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TSPO Gene

protein-coding   GIFtS: 63
GCID: GC22P043547

Translocator Protein (18kDa)

(Previous name: benzodiazapine receptor (peripheral))
(Previous symbol: BZRP)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocator Protein (18kDa)1 2     Peripheral-Type Benzodiazepine Receptor/Recognition Site1
BZRP1 2 3 5     DBI2
PBR2 3 5     IBP2
Mitochondrial Benzodiazepine Receptor2 3     PTBR2
Peripheral-Type Benzodiazepine Receptor2 3     Benzodiazepine Peripheral Binding Site2
MBR2 3     mDRC2
PKBS2 3     pk182
BPBS2 5     Translocator Protein2
PBS2 5     PBRS3
Benzodiazapine Receptor (Peripheral)1     

External Ids:    HGNC: 11581   Entrez Gene: 7062   Ensembl: ENSG000001003007   OMIM: 1096105   UniProtKB: P305363   
UniProtKB: B1AH883   

Export aliases for TSPO gene to outside databases

Previous GC identifers: GC22P041877 GC22P026505


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPO Gene:
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts
with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key
factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis.
Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is
considered non-coding, and the other variants encode the same protein. (provided by RefSeq, Feb 2012)

GeneCards Summary for TSPO Gene:
TSPO (translocator protein (18kDa)) is a protein-coding gene. Diseases associated with TSPO include wernicke encephalopathy, and hepatic encephalopathy. GO annotations related to this gene include cholesterol binding and androgen binding. An important paralog of this gene is TSPO2.

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536
Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely
to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport
of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in
steroidogenic cells (By similarity)

Gene Wiki entry for TSPO (Translocator protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPO gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPO promoter sequence
   Search Chromatin IP Primers for TSPO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.3

TSPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPO gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P043547:  view genomic region     (about GC identifiers)

Start:
43,547,520 bp from pter      End:
43,559,248 bp from pter
Size:
11,729 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536 (See protein sequence)
Recommended Name: Translocator protein  
Size: 169 amino acids; 18828 Da
Subunit: Interacts with BZRAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1
Secondary accessions: Q53Y59 Q6ICF9 Q96TF6
Alternative splicing: 2 isoforms:  P30536-1   B1AH88-1   (No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support)

UniProtKB/Swiss-Prot: TSPOB_HUMAN, B1AH88 (See protein sequence)

Recommended Name: Putative peripheral benzodiazepine receptor-related protein  
Size: 102 amino acids; 10537 Da
Caution: Product of a dubious CDS prediction
Secondary accessions: Q13849 Q6IAZ7
Alternative splicing: 2 isoforms:  B1AH88-1   P30536-1   (No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support)

Explore the universe of human proteins at neXtProt for TSPO: NX_B1AH88

Explore proteomics data for TSPO at MOPED


See TSPO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_000705.2  NP_001243459.1  NP_001243460.1  

ENSEMBL proteins: 
 ENSP00000338004   ENSP00000463495   ENSP00000405685   ENSP00000328973   ENSP00000379563  

TSPO Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for TSPO


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR004307 TspO_MBR

Graphical View of Domain Structure for InterPro Entry P30536
Graphical View of Domain Structure for InterPro Entry B1AH88

ProtoNet protein and cluster: P30536

1 Blocks protein domain: IPB004307 TspO and MBR related proteins

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536
Similarity: Belongs to the TspO/BZRP family


TSPO for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TSPOA_HUMAN, P30536
Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely
to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport
of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in
steroidogenic cells (By similarity)

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005497androgen binding IEA--
GO:0005515protein binding ----
GO:0008503benzodiazepine receptor activity IEA--
GO:0015485cholesterol binding TAS16822554
     
TSPO for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TSPO:
 Decreased Salmonella enterica  

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPO
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPO

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Predesigned siRNA for gene silencing in human, mouse, rat TSPO

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TSPOA_HUMAN, P30536: Mitochondrion membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
extracellular3
cytoskeleton2
endoplasmic reticulum2
nucleus2
plasma membrane2
vacuole2
chloroplast1
cytosol1
lysosome1
peroxisome1

Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA--
GO:0005739mitochondrion IDA--
GO:0005741mitochondrial outer membrane IEA--
GO:0016021integral component of membrane IEA--
GO:0031965nuclear membrane IDA--

TSPO for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TSPO About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Peptide ligand-binding receptors
Neuroactive ligand-receptor interaction0.36
2HTLV-I infection
HTLV-I infection
3Glucose / Energy Metabolism
Glucose / Energy Metabolism
4Cholesterol and Sphingolipids transport Distribution to the intracellular membrane compartments normal and CF
Cholesterol and Sphingolipids transport Distribution to the intracellular membrane compartments normal and CF
5Ca, cAMP and Lipid Signaling
Ca, cAMP and Lipid Signaling

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TSPO
    Mitochondrial Apoptosis
Cellular Apoptosis Pathway

2 Cell Signaling Technology (CST) Pathways for TSPO
    Ca, cAMP and Lipid Signaling
Glucose / Energy Metabolism

1 GeneGo (Thomson Reuters) Pathway for TSPO
    Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)


1 PharmGKB Pathway for TSPO
    Benzodiazepine Pathway, Pharmacodynamics

2 Kegg Pathways  (Kegg details for TSPO):
    Neuroactive ligand-receptor interaction
HTLV-I infection


TSPO for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including TSPO: 
          Neurotransmitter Receptors in human mouse rat
          Mitochondria in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for TSPO

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TSPO (P305363 ENSP000003289734) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
InteractantInteraction Details
GeneCardExternal ID(s)
BZRAP1O951533, ENSP000003458244I2D: score=3 STRING: ENSP00000345824
SLX1AQ9BQ833I2D: score=1 
SLX1BQ9BQ833I2D: score=1 
DBIP071083, ENSP000003111174I2D: score=2 STRING: ENSP00000311117
INTS1Q8N2013I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006626protein targeting to mitochondrion TAS1326278
GO:0006694steroid biosynthetic process IEA--
GO:0006783heme biosynthetic process TAS16822554
GO:0006811ion transport ----
GO:0006820anion transport TAS16822554

TSPO for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Enzo Life Sciences drugs & compounds for TSPO
  Browse compounds at ApexBio 

Browse Tocris compounds for TSPO (TSPOB)

2 HMDB Compounds for TSPO    About this table
CompoundSynonyms CAS #PubMed Ids
Heme(protoporphyrinato)iron (see all 19)14875-96-8--
ZolpidemAmbien (see all 7)82626-48-0--

Selected DrugBank Compounds for TSPO (see all 13)    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
ClonazepamChlonazepam (see all 2)1622-61-3targetother/unknown10558889 2723642 1691678 11752352 10423168 2364987
Flunitrazepam-- 1622-62-4targetagonist1847384 2723642 1651852 19443999 9098698 1320691
Eszopiclone-- 138729-47-2targetagonist18265473 17139284 17016423 19744401
Lorazepam(+/-)-Lorazepam (see all 3)846-49-1targetother1647706 8787774 17156911 16959136
ChlormezanoneChlormethazanone (see all 12)80-77-3targetagonist17139284 11752352 17016423
Ketazolam-- 27223-35-4targetagonist11752352 17631921 11443263
TemazepamHydroxydiazepam (see all 4)846-50-4targetother12850901 7911332 16959136
Alprazolam-- 28981-97-7targetother17139284 17016423
Diazepam-- 439-14-5targetpotentiator11752352 17631921
Zaleplon-- 151319-34-5targetother17139284 17016423

Selected Novoseek inferred chemical compound relationships for TSPO gene (see all 119)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
benzodiazepine 98.6 2697 8306240 (10), 10664825 (9), 17027961 (8), 8868371 (7) (see all 99)
pk 11195 94.4 93 17291492 (3), 16051742 (2), 17555551 (2), 18800007 (2) (see all 52)
iomazenil 93.1 17 7662908 (1), 12440611 (1), 8691270 (1), 9212889 (1) (see all 16)
flumazenil 92.6 89 10023509 (3), 8880096 (3), 8282018 (2), 8545530 (2) (see all 73)
benzodiazepines 86.6 76 1980690 (3), 1637606 (2), 8262176 (2), 14678758 (2) (see all 63)
diazepam 85.1 118 10576594 (5), 1316281 (3), 8080486 (3), 1321091 (3) (see all 78)
bretazenil 80.1 8 8981602 (2), 8748388 (1), 9839004 (1), 8868371 (1) (see all 7)
zolpidem 79.1 34 8925872 (3), 1361878 (3), 11370287 (2), 10755807 (2) (see all 26)
gaba 77 122 1965016 (6), 2160756 (2), 1649416 (2), 8306240 (2) (see all 76)
triakontatetraneuropeptide 77 5 19456330 (1), 8380885 (1), 9460762 (1)



TSPO for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TSPO gene (4 alternative transcripts): 
NM_000714.5  NM_001256530.1  NM_001256531.1  NM_007311.3  

Unigene Cluster for TSPO:

Translocator protein (18kDa)
Hs.202  [show with all ESTs]
Unigene Representative Sequence: BM924710
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000337554(uc003bdn.3 uc003bdo.3) ENST00000583777 ENST00000472378
ENST00000428336 ENST00000329563 ENST00000396265
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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  QuantiFast Probe-based Assays in human, mouse, rat TSPO

Additional mRNA sequence: 

AF075589.1 AF075590.1 AY998017.1 BC001110.2 BT006949.1 CR456409.1 CR457007.1 L21950.1 
M36035.1 NR_046308.1 

7 DOTS entries:

DT.40127929  DT.98131737  DT.100801819  DT.100643566  DT.97855685  DT.97855686  DT.97821978 

Selected AceView cDNA sequences (see all 442):

BM842268 AW328575 AF075590 AW469169 BM756266 CA307061 BM905068 CR617902 
BQ773690 BM784742 CD370271 BG171507 CR619651 BE908317 BQ927812 BU177060 
BM549915 BU625404 CR590116 BX391144 BM853651 BM761374 BM810547 BQ083702 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TSPO    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
SP1:        -     -     -                                             
SP2:                    -                                             
SP3:                                      -                           
SP4:        -     -     -     -     -     -                           
SP5:                                                                  


ECgene alternative splicing isoforms for TSPO

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TSPO expression in normal human tissues (normalized intensities)      TSPO embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAATTTTATA
TSPO Expression
About this image


TSPO expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 13) fully expand
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Eye (Sensory Organs)
         Mature Horizontal Cells Inner Nuclear Layer
 
 Yolk Sac (Extraembryonic Tissues)
         Definitive Hematopoietic Stem Cells Definitive Yolk Sac
 
 Neurons
         Mature Horizontal Cells Inner Nuclear Layer
 
 Blood (Cardiovascular System)
         Definitive Hematopoietic Stem Cells Definitive Yolk Sac
TSPO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TSPO Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.202

UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536
Tissue specificity: Found in many tissue types. Expressed at the highest levels under normal conditions in tissues
that synthesize steroids

UniProtKB/Swiss-Prot: TSPOB_HUMAN, B1AH88
Tissue specificity: Ubiquitous

    Pathway & Disease-focused RT2 Profiler PCR Arrays including TSPO: 
          Neurotransmitter Receptors in human mouse rat
          Mitochondria in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TSPO
OriGene qSTAR qPCR primer pairs in human, mouse for TSPO
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QuantiFast Probe-based Assays in human, mouse, rat TSPO
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPO

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TSPO gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tspo1 , 5 translocator protein1, 5 81.66(n)1
81.07(a)1
  15 (39.40 cM)5
122571  NM_009775.41  NP_033905.31 
 835635735 
chicken
(Gallus gallus)
Aves TSPO1 translocator protein (18kDa) 63.33(n)
61.87(a)
  418226  NM_001278057.1  NP_001264986.1 
lizard
(Anolis carolinensis)
Reptilia TSPO6
translocator protein (18kDa)
59(a)
1 ↔ 1
5(86755491-86774618)
African clawed frog
(Xenopus laevis)
Amphibia bzrp-A-prov2 Benzodiazepin receptor (peripheral) 76.54(n)    BC041505.1 
zebrafish
(Danio rerio)
Actinopterygii BI842839.12   -- 81.07(n)    BI842839.1 
fruit fly
(Drosophila melanogaster)
Insecta CG27891 CG2789 56.82(n)
46.98(a)
  33231  NM_134687.4  NP_608531.1 
worm
(Caenorhabditis elegans)
Secernentea C41G7.96
Protein C41G7.9, isoform b
25(a)
1 → many
I(9515001-9516776) WBGene00077771


ENSEMBL Gene Tree for TSPO (if available)
TreeFam Gene Tree for TSPO (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TSPO gene
TSPO22  
2 SIMAP similar genes for TSPO using alignment to 4 protein entries:     TSPOA_HUMAN (see all proteins):
PBR    TSPO2

TSPO for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TSPO (see all 351)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs57591921,2
C,A,H--26503749(+) GCTGGG/CATTAA 2 -- us2k11Minor allele frequency- C:0.00NA 2
rs72855901,2
C,F--26503770(+) cacaaC/Tgccca 2 -- us2k11Minor allele frequency- T:0.50WA 2
rs1808319341,2
--26503806(+) ATGGGG/TTTTCA 2 -- us2k10--------
rs1874342981,2
--43545660(+) TCAAGA/CGATTC 2 -- us2k10--------
rs1917921201,2
--43545944(+) CACTGA/CAACCT 4 -- us2k10--------
rs1389071,2
C,F--43546013(+) ggcacG/Acacca 4 -- us2k11Minor allele frequency- A:0.00CSA 1
rs1829516851,2
C--43546085(+) GGTCTC/TGAACT 4 -- us2k10--------
rs1900514671,2
C--43546182(+) AAAAAA/GAAAAA 4 -- us2k10--------
rs1496358291,2
C--43546225(+) GCTCAC/TGCCTG 4 -- us2k10--------
rs1857198971,2
--43546284(+) GAGTTC/TGAGAC 4 -- us2k10--------

HapMap Linkage Disequilibrium report for TSPO (43547520 - 43559248 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TSPO (see all 16):    About this table    
Variant IDTypeSubtypePubMed ID
esv2671621CNV Deletion23128226
esv2724299CNV Deletion23290073
esv1998181CNV Deletion18987734
esv3468CNV Deletion18987735
dgv4988n71CNV Loss21882294
esv8520CNV Loss19470904
nsv915215CNV Loss21882294
nsv520927CNV Loss19592680
nsv915201CNV Loss21882294
dgv4987n71CNV Loss21882294

Human Gene Mutation Database (HGMD): TSPO
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TSPO
DNA2.0 Custom Variant and Variant Library Synthesis for TSPO

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 109610    OMIM disorders: --

Selected diseases for TSPO (see all 111):    About MalaCards
wernicke encephalopathy    hepatic encephalopathy    hepatic coma    anxiety disorder
generalized anxiety disorder    fibromyalgia    insomnia    lipoid adrenal hyperplasia
parametritis    focal epilepsy    olivopontocerebellar atrophy    somatoform disorder
cerebral artery occlusion    panic disorder    acute liver failure    stiff-person syndrome
temporal lobe epilepsy    memory impairment    cystitis    skin melanoma

8 diseases from the University of Copenhagen DISEASES database for TSPO:
Cancer     Interstitial cystitis     Vascular disease     Eye disease
Asthma     Brain disease     Neurodegenerative disease     Heart disease

TSPO for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for TSPO gene (see all 93)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hepatic encephalopathy 78.4 53 8276347 (5), 11687160 (4), 15106178 (4), 2172467 (3) (see all 31)
hepatic coma 60.7 5 2161396 (1), 9347201 (1), 16563564 (1), 7748297 (1) (see all 5)
chronic insomnia 60.3 1 19201632 (1)
epilepsy temporal lobe 57.7 17 11893007 (2), 12199729 (2), 11518000 (2), 10599778 (1) (see all 14)
panic disorder 53.6 29 10664825 (5), 10023509 (3), 7624108 (3), 9928900 (3) (see all 16)
epilepsies partial 52.8 14 10390953 (2), 1317662 (2), 8956845 (1), 9795703 (1) (see all 12)
anxiety disorders 48.6 10 8748388 (1), 1324584 (1), 10103141 (1), 1687977 (1) (see all 10)
glioma 47.8 40 16026165 (4), 7714547 (3), 9540054 (3), 15276076 (3) (see all 21)
stupor 45.6 2 1357403 (1), 19477714 (1)
epilepsy 45.2 11 11882054 (2), 9237052 (1), 8797068 (1), 10390953 (1) (see all 7)

Genetic Association Database (GAD): TSPO
Human Genome Epidemiology (HuGE) Navigator: TSPO (8 documents)

Export disorders for TSPO gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TSPO gene, integrated from 10 sources (see all 895):
(articles sorted by number of sources associating them with TSPO)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. (PubMed id 8307574)1, 2, 9 Lin D.... Miller W.L. (Genomics 1993)
  2. The human &quot;peripheral-type&quot; benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. (PubMed id 1326278)1, 3, 9 Chang Y.J....Strauss J.F. (DNA Cell Biol. 1992)
  3. Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder. (PubMed id 16511838)1, 4, 9 Nakamura K....Mori N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
  6. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
  7. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
  8. Translocator protein (18kDa): new nomenclature for the peripheral- type benzodiazepine receptor based on its structure and molecular function. (PubMed id 16822554)1, 3 Papadopoulos V.... Gavish M. (Trends Pharmacol. Sci. 2006)
  9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
  10. Molecular cloning and chromosomal localization of a human peripheral- type benzodiazepine receptor. (PubMed id 1847678)1, 3 Riond J.... Ferrara P. (Eur. J. Biochem. 1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 706 HGNC: 1158 AceView: BZRP Ensembl:ENSG00000100300 euGenes: HUgn706
ECgene: TSPO Kegg: 706 H-InvDB: TSPO

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TSPO Pharmacogenomics, SNPs, Pathways
NIEHS-SNPshttp://egp.gs.washington.edu/data/bzrp/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TSPO gene:
Search GeneIP for patents involving TSPO

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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