Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TSPEAR Gene

protein-coding   GIFtS: 40
GCID: GC21M046655

Thrombospondin-Type Laminin G Domain And EAR Repeats

(Previous names: chromosome 21 open reading frame 29, deafness, autosomal...)
(Previous symbols: C21orf29, DFNB98)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Thrombospondin-Type Laminin G Domain And EAR Repeats1 2     Chromosome 21 Open Reading Frame 291
C21orf291 2 3 5     Deafness, Autosomal Recessive 981
DFNB981 2 5     Thrombospondin-Type Laminin G Domain And EAR Repeat-Containing Protein2
TSP-EAR2 3     Thrombospondin-Type Laminin G Domain And EAR Repeats-Containing Protein2

External Ids:    HGNC: 12681   Entrez Gene: 540842   Ensembl: ENSG000001758947   OMIM: 6129205   UniProtKB: Q8WU663   

Export aliases for TSPEAR gene to outside databases

Previous GC identifers: GC21M042438 GC21M045918 GC21M045919 GC21M046047 GC21M046309 GC21M046459


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TSPEAR Gene:
This gene encodes a protein that contains a N-terminal thrombospondin-type laminin G domain and several tandem
arranged epilepsy-associated repeats (EARs). A mutation in this gene is the cause of autosomal recessive
deafness-98. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Dec 2012)

GeneCards Summary for TSPEAR Gene:
TSPEAR (thrombospondin-type laminin G domain and EAR repeats) is a protein-coding gene. Diseases associated with TSPEAR include deafness, autosomal recessive 98, and deafness, autosomal recessive 76.

UniProtKB/Swiss-Prot: TSEAR_HUMAN, Q8WU66
Function: May play a role in development or function of the auditory system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TSPEAR
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TSPEAR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPEAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

TSPEAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPEAR gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M046655:  view genomic region     (about GC identifiers)

Start:
45,917,775 bp from pter      End:
46,131,495 bp from pter
Size:
213,721 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TSEAR_HUMAN, Q8WU66 (See protein sequence)
Recommended Name: Thrombospondin-type laminin G domain and EAR repeat-containing protein precursor  
Size: 669 amino acids; 74924 Da
Sequence caution: Sequence=AAH21197.2; Type=Miscellaneous discrepancy; Note=Intron retention;
Alternative splicing: 2 isoforms:  Q8WU66-1   Q8WU66-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TSPEAR: NX_Q8WU66

Explore proteomics data for TSPEAR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn320, Asn468, Asn497, Asn556, Asn569

  • See TSPEAR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258966.1  NP_659428.2  

    ENSEMBL proteins: 
     ENSP00000321987   ENSP00000381012  

    TSPEAR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TSPEAR
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TSPEAR
    GenScript Custom Purified and Recombinant Proteins Services for TSPEAR
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TSPEAR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TSPEAR
    Search for Antibodies for TSPEAR at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for TSPEAR
    LSBio Antibodies in human, mouse, rat for TSPEAR

    TSPEAR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TSPEAR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TSPEAR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR001791 Laminin_G
     IPR005492 EPTP
     IPR009039 EAR
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q8WU66

    ProtoNet protein and cluster: Q8WU66

    2 Blocks protein domains:
    IPB001791 Laminin G
    IPB003129 Thrombospondin


    UniProtKB/Swiss-Prot: TSEAR_HUMAN, Q8WU66
    Similarity: Contains 7 EAR repeats
    Similarity: Contains 1 laminin G-like domain


    TSPEAR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSEAR_HUMAN, Q8WU66
    Function: May play a role in development or function of the auditory system

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TSPEAR for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPEAR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSPEAR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TSPEAR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TSPEAR

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TSPEAR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPEAR (see all 11):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidTSPEAR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSPEAR
    Predesigned siRNA for gene silencing in human, mouse, rat TSPEAR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TSPEAR

    Clone
    Products:
         
    OriGene clones in human, mouse for TSPEAR (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPEAR (NM_144991)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPEAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPEAR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TSPEAR
    Browse ESI BIO Cell Lines and PureStem Progenitors for TSPEAR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPEAR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TSEAR_HUMAN, Q8WU66: Secreted (By similarity). Cell surface (By similarity). Cell projection, stereocilium (By
    similarity). Note=Secreted protein which may bind to the cell surface via a membrane receptor (By similarity)

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0009986cell surface ISS--
    GO:0032420stereocilium ISS--
    GO:0060170ciliary membrane IEA--

    TSPEAR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPEAR
    Interactions:

        Search GeneGlobe Interaction Network for TSPEAR

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007605sensory perception of sound IMP--

    TSPEAR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPEAR (TSEAR)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TSPEAR gene (2 alternative transcripts): 
    NM_001272037.1  NM_144991.2  

    Unigene Cluster for TSPEAR:

    Thrombospondin-type laminin G domain and EAR repeats
    Hs.660703  [show with all ESTs]
    Unigene Representative Sequence: NM_001272037
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323084(uc002zfe.1 uc010gpv.1) ENST00000397916
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TSPEAR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TSPEAR (see all 11):
    hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidTSPEAR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TSPEAR
    Predesigned siRNA for gene silencing in human, mouse, rat TSPEAR
    Clone
    Products:
         
    OriGene clones in human, mouse for TSPEAR (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TSPEAR (NM_144991)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TSPEAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPEAR
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPEAR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPEAR
      QuantiTect SYBR Green Assays in human, mouse, rat TSPEAR
      QuantiFast Probe-based Assays in human, mouse, rat TSPEAR

    Additional mRNA sequence: 

    AJ487962.1 BC021197.2 BC115414.1 BC115415.1 

    3 DOTS entries:

    DT.434038  DT.40130339  DT.121134152 

    11 AceView cDNA sequences:

    AW104845 AJ487962 BC021197 NM_144991 BE465312 AA233247 AI143367 AA233171 
    AA083499 AJ003556 AA253086 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TSPEAR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TSPEAR Expression
    About this image

    TSPEAR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPEAR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660703
        Custom PCR Arrays for TSPEAR
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TSPEAR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPEAR
    QuantiTect SYBR Green Assays in human, mouse, rat TSPEAR
    QuantiFast Probe-based Assays in human, mouse, rat TSPEAR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPEAR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TSPEAR gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspear1 , 5 RIKEN cDNA C330046G03 gene5
    thrombospondin type laminin G domain and EAR repeats1
    81.79(n)1
    82.19(a)1
      10 (39.72 cM)5
    2529741  NM_001287074.11  NP_001274003.11 
     778294675 
    chicken
    (Gallus gallus)
    Aves TSPEAR1 thrombospondin-type laminin G domain and EAR repeats 72.63(n)
    68.98(a)
      424836  XM_422647.4  XP_422647.3 
    lizard
    (Anolis carolinensis)
    Reptilia TSPEAR6
    thrombospondin-type laminin G domain and EAR repea...
    66(a)
    1 ↔ 1
    3(33767887-33795332)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tspear1 thrombospondin-type laminin G domain and EAR repeats 64.66(n)
    63.06(a)
      100492500  XM_002936523.2  XP_002936569.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tspearb1 thrombospondin-type laminin G domain and EAR repeats more 62.22(n)
    58.27(a)
      555223  XM_677678.5  XP_682770.2 


    ENSEMBL Gene Tree for TSPEAR (if available)
    TreeFam Gene Tree for TSPEAR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TSPEAR gene
    1 SIMAP similar gene for TSPEAR using alignment to 2 protein entries:     TSEAR_HUMAN (see all proteins):
    C21orf29

    TSPEAR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TSPEAR (see all 4383)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362714
    A colorectal cancer sample4--see VAR_0362712 A T mis40--------
    rs1397029211,2
    C--45917275(+) TTAAAA/GCCTCC 2 -- ds50010--------
    rs771876751,2
    C,F--45917391(+) CTCTCT/CGGAAA 2 -- ds50011Minor allele frequency- C:0.06NA 120
    rs1444949361,2
    --45917471(+) TAACCC/GTCTAA 2 -- ds50010--------
    rs1832984001,2
    --45917570(+) ACTCAA/GGCCAG 2 -- ds50010--------
    rs19954621,2
    C,F,H--45917591(-) ACTTAT/CTTTGG 2 -- ds500110Minor allele frequency- C:0.09NS EA NA WA 1310
    rs119116231,2
    C,F,H--45917621(+) GGGAAG/TGAAGG 2 -- ds50010--------
    rs732330311,2
    C,F--45917661(+) GTTGCG/AACACC 2 -- ds50012Minor allele frequency- A:0.04NA 130
    rs1887440621,2
    --45917678(+) CTCACA/GTGAAC 2 -- ds50010--------
    rs1154548041,2
    C--45917734(+) AAGCAC/TGTGGG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TSPEAR (45917775 - 46131495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TSPEAR (see all 43):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660233CNV Deletion23128226
    esv2723674CNV Deletion23290073
    esv1943808CNV Deletion18987734
    esv2723670CNV Deletion23290073
    esv2723668CNV Deletion23290073
    esv2723675CNV Deletion23290073
    esv2109234CNV Deletion18987734
    esv2723677CNV Deletion23290073
    esv2723638CNV Deletion23290073
    esv2723673CNV Deletion23290073

    Human Gene Mutation Database (HGMD): TSPEAR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSPEAR
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPEAR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612920   
    OMIM disorders: 614861  
    UniProtKB/Swiss-Prot: TSEAR_HUMAN, Q8WU66
  • Deafness, autosomal recessive, 98 (DFNB98) [MIM:614861]: A form of non-syndromic sensorineural hearing
    loss with prelingual onset. Sensorineural deafness results from damage to the neural receptors of the inner ear,
    the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 7 diseases for TSPEAR:    
    About MalaCards
    deafness, autosomal recessive 98    deafness, autosomal recessive 76    sensorineural hearing loss    breast and colorectal cancer
    colorectal cancer    multiple myeloma    myeloma


    TSPEAR for disorders           About GeneDecksing


    Export disorders for TSPEAR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TSPEAR gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TSPEAR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness. (PubMed id 22678063)1, 2, 3 Delmaghani S.... Petit C. (Hum. Mol. Genet. 2012)
    2. A common protein interaction domain links two recently identified epilepsy genes. (PubMed id 12095917)1, 2, 3 Scheel H.... Hofmann K. (Hum. Mol. Genet. 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. (PubMed id 20494980)1 Warnatz H.J....Yaspo M.L. (Nucleic Acids Res. 2010)
    5. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1 Hattori M.... Yaspo M.-L. (Nature 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54084 HGNC: 1268 AceView: C21orf29 Ensembl:ENSG00000175894 euGenes: HUgn54084
    ECgene: TSPEAR H-InvDB: TSPEAR

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TSPEAR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TSPEAR gene:
    Search GeneIP for patents involving TSPEAR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TSPEAR  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TSPEAR  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TSPEAR  
     OriGene qSTAR qPCR primer pairs in human, mouse for TSPEAR   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TSPEAR   OriGene Custom Protein Services for TSPEAR  

     
     
     Block miRNA regulation of human, mouse, rat TSPEAR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TSPEAR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPEAR Predesigned siRNA for gene silencing in human, mouse, rat TSPEAR
     QuantiFast Probe-based Assays in human, mouse, rat TSPEAR QuantiTect SYBR Green Assays in human, mouse, rat TSPEAR
     Custom PCR Arrays for TSPEAR Search Chromatin IP Primers for TSPEAR
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPEAR  Search GeneGlobe Interaction Network for TSPEAR
     Search Regulatory tfbs for TSPEAR
     GenScript Custom Purified and Recombinant Proteins Services for TSPEAR GenScript cDNA clones with any tag delivered in your preferred vector for TSPEAR
     GenScript Custom Assay Services for TSPEAR GenScript Custom overexpressing Cell Line Services for TSPEAR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TSPEAR (TSEAR)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for TSPEAR at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TSPEAR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TSPEAR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPEAR
     SwitchGear 3'UTR luciferase reporter plasmids for TSPEAR
     Browse SwitchGear Promoter luciferase reporter plasmids for TSPEAR
     ThermoFisher Antibody for TSPEAR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TSPEAR
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TSPEAR
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TSPEAR
     LSBio Antibodies in human, mouse, rat for TSPEAR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TSPEAR gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4