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Aliases for TSPEAR-AS2 Gene

Subcategory (RNA class) for TSPEAR-AS2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for TSPEAR-AS2 Gene

  • TSPEAR Antisense RNA 2 2 3 4 5
  • C21orf90 3 4
  • Chromosome 21 Open Reading Frame 90 2
  • TSPEAR Antisense Gene Protein 2 4

External Ids for TSPEAR-AS2 Gene

Previous HGNC Symbols for TSPEAR-AS2 Gene

  • C21orf90

Previous GeneCards Identifiers for TSPEAR-AS2 Gene

  • GC21P044518
  • GC21P044519
  • GC21P044531
  • GC21P044542
  • GC21P044554

Summaries for TSPEAR-AS2 Gene

GeneCards Summary for TSPEAR-AS2 Gene

TSPEAR-AS2 (TSPEAR Antisense RNA 2) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPEAR-AS2 Gene

Genomics for TSPEAR-AS2 Gene

Regulatory Elements for TSPEAR-AS2 Gene

Enhancers for TSPEAR-AS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G044791 1.1 Ensembl ENCODE 10.7 +275.7 275747 2.9 HDAC1 FOXA2 CBX3 RB1 KLF17 ZNF48 RAD21 YY1 ZNF143 ZNF548 UBE2G2 SUMO3 TSPEAR-AS1 TSPEAR-AS2 KRTAP10-1 KRTAP10-2 PTTG1IP IMMTP1 KRTAP12-1 PWP2
GH21G044961 1.2 Ensembl ENCODE dbSUPER 9.8 +445.5 445466 2.7 ZNF202 JUN BHLHE40 MAX NR2F2 JUND ZNF316 GATA2 ZBTB33 FOS ADARB1 SSR4P1 UBE2G2 LINC01424 SUMO3 LINC01547 TSPEAR-AS2 LINC00334 FAM207A LINC00163
GH21G044957 1.2 Ensembl ENCODE dbSUPER 9.8 +441.7 441747 3.4 SCRT1 RFX1 L3MBTL2 MAX ZNF384 RAD21 NR2F2 SCRT2 HNF4A RBFOX2 ENSG00000273027 ADARB1 SSR4P1 LINC01424 UBE2G2 SUMO3 LINC01547 TSPEAR-AS2 LINC00334 ITGB2-AS1
GH21G044482 0.9 ENCODE 11 -34.3 -34333 0.3 ELF3 TBP FOXA2 ATF1 ARID4B DMAP1 DNMT3B THRB ZSCAN9 RAD21 TSPEAR-AS1 TSPEAR-AS2 LINC01424 UBE2G2 ENSG00000184441 PWP2 GC21M045281 PIR49959 PIR43206
GH21G044778 0.9 ENCODE 10.9 +261.4 261412 0.4 ELF3 PKNOX1 FOXA2 ARID4B RAD21 RARA KAT2B FOS CREM ZNF362 UBE2G2 LINC01424 SUMO3 TSPEAR-AS2 PTTG1IP TSPEAR-AS1 ADARB1 SSR4P1 GC21M045390 PIR42817
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPEAR-AS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPEAR-AS2 Gene

Chromosome:
21
Start:
44,517,215 bp from pter
End:
44,525,952 bp from pter
Size:
8,738 bases
Orientation:
Plus strand

Genomic View for TSPEAR-AS2 Gene

Genes around TSPEAR-AS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPEAR-AS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPEAR-AS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPEAR-AS2 Gene

Proteins for TSPEAR-AS2 Gene

  • Protein details for TSPEAR-AS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59090-TSAS2_HUMAN
    Recommended name:
    Putative uncharacterized protein TSPEAR-AS2
    Protein Accession:
    P59090
    Secondary Accessions:
    • Q3MIX8

    Protein attributes for TSPEAR-AS2 Gene

    Size:
    65 amino acids
    Molecular mass:
    7097 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSPEAR-AS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSPEAR-AS2 Gene

Post-translational modifications for TSPEAR-AS2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TSPEAR-AS2 Gene

Domains & Families for TSPEAR-AS2 Gene

Protein Domains for TSPEAR-AS2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSPEAR-AS2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TSPEAR-AS2 Gene

Function for TSPEAR-AS2 Gene

Phenotypes for TSPEAR-AS2 Gene

GenomeRNAi human phenotypes for TSPEAR-AS2:
genes like me logo Genes that share phenotypes with TSPEAR-AS2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSPEAR-AS2 Gene

Localization for TSPEAR-AS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPEAR-AS2 gene
Compartment Confidence
mitochondrion 2
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TSPEAR-AS2 Gene

Pathways & Interactions for TSPEAR-AS2 Gene

SuperPathways for TSPEAR-AS2 Gene

No Data Available

Interacting Proteins for TSPEAR-AS2 Gene

Gene Ontology (GO) - Biological Process for TSPEAR-AS2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TSPEAR-AS2 Gene

Transcripts for TSPEAR-AS2 Gene

mRNA/cDNA for TSPEAR-AS2 Gene

(1) REFSEQ mRNAs :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TSPEAR-AS2 Gene

No ASD Table

Relevant External Links for TSPEAR-AS2 Gene

GeneLoc Exon Structure for
TSPEAR-AS2
ECgene alternative splicing isoforms for
TSPEAR-AS2

Expression for TSPEAR-AS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPEAR-AS2 Gene

mRNA Expression by UniProt/SwissProt for TSPEAR-AS2 Gene:

P59090-TSAS2_HUMAN
Tissue specificity: Widely expressed. Not expressed in liver and muscle.
genes like me logo Genes that share expression patterns with TSPEAR-AS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPEAR-AS2 Gene

Orthologs for TSPEAR-AS2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TSPEAR-AS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C21orf90 35
  • 98 (a)
OneToOne
Species where no ortholog for TSPEAR-AS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSPEAR-AS2 Gene

ENSEMBL:
Gene Tree for TSPEAR-AS2 (if available)
TreeFam:
Gene Tree for TSPEAR-AS2 (if available)

Paralogs for TSPEAR-AS2 Gene

No data available for Paralogs for TSPEAR-AS2 Gene

Variants for TSPEAR-AS2 Gene

Sequence variations from dbSNP and Humsavar for TSPEAR-AS2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000409227 -- 44,518,179(+) ACAAG(C/T)ATAAC intron-variant
rs1001262562 -- 44,518,718(+) CCTAC(A/G)TCTTC intron-variant, nc-transcript-variant
rs1001292269 -- 44,518,481(+) CCCAA(A/C)CCACT intron-variant
rs1002235134 -- 44,515,391(+) CCAGG(A/T)CCCCG intron-variant, upstream-variant-2KB
rs1003378572 -- 44,519,361(+) CCCCG(C/T)GTATC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TSPEAR-AS2 Gene

Variant ID Type Subtype PubMed ID
esv2723638 CNV deletion 23290073
esv33817 CNV loss 17666407
nsv1055163 CNV gain 25217958
nsv1058359 CNV gain 25217958
nsv587803 CNV loss 21841781
nsv587804 CNV loss 21841781
nsv953646 CNV deletion 24416366

Variation tolerance for TSPEAR-AS2 Gene

Gene Damage Index Score: 0.05; 1.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPEAR-AS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPEAR-AS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPEAR-AS2 Gene

Disorders for TSPEAR-AS2 Gene

Relevant External Links for TSPEAR-AS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPEAR-AS2

No disorders were found for TSPEAR-AS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPEAR-AS2 Gene

Publications for TSPEAR-AS2 Gene

  1. Nineteen additional unpredicted transcripts from human chromosome 21. (PMID: 12036297) Reymond A. … Antonarakis S.E. (Genomics 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 4 64

Products for TSPEAR-AS2 Gene

Sources for TSPEAR-AS2 Gene

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