
Pk18¹		PBRS³

External Ids:	HGNC: 1158¹	Entrez Gene: 706²	Ensembl: ENSG00000100300⁷	OMIM: 109610⁵	UniProtKB: P30536³
	UniProtKB: B1AH88³

Export aliases for TSPO gene to outside databases

Previous GC identifers: GC22P041877 GC22P026505

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TSPO:

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with

some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the

flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced

transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and

the other variants encode the same protein. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536

Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to

comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of

porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic

cells (By similarity)

Gene Wiki entry for TSPO (Translocator protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TSPO gene promoter:
CREB deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TSPO promoter sequence

Search SABiosciences Chromatin IP Primers for TSPO

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TSPO

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.3

TSPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPO gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P043547: view genomic region (about GC identifiers)

Start:	43,547,520 bp from pter	End:	43,559,248 bp from pter
Size:	11,729 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536 (See protein sequence)

Recommended Name: Translocator protein

Size: 169 amino acids; 18828 Da

Subunit: Interacts with BZRAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1

Subcellular location: Mitochondrion membrane; Multi-pass membrane protein

Secondary accessions: Q53Y59 Q6ICF9 Q96TF6

Alternative splicing: 2 isoforms: P30536-1 B1AH88-1 (No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support)

UniProtKB/Swiss-Prot: TSPOB_HUMAN, B1AH88 (See protein sequence)

Recommended Name: Putative peripheral benzodiazepine receptor-related protein

Size: 102 amino acids; 10537 Da

Caution: Product of a dubious CDS prediction

Secondary accessions: Q13849 Q6IAZ7

Alternative splicing: 2 isoforms: B1AH88-1 P30536-1 (No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support)

Explore the universe of human proteins at neXtProt for TSPO: NX_B1AH88

TSPO Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000705.2 NP_001243459.1 NP_001243460.1

ENSEMBL proteins:

ENSP00000338004 ENSP00000463495 ENSP00000405685 ENSP00000328973 ENSP00000379563

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	Uscn Proteins for TSPO

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

TSPO for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TSPO

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TSPO for domains About GeneDecksing

1 InterPro domain/family:

IPR004307 TspO_MBR

Graphical View of Domain Structure for InterPro Entry P30536

Graphical View of Domain Structure for InterPro Entry B1AH88

ProtoNet protein and cluster: P30536

1 Blocks protein family: IPB004307 TspO and MBR related proteins

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536

Similarity: Belongs to the TspO/BZRP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536

Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to

comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of

porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic

cells (By similarity)

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005497	androgen binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008503	benzodiazepine receptor activity	IEA	--
GO:0015485	cholesterol binding	TAS	16822554

TSPO for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TSPO:

Decreased Salmonella enterica

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Ca, cAMP and Lipid Signaling

Ca, cAMP and Lipid Signaling

1.00

Benzodiazepine Pathway, Pharmacodynamics

Benzodiazepine Pathway, Pharmacodynamics

1.00

Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)

Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)

1.00

Class A/1 (Rhodopsin-like receptors)

Neuroactive ligand-receptor interaction

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for TSPO

	Ca, cAMP and Lipid Signaling
	Glucose / Energy Metabolism

1 GeneGo (Thomson Reuters) Pathway for TSPO

Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)

1 PharmGKB Pathway for TSPO

Benzodiazepine Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for TSPO):

Neuroactive ligand-receptor interaction

TSPO for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TSPO

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/29 Interacting proteins for TSPO (P30536³ ENSP00000328973⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BZRAP1	O95153³, ENSP00000345824⁴	I2D: score=3 STRING: ENSP00000345824
SLX1A	Q9BQ83³	I2D: score=1
SLX1B	Q9BQ83³	I2D: score=1
DBI	P07108³, ENSP00000311117⁴	I2D: score=2 STRING: ENSP00000311117
INTS1	Q8N201³	I2D: score=1

About this table

Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006626	protein targeting to mitochondrion	TAS	1326278
GO:0006694	steroid biosynthetic process	IEA	--
GO:0006783	heme biosynthetic process	TAS	16822554
GO:0006820	anion transport	TAS	16822554
GO:0006915	apoptotic process	TAS	16822554

TSPO for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TSPO for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for TSPO

Browse Tocris compounds for TSPO

2 HMDB Compounds for TSPO About this table

Compound	Synonyms	CAS #	PubMed Ids
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
Zolpidem	Ambien (see all 7)	82626-48-0	--

10/13 DrugBank Compounds for TSPO (see all 13) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Clonazepam	Chlonazepam (see all 2)	1622-61-3	target	other/unknown	10558889 2723642 1691678 11752352 10423168 2364987
Flunitrazepam	--	1622-62-4	target	agonist	1847384 2723642 1651852 19443999 9098698 1320691
Eszopiclone	--	138729-47-2	target	agonist	18265473 17139284 17016423 19744401
Lorazepam	(+/-)-Lorazepam (see all 3)	846-49-1	target	other	1647706 8787774 17156911 16959136
Chlormezanone	Chlormethazanone (see all 12)	80-77-3	target	agonist	17139284 11752352 17016423
Ketazolam	--	27223-35-4	target	agonist	11752352 17631921 11443263
Temazepam	Hydroxydiazepam (see all 4)	846-50-4	target	other	12850901 7911332 16959136
Alprazolam	--	28981-97-7	target	other	17139284 17016423
Diazepam	--	439-14-5	target	potentiator	11752352 17631921
Zaleplon	--	151319-34-5	target	other	17139284 17016423

10/119 Novoseek chemical compound relationships for TSPO gene (see all 119) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
benzodiazepine	98.6	2697	8306240 (10), 10664825 (9), 17027961 (8), 8868371 (7) (see all 99)
pk 11195	94.4	93	17291492 (3), 16051742 (2), 17555551 (2), 18800007 (2) (see all 52)
iomazenil	93.1	17	7662908 (1), 12440611 (1), 8691270 (1), 9212889 (1) (see all 16)
flumazenil	92.6	89	10023509 (3), 8880096 (3), 8282018 (2), 8545530 (2) (see all 73)
benzodiazepines	86.6	76	1980690 (3), 1637606 (2), 8262176 (2), 14678758 (2) (see all 63)
diazepam	85.1	118	10576594 (5), 1316281 (3), 8080486 (3), 1321091 (3) (see all 78)
bretazenil	80.1	8	8981602 (2), 8748388 (1), 9839004 (1), 8868371 (1) (see all 7)
zolpidem	79.1	34	8925872 (3), 1361878 (3), 11370287 (2), 10755807 (2) (see all 26)
gaba	77	122	1965016 (6), 2160756 (2), 1649416 (2), 8306240 (2) (see all 76)
triakontatetraneuropeptide	77	5	19456330 (1), 8380885 (1), 9460762 (1)

Search CenterWatch for drugs/clinical trials and news about TSPO / TSPOB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TSPO gene (4 alternative transcripts):

NM_000714.5 NM_001256530.1 NM_001256531.1 NM_007311.3

Unigene Cluster for TSPO:

Translocator protein (18kDa)

Hs.202 [show with all ESTs]

Unigene Representative Sequence: BM924710

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000337554(uc003bdn.3 uc003bdo.3) ENST00000583777 ENST00000472378

ENST00000428336 ENST00000329563 ENST00000396265

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Additional cDNA sequence:

AF075589.1 AF075590.1 AY998017.1 BC001110.2 BT006949.1 CR456409.1 CR457007.1 L21950.1

M36035.1 NR_046308.1

7 DOTS entries:

DT.40127929 DT.98131737 DT.100801819 DT.100643566 DT.97855685 DT.97855686 DT.97821978

24/442 AceView cDNA sequences (see all 442):

BE908317 BM842268 BQ083702 BM014524 BQ182755 BX391144 CD370271 BM905068

BU177060 BM810547 BU625404 AA314709 BM694225 BM853651 CA307061 CR617902

AW469169 BM756266 CR456409 BM549915 BG171507 CR619651 BQ773690 BM784742

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TSPO About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c
SP1:			-		-		-
SP2:							-
SP3:													-
SP4:			-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for TSPO

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TSPO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATTTTATA

About this image

TSPO expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TSPO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TSPO

SOURCE GeneReport for Unigene cluster: Hs.202

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536

Tissue specificity: Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that

synthesize steroids

UniProtKB/Swiss-Prot: TSPOB_HUMAN, B1AH88

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including TSPO:

Neurotransmitter Receptors in human mouse rat

Mitochondria in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for TSPO gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TSPO¹	translocator protein (18kDa)	63.71(n) 62.66(a)		418226 XM_416451.3 XP_416451.1
lizard (Anolis carolinensis)	Reptilia	TSPO⁶	--	58(a)	1 ↔ 1	5(86755042-86761098)
African clawed frog (Xenopus laevis)	Amphibia	bzrp-A-prov²	Benzodiazepin receptor (peripheral)	76.54(n)		BC041505.1
zebrafish (Danio rerio)	Actinopterygii	BI842839.1²	--	81.07(n)		BI842839.1
fruit fly (Drosophila melanogaster)	Insecta	CG2789¹	CG2789	56.82(n) 46.98(a)		33231 NM_134687.3 NP_608531.1
K. lactis yeast (Kluyveromyces lactis)	Saccharomycetes	KLLA0A00220g¹	hypothetical protein	40.65(n) 30.89(a)		2896501 XM_451009.1 XP_451009.1

ENSEMBL Gene Tree for TSPO (if available)
TreeFam Gene Tree for TSPO (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TSPO gene

TSPO2²

2 SIMAP similar genes for TSPO using alignment to 4 protein entries: TSPOA_HUMAN (see all proteins):

PBR TSPO2

TSPO for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187434298^1,2		--	43545660(+)	`TCAAGA/CGATTC`	2	--	us2k¹		0	--	--	--	--
rs191792120^1,2		--	43545944(+)	`CACTGA/CAACCT`	4	--	us2k¹		0	--	--	--	--
rs138907^1,2	C,	--	43546013(+)	`GGCACG/ACACCA`	4	--	us2k¹		1		CSA	1
rs182951685^1,2		--	43546085(+)	`GGTCTC/TGAACT`	4	--	us2k¹		0	--	--	--	--
rs149635829^1,2		--	43546225(+)	`GCTCAC/TGCCTG`	4	--	us2k¹		0	--	--	--	--
rs185719897^1,2		--	43546284(+)	`GAGTTC/TGAGAC`	4	--	us2k¹		0	--	--	--	--
rs200984293^1,2	C	--	43546504(-)	`GGTTTC/TTTTTT`	4	--	us2k¹		0	--	--	--	--
rs144376496^1,2		--	43546573(+)	`CAACAC/TAGTAA`	4	--	us2k¹		0	--	--	--	--
rs190424857^1,2		--	43546595(+)	`ATGTAC/TGTTTG`	4	--	us2k¹		0	--	--	--	--
rs5996279^1,2	C,F,A,H,	--	43546733(+)	`CTTGGA/CCCCTG`	4	--	us2k¹		15		NS EA NA WA	2014

HapMap Linkage Disequilibrium report for TSPO (43547520 - 43559248 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TSPO
1 CNV: 7352
5 Indels: 40505 62009 40504 46230 41951
Human Gene Mutation Database (HGMD): TSPO

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TSPO for disorders           About GeneDecksing

OMIM gene information: 109610    OMIM disorders: --

20/116 diseases for TSPO (see all 116):    About MalaCards

obsessive-compulsive disorder generalized anxiety disorder stiff-person syndrome machado-joseph disease

hypersensitivity reaction type ii disease wernicke encephalopathy anxiety disorder lipoid adrenal hyperplasia

olivopontocerebellar atrophy amyotrophic lateral sclerosis central nervous system disease temporal lobe epilepsy

epilepsies, partial leydig cell tumor nervous system disease memory impairment

traumatic brain injury multiple system atrophy adrenal hyperplasia cholesterol

9 diseases from the University of Copenhagen DISEASES database for TSPO:

Cancer Interstitial cystitis Vascular disease Eye disease

Asthma Neurodegenerative disease Brain disease Heart disease

Hepatic encephalopathy

10/93 Novoseek disease relationships for TSPO gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatic encephalopathy	78.4	53	8276347 (5), 11687160 (4), 15106178 (4), 2172467 (3) (see all 31)
hepatic coma	60.7	5	2161396 (1), 9347201 (1), 16563564 (1), 7748297 (1) (see all 5)
chronic insomnia	60.3	1	19201632 (1)
epilepsy temporal lobe	57.7	17	11893007 (2), 12199729 (2), 11518000 (2), 10599778 (1) (see all 14)
panic disorder	53.6	29	10664825 (5), 10023509 (3), 7624108 (3), 9928900 (3) (see all 16)
epilepsies partial	52.8	14	10390953 (2), 1317662 (2), 8956845 (1), 9795703 (1) (see all 12)
anxiety disorders	48.6	10	8748388 (1), 1324584 (1), 10103141 (1), 1687977 (1) (see all 10)
glioma	47.8	40	16026165 (4), 7714547 (3), 9540054 (3), 15276076 (3) (see all 21)
stupor	45.6	2	1357403 (1), 19477714 (1)
epilepsy	45.2	11	11882054 (2), 9237052 (1), 8797068 (1), 10390953 (1) (see all 7)

Human Genome Epidemiology (HuGE) Navigator: TSPO (8 documents)

Export disorders for TSPO gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TSPO gene, integrated from 9 sources (see all 886):
(articles sorted by number of sources associating them with TSPO)

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The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. (PubMed id 8307574)^{1, 2, 9} Lin D.... Miller W.L. (1993)
The human 'peripheral-type' benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. (PubMed id 1326278)^{1, 3, 9} Chang Y.J....Strauss J.F. (1992)
Translocator protein (18kDa): new nomenclature for the peripheral- type benzodiazepine receptor based on its structure and molecular function. (PubMed id 16822554)^{1, 3} Papadopoulos V.... Gavish M. (2006)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. (PubMed id 1847678)^{1, 3} Riond J....Ferrara P. (1991)
Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression. (PubMed id 14626449)^{1, 9} Han Z....Papadopoulos V. (2003)
Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells. (PubMed id 14584048)^{1, 9} Lee D.H....Jung J.S. (2004)
Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities. (PubMed id 10558889)^{7, 9} Bono F....Herbert J.M. (1999)
Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation. (PubMed id 15769477)^{1, 9} Corsi L....Baraldi M. (2005)
Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival. (PubMed id 15041726)^{1, 9} Galiegue S....Simony-Lafontaine J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 706	HGNC: 1158	AceView: BZRP	Ensembl:ENSG00000100300	euGenes: HUgn706
ECgene: TSPO	Kegg: 706	H-InvDB: TSPO

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TSPO	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/bzrp/

Intellectual Property for TSPO gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TSPO gene:
Search GeneIP for patents involving TSPO

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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translocator protein (18kDa)

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TSPO Gene

translocator protein (18kDa)

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