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Aliases for TSPAN9 Gene

Aliases for TSPAN9 Gene

  • Tetraspanin 9 2 3 5
  • Tetraspan NET-5 3 4
  • Tspan-9 3 4
  • NET5 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-5 3
  • New EST Tetraspan 5 3
  • Tetraspanin-9 3
  • PP1057 3
  • NET-5 3

External Ids for TSPAN9 Gene

Previous GeneCards Identifiers for TSPAN9 Gene

  • GC12P003186

Summaries for TSPAN9 Gene

Entrez Gene Summary for TSPAN9 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009]

GeneCards Summary for TSPAN9 Gene

TSPAN9 (Tetraspanin 9) is a Protein Coding gene. An important paralog of this gene is TSPAN4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN9 Gene

Genomics for TSPAN9 Gene

Regulatory Elements for TSPAN9 Gene

Enhancers for TSPAN9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F003115 1.3 FANTOM5 Ensembl ENCODE 22.8 +39.7 39736 2.4 BHLHE40 ZIC2 RAD21 NR2F2 ZNF121 JUND ZFHX2 POLR2A SMARCA4 ZNF341 TSPAN9 GC12M003110 ENSG00000278469
GH12F003076 1 ENCODE 26.3 0.0 -4 2.2 PKNOX1 ARID4B SIN3A ZNF48 ZNF2 YY1 ZNF121 GLIS2 SP3 JUNB TSPAN9 RPL13AP24
GH12F003084 1.1 FANTOM5 ENCODE 23.9 +8.4 8413 3.3 ELF3 ARID4B DMAP1 THRB ZNF48 YY1 GATA4 CREM MIXL1 EGR2 TSPAN9 FOXM1 RHNO1 TULP3 GC12P003091 PIR34599
GH12F003118 0.8 Ensembl ENCODE 28.4 +42.5 42535 2.5 SCRT1 PKNOX1 ZBTB33 ZIC2 TSPAN9 ENSG00000278469 GC12M003110
GH12F003096 1.2 Ensembl ENCODE 18.4 +20.3 20287 2.7 MLX ARID4B DMAP1 ZNF2 ZNF48 YY1 MXD4 REST PPARG ZNF518A TSPAN9 IQSEC3P1 GC12P003091 PIR34599 GC12P003110
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN9 on UCSC Golden Path with GeneCards custom track

Promoters for TSPAN9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000425323 345 2200 ARID4B SIN3A ZNF48 ZNF2 YY1 ZNF121 GLIS2 SP3 JUNB MXD4

Genomic Location for TSPAN9 Gene

3,077,355 bp from pter
3,286,564 bp from pter
209,210 bases
Plus strand

Genomic View for TSPAN9 Gene

Genes around TSPAN9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN9 Gene

Proteins for TSPAN9 Gene

  • Protein details for TSPAN9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DUQ7
    • Q53FV2
    • Q6FGJ8

    Protein attributes for TSPAN9 Gene

    239 amino acids
    Molecular mass:
    26779 Da
    Quaternary structure:
    • Found in a complex with GP6.

neXtProt entry for TSPAN9 Gene

Post-translational modifications for TSPAN9 Gene

Other Protein References for TSPAN9 Gene

Antibody Products

No data available for DME Specific Peptides for TSPAN9 Gene

Domains & Families for TSPAN9 Gene

Gene Families for TSPAN9 Gene

Suggested Antigen Peptide Sequences for TSPAN9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN9: view

Function for TSPAN9 Gene

Gene Ontology (GO) - Molecular Function for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TSPAN9: view
genes like me logo Genes that share phenotypes with TSPAN9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN9

miRNA for TSPAN9 Gene

miRTarBase miRNAs that target TSPAN9

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN9 Gene

Localization for TSPAN9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN9 Gene

Membrane; Multi-pass membrane protein. Note=Colocalizes with GP6 in tetraspanin microdomains on the platelet surface. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN9 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
golgi apparatus 2
endosome 1

Gene Ontology (GO) - Cellular Components for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 18795891
GO:0005887 integral component of plasma membrane IBA --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN9: view

Pathways & Interactions for TSPAN9 Gene

SuperPathways for TSPAN9 Gene

No Data Available

Interacting Proteins for TSPAN9 Gene

Gene Ontology (GO) - Biological Process for TSPAN9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TSPAN9: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN9 Gene

Transcripts for TSPAN9 Gene

Unigene Clusters for TSPAN9 Gene

Tetraspanin 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN9 Gene

No ASD Table

Relevant External Links for TSPAN9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN9 Gene

This gene is overexpressed in Brain - Cerebellum (x5.1), Brain - Cerebellar Hemisphere (x4.7), and Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for TSPAN9 Gene

This gene is overexpressed in Bone (12.4) and Peripheral blood mononuclear cells (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TSPAN9 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN9 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN9 Gene:


mRNA Expression by UniProt/SwissProt for TSPAN9 Gene:

Tissue specificity: Expressed in megakaryocytes and platelets (at protein level).
genes like me logo Genes that share expression patterns with TSPAN9: view

No data available for Protein tissue co-expression partners for TSPAN9 Gene

Orthologs for TSPAN9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN9 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TSPAN9 34 35
  • 94.14 (n)
(Pan troglodytes)
Mammalia TSPAN9 34 35
  • 91.18 (n)
(Rattus norvegicus)
Mammalia Tspan9 34
  • 90.38 (n)
(Mus musculus)
Mammalia Tspan9 34 16 35
  • 90.24 (n)
(Bos Taurus)
Mammalia TSPAN9 35
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
-- 35
  • 67 (a)
(Monodelphis domestica)
Mammalia TSPAN9 35
  • 65 (a)
(Gallus gallus)
Aves TSPAN9 34 35
  • 77.27 (n)
(Anolis carolinensis)
Reptilia TSPAN9 35
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan9 34
  • 79.92 (n)
(Danio rerio)
Actinopterygii tspan9b 35
  • 77 (a)
tspan9a 34 35
  • 75.87 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13798 34
fruit fly
(Drosophila melanogaster)
Insecta Tsp5D 34 35
  • 50.45 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007373 34
  • 50 (n)
(Caenorhabditis elegans)
Secernentea tsp-8 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
Species where no ortholog for TSPAN9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN9 Gene

Gene Tree for TSPAN9 (if available)
Gene Tree for TSPAN9 (if available)

Paralogs for TSPAN9 Gene

(20) SIMAP similar genes for TSPAN9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TSPAN9: view

Variants for TSPAN9 Gene

Sequence variations from dbSNP and Humsavar for TSPAN9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000970 -- 3,110,334(-) ATTTT(G/T)TATTG intron-variant
rs1001214 -- 3,130,478(-) CTGTC(C/T)GTCAC intron-variant
rs1002284 -- 3,222,508(+) TGCAT(C/T)TGGAT intron-variant
rs1003559 -- 3,236,049(-) CCCTG(C/G)GGAAG intron-variant
rs1004499 -- 3,135,145(-) cgatc(A/G)tgaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN9 Gene

Variant ID Type Subtype PubMed ID
dgv1345n100 CNV gain 25217958
dgv2292n54 CNV loss 21841781
dgv2293n54 CNV loss 21841781
dgv2294n54 CNV loss 21841781
dgv2295n54 CNV loss 21841781
dgv741e59 CNV duplication 20981092
dgv742e59 CNV duplication 20981092
dgv753n106 CNV deletion 24896259
esv1000555 CNV deletion 20482838
esv1080066 CNV insertion 17803354
esv1506846 CNV insertion 17803354
esv1628800 CNV deletion 17803354
esv2657581 CNV deletion 23128226
esv2673166 CNV deletion 23128226
esv27287 CNV gain 19812545
esv2745427 CNV deletion 23290073
esv2745428 CNV deletion 23290073
esv2745429 CNV deletion 23290073
esv2745431 CNV deletion 23290073
esv2745432 CNV deletion 23290073
esv2745433 CNV deletion 23290073
esv2745434 CNV deletion 23290073
esv2761722 CNV gain 21179565
esv29653 CNV loss 19812545
nsv976556 CNV duplication 23825009
nsv8892 CNV loss 18304495
nsv8890 CNV loss 18304495
nsv832312 CNV loss 17160897
nsv821465 CNV deletion 20802225
nsv821042 CNV deletion 20802225
nsv557114 CNV gain 21841781
nsv557113 CNV loss 21841781
nsv557112 CNV loss 21841781
nsv557111 CNV loss 21841781
nsv557110 CNV loss 21841781
nsv557107 CNV loss 21841781
nsv557106 CNV loss 21841781
nsv557105 CNV loss 21841781
nsv557101 CNV loss 21841781
nsv557096 CNV loss 21841781
nsv557089 CNV gain 21841781
nsv557085 CNV loss 21841781
nsv557084 CNV loss 21841781
nsv53179 CNV deletion 16902084
nsv528150 CNV loss 19592680
nsv527091 CNV loss 19592680
nsv527090 CNV loss 19592680
nsv526531 CNV loss 19592680
nsv516931 CNV loss 19592680
nsv483060 CNV loss 15286789
nsv472904 CNV novel sequence insertion 20440878
nsv472896 CNV novel sequence insertion 20440878
nsv468978 CNV loss 19166990
nsv468977 CNV loss 19166990
nsv468976 CNV loss 19166990
nsv1147991 CNV deletion 26484159
nsv1126308 CNV deletion 24896259
nsv1071002 CNV deletion 25765185
nsv1068058 CNV deletion 25765185
nsv1048174 CNV gain 25217958
esv8687 CNV loss 19470904
esv4288 CNV loss 18987735
esv3628342 CNV loss 21293372
esv3628341 CNV loss 21293372
esv3628340 CNV loss 21293372
esv3628339 CNV loss 21293372
esv3580361 CNV gain 25503493
esv3548648 CNV deletion 23714750

Variation tolerance for TSPAN9 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN9 Gene

Disorders for TSPAN9 Gene

Relevant External Links for TSPAN9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TSPAN9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN9 Gene

Publications for TSPAN9 Gene

  1. Sequence and expression of seven new tetraspans. (PMID: 10719184) Serru V. … Rubinstein E. (Biochim. Biophys. Acta 2000) 2 3 4 64
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  4. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. (PMID: 18795891) Protty M.B. … Tomlinson M.G. (Biochem. J. 2009) 3 4 64
  5. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64

Products for TSPAN9 Gene

Sources for TSPAN9 Gene

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