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Aliases for TSPAN9 Gene

Aliases for TSPAN9 Gene

  • Tetraspanin 9 2 3 5
  • Tetraspan NET-5 3 4
  • Tspan-9 3 4
  • NET5 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-5 3
  • New EST Tetraspan 5 3
  • PP1057 3
  • NET-5 3

External Ids for TSPAN9 Gene

Previous GeneCards Identifiers for TSPAN9 Gene

  • GC12P003186

Summaries for TSPAN9 Gene

Entrez Gene Summary for TSPAN9 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009]

GeneCards Summary for TSPAN9 Gene

TSPAN9 (Tetraspanin 9) is a Protein Coding gene. An important paralog of this gene is TSPAN18.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN9 Gene

Genomics for TSPAN9 Gene

Regulatory Elements for TSPAN9 Gene

Enhancers for TSPAN9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TSPAN9 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN9 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN9 Gene

3,077,355 bp from pter
3,286,564 bp from pter
209,210 bases
Plus strand

Genomic View for TSPAN9 Gene

Genes around TSPAN9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN9 Gene

Proteins for TSPAN9 Gene

  • Protein details for TSPAN9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DUQ7
    • Q53FV2
    • Q6FGJ8

    Protein attributes for TSPAN9 Gene

    239 amino acids
    Molecular mass:
    26779 Da
    Quaternary structure:
    • Found in a complex with GP6.

neXtProt entry for TSPAN9 Gene

Proteomics data for TSPAN9 Gene at MOPED

Post-translational modifications for TSPAN9 Gene

Other Protein References for TSPAN9 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TSPAN9

No data available for DME Specific Peptides for TSPAN9 Gene

Domains & Families for TSPAN9 Gene

Gene Families for TSPAN9 Gene

Suggested Antigen Peptide Sequences for TSPAN9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN9: view

Function for TSPAN9 Gene

genes like me logo Genes that share phenotypes with TSPAN9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN9

CRISPR Products

miRNA for TSPAN9 Gene

miRTarBase miRNAs that target TSPAN9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN9 Gene

Localization for TSPAN9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN9 Gene

Membrane; Multi-pass membrane protein. Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TSPAN9 Gene COMPARTMENTS Subcellular localization image for TSPAN9 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 2
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18795891
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0097197 tetraspanin-enriched microdomain IDA 18795891
genes like me logo Genes that share ontologies with TSPAN9: view

Pathways & Interactions for TSPAN9 Gene

SuperPathways for TSPAN9 Gene

No Data Available

Interacting Proteins for TSPAN9 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: O75954-TSN9_HUMAN ENSP00000011898 for TSPAN9 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with TSPAN9: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN9 Gene

Drugs & Compounds for TSPAN9 Gene

No Compound Related Data Available

Transcripts for TSPAN9 Gene

Unigene Clusters for TSPAN9 Gene

Tetraspanin 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN9 Gene

No ASD Table

Relevant External Links for TSPAN9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN9 Gene

mRNA expression in normal human tissues for TSPAN9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN9 Gene

This gene is overexpressed in Brain - Cerebellum (x5.1), Brain - Cerebellar Hemisphere (x4.7), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for TSPAN9 Gene

This gene is overexpressed in Bone (12.4) and Peripheral blood mononuclear cells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TSPAN9 Gene

SOURCE GeneReport for Unigene cluster for TSPAN9 Gene Hs.504517

mRNA Expression by UniProt/SwissProt for TSPAN9 Gene

Tissue specificity: Expressed in megakaryocytes and platelets (at protein level).
genes like me logo Genes that share expression patterns with TSPAN9: view

Primer Products

No data available for Protein tissue co-expression partners for TSPAN9 Gene

Orthologs for TSPAN9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN9 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TSPAN9 35
  • 94.14 (n)
  • 97.91 (a)
  • 86 (a)
(Mus musculus)
Mammalia Tspan9 35
  • 90.24 (n)
  • 97.07 (a)
Tspan9 16
Tspan9 36
  • 97 (a)
(Pan troglodytes)
Mammalia TSPAN9 35
  • 91.18 (n)
  • 88.66 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tspan9 35
  • 90.38 (n)
  • 97.07 (a)
(Bos Taurus)
Mammalia TSPAN9 36
  • 90 (a)
(Monodelphis domestica)
Mammalia TSPAN9 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
-- 36
  • 67 (a)
(Gallus gallus)
Aves TSPAN9 35
  • 77.27 (n)
  • 87.45 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia TSPAN9 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan9 35
  • 79.92 (n)
  • 93.31 (a)
(Danio rerio)
Actinopterygii tspan9a 35
  • 75.87 (n)
  • 81.17 (a)
tspan9a 36
  • 73 (a)
tspan9b 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13798 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007373 35
  • 50 (n)
  • 34.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp5D 35
  • 50.45 (n)
  • 33.18 (a)
Tsp5D 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea tsp-8 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for TSPAN9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN9 Gene

Gene Tree for TSPAN9 (if available)
Gene Tree for TSPAN9 (if available)

Paralogs for TSPAN9 Gene

Paralogs for TSPAN9 Gene

(20) SIMAP similar genes for TSPAN9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN9: view

Variants for TSPAN9 Gene

Sequence variations from dbSNP and Humsavar for TSPAN9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1978239 -- 3,270,540(+) GCCCC(A/C)AGGCA intron-variant
rs1990327 -- 3,090,635(-) GCCCC(C/T)GGAGT intron-variant
rs1990328 -- 3,090,493(-) CCACG(C/T)AGCAG intron-variant
rs1990331 -- 3,164,833(-) CTCTA(C/T)CCAAG intron-variant
rs2001429 -- 3,087,632(-) gatgg(G/T)gtttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN9 Gene

Variant ID Type Subtype PubMed ID
dgv1345n71 CNV Loss 21882294
esv1628800 CNV Deletion 17803354
nsv483060 CNV Loss 15286789
esv1000555 CNV Deletion 20482838
nsv527090 CNV Loss 19592680
nsv528150 CNV Loss 19592680
nsv832312 CNV Loss 17160897
nsv468976 CNV Loss 19166990
nsv468977 CNV Loss 19166990
nsv8890 CNV Loss 18304495
nsv821465 CNV Deletion 20802225
esv29653 CNV Loss 19812545
esv4288 CNV Deletion 18987735
esv2745427 CNV Deletion 23290073
nsv53179 CNV Loss 16902084
esv2745428 CNV Deletion 23290073
esv8687 CNV Loss 19470904
esv2745429 CNV Deletion 23290073
esv1080066 CNV Insertion 17803354
esv2745431 CNV Deletion 23290073
esv1506846 CNV Insertion 17803354
nsv468978 CNV Loss 19166990
esv2745432 CNV Deletion 23290073
esv2657581 CNV Deletion 23128226
esv2673166 CNV Deletion 23128226
nsv516931 CNV Loss 19592680
nsv526531 CNV Loss 19592680
nsv898614 CNV Loss 21882294
nsv527091 CNV Loss 19592680
esv2745433 CNV Deletion 23290073
esv27287 CNV Gain 19812545
nsv821042 CNV Deletion 20802225
esv2745434 CNV Deletion 23290073
nsv8892 CNV Loss 18304495

Variation tolerance for TSPAN9 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TSPAN9 Gene

Disorders for TSPAN9 Gene

Relevant External Links for TSPAN9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN9 Gene

Publications for TSPAN9 Gene

  1. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V. … Rubinstein E. (Biochim. Biophys. Acta 2000) 2 3 4 67
  2. Complexes of tetraspanins with integrins: more than meets the eye. (PMID: 11739647) Berditchevski F. (J. Cell. Sci. 2001) 2 3
  3. Genome-wide association study of degenerative bony changes of the temporomandibular joint. (PMID: 23746317) Yamaguchi T. … Inoue I. (Oral Dis 2014) 3
  4. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3
  5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for I^-Pix in negative regulation of focal adhesion maturation. (PMID: 21423176) Kuo J.C. … Waterman C.M. (Nat. Cell Biol. 2011) 3

Products for TSPAN9 Gene

Sources for TSPAN9 Gene