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Aliases for TSPAN7 Gene

Aliases for TSPAN7 Gene

  • Tetraspanin 7 2 3 5
  • Transmembrane 4 Superfamily Member 2 2 3 4
  • T-Cell Acute Lymphoblastic Leukemia-Associated Antigen 1 3 4
  • Membrane Component Chromosome X Surface Marker 1 3 4
  • Cell Surface Glycoprotein A15 3 4
  • CD231 Antigen 3 4
  • DXS1692E 3 4
  • Tspan-7 3 4
  • TALLA-1 3 4
  • TM4SF2 3 4
  • MXS1 3 4
  • A15 3 4
  • T-Cell Acute Lymphoblastic Leukemia Associated Antigen 1 3
  • Membrane Component, X Chromosome, Surface Marker 1 3
  • Mental Retardation, X-Linked 58 2
  • Transmembrane 4 Superfamily 2b 3
  • Transmembrane Protein A15 3
  • Tetraspanin Protein 3
  • TM4SF2b 3
  • CCG-B7 3
  • CD231 3
  • MRX58 3

External Ids for TSPAN7 Gene

Previous HGNC Symbols for TSPAN7 Gene

  • MXS1
  • TM4SF2
  • MRX58

Previous GeneCards Identifiers for TSPAN7 Gene

  • GC00U921555
  • GC0XP038177
  • GC0XP038305
  • GC0XP037208
  • GC0XP038420
  • GC0XP036165

Summaries for TSPAN7 Gene

Entrez Gene Summary for TSPAN7 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN7 Gene

TSPAN7 (Tetraspanin 7) is a Protein Coding gene. Diseases associated with TSPAN7 include non-syndromic x-linked intellectual disability and miliaria rubra. Among its related pathways are Transmission across Chemical Synapses and Transcriptional misregulation in cancer. An important paralog of this gene is ENSG00000250349.

UniProtKB/Swiss-Prot for TSPAN7 Gene

  • May be involved in cell proliferation and cell motility.

Gene Wiki entry for TSPAN7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN7 Gene

Genomics for TSPAN7 Gene

Regulatory Elements for TSPAN7 Gene

Promoters for TSPAN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TSPAN7 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TSPAN7 gene promoter:

Genomic Location for TSPAN7 Gene

Chromosome:
X
Start:
38,561,370 bp from pter
End:
38,688,920 bp from pter
Size:
127,551 bases
Orientation:
Plus strand

Genomic View for TSPAN7 Gene

Genes around TSPAN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN7 Gene

Proteins for TSPAN7 Gene

  • Protein details for TSPAN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41732-TSN7_HUMAN
    Recommended name:
    Tetraspanin-7
    Protein Accession:
    P41732
    Secondary Accessions:
    • B2R5W7
    • D3DWB1
    • Q8WVG5
    • Q9UEY9

    Protein attributes for TSPAN7 Gene

    Size:
    249 amino acids
    Molecular mass:
    27574 Da
    Quaternary structure:
    • Interacts with herpes simplex virus 1 (HHV-1) UL35.
    SequenceCaution:
    • Sequence=BAA01501.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA06191.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TSPAN7 Gene

Proteomics data for TSPAN7 Gene at MOPED

Post-translational modifications for TSPAN7 Gene

  • Glycosylation at Asn 54, Asn 155, Asn 158, Asn 177, and Asn 188
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN7 Gene

No data available for DME Specific Peptides for TSPAN7 Gene

Domains & Families for TSPAN7 Gene

Graphical View of Domain Structure for InterPro Entry

P41732

UniProtKB/Swiss-Prot:

TSN7_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN7: view

Function for TSPAN7 Gene

Molecular function for TSPAN7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell proliferation and cell motility.

Phenotypes for TSPAN7 Gene

GenomeRNAi human phenotypes for TSPAN7:
genes like me logo Genes that share phenotypes with TSPAN7: view

Human Phenotype Ontology for TSPAN7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for TSPAN7 Gene

miRTarBase miRNAs that target TSPAN7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN7 Gene

Localization for TSPAN7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TSPAN7 Gene COMPARTMENTS Subcellular localization image for TSPAN7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TSPAN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN7: view

Pathways & Interactions for TSPAN7 Gene

genes like me logo Genes that share pathways with TSPAN7: view

Gene Ontology (GO) - Biological Process for TSPAN7 Gene

None

No data available for SIGNOR curated interactions for TSPAN7 Gene

Drugs & Compounds for TSPAN7 Gene

(1) Drugs for TSPAN7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TSPAN7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSPAN7: view

Transcripts for TSPAN7 Gene

Unigene Clusters for TSPAN7 Gene

Tetraspanin 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN7 Gene

No ASD Table

Relevant External Links for TSPAN7 Gene

GeneLoc Exon Structure for
TSPAN7
ECgene alternative splicing isoforms for
TSPAN7

Expression for TSPAN7 Gene

mRNA expression in normal human tissues for TSPAN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.1), Brain - Putamen (basal ganglia) (x4.9), Brain - Frontal Cortex (BA9) (x4.8), Brain - Caudate (basal ganglia) (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for TSPAN7 Gene

This gene is overexpressed in Pancreas (12.8), Frontal cortex (11.9), Cervix (9.9), Adrenal (8.0), and Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN7 Gene



SOURCE GeneReport for Unigene cluster for TSPAN7 Gene Hs.441664

mRNA Expression by UniProt/SwissProt for TSPAN7 Gene

P41732-TSN7_HUMAN
Tissue specificity: Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.
genes like me logo Genes that share expression patterns with TSPAN7: view

Protein tissue co-expression partners for TSPAN7 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TSPAN7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN7 36
  • 100 (a)
OneToOne
TSPAN7 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TSPAN7 35
  • 93.44 (n)
  • 97.59 (a)
TSPAN7 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 85 (a)
OneToMany
TSPAN7 35
  • 94.11 (n)
  • 99.6 (a)
mouse
(Mus musculus)
Mammalia Gm5334 36
  • 64 (a)
ManyToMany
Tspan7 36
  • 98 (a)
ManyToMany
Tspan7 16
Tspan7 35
  • 93.44 (n)
  • 98.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tspan7 35
  • 93.51 (n)
  • 97.74 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 83 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia tm4sf2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76243 35
tspan7 35
  • 79.52 (n)
  • 89.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.702 35
zebrafish
(Danio rerio)
Actinopterygii tspan7b 36
  • 84 (a)
OneToMany
tspan7b 35
  • 77.24 (n)
  • 83.94 (a)
wufb53h11 35
worm
(Caenorhabditis elegans)
Secernentea tsp-14 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7928 36
  • 38 (a)
OneToMany
Species with no ortholog for TSPAN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN7 Gene

ENSEMBL:
Gene Tree for TSPAN7 (if available)
TreeFam:
Gene Tree for TSPAN7 (if available)

Paralogs for TSPAN7 Gene

genes like me logo Genes that share paralogs with TSPAN7: view

Variants for TSPAN7 Gene

Sequence variations from dbSNP and Humsavar for TSPAN7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_009259 Mental retardation, X-linked 58 (MRX58)
rs17851592 - 38,666,196(+) TTGCC(A/G)AGAAC reference, missense
rs17851593 - 38,674,254(+) CGGAC(A/G)CTATG reference, missense
rs754341 -- 38,600,898(+) AGTGG(C/T)GTTTT intron-variant
rs963481 -- 38,625,725(+) ATTAG(A/T)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN7 Gene

Variant ID Type Subtype PubMed ID
nsv520210 CNV Gain 19592680

Variation tolerance for TSPAN7 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN7 Gene

HapMap Linkage Disequilibrium report
TSPAN7
Human Gene Mutation Database (HGMD)
TSPAN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN7 Gene

Disorders for TSPAN7 Gene

MalaCards: The human disease database

(12) MalaCards diseases for TSPAN7 Gene - From: GeneTests, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TSN7_HUMAN
  • Mental retardation, X-linked 58 (MRX58) [MIM:300210]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:10655063}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TSPAN7

Genetic Association Database (GAD)
TSPAN7
Human Genome Epidemiology (HuGE) Navigator
TSPAN7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN7
genes like me logo Genes that share disorders with TSPAN7: view

No data available for Genatlas for TSPAN7 Gene

Publications for TSPAN7 Gene

  1. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. (PMID: 10655063) Zemni R. … Chelly J. (Nat. Genet. 2000) 3 4 23 67
  2. Novel partners of SPAG11B isoform D in the human male reproductive tract. (PMID: 19535787) Radhakrishnan Y. … French F.S. (Biol. Reprod. 2009) 3 23
  3. Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins. (PMID: 17989173) Sato K. … Koyanagi Y. (J. Virol. 2008) 3 23
  4. A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58. (PMID: 12070254) Abidi F.E. … Schwartz C.E. (J. Med. Genet. 2002) 2 3
  5. Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins. (PMID: 8168850) Virtaneva K.I. … SchrAPder J.P. (Immunogenetics 1994) 3 23

Products for TSPAN7 Gene

Sources for TSPAN7 Gene

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