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Aliases for TSPAN9 Gene

Aliases for TSPAN9 Gene

  • Tetraspanin 9 2 3 5
  • Tetraspan NET-5 3 4
  • Tspan-9 3 4
  • NET5 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-5 3
  • New EST Tetraspan 5 3
  • Tetraspanin-9 3
  • PP1057 3
  • NET-5 3

External Ids for TSPAN9 Gene

Previous GeneCards Identifiers for TSPAN9 Gene

  • GC12P003186

Summaries for TSPAN9 Gene

Entrez Gene Summary for TSPAN9 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009]

GeneCards Summary for TSPAN9 Gene

TSPAN9 (Tetraspanin 9) is a Protein Coding gene. An important paralog of this gene is TSPAN4.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN9 Gene

Genomics for TSPAN9 Gene

Regulatory Elements for TSPAN9 Gene

Enhancers for TSPAN9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G003115 1.5 FANTOM5 Ensembl ENCODE dbSUPER 22.8 +39.7 39736 2.4 CTCF ZIC2 RAD21 ZNF121 ZFHX2 POLR2A SCRT2 FOS MAFK EGR2 TSPAN9 GC12M003110 ENSG00000278469
GH12G003084 1.4 FANTOM5 ENCODE dbSUPER 23.9 +8.4 8413 3.3 ELF3 FOXA2 ARID4B ZNF195 DMAP1 THRB ZNF48 RAD21 YY1 GATA4 TSPAN9 FOXM1 RHNO1 TULP3 PIR34599 GC12P003091
GH12G003076 1.2 ENCODE dbSUPER 26.3 0.0 -4 2.2 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF48 YY1 ZNF121 GLIS2 SP3 TSPAN9 RPL13AP24
GH12G003118 1.1 Ensembl ENCODE dbSUPER 28.4 +42.5 42535 2.5 SCRT1 PKNOX1 MAX HNF4A ZBTB33 ZIC2 TSPAN9 ENSG00000278469 GC12M003110
GH12G003096 1.5 Ensembl ENCODE dbSUPER 18.5 +20.3 20287 2.7 MLX ARID4B DMAP1 ZNF2 ZNF48 YY1 GATA2 ZHX2 MXD4 REST TSPAN9 GC12P003091 PIR34599 GC12P003110
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN9 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047920 145 1401 HDGF ARID4B SIN3A ZNF2 ZNF48 YY1 ZNF121 GLIS2 SP3 MXD4

Genomic Location for TSPAN9 Gene

Chromosome:
12
Start:
3,077,355 bp from pter
End:
3,286,564 bp from pter
Size:
209,210 bases
Orientation:
Plus strand

Genomic View for TSPAN9 Gene

Genes around TSPAN9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN9 Gene

Proteins for TSPAN9 Gene

  • Protein details for TSPAN9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75954-TSN9_HUMAN
    Recommended name:
    Tetraspanin-9
    Protein Accession:
    O75954
    Secondary Accessions:
    • D3DUQ7
    • Q53FV2
    • Q6FGJ8

    Protein attributes for TSPAN9 Gene

    Size:
    239 amino acids
    Molecular mass:
    26779 Da
    Quaternary structure:
    • Found in a complex with GP6.

neXtProt entry for TSPAN9 Gene

Post-translational modifications for TSPAN9 Gene

Other Protein References for TSPAN9 Gene

No data available for DME Specific Peptides for TSPAN9 Gene

Domains & Families for TSPAN9 Gene

Gene Families for TSPAN9 Gene

Suggested Antigen Peptide Sequences for TSPAN9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75954

UniProtKB/Swiss-Prot:

TSN9_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN9: view

Function for TSPAN9 Gene

Gene Ontology (GO) - Molecular Function for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TSPAN9: view
genes like me logo Genes that share phenotypes with TSPAN9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN9

CRISPR Products

miRNA for TSPAN9 Gene

miRTarBase miRNAs that target TSPAN9

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN9 Gene

Localization for TSPAN9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN9 Gene

Membrane; Multi-pass membrane protein. Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN9 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
golgi apparatus 2
endosome 1

Gene Ontology (GO) - Cellular Components for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18795891
GO:0005887 integral component of plasma membrane IBA --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN9: view

Pathways & Interactions for TSPAN9 Gene

SuperPathways for TSPAN9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TSPAN9: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN9 Gene

Drugs & Compounds for TSPAN9 Gene

No Compound Related Data Available

Transcripts for TSPAN9 Gene

Unigene Clusters for TSPAN9 Gene

Tetraspanin 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN9 Gene

No ASD Table

Relevant External Links for TSPAN9 Gene

GeneLoc Exon Structure for
TSPAN9
ECgene alternative splicing isoforms for
TSPAN9

Expression for TSPAN9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN9 Gene

This gene is overexpressed in Brain - Cerebellum (x5.1), Brain - Cerebellar Hemisphere (x4.7), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for TSPAN9 Gene

This gene is overexpressed in Bone (12.4) and Peripheral blood mononuclear cells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSPAN9 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSPAN9 Gene:

TSPAN9

SOURCE GeneReport for Unigene cluster for TSPAN9 Gene:

Hs.504517

mRNA Expression by UniProt/SwissProt for TSPAN9 Gene:

O75954-TSN9_HUMAN
Tissue specificity: Expressed in megakaryocytes and platelets (at protein level).

Evidence on tissue expression from TISSUES for TSPAN9 Gene

  • Pancreas(4.1)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with TSPAN9: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN9 Gene

Orthologs for TSPAN9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN9 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TSPAN9 34 35
  • 94.14 (n)
chimpanzee
(Pan troglodytes)
Mammalia TSPAN9 34 35
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Tspan9 34
  • 90.38 (n)
mouse
(Mus musculus)
Mammalia Tspan9 34 16 35
  • 90.24 (n)
cow
(Bos Taurus)
Mammalia TSPAN9 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TSPAN9 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN9 34 35
  • 77.27 (n)
lizard
(Anolis carolinensis)
Reptilia TSPAN9 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan9 34
  • 79.92 (n)
zebrafish
(Danio rerio)
Actinopterygii tspan9b 35
  • 77 (a)
OneToMany
tspan9a 34 35
  • 75.87 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13798 34
fruit fly
(Drosophila melanogaster)
Insecta Tsp5D 34 35
  • 50.45 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007373 34
  • 50 (n)
worm
(Caenorhabditis elegans)
Secernentea tsp-8 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for TSPAN9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN9 Gene

ENSEMBL:
Gene Tree for TSPAN9 (if available)
TreeFam:
Gene Tree for TSPAN9 (if available)

Paralogs for TSPAN9 Gene

Paralogs for TSPAN9 Gene

(20) SIMAP similar genes for TSPAN9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN9: view

Variants for TSPAN9 Gene

Sequence variations from dbSNP and Humsavar for TSPAN9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000025806 -- 3,083,828(+) GGGCA(A/G)GATAG intron-variant
rs1000032889 -- 3,147,285(+) GAGCC(C/T)GCCAG intron-variant
rs1000034161 -- 3,212,229(+) CCTCC(C/T)AAAGT intron-variant
rs1000044296 -- 3,180,968(+) TAGGA(A/G)TTCAG intron-variant
rs1000100527 -- 3,190,262(+) TGTGG(A/G)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN9 Gene

Variant ID Type Subtype PubMed ID
dgv1345n100 CNV gain 25217958
dgv2292n54 CNV loss 21841781
dgv2293n54 CNV loss 21841781
dgv2294n54 CNV loss 21841781
dgv2295n54 CNV loss 21841781
dgv741e59 CNV duplication 20981092
dgv742e59 CNV duplication 20981092
dgv753n106 CNV deletion 24896259
esv1000555 CNV deletion 20482838
esv1080066 CNV insertion 17803354
esv1506846 CNV insertion 17803354
esv1628800 CNV deletion 17803354
esv2657581 CNV deletion 23128226
esv2673166 CNV deletion 23128226
esv27287 CNV gain 19812545
esv2745427 CNV deletion 23290073
esv2745428 CNV deletion 23290073
esv2745429 CNV deletion 23290073
esv2745431 CNV deletion 23290073
esv2745432 CNV deletion 23290073
esv2745433 CNV deletion 23290073
esv2745434 CNV deletion 23290073
esv2761722 CNV gain 21179565
esv29653 CNV loss 19812545
esv3548648 CNV deletion 23714750
esv3580361 CNV gain 25503493
esv3628339 CNV loss 21293372
esv3628340 CNV loss 21293372
esv3628341 CNV loss 21293372
esv3628342 CNV loss 21293372
esv4288 CNV loss 18987735
esv8687 CNV loss 19470904
nsv1048174 CNV gain 25217958
nsv1068058 CNV deletion 25765185
nsv1071002 CNV deletion 25765185
nsv1126308 CNV deletion 24896259
nsv1147991 CNV deletion 26484159
nsv468976 CNV loss 19166990
nsv468977 CNV loss 19166990
nsv468978 CNV loss 19166990
nsv472896 CNV novel sequence insertion 20440878
nsv472904 CNV novel sequence insertion 20440878
nsv483060 CNV loss 15286789
nsv516931 CNV loss 19592680
nsv526531 CNV loss 19592680
nsv527090 CNV loss 19592680
nsv527091 CNV loss 19592680
nsv528150 CNV loss 19592680
nsv53179 CNV deletion 16902084
nsv557084 CNV loss 21841781
nsv557085 CNV loss 21841781
nsv557089 CNV gain 21841781
nsv557096 CNV loss 21841781
nsv557101 CNV loss 21841781
nsv557105 CNV loss 21841781
nsv557106 CNV loss 21841781
nsv557107 CNV loss 21841781
nsv557110 CNV loss 21841781
nsv557111 CNV loss 21841781
nsv557112 CNV loss 21841781
nsv557113 CNV loss 21841781
nsv557114 CNV gain 21841781
nsv821042 CNV deletion 20802225
nsv821465 CNV deletion 20802225
nsv832312 CNV loss 17160897
nsv8890 CNV loss 18304495
nsv8892 CNV loss 18304495
nsv976556 CNV duplication 23825009

Variation tolerance for TSPAN9 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN9 Gene

Disorders for TSPAN9 Gene

Relevant External Links for TSPAN9

Genetic Association Database (GAD)
TSPAN9
Human Genome Epidemiology (HuGE) Navigator
TSPAN9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN9

No disorders were found for TSPAN9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN9 Gene

Publications for TSPAN9 Gene

  1. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V. … Rubinstein E. (Biochim. Biophys. Acta 2000) 2 3 4 64
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  4. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. (PMID: 18795891) Protty M.B. … Tomlinson M.G. (Biochem. J. 2009) 3 4 64
  5. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64

Products for TSPAN9 Gene

Sources for TSPAN9 Gene

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