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TSPAN7 Gene

protein-coding   GIFtS: 61
GCID: GC0XP038420

Tetraspanin 7

(Previous names: transmembrane 4 superfamily member 2, mental retardation,...)
(Previous symbols: MXS1, TM4SF2, MRX58)
  See TSPAN7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetraspanin 71 2     Mental Retardation, X-Linked 581
MXS11 2 3 5     CCG-B72
TM4SF21 2 3 5     CD2312
Transmembrane 4 Superfamily Member 21 2 3     TM4SF2b2
MRX581 2 5     Membrane Component, X Chromosome, Surface Marker 12
A152 3 5     T-Cell Acute Lymphoblastic Leukemia Associated Antigen 12
Cell Surface Glycoprotein A152 3     Tetraspanin Protein2
Membrane Component Chromosome X Surface Marker 12 3     tetraspanin-72
DXS1692E2 3     Transmembrane 4 Superfamily 2b2
TALLA-12 3     Transmembrane Protein A152
CD231 Antigen2 3     tspan-72
T-Cell Acute Lymphoblastic Leukemia-Associated Antigen 12 3     Tspan-73

External Ids:    HGNC: 118541   Entrez Gene: 71022   Ensembl: ENSG000001562987   OMIM: 3000965   UniProtKB: P417323   

Export aliases for TSPAN7 gene to outside databases

Previous GC identifers: GC00U921555 GC0XP038177 GC0XP038305 GC0XP037208 GC0XP036165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TSPAN7 Gene:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin
family. Most of these members are cell-surface proteins that are characterized by the presence of four
hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell
development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a
role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with
X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and
myotonic dystrophy. (provided by RefSeq, Jul 2008)

GeneCards Summary for TSPAN7 Gene:
TSPAN7 (tetraspanin 7) is a protein-coding gene. Diseases associated with TSPAN7 include lymphoblastic leukemia, and chorea. An important paralog of this gene is CD151.

UniProtKB/Swiss-Prot: TSN7_HUMAN, P41732
Function: May be involved in cell proliferation and cell motility

Gene Wiki entry for TSPAN7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the TSPAN7 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTSPAN7 promoter sequence
   Search Chromatin IP Primers for TSPAN7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TSPAN7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp11.4

TSPAN7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TSPAN7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP038420:  view genomic region     (about GC identifiers)

Start:
38,420,623 bp from pter      End:
38,548,172 bp from pter
Size:
127,550 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSN7_HUMAN, P41732 (See protein sequence)
Recommended Name: Tetraspanin-7  
Size: 249 amino acids; 27574 Da
Subunit: Interacts with herpes simplex virus 1 (HHV-1) UL35
Sequence caution: Sequence=BAA01501.1; Type=Erroneous initiation; Sequence=BAA06191.1; Type=Erroneous initiation;
Secondary accessions: B2R5W7 D3DWB1 Q8WVG5 Q9UEY9

Explore the universe of human proteins at neXtProt for TSPAN7: NX_P41732

Explore proteomics data for TSPAN7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn54, Asn155, Asn158, Asn177, Asn188
  • Modification sites at PhosphoSitePlus

  • See TSPAN7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004606.2  
    ENSEMBL proteins: 
     ENSP00000367743   ENSP00000419290   ENSP00000419321   ENSP00000418586   ENSP00000286824  
     ENSP00000388954   ENSP00000441540  

    TSPAN7 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for TSPAN7
    Sino Biological Cell Lysate for TSPAN7
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    Cloud-Clone Corp. Proteins for TSPAN7

     
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    antibodies-online proteins for TSPAN7 (3 products) 

     
    antibodies-online peptides for TSPAN7

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    antibodies-online antibodies for TSPAN7 (31 products) 

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    antibodies-online kits for TSPAN7 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    TSPAN: Tetraspanins

    4 InterPro protein domains:
     IPR018499 Tetraspanin/Peripherin
     IPR000301 Tetraspanin
     IPR008952 Tetraspanin_EC2
     IPR018503 Tetraspanin_CS

    Graphical View of Domain Structure for InterPro Entry P41732

    ProtoNet protein and cluster: P41732

    1 Blocks protein domain: IPB000301 Transmembrane four family signature

    UniProtKB/Swiss-Prot: TSN7_HUMAN, P41732
    Similarity: Belongs to the tetraspanin (TM4SF) family


    Find genes that share domains with TSPAN7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSN7_HUMAN, P41732
    Function: May be involved in cell proliferation and cell motility

    Animal Models:

       genOway: Develop your customized and physiologically relevant rodent model for TSPAN7

    miRNA
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    miRTarBase miRNAs that target TSPAN7:
    hsa-mir-744-5p (MIRT037691)

    Block miRNA regulation of human, mouse, rat TSPAN7 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TSPAN7:
    hsa-miR-3146 hsa-miR-4305 hsa-miR-374c hsa-miR-338-5p hsa-miR-655 hsa-miR-1264 hsa-miR-194 hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TSPAN7
    Predesigned siRNA for gene silencing in human, mouse, rat TSPAN7

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TSPAN7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSN7_HUMAN, P41732: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS8420826
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with TSPAN7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TSPAN7 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with TSPAN7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for TSPAN7):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TSPAN7
    Interactions:

        Search GeneGlobe Interaction Network for TSPAN7

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for TSPAN7 (P417322, 3 ENSP000003677434) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYTTD1Q96QD92, 3, ENSP000002415024MINT-65312 I2D: score=3 STRING: ENSP00000241502
    KPTNQ9Y6643, ENSP000003378504I2D: score=1 STRING: ENSP00000337850
    RBL1P287493, ENSP000003627684I2D: score=1 STRING: ENSP00000362768
    CACNA1AO005553I2D: score=1 
    CREB3O438893I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with TSPAN7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TSPAN7 (TSN7)

    4 Novoseek inferred chemical compound relationships for TSPAN7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 26.8 1 10491398 (1)
    phosphoinositide 19.8 1 11042117 (1)
    lipid 10.7 3 17727684 (1), 11113129 (1), 16753027 (1)
    cholesterol 6.91 1 15496196 (1)



    Find genes that share compounds with TSPAN7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TSPAN7 gene: 
    NM_004615.3  

    Unigene Cluster for TSPAN7:

    Tetraspanin 7
    Hs.441664  [show with all ESTs]
    Unigene Representative Sequence: AB062057
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378482(uc004deg.4 uc011mkj.2 uc011mkk.2) ENST00000471410
    ENST00000480976 ENST00000475216 ENST00000286824 ENST00000488893 ENST00000494037
    ENST00000419600 ENST00000422612 ENST00000545599
    miRNA
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    Block miRNA regulation of human, mouse, rat TSPAN7 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TSPAN7:
    hsa-miR-3146 hsa-miR-4305 hsa-miR-374c hsa-miR-338-5p hsa-miR-655 hsa-miR-1264 hsa-miR-194 hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidTSPAN7 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TSPAN7 (NM_004615)
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    Primer
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    OriGene qPCR primer pairs and template standards for TSPAN7
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TSPAN7
      QuantiTect SYBR Green Assays in human, mouse, rat TSPAN7
      QuantiFast Probe-based Assays in human, mouse, rat TSPAN7

    Additional mRNA sequence: 

    AB062057.1 AB102665.1 AF147326.1 AK293178.1 AK293534.1 AK293552.1 AK312343.1 BC018036.1 
    D10653.1 D29808.1 L10373.1 

    Selected DOTS entries (see all 26):

    DT.100825949  DT.100825963  DT.418809  DT.92458951  DT.95180519  DT.92458947  DT.95180514  DT.102827049 
    DT.100825965  DT.100825962  DT.97848331  DT.100825973  DT.101970988  DT.121280495  DT.40230686  DT.95180525 
    DT.100658660  DT.100825958  DT.100825961  DT.121280466  DT.121280480  DT.121280491  DT.121280515  DT.40297344 

    Selected AceView cDNA sequences (see all 563):

    AW090504 BP362414 CR601568 BG655490 CR607095 CR607558 CR602586 BM353006 
    BQ684462 CR610848 D29808 BP348331 AW089614 BI550533 AW264054 CA943758 
    BI772400 BM672060 CR605008 AB102665 CR604054 BU151413 BP342341 AA322362 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TSPAN7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAACAAGAA
    TSPAN7 Expression
    About this image


    TSPAN7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Medulla Oblongata
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Inner Cell Mass (Early Embryonic Tissues)
             hIPS1
     
     Eye (Sensory Organs)
             Retina
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    TSPAN7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TSPAN7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.441664

    UniProtKB/Swiss-Prot: TSN7_HUMAN, P41732
    Tissue specificity: Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TSPAN7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tspan71 , 5 tetraspanin 71, 5 93.44(n)1
    98.39(a)1
      X (4.85 cM)5
    219121  NM_019634.21  NP_062608.21 
     104851585 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    83(a)
    1 → many
    1(112106635-112126203)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    93(a)
    1 → many
    3(132519863-132616714)
    African clawed frog
    (Xenopus laevis)
    Amphibia tm4sf2-prov2 transmembrane 4 superfamily member 2 81.99(n)    BC044697.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb53h112 wufb53h11 80.31(n)   322231  CK362475.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tsp-146
    Protein TSP-14, isoform a (tsp-14) mRNA, complete ...
    13(a)
    1 → many
    X(4866683-4874657) WBGene00006640


    ENSEMBL Gene Tree for TSPAN7 (if available)
    TreeFam Gene Tree for TSPAN7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TSPAN7 gene
    CD1512  TSPAN52  TSPAN102  TSPAN172  TSPAN332  TSPAN62  CD632  TSPAN32  
    TSPAN152  TSPAN112  TSPAN142  ENSG000002503492  
    15 SIMAP similar genes for TSPAN7 using alignment to 7 protein entries:     TSN7_HUMAN (see all proteins):
    TM4SF2    TSPAN6    CD63    CD151    TSPAN8    TSPAN33
    CD82    TSPAN17    TSPAN1    TSPAN3    TM4SF9    TSPAN11
    TSPAN18    TSPAN9    TSPAN5

    Find genes that share paralogs with TSPAN7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TSPAN7 (see all 1648)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0092594
    Mental retardation, X-linked 58 (MRX58)4--see VAR_0092592 P H mis40--------
    rs1048949511,2
    C,Fpathogenic138535032(+) CCCCCC/ACAGCT 2 /H /P mis11Minor allele frequency- A:0.00NA 4548
    rs1048949501,2
    Cpathogenic138540512(+) TCGCTG/TGAGTG 2 G * stg10--------
    rs1857648891,2
    --36163444(+) CACAAC/TTGGAG 1 -- us2k10--------
    rs1894335141,2
    --36163446(+) CAATTA/GGAGAG 1 -- us2k10--------
    rs64178281,2
    C,F,A,H--36163726(+) TGACCT/CCTTTA 1 -- us2k115Minor allele frequency- C:0.35NS EA WA NA 1980
    rs64178291,2
    C,F,A,H--36163772(+) TAAGGA/TTACCC 1 -- us2k18Minor allele frequency- T:0.35NS EA NA WA 424
    rs38274351,2
    C,F,A,H--36163898(-) GCCCCA/GTACTG 1 -- us2k1 tfbs37Minor allele frequency- G:0.35NS EA WA NA 422
    rs37615701,2
    C,A--38418786(-) TCCGCT/GTTTTA 1 -- us2k14Minor allele frequency- G:0.00WA NA CSA 7
    rs10403501,2
    C,F,O,A,H--38419130(+) ACCTTA/GGCAGG 1 -- us2k124Minor allele frequency- G:0.34NA EA MN NS WA 2778

    HapMap Linkage Disequilibrium report for TSPAN7 (38420623 - 38548172 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TSPAN7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520210CNV Gain19592680

    Human Gene Mutation Database (HGMD): TSPAN7
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing TSPAN7:
    Intellectual Disability
    SeqTarget long-range PCR primers for resequencing TSPAN7
    DNA2.0 Custom Variant and Variant Library Synthesis for TSPAN7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300096   
    OMIM disorders: 300210  
    UniProtKB/Swiss-Prot: TSN7_HUMAN, P41732
  • Mental retardation, X-linked 58 (MRX58) [MIM:300210]: A disorder characterized by significantly below
    average general intellectual functioning associated with impairments in adaptive behavior and manifested during
    the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental
    retardation, while syndromic mental retardation presents with associated physical, neurological and/or
    psychiatric manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for TSPAN7:    
    About MalaCards
    lymphoblastic leukemia    chorea    miliaria rubra    fragile x syndrome
    miliaria    myotonic dystrophy    mental retardation    mental retardation, x-linked 17/31, microduplication

    2 diseases from the University of Copenhagen DISEASES database for TSPAN7:
    Miliaria rubra     Intellectual disability

    Find genes that share disorders with TSPAN7           About GenesLikeMe

    4 Novoseek inferred disease relationships for TSPAN7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 24.7 3 16271511 (1), 16331263 (1), 18415123 (1)
    tumors 13.5 3 17018612 (1), 14633590 (1), 16537545 (1)
    prostate cancer 0 1 16331263 (1)
    cancer 0 1 17727684 (1)

    Genetic Association Database (GAD): TSPAN7
    Human Genome Epidemiology (HuGE) Navigator: TSPAN7 (1 document)

    Export disorders for TSPAN7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TSPAN7 gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with TSPAN7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. (PubMed id 10655063)1, 2, 9 Zemni R.... Chelly J. (Nat. Genet. 2000)
    2. Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein. (PubMed id 20630051)1, 2 Wang L.... Li Q. (Virol. J. 2010)
    3. Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. (PubMed id 19736351)1, 4 Guilmatre A....Campion D. (Arch. Gen. Psychiatry 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58. (PubMed id 12070254)1, 3 Abidi F.E....Schwartz C.E. (J. Med. Genet. 2002)
    6. Identification of a highly specific surface marker of T-cell acute lymphoblastic leukemia and neuroblastoma as a new member of the transmembrane 4 superfamily. (PubMed id 7768645)1, 2 Takagi S.... Yoshie O. (Int. J. Cancer 1995)
    7. Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily. (PubMed id 8420826)1, 2 Emi N.... Takahashi T. (Immunogenetics 1993)
    8. Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins. (PubMed id 8168850)1, 9 Virtaneva K.I....SchrAPder J.P. (Immunogenetics 1994)
    9. Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. (PubMed id 17989173)1, 9 Sato K....Koyanagi Y. (J. Virol. 2008)
    10. Novel partners of SPAG11B isoform D in the human male reproductive tract. (PubMed id 19535787)1, 9 Radhakrishnan Y....French F.S. (Biol. Reprod. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7102 HGNC: 11854 AceView: TM4SF2 Ensembl:ENSG00000156298 euGenes: HUgn7102
    ECgene: TSPAN7 Kegg: 7102 H-InvDB: TSPAN7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TSPAN7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TSPAN7 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TSPAN7[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TSPAN7 gene:
    Search GeneIP for patents involving TSPAN7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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