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TSPAN8 Gene

protein-coding   GIFtS: 56
GCID: GC12M071518

Tetraspanin 8

(Previous name: transmembrane 4 superfamily member 3)
(Previous symbol: TM4SF3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetraspanin 81 2     CO-0292
TM4SF31 2 3 5     tetraspanin-82
Transmembrane 4 Superfamily Member 31 2 3     tspan-82
Tumor-Associated Antigen CO-0292 3     Tspan-83

External Ids:    HGNC: 118551   Entrez Gene: 71032   Ensembl: ENSG000001273247   OMIM: 6007695   UniProtKB: P190753   

Export aliases for TSPAN8 gene to outside databases

Previous GC identifers: GC12M069806 GC12M068568


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPAN8 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known
to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation
sites has been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSPAN8 Gene:
TSPAN8 (tetraspanin 8) is a protein-coding gene. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is TSPAN2.

Gene Wiki entry for TSPAN8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN8 gene promoter:
         SRF   TBP   Bach2   SRF (504 AA)   LCR-F1   E47   FAC1   POU2F1   POU2F1a   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN8 promoter sequence
   Search Chromatin IP Primers for TSPAN8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1-q21.1   Ensembl cytogenetic band:  12q21.1   HGNC cytogenetic band: 12q14.1-q21.1

TSPAN8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M071518:  view genomic region     (about GC identifiers)

Start:
71,518,865 bp from pter      End:
71,835,678 bp from pter
Size:
316,814 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSN8_HUMAN, P19075 (See protein sequence)
Recommended Name: Tetraspanin-8  
Size: 237 amino acids; 26044 Da
Secondary accessions: B2R7T7 Q9BS78

Explore the universe of human proteins at neXtProt for TSPAN8: NX_P19075

Explore proteomics data for TSPAN8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn118
  • Modification sites at PhosphoSitePlus

  • See TSPAN8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004607.1  
    ENSEMBL proteins: 
     ENSP00000377003   ENSP00000247829   ENSP00000447160   ENSP00000449820  

    TSPAN8 Human Recombinant Protein Products:

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    antibodies-online proteins for TSPAN8 (7 products) 

     
    antibodies-online peptides for TSPAN8

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    antibodies-online antibodies for TSPAN8 (61 products) 

    TSPAN8 Assay Products:

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    antibodies-online kits for TSPAN8 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P19075

    ProtoNet protein and cluster: P19075

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN8_HUMAN, P19075
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Find genes that share domains with TSPAN8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity TAS2395876
         
    Find genes that share ontologies with TSPAN8           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TSPAN8

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN8_HUMAN, P19075: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome4
    vacuole4
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome TAS8661157
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TSPAN8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN8
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN8

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TSPAN8 (ENSP000002478294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1ENSP000003556454STRING: ENSP00000355645
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS2395876
    GO:0007165signal transduction TAS2395876
    GO:0030195negative regulation of blood coagulation IEA--

    Find genes that share ontologies with TSPAN8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN8 (TSN8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSPAN8 gene: 
    NM_004616.2  

    Unigene Cluster for TSPAN8:

    Tetraspanin 8
    Hs.170563  [show with all ESTs]
    Unigene Representative Sequence: BC070168
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393330(uc001swk.1) ENST00000247829(uc001swj.1) ENST00000546561(uc009zrt.1)
    ENST00000552128 ENST00000552786 ENST00000550818 ENST00000549421
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TSPAN8
      QuantiFast Probe-based Assays in human, mouse, rat TSPAN8

    Additional mRNA sequence: 

    AK223022.1 AK313112.1 BC005246.1 BC070168.1 M35252.1 

    11 DOTS entries:

    DT.91761980  DT.100679247  DT.100795484  DT.99958781  DT.97851205  DT.121127945  DT.121127930  DT.100025136 
    DT.40283665  DT.91761979  DT.95118117 

    Selected AceView cDNA sequences (see all 278):

    NM_004616 AI720812 BM829765 AW469383 BM836533 BM817951 AI075026 AI582486 
    CB115587 BM832339 BX448830 CB110161 CB111217 BM820405 CB110798 BM789526 
    CB158527 BQ084137 BQ083794 BQ717599 AA581843 BM856451 AW027816 AA135381 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAGCTAT
    TSPAN8 Expression
    About this image


    TSPAN8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    TSPAN8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170563

    UniProtKB/Swiss-Prot: TSN8_HUMAN, P19075
    Tissue specificity: Gastric, colon, rectal, and pancreatic carcinomas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN8 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspan81 , 5 tetraspanin 81, 5 73.48(n)1
    70.64(a)1
      10 (63.51 cM)5
    2163501  NM_146010.21  NP_666122.11 
     1158172845 
    chicken
    (Gallus gallus)
    Aves TSPAN81 tetraspanin 8 62.27(n)
    56.6(a)
      417854  NM_001199650.1  NP_001186579.1 
    lizard
    (Anolis carolinensis)
    Reptilia TSPAN86
    tetraspanin 8
    51(a)
    1 ↔ 1
    5(38174127-38197717)
    African clawed frog
    (Xenopus laevis)
    Amphibia tm4sf3-prov2 transmembrane 4 superfamily member 3 75.35(n)    BC054295.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tspan4b6
    tetraspanin 4b
    30(a)
    many ↔ many
    3(32723986-32733370) ENSDARG00000070391
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp5D6
    Tetraspanin 5D
    20(a)
    1 → many
    X(5963164-5968890)
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-86
    Protein TSP-8 (tsp-8) mRNA, complete cds
    22(a)
    1 → many
    X(14726626-14729482) WBGene00006634


    ENSEMBL Gene Tree for TSPAN8 (if available)
    TreeFam Gene Tree for TSPAN8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN8 gene
    TSPAN22  CD92  TSPAN12  CD372  TSPAN92  CD532  CD822  TSPAN182  
    CD812  TSPAN42  
    Selected SIMAP similar genes for TSPAN8 using alignment to 2 protein entries:     TSN8_HUMAN (see all proteins) (see all similar genes):
    BTCC-1    CD9    TSPAN2    CD151    TSPAN4    CD81
    TSPAN1    TSPAN18    TM4SF2    TSPAN33    TSPAN7    TSPAN9
    TSPAN6    CD63    TSPAN11    CD53    TSPAN3    CD82

    Find genes that share paralogs with TSPAN8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN8 (see all 804)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429660001,2
    Cuntested171531834(+) AATGCA/GATCAG 2 R C mis10--------
    rs603824231,2
    C--71518392(+) AAAGAG/ACTATA 1 -- ds50012Minor allele frequency- A:0.04WA 120
    rs1131996101,2
    F--71518454(+) AAAAAC/TGTTAA 1 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs774218941,2
    C--71518470(+) TCTGAG/TAACTA 1 -- ds50010--------
    rs111786351,2
    C,F,H--71518710(+) CAATGG/TTTGAT 1 -- ds50016Minor allele frequency- T:0.04NS CSA WA EA 351
    rs798559171,2
    F--71518744(+) TCTGAA/TAAGCC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1917987631,2
    --71518773(+) CTATCA/TATGGC 1 -- ds50010--------
    rs784413471,2
    C,F--71518794(+) TAGAGA/GTGATT 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs13902071,2
    C,F,O,A,H--71518841(-) AGGTGG/CTACAG 1 -- ds500124Minor allele frequency- C:0.15EA MN NS NA WA CSA 2741
    rs1466693281,2
    --71518887(+) AAACAA/GTTACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TSPAN8 (71518865 - 71768865 bp, first 250kb of TSPAN8)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TSPAN8 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746034CNV Deletion23290073
    esv2746035CNV Deletion23290073
    esv2746033CNV Deletion23290073
    nsv821005CNV Duplication20802225
    esv268889CNV Insertion20981092
    esv1243916CNV Insertion17803354
    esv274017CNV Insertion20981092
    esv2569493CNV Insertion19546169
    esv24361CNV Loss19812545
    dgv294n67CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TSPAN8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600769    OMIM disorders: --


    Find genes that share disorders with TSPAN8           About GenesLikeMe

    Genetic Association Database (GAD): TSPAN8
    Human Genome Epidemiology (HuGE) Navigator: TSPAN8 (42 documents)

    Export disorders for TSPAN8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN8 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with TSPAN8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA for the human tumor-associated antigen CO- 029 and identification of related transmembrane antigens. (PubMed id 2395876)1, 2, 3, 9 Szala S....Linnenbach A.J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
    3. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. (PubMed id 19833888)1, 4 Simonis-Bik A.M....'t Hart L.M. (Diabetes 2010)
    4. Impact of single nucleotide polymorphisms and of clinical risk factors on newa89onset diabetes mellitus in HIVa89infected individuals. (PubMed id 20879858)1, 4 Rotger M....Tarr P.E. (Clin. Infect. Dis. 2010)
    5. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. (PubMed id 20490451)1, 4 Andersson E.A....Pedersen O. (Diabetologia 2010)
    6. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. (PubMed id 20161779)1, 4 Wen J....Hu R. (PLoS ONE 2010)
    7. Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (Hum. Hered. 2010)
    8. Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia. (PubMed id 20052686)1, 4 Scholz C.J....Reif A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1, 4 Voight B.F.... . (Nat. Genet. 2010)
    10. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7103 HGNC: 11855 AceView: TM4SF3 Ensembl:ENSG00000127324 euGenes: HUgn7103
    ECgene: TSPAN8 H-InvDB: TSPAN8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TSPAN8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPAN8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for TSPAN8 gene:
    Search GeneIP for patents involving TSPAN8

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